KEGG   ENZYME: 1.14.99.57
Entry
EC 1.14.99.57               Enzyme                                 

Name
heme oxygenase (mycobilin-producing);
mhuD (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
Sysname
protoheme,donor:oxygen oxidoreductase (mycobilin-producing)
Reaction(IUBMB)
(1) protoheme + 3 reduced acceptor + 3 O2 = mycobilin a + Fe2+ + 3 acceptor + 3 H2O [RN:R11741];
(2) protoheme + 3 reduced acceptor + 3 O2 = mycobilin b + Fe2+ + 3 acceptor + 3 H2O [RN:R11742]
Reaction(KEGG)
R11741 R11742
Substrate
protoheme [CPD:C00032];
reduced acceptor [CPD:C00030];
O2 [CPD:C00007]
Product
mycobilin a [CPD:C21624];
Fe2+ [CPD:C14818];
acceptor [CPD:C00028];
H2O [CPD:C00001];
mycobilin b [CPD:C21625]
Comment
The enzyme, characterized from the bacterium Mycobacterium tuberculosis, is involved in heme degradation and iron utilization. The enzyme binds two stacked protoheme molecules per monomer. Unlike the canonical heme oxygenases, the enzyme does not release carbon monoxide or formaldehyde. Instead, it forms unique products, named mycobilins, that retain the alpha-meso-carbon at the ring cleavage site as an aldehyde group. EC 1.6.2.4, NADPH-hemoprotein reductase, can act as electron donor in vitro.
History
EC 1.14.99.57 created 2017
Orthology
K21481  heme oxygenase (mycobilin-producing)
Genes
XCZ: EBN15_15650
LYJ: FKV23_07820
PFS: PFLU_3497
PAZO: AYR47_23955
PFX: A7318_14735
SLO: Shew_0076
SPSW: Sps_01023
SMAV: CFF01_00360
SBK: SHEWBE_2656
COM: CMT41_06260
THIP: N838_05295
HAM: HALO1916
BTD: BTI_5309
BUL: BW21_4956
ADE: Adeh_0545
SFU: Sfum_2110
MHUA: MCHK_5364
KAI: K32_11570
RPC: RPC_4759
SWI: Swit_1205
SPHD: HY78_20550
SPHM: G432_17405
SPKC: KC8_07445
SINB: SIDU_04415
SPHT: K426_12290
MAGQ: MGMAQ_2889
ATX: GCD22_03297(hmoB)
BSU: BSU10100(yhgC)
BSR: I33_1141
BSH: BSU6051_10100(yhgC)
BSUT: BSUB_01107
BSUL: BSUA_01107(hmoB)
BSUS: Q433_05715
BSO: BSNT_07446(yhgC)
BSQ: B657_10100(hmoB)
BSX: C663_1034
BSS: BSUW23_05110(yhgC)
BST: GYO_1305
BLI: BL01106(yhgC)
BLD: BLi01090(hmoB)
BLH: BaLi_c12110(yhgC)
BAY: RBAM_010330(hmoB)
BAQ: BACAU_0994(yhgC)
BYA: BANAU_0938(yhgC)
BAMP: B938_04970
BAML: BAM5036_0936(hmoB)
BAMA: RBAU_0995(hmoB)
BAMN: BASU_0972(hmoB)
BAMT: AJ82_05810
BAMY: V529_09740
BMP: NG74_01041(hmoB)
BAO: BAMF_1103(yhgC)
BAZ: BAMTA208_04745(yhgC)
BQL: LL3_01099
