KEGG   ENZYME: 1.14.99.50
Entry
EC 1.14.99.50               Enzyme                                 
Name
gamma-glutamyl hercynylcysteine S-oxide synthase;
EgtB
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
Sysname
hercynine,gamma-L-glutamyl-L-cysteine:oxygen oxidoreductase [gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide-forming]
Reaction(IUBMB)
hercynine + gamma-L-glutamyl-L-cysteine + O2 = gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O [RN:R11013]
Reaction(KEGG)
R11013
Substrate
hercynine [CPD:C05575];
gamma-L-glutamyl-L-cysteine [CPD:C00669];
O2 [CPD:C00007]
Product
gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide [CPD:C20995];
H2O [CPD:C00001]
Comment
Requires Fe2+ for activity. The enzyme, found in bacteria, is specific for both hercynine and gamma-L-glutamyl-L-cysteine. It is part of the biosynthesis pathway of ergothioneine.
History
EC 1.14.99.50 created 2015
Pathway
ec00340  Histidine metabolism
ec01100  Metabolic pathways
Orthology
K18912  gamma-glutamyl hercynylcysteine S-oxide synthase
Genes
MXAMXAN_7471
MSDMYSTI_08112
MYMA176_007056
MFBMFUL124B02_43140
CCXCOCOR_08067
MFULILAB_08965
MMASMYMAC_007188
SURSTAUR_8337
AGEAA314_00408
AVMJQX13_14740(egtB)
MBDMEBOL_003283
CFUSCYFUS_009889
VINAKJ08_3637
EUZDVS28_a3891
MTURv3703c(etgB)
MTVRVBD_3703c
MTCMT3806
MRAMRA_3739
MTFTBFG_13734
MTBTBMG_03746
MTKTBSG_03770
MTZTBXG_003717
MTIMRGA423_23350
MTECCDC5079_3434
MTURCFBS_3924
MTLCCDC5180_3385
MTOMTCTRI2_3773
MTDUDA_3703c
MTNERDMAN_4056
MTJJ112_19900
MTUBMT7199_3768
MTUEJ114_19780
MTXM943_19025
MTUHI917_25965
MTULTBHG_03638
MTUTHKBT1_3908
MTUUHKBT2_3918
MTQHKBS1_3921
MBOBQ2027_MB3729C
MBBBCG_3762c
MBTJTY_3764
MBMBCGMEX_3763c
MBKK60_038420
MBXBCGT_3565
MAFMAF_37110
MMICRN08_4083
MCEMCAN_37241
MCQBN44_120101
MCVBN43_90210
MCXBN42_90219
MCZBN45_110059
MORYMO_003859(egtB)
MPAMAP_0305c
MAOMAP4_3566
MAVIRC58_17720
MAVURE97_17750
MAVMAV_0400
MITOCO_03530
MIAOCU_03600
MIDMIP_00737
MYOOEM_03650
MCHIAN480_01800
MIROCQ_03550
MMALCKJ54_01705
MMANMMAN_46290(egtB)
MSAMycsm_06029
MULMUL_4287
MMIMMAR_5214
MMAEMMARE11_50370
MLIMULP_05491(egtB)
MPSEMPSD_02550(egtB)
MSHOMSHO_10430(egtB)
MMCMmcs_4881
MKMMkms_4970
MJLMjls_5249
MMMW7S_01735
MKNMKAN_13330
MYVG155_27730
MYEAB431_27335
MHADB586_03745
MDXBTO20_03100
MSHGMSG_04707(egtB)
MFJMFLOJ_39060(egtB)
MSTOMSTO_42920(egtB)
MSIMMSIM_27470(egtB)
