KEGG   ENZYME: 1.14.99.51Help
Entry
EC 1.14.99.51               Enzyme                                 

Name
hercynylcysteine S-oxide synthase;
Egt1;
Egt-1
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
BRITE hierarchy
Sysname
hercynine,L-cysteine:oxygen [S-(hercyn-2-yl)-L-cysteine S-oxide-forming]
Reaction(IUBMB)
hercynine + L-cysteine + O2 = S-(hercyn-2-yl)-L-cysteine S-oxide + H2O [RN:R11014]
Reaction(KEGG)
Substrate
hercynine [CPD:C05575];
L-cysteine [CPD:C00097];
O2 [CPD:C00007]
Product
S-(hercyn-2-yl)-L-cysteine S-oxide [CPD:C20994];
H2O [CPD:C00001]
Comment
Requires Fe2+ for activity. The enzyme, found in fungal species, is part of a fusion protein that also has the the activity of EC 2.1.1.44, L-histidine Nalpha-methyltransferase. It is part of the biosynthesis pathway of ergothioneine. The enzyme can also use L-selenocysteine to produce hercynylselenocysteine, which can be converted to selenoneine.
History
EC 1.14.99.51 created 2015
Pathway
ec00340  Histidine metabolism
ec01100  Metabolic pathways
Orthology
K20246  L-histidine Nalpha-methyltransferase / hercynylcysteine S-oxide synthase
Genes
QSU: 111995461
SMO: SELMODRAFT_440291 SELMODRAFT_441187
PPP: 112273553
MNG: MNEG_11096
APRO: F751_0470
CME: CYME_CMR147C
GSL: Gasu_29030
CCP: CHC_T00005848001
NCR: NCU04343(egt-1)
NTE: NEUTE1DRAFT145472(NEUTE1DRAFT_145472)
SSCK: SPSK_08945
MAW: MAC_09617
MAJ: MAA_04856
CMT: CCM_07351
MBE: MBM_01989
ANI: AN7620.2
ANG: ANI_1_792134(An15g05880)
ABE: ARB_02453
TVE: TRV_08045
PNO: SNOG_13930(SNOG_13929)
PTE: PTT_06791
SPO: SPBC1604.01(mug158)
CNE: CNJ01670
CNB: CNBJ1790
TASA: A1Q1_06211
ABP: AGABI1DRAFT112491(AGABI1DRAFT_112491) AGABI1DRAFT120644(AGABI1DRAFT_120644)
ABV: AGABI2DRAFT186400(AGABI2DRAFT_186400) AGABI2DRAFT192459(AGABI2DRAFT_192459)
SPAR: SPRG_06858
SCL: sce7073
 » show all
Taxonomy
Reference
1  [PMID:24828577]
  Authors
Pluskal T, Ueno M, Yanagida M
  Title
Genetic and metabolomic dissection of the ergothioneine and selenoneine biosynthetic pathway in the fission yeast, S. pombe, and construction of an overproduction system.
  Journal
PLoS One 9:e97774 (2014)
DOI:10.1371/journal.pone.0097774
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.99.51
IUBMB Enzyme Nomenclature: 1.14.99.51
ExPASy - ENZYME nomenclature database: 1.14.99.51
BRENDA, the Enzyme Database: 1.14.99.51

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