BXH: BAXH7_00994(yhgC)
BQY: MUS_1062
BAMI: KSO_014700
BAMC: U471_10250
BAMF: U722_05240
BSIA: CWD84_16575(hmoB)
BHT: DIC78_04570(hmoB)
BMOJ: HC660_10670(hmoB)
BTEQ: G4P54_05365(hmoB)
BAN: BA_1068
BAR: GBAA_1068
BAT: BAS0997
BAI: BAA_1157
BANT: A16_11310
BANR: A16R_11450
BANS: BAPAT_1013
BANV: DJ46_5521
BCE: BC1066
BCA: BCE_1165
BCZ: BCE33L0984(yhgC)
BCQ: BCQ_1136(yhgC)
BCX: BCA_1116
BAL: BACI_c11090(yhgC)
BNC: BCN_1045
BCF: bcf_05400
BCER: BCK_02990
BTK: BT9727_0982(yhgC)
BTL: BALH_0948
BTT: HD73_1220
BTHI: BTK_06145
BTM: MC28_0300
BTG: BTB_c11340(tRAP)
BTI: BTG_15615
BTW: BF38_2309
BWW: bwei_3928
BMYO: BG05_4815
BMYC: DJ92_3708
BPU: BPUM_0956
BPUM: BW16_05185
BPUS: UP12_05140
BJS: MY9_1110
BMET: BMMGA3_04125(yhgC)
BACW: QR42_04985
BACP: SB24_04710
BACB: OY17_07850
BACO: OXB_1660
BACY: QF06_03980
BACL: BS34A_11260(hmoB)
BALM: BsLM_1051
BGY: BGLY_1124
BFD: NCTC4823_02835(traP)
BMQ: BMQ_0596
BMD: BMD_0599
BMH: BMWSH_4640(yhgC)
BMEG: BG04_2888
BAG: Bcoa_0405
BCOA: BF29_3307
BPF: BpOF4_11570(yhgC)
BKW: BkAM31D_04540(hmoB)
OIH: OB1165
AFL: Aflv_2281
AAMY: GFC30_1033
LSP: Bsph_0406
HHD: HBHAL_2227(yhgC)
HLI: HLI_05275
VPN: A21D_02695(hmoB_1) A21D_03934(hmoB_2)
PASA: BAOM_1009
PSYO: PB01_15445
BLEN: NCTC4824_03028(traP)
SAV: SAV1835(traP)
SAW: SAHV_1820(traP)
SAM: MW1775(TRAP)
SAS: SAS1756
SAR: SAR1926(trap)
SAC: SACOL1891
SAE: NWMN_1726
SAD: SAAV_1854
SUE: SAOV_1830(traP)
SUZ: MS7_1840(traP)
SUX: SAEMRSA15_17390(trap)
SUW: SATW20_18290(trap)
SUG: SAPIG1900
SUF: SARLGA251_17180(trap)
SAUA: SAAG_01736
SAUS: SA40_1676(trap)
SAUU: SA957_1760(trap)
SAUG: SA268_1832(trap) SA268_2545
SAUZ: SAZ172_1846(trap)
SAUF: X998_1859
SAB: SAB1766(traP)
SUY: SA2981_1791(yhgC)
SAUB: C248_1876(trap)
SAUC: CA347_1822
SAUR: SABB_01954(traP) SABB_02019
SAUI: AZ30_09325
SAMS: NI36_09790
SER: SERP2173
SEPS: DP17_1099 DP17_431(traP)
SHA: SH0435 SH1127(traP)
SCA: SCA_1409
SLN: SLUG_11340(trap)
SDT: SPSE_0971(traP)
SDP: NCTC12225_01175(traP_1) NCTC12225_02586(traP_2)
SCAP: AYP1020_1081(traP) AYP1020_1787(hmoB)
SPIC: SAMEA4384060_1145(traP)
SSIM: SAMEA4384339_1722(trap)
SSTE: SAMEA4384403_0911(traP)
MCL: MCCL_1551
MCAK: MCCS_19640(traP)
LMO: lmo2213
LMOE: BN418_2663
LMOB: BN419_2667
LMOD: LMON_2289
LMOW: AX10_05360
LMOM: IJ09_13845
LMP: MUO_11360
LMOX: AX24_08975
LMQ: LMM7_2315
LMS: LMLG_3007