MSAKMSAS_31090(egtB)
MKUI2456_26530
MLWMJO58_25950(egtB)
MXEMYXE_03630(egtB)
MNVMNVI_14050(egtB)
MPAGC0J29_28790
MNMMNVM_22160(egtB)
MGORH0P51_26685
MCOOMCOO_28660(egtB)
MBAIMB901379_04624(egtB)
MSEOMSEO_36230(egtB)
MHEKJMUB5695_00320(egtB_1)
MGAUMGALJ_40200(egtB)
MLJMLAC_45720(egtB)
MBRDMBRA_18290(egtB)
MSHJMSHI_37070(egtB)
MMAMK3U93_23420(egtB)
MSPGF6B93_21315(egtB)
MOTLTS72_26790(egtB)
MPAAMKK62_01130(egtB)
MMEHM5I08_01165(egtB)
MKYIWGMT90018_59440(egtB)
MADIA7U43_05425
MWUPT015_16290(egtB)
MSMMSMEG_6249
MSGMSMEI_6088
MSBLJ00_30900
MSNLI99_30905
MSHLI98_30910
MVAMvan_5485
MGIMflv_1316
MSPMspyr1_48630
MCBMycch_4830
MNED174_25565
MYNMyAD_25105
MFTXA26_56040
MPHLMPHLCCUG_00352(egtB)
MVQMYVA_5375
MLLB1R94_26515
MRHMycrhN_2099
MTHN4412656_04308(egtB)
MHASMHAS_03908(egtB)
MDUMDUV_47500(egtB)
MCHTMCHIJ_17960(egtB)
MDRMDOR_34100(egtB)
MAUUNCTC10437_05230(egtB)
MMAGMMAD_50030(egtB)
MMORMMOR_09290(egtB)
MFXMFAL_07400(egtB)
MAICMAIC_03580(egtB)
MIJMINS_21330(egtB)
MALVMALV_39930(egtB)
MTYMTOK_19900(egtB)
MPSCMPSYJ_14310(egtB)
MARZMARA_45900(egtB)
MGADMGAD_39090(egtB)
MHEVMHEL_26090(egtB)
MSARMSAR_12310(egtB)
MANYMANY_34910(egtB)
MAUBMAUB_28610(egtB)
MPOFMPOR_01140(egtB)
MPHUMPHO_41570(egtB)
MMUCC1S78_026770
MMATMMAGJ_31190(egtB)
MBOKMBOE_07350(egtB)
MFGK6L26_04005(egtB)
MSEIMSEDJ_04770(egtB)
MFLVNCTC10271_00325(egtB)
MCEEMCEL_35670(egtB)
MMONEWR22_26370(egtB)
MGOAFA91_03455
MHOLK3U96_02215(egtB)
MSENK3U95_26780(egtB)
MPAEK0O64_26860(egtB)
MRFMJO55_25030(egtB)
MDFK0O62_26750(egtB)
MCROMI149_27195(egtB)
MGROFZ046_03795
MKRMKOR_31820(egtB)
MPAKMIU77_00535(egtB)
MABMAB_0370
MMVMYCMA_0194
MABBMASS_0366
MABLMMASJCM_0362
MCHEBB28_01805
MIZBAB75_02370
MSTEMSTE_00329(egtB)
MSAOMYCSP_01620
MSALDSM43276_00320(egtB)
MJDJDM601_3983
MTER4434518_03930(egtB)
MMINMMIN_14030(egtB)
MHIBMHIB_32430(egtB)
MHERK3U94_21795(egtB)
MVMMJO54_21650(egtB)
ASDAS9A_2109
NFANFA_48860
NFRERS450000_05023(egtB)
NCYNOCYR_4672
NBRO3I_037000
NNONONO_c66360(egtB)
NSLBOX37_27040
NSRNS506_01659
NTPCRH09_34705
NOZDMB37_15940
NODFOH10_01805
NAHF5544_39500(egtB)
NADNCTC11293_06260(egtB)
NWLNWFMUON74_10230(egtB)
NIEKV110_36250(egtB)
NTCKHQ06_11070(egtB)
NHUH0264_10230
NYALTV02_22545(egtB)
NGPLTT66_17700(egtB)
NSPUIFM12276_06320(egtB)
RHARHA1_ro05701
RERRER_43190
REYO5Y_20240
REBXU06_20410
RQIC1M55_21755
ROPROP_57700
ROAPd630_LPD02316
RPYY013_21555
