KEGG   ENZYME: 1.14.99.62
Entry
EC 1.14.99.62               Enzyme                                 

Name
cyclooctatin synthase;
CotB4
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
Sysname
cyclooctat-9-ene-5,7-diol,hydrogen-donor:oxygen oxidoreductase (18-hydroxylating)
Reaction(IUBMB)
cyclooctat-9-ene-5,7-diol + reduced acceptor + O2 = cyclooctatin + acceptor + H2O [RN:R12178]
Reaction(KEGG)
R12178
Substrate
cyclooctat-9-ene-5,7-diol [CPD:C21978];
reduced acceptor [CPD:C00030];
O2 [CPD:C00007]
Product
cyclooctatin [CPD:C21979];
acceptor [CPD:C00028];
H2O [CPD:C00001]
Comment
Isolated from the bacterium Streptomyces melanosporofaciens M1614-43f2.
History
EC 1.14.99.62 created 2018
Pathway
ec00999  Biosynthesis of various secondary metabolites - part 1
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K22998  cyclooctatin synthase
Genes
SVL: Strvi_5781
SRC: M271_43265
SMAL: SMALA_0744
SCI: B446_28650
SRN: A4G23_04519(ptlI_3)
SAUO: BV401_07570
Reference
1  [PMID:19635410]
  Authors
Kim SY, Zhao P, Igarashi M, Sawa R, Tomita T, Nishiyama M, Kuzuyama T
  Title
Cloning and heterologous expression of the cyclooctatin biosynthetic gene cluster afford a diterpene cyclase and two p450 hydroxylases.
  Journal
Chem Biol 16:736-43 (2009)
DOI:10.1016/j.chembiol.2009.06.007
  Sequence
Reference
2  [PMID:27216162]
  Authors
Gorner C, Schrepfer P, Redai V, Wallrapp F, Loll B, Eisenreich W, Haslbeck M, Bruck T
  Title
Identification, characterization and molecular adaptation of class I redox systems for the production of hydroxylated diterpenoids.
  Journal
Microb Cell Fact 15:86 (2016)
DOI:10.1186/s12934-016-0487-6
Other DBs
ExplorEnz - The Enzyme Database: 1.14.99.62
IUBMB Enzyme Nomenclature: 1.14.99.62
ExPASy - ENZYME nomenclature database: 1.14.99.62
BRENDA, the Enzyme Database: 1.14.99.62

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