LMOK: CQ02_11485
LIN: lin2316
LWE: lwe2230
LSG: lse_2193
LIV: LIV_2200
SIV: SSIL_0711
JEO: JMA_13500
KUR: ASO14_559
KZO: NCTC404_01446(traP)
LRE: Lreu_0566
LRF: LAR_0550
LRT: LRI_1347
LSN: LSA_10320
LSJ: LSJ_0133
LOL: LACOL_1209(yhgC)
WCE: WS08_0351
WCT: WS74_0351
DRM: Dred_2322
MTU: Rv3592(TB11.2)
MTV: RVBD_3592
MTC: MT3698
MRA: MRA_3631
MTUR: CFBS_3809
MTO: MTCTRI2_3657(TB11.2)
MTD: UDA_3592(TB11.2)
MTN: ERDMAN_3940(TB11.2)
MTUB: MT7199_3655(TB11.2)
MTUE: J114_19205
MTUL: TBHG_03533
MTUT: HKBT1_3794
MTUU: HKBT2_3803
MBO: BQ2027_MB3623(mhud)
MBB: BCG_3657(TB11.2)
MBT: JTY_3658(TB11.2)
MBX: BCGT_3463
MAF: MAF_36050(TB11.2)
MMIC: RN08_3972
MCE: MCAN_36041(TB11.2)
MCQ: BN44_110087(TB11)
MCV: BN43_90093(TB11)
MCX: BN42_90090(TB11)
MCZ: BN45_100106(TB11)
MLE: ML1922
MLB: MLBr01922
MPA: MAP_0467c
MAO: MAP4_3400
MAVI: RC58_16860
MAVU: RE97_16895
MAV: MAV_0562
MIT: OCO_04710
MIA: OCU_04740
MID: MIP_00899
MYO: OEM_04770
MIR: OCQ_04870
MLP: MLM_0706
MMC: Mmcs_4751
MKM: Mkms_4837
MJL: Mjls_5137
MMI: MMAR_5091
MMM: W7S_02300
MHAD: B586_04315
MSHG: MSG_04590(mhuD)
MFJ: MFLOJ_40360(mhuD)
MSTO: MSTO_44320(mhuD)
MGRO: FZ046_03105(mhuD)
MXE: MYXE_04850(mhuD)
MNV: MNVI_12780(mhuD)
MPAG: C0J29_28005(mhuD)
MNM: MNVM_23140(mhuD)
MGOR: H0P51_25995(mhuD)
MCOO: MCOO_27650
MBAI: MB901379_04491(hmoB)
MSEO: MSEO_34910
MVA: Mvan_5352
MPHL: MPHLCCUG_00457(mhuD)
MVQ: MYVA_5246
MTHN: 4412656_04124(isdG)
MHAS: MHAS_03809(mhuD)
MMAG: MMAD_48910
MMOR: MMOR_11430
MFX: MFAL_32330(mhuD)
MAIC: MAIC_04910
MIJ: MINS_01000(mhuD)
MALV: MALV_41740
MARZ: MARA_47080
MGAD: MGAD_38040
MHEV: MHEL_27370
MSAR: MSAR_11250
MANY: MANY_33360(TB11.2)
MAUB: MAUB_27460
MPOF: MPOR_54500
MAB: MAB_0553c
MABB: MASS_0522
MCHE: BB28_02610
MSTE: MSTE_00506
MSAL: DSM43276_00464(mhuD)
MTER: 4434518_03758(isdG)
MMIN: MMIN_12780(TB11.2)
MHIB: MHIB_31450(TB11.2)
ASD: AS9A_0344
CGL: NCgl2584(Cgl2677) NCgl2889(Cgl2991)
CEF: CE2829
CDI: DIP1841
CPSE: CPTA_00011
CPSU: CPTB_01516
CPSF: CPTC_02237
CVA: CVAR_1807
CTER: A606_07295
COA: DR71_1515
CGV: CGLAU_03670(mhuD)
CAMG: CAMM_04835
CEE: CENDO_03385(mhuD)
CRL: NCTC7448_00724(isdG)
CPRE: Csp1_10530(mhuD)
NFA: NFA_4270
NOZ: DMB37_23365(mhuD)
RER: RER_06640
REY: O5Y_03215
ROP: ROP_43520
REQ: REQ_06210
RFA: A3L23_02524(mhuD)
RHS: A3Q41_00841(mhuD)
RHU: A3Q40_03247(mhuD)