RBYCEJ39_08075
RHBNY08_2332
RAVAAT18_07295
RFAA3L23_00521(egtB)
RHSA3Q41_02832(egtB)
RHWBFN03_01855
RRZCS378_22365
RHUA3Q40_02533(egtB)
RHQIM25_11345
RHODAOT96_01800
RRT4535765_01115(egtB)
RCRNCTC10994_01625(egtB)
RTMG4H71_04785
RKOJWS14_31225(egtB)
RGOKYT97_28830(egtB)
ROZCBI38_22565
RPSKJWS13_13070(egtB)
RGORNMQ04_04970(egtB)
RANTRHODO2019_07230(egtB)
RHOPD8W71_11045
REQREQ_12470
WHROG579_12990(egtB)
SPINKV203_14470(egtB)
TPULTPB0596_00190(egtB)
TOYFO059_06625(egtB)
SCOSCO0911(SCM1.44)
SALBXNR_5671
SMASAVERM_7340(egtB)
SGRSGR_696
SGBWQO_31710
SFISFUL_6745
SANLKZO11_35050(egtB)
SGRFSGFS_097280
SCYER2B67_02180(egtB)
SCBSCAB_11221
SSXSACTE_6224
SVLStrvi_4091
SHYSHJG_7894
SHOSHJGH_7656
SRCM271_04965
SMALSMALA_7432
SSOII1A49_40920
SFASfla_0405
SBHSBI_01719
SVESVEN_6869
SDVBN159_1330
SALSSLNWT_7177
STRPF750_6594
SCIB446_32015
SLVSLIV_33375(egtB)
SGUSGLAU_29365(egtB)
SVTSVTN_34055
STREGZL_01888
SCWTU94_30475
SLDT261_1095
SLCSL103_23135
SXISXIM_40580
STRMM444_29585
SAMBSAM23877_6629(egtB)
SPRISPRI_0729
SCZABE83_02230
SCXAS200_07585
SRWTUE45_00193(egtB)
STRFASR50_31995
SLEsle_06840(sle_06840)
SRNA4G23_05244(egtB)
SPAVSpa2297_29075
STRTA8713_28675
SCLFBB341_01705
SGSAVL59_16360
STSIA4E84_35870
SKYD0C37_30435
SALWCP975_32110(egtB)
SGMGCM10017557_08710(egtB)
SCADDN051_06565
SPHWNFX46_13780(egtB)
SLSSLINC_7408
SNRSNOUR_08405(egtB)
SALUDC74_6878
SALLSAZ_35730
SPLULK06_001540
STRDNI25_03145
SNWBBN63_03435
SAUOBV401_40780
SSIAA7J05_03970
SVUB1H20_32555
SPUNBFF78_04715
SGVB1H19_34880
SLAUSLA_6650
SALFSMD44_07736
SALJSMD11_0805
SLXSLAV_06110(egtB)
STROSTRMOE7_32370
SFKKY5_7467c
SNZDC008_30825
SGEDWG14_01145(egtB)
SRJSRO_0886
SLKSLUN_35085
SDXC4B68_03750
SGDELQ87_04130
SQZFQU76_31355
SCYAEJ357_04505
SASTCD934_31550
SNQCP978_05155(egtB)
STIRDDW44_28485
SKACP970_02855(egtB)
SGZC0216_12620
SVNCP980_05100
SNKCP967_00605
SHAWCEB94_36725
SRKFGW37_27940
SFICEIZ62_03275
SGALCP966_32090
SSPODDQ41_29465
SVRCP971_05375
SPADDVK44_31780
SFYGFH48_07295(egtB)
SAQUEJC51_40715
SGFHEP81_00865(egtB)
SCAVCVT27_31300
SSEOD0Z67_26305(egtB)
SBYH7H31_32640
SRIMCP984_04945(egtB)
SSUBCP968_05390
SPHVF9278_42715
SCINCP977_30680(egtB)
SFUGCNQ36_03150
SPACB1H29_03970
STSUB7R87_31265
SCHACP983_04570
SGXH4W23_35705
SCOECP976_38165
SBATG4Z16_03285
SSPBCP982_35770
SNFJYK04_07184(egtB)
SPLACP981_32930(egtB)
SBROGQF42_38865(egtB)
