| Entry |
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| Name |
ferric-chelate reductase (NADH);
ferric chelate reductase (ambiguous);
iron chelate reductase (ambiguous);
NADH:Fe3+-EDTA reductase;
NADH2:Fe3+ oxidoreductase;
ferB (gene name);
Fe(II):NAD+ oxidoreductase
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| Class |
Oxidoreductases;
Oxidizing metal ions;
With NAD+ or NADP+ as acceptor
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| Sysname |
Fe(II)-siderophore:NAD+ oxidoreductase
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| Reaction(IUBMB) |
2 Fe(II)-siderophore + NAD+ + H+ = 2 Fe(III)-siderophore + NADH [RN: R00092]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
Fe(III)-siderophore;
NADH [CPD: C00004]
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| Comment |
Contains FAD. The enzyme catalyses the reduction of bound ferric iron in a variety of iron chelators (siderophores), resulting in the release of ferrous iron. The plant enzyme is involved in the transport of iron across plant plasma membranes. The enzyme from the bacterium Paracoccus denitrificans can also reduce chromate. cf. EC 1.16.1.9, ferric-chelate reductase (NADPH) and EC 1.16.1.10, ferric-chelate reductase [NAD(P)H].
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| History |
EC 1.16.1.7 created 1992 as EC 1.6.99.13, transferred 2002 to EC 1.16.1.7, modified 2011, modified 2014
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| Orthology |
| K00521 | ferric-chelate reductase |
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| Genes |
» show all
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| Reference |
1 |
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| Authors |
Askerlund, P., Larrson, C. and Widell, S. |
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| Title |
Localization of donor and acceptor sites of NADH dehydrogenase activities using inside-out and right-side-out plasma membrane vesicles from plants. |
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| Journal |
FEBS Lett 239:23-28 (1988) |
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| Reference |
2 |
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| Authors |
Bruggemann, W. and Moog, P.R. |
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| Title |
NADH-dependent Fe3+ EDTA and oxygen reduction by plasma membrane vesicles from barley roots. |
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| Journal |
Physiol Plant 75:245-254 (1989) |
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| Reference |
3 |
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| Authors |
Bruggemann, W., Moog, P.R., Nakagawa, H., Janiesch, P. and Kuiper, P.J.C. |
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| Title |
Plasma membrane-bound NADH:Fe3+-EDTA reductase and iron deficiency in tomato (Lycopersicon esculentum). Is there a Turbo reductase ?. |
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| Journal |
Physiol Plant 79:339-346 (1990) |
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| Reference |
4 |
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| Authors |
Buckhout, T.J. and Hrubec, T.C. |
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| Title |
Pyridine nucleotide-dependent ferricyanide reduction associated with isolated plasma membranes of maize (Zea mays L.) roots. |
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| Journal |
Protoplasma 135:144-154 (1986) |
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| Reference |
5 |
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| Authors |
Sandelius, A.S., Barr, R., Crane, F.L. and Morre, D.J. |
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| Title |
Redox reactions of plasma membranes isolated from soybean hypocotyls by phase partition. |
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| Journal |
Plant Sci 48:1-10 (1986) |
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| Reference |
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| Authors |
Mazoch J, Tesarik R, Sedlacek V, Kucera I, Turanek J |
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| Title |
Isolation and biochemical characterization of two soluble iron(III) reductases from Paracoccus denitrificans. |
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| Journal |
Eur J Biochem 271:553-62 (2004) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.16.1.7 |
| ExPASy - ENZYME nomenclature database: | 1.16.1.7 |
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