RQI: C1M55_03695(mhuD)
GBR: Gbro_0960
GOR: KTR9_0858
GRU: GCWB2_04515(mhuD)
GOM: D7316_04543(mhuD)
TPR: Tpau_0586
SRT: Srot_2179
SALB: XNR_4554
SGR: SGR_276
SGB: WQO_33200
SMAL: SMALA_2283
SBH: SBI_07545
SVE: SVEN_2050
STRE: GZL_06159
STRM: M444_11820
SAMB: SAM23877_6981(mhuD)
SLE: sle_40240(sle_40240)
SLAU: SLA_1956
SALJ: SMD11_0633
SLX: SLAV_25545(mhuD)
SFK: KY5_2409
SGE: DWG14_04115(mhuD)
SRJ: SRO_3500
KSK: KSE_24270
CMI: CMM_1082
CMS: CMS1402
CMC: CMN_01047
KRH: KRH_17320
KVR: CIB50_0001371(mhuD)
JDE: Jden_0205
LMOI: VV02_17955
BLIN: BLSMQ_0403
MPH: MLP_35310
NDK: I601_3700(mhuD)
PSIM: KR76_23480
TFU: Tfu_0619
NDA: Ndas_3524
NAL: B005_0659
TCU: Tcur_3540
TBI: Tbis_2807
NML: Namu_3377
GOB: Gobs_3958
MMAR: MODMU_4368
KRA: Krad_1347
SEN: SACE_0428
AMD: AMED_8707
AMYY: YIM_02735(mhuD)
AORI: SD37_03055
PDX: Psed_6110
PSEA: WY02_14420
PSEE: FRP1_28025
PSEH: XF36_26355
PAUT: Pdca_63610
AMI: Amir_0339
SESP: BN6_03750
KAL: KALB_5148
AHG: AHOG_01635(mhuD1) AHOG_10380(mhuD2)
SAQ: Sare_0274
MIL: ML5_3480
CALH: IJ00_08890
TAQ: TO73_2831
TBC: A0O31_02360(hmoB)
RUL: UC8_37090(mhuD)
MRI: Mal4_12700(mhuD)
NDE: NIDE0039
NJA: NSJP_1685
HALH: HTSR_2064
HHSR: HSR6_2140
CDIV: CPM_1141
 » show all
Reference
1  [PMID:19917297]
  Authors
Chim N, Iniguez A, Nguyen TQ, Goulding CW
  Title
Unusual diheme conformation of the heme-degrading protein from Mycobacterium tuberculosis.
  Journal
J Mol Biol 395:595-608 (2010)
DOI:10.1016/j.jmb.2009.11.025
  Sequence
[mtu:Rv3592]
Reference
2  [PMID:23420845]
  Authors
Nambu S, Matsui T, Goulding CW, Takahashi S, Ikeda-Saito M
  Title
A new way to degrade heme: the Mycobacterium tuberculosis enzyme MhuD catalyzes heme degradation without generating CO.
  Journal
J Biol Chem 288:10101-9 (2013)
DOI:10.1074/jbc.M112.448399
Reference
3  [PMID:24901029]
  Authors
Graves AB, Morse RP, Chao A, Iniguez A, Goulding CW, Liptak MD
  Title
Crystallographic and spectroscopic insights into heme degradation by Mycobacterium tuberculosis MhuD.
  Journal
Inorg Chem 53:5931-40 (2014)
DOI:10.1021/ic500033b
  Sequence
[mtu:Rv3592]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.99.57
IUBMB Enzyme Nomenclature: 1.14.99.57
ExPASy - ENZYME nomenclature database: 1.14.99.57
BRENDA, the Enzyme Database: 1.14.99.57

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