STUIGCM10017668_06260(egtB)
SATAC5746_37025
SCHFIPT68_32700
SHUNDWB77_01277(egtB)
SHARHUT13_20290
SCYGS1361_34730(egtB)
SFEUIM697_19430
SLIAHA039_02855
SDWK7C20_31600(egtB)
SCALI6J39_32355(egtB)
SAUHSU9_029825(egtB)
SFBCP974_27945(egtB)
SMOBJ7W19_29440(egtB)
SPRACP972_32050(egtB)
SPEUCGZ69_32690
SXNIAG42_04100
SGJIAG43_01375
SHKJ2N69_33980(egtB)
SANUK7396_05820(egtB)
STRYEQG64_32500
SDDD9753_03465
SMAOCAG99_16345
SGOBtest1122_11460(egtB)
SINEKI385_37420(egtB)
SLFJEQ17_07325(egtB)
SDECL3078_39945(egtB)
SAOVG3H79_03200
SDURM4V62_05420(egtB)
SYANNRK68_30045(egtB)
SRUGF0345_02140(egtB)
SAKBK1J60_03875(egtB)
STAALDH80_06190(egtB)
SNIGHEK616_44630(egtB)
SVIOHWN34_28580
SCAEIHE65_04805(egtB)
STUBMMF93_31015(egtB)
SSPNLXH13_34675(egtB)
SCIRSTRCI_007144(egtB)
SXTKPP03845_106341(egtB)
SLONLGI35_37955(egtB)
SDRZNEH16_02405(egtB)
STUDSTRTU_000913(egtB)
STEEF3L20_16280
SENGOJ254_26885(egtB)
SGKPET44_28115(egtB)
SANTQR300_04035(egtB)
SYUNMOV08_08295(egtB)
SARGHKX69_03445
SJNRI060_04025(egtB)
SCYNN8I84_05485(egtB)
SOVQZH56_03765(egtB)
SFIYF0344_02025(egtB)
SHAUK9S39_07355(egtB)
SKGKJK29_03095(egtB)
SCOAQU709_03330(egtB)
SLAIP8A22_02840(egtB)
SROCRGF97_02160(egtB)
SFPQUY26_04215(egtB)
SCTSCAT_4660
SCYSCATT_46520
KSKKSE_64560
KABB7C62_33780
KAUB6264_00780
KITCFP65_6448
KISHUT16_30595
STRIC7M71_003910
YIALO772_26265(egtB)
ABRYNYE86_31865(egtB)
AGLAOIE69_07970(egtB)
ARTPE5206_18085
LMOIVV02_12405
NAQUENKNEFLB_01973(egtB)
NPSKRR39_12850(egtB)
NBTKLP28_01675(egtB)
KFLKfla_5162
KQIF1D05_08735
KSLOG809_00520(egtB)
NDANdas_0638
NALB005_3533
NGVCDO52_21015
NEXNE857_10255(egtB)
NECKGD82_19795(egtB)
NAKEKGD83_22520(egtB)
NCGKGD84_24170(egtB)
STRREKD16_07225(egtB)
SNAHOUQ99_23985(egtB)
TCUTcur_3640
ACTWF7P10_32755
AGRAAGRA3207_006136
AMAZLUW76_38345(egtB)
SPIQOHA34_32120(egtB)
ACTQOG417_15295(egtB)
SROSros_0331
NOABKM31_30905
NOWGBF35_07825(egtB)
NCXNocox_11925(egtB)
NGNLCN96_14305(egtB)
TBITbis_2650
MHAIOHB01_01405(egtB)
FRAFrancci3_4512
FREFranean1_7301
FALFRAAL6841
FSYFsymDg_4502
FRIFraEuI1c_7153
NMLNamu_1081
GOBGobs_0204
SENSACE_3825
SACGFDZ84_35815
SVISvir_22460
SACCEYD13_12500(egtB)
AMDAMED_4963
AMNRAM_25265
AMMAMES_4904
AMZB737_4904
AOIAORI_3753
AJAAJAP_20390(egtB)
AMQAMETH_3012
AMYCCU254_17950
AMYBBKN51_11240
AABA4R43_11145
AMYYYIM_27655(egtB)
AORISD37_19250
AACDLWP59_14990(egtB)
APRTMUY14_12795(egtB)
AROONQK81_03815(egtB)
ATHML1857_17955(egtB)
ARHDVSH64_13540(egtB)
PDXPsed_3382
PSEAWY02_03175
PSEEFRP1_09620
PSEHXF36_11005
PSEQAD006_17180
PECQAD017_25015
PHHAFB00_25180
PAUTPdca_32230(egtB)
PBROHOP40_24480
PPELH6H00_23185
APRECNX65_10825
AMIAmir_2123
SESPBN6_30860
SSYIEKG83_34695
KALKALB_2951
KUTJJ691_43090(egtB)
KBUQ4V64_04975(egtB)
KPHYAOZ06_20020
LEDBBK82_27275
AHMTL08_10805
ACTIUA75_11530
ACADUA74_11445
AHGAHOG_10780(egtB1)
ACTAC1701_22030
ALOCRK56188
PMADBAY61_17185
SACEGIY23_10325(egtB)
ACTUActkin_04015(egtB)
CROSN8J89_13720(egtB)
ACTYOG774_05545(egtB)
STPStrop_2114
SAQSare_2257
MAUMicau_3410
MILML5_4984
MICBMicB006_2467
MTUACSH63_08010
MICHFJK98_16740
MTEMGCE86_13005(egtB)
MCABHXZ27_18515
MSAGGCM10017556_54340(egtB)
VMAVAB18032_23565
MCRAID554_01385
VERHUT12_20340
MENOJiend_00930(egtB)
MCHLPVK74_07290(egtB)
MFEUH1D33_22675(egtB)
MPRNQ3V37_22425(egtB)
MHAWRMN56_24840(egtB)
ASEACPL_6426
AMSAMIS_61650
ACTNL083_7399
AFSAFR_38615
ACTSACWT_6293
AIHAiant_21070(egtB)
ACTRAsp14428_55930(egtB)
ACTLL3i22_086970(egtB)
ASICQ0Z83_108340(egtB)
AOUACTOB_006697(egtB)
PLKCIK06_14645
PLABC6361_04535
PLATC6W10_01060
PFLAPflav_033890
PSUUPsuf_077000(egtB)
CATICS0771_27250(egtB)
DVCDvina_39820
DFUDfulv_30240(egtB)
DROSDrose_22730(egtB)
DAURDaura_38930(egtB)
DMATDmats_34700
NHYJQS43_04865(egtB)
CCAZCOUCH_05005(egtB)
CAICaci_8029
SNASnas_5169
GLYK3N28_10180(egtB)
AEYCDG81_09250
RXYRxyl_0687
RRDRradSPS_2177
RUBGBA63_15135(egtB)
RMARGBA65_19945(egtB)
BSOLFSW04_08725(egtB)
BALADSM104299_01323(egtB)
CWOCwoe_4693
PARNNBH00_09425
SBAEDSM104329_01349(egtB)
TALUJDY09_01910(egtB)
BREMPSR63_18085
 » show all
Reference
1  [PMID:20420449]
  Authors
Seebeck FP
  Title
In vitro reconstitution of Mycobacterial ergothioneine biosynthesis.
  Journal
J Am Chem Soc 132:6632-3 (2010)
DOI:10.1021/ja101721e
  Sequence
Reference
2  [PMID:24828577]
  Authors
Pluskal T, Ueno M, Yanagida M
  Title
Genetic and metabolomic dissection of the ergothioneine and selenoneine biosynthetic pathway in the fission yeast, S. pombe, and construction of an overproduction system.
  Journal
PLoS One 9:e97774 (2014)
DOI:10.1371/journal.pone.0097774
Other DBs
ExplorEnz - The Enzyme Database: 1.14.99.50
IUBMB Enzyme Nomenclature: 1.14.99.50
ExPASy - ENZYME nomenclature database: 1.14.99.50
BRENDA, the Enzyme Database: 1.14.99.50

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