KEGG ENZYME: 1.16.1.7

ENZYME: 1.16.1.7

Entry

EC 1.16.1.7                 Enzyme

Name

ferric-chelate reductase (NADH);
ferric chelate reductase (ambiguous);
iron chelate reductase (ambiguous);
NADH:Fe3+-EDTA reductase;
NADH2:Fe3+ oxidoreductase;
ferB (gene name);
Fe(II):NAD+ oxidoreductase

Class

Oxidoreductases;
Oxidizing metal ions;
With NAD+ or NADP+ as acceptor

Sysname

Fe(II)-siderophore:NAD+ oxidoreductase

Reaction(IUBMB)

2 Fe(II)-siderophore + NAD+ + H+ = 2 Fe(III)-siderophore + NADH [RN:R00092]

Reaction(KEGG)

R00092

Substrate

Fe(II)-siderophore;
NAD+ [CPD:C00003];
H+ [CPD:C00080]

Product

Fe(III)-siderophore;
NADH [CPD:C00004]

Comment

Contains FAD. The enzyme catalyses the reduction of bound ferric iron in a variety of iron chelators (siderophores), resulting in the release of ferrous iron. The plant enzyme is involved in the transport of iron across plant plasma membranes. The enzyme from the bacterium Paracoccus denitrificans can also reduce chromate. cf. EC 1.16.1.9, ferric-chelate reductase (NADPH) and EC 1.16.1.10, ferric-chelate reductase [NAD(P)H].

History

EC 1.16.1.7 created 1992 as EC 1.6.99.13, transferred 2002 to EC 1.16.1.7, modified 2011, modified 2014

Orthology

K00521

ferric-chelate reductase

Genes

ATH:	AT1G01580(FRO2) AT1G01590(FRO1) AT1G23020(FRO3) AT5G23980(FRO4) AT5G23990(FRO5) AT5G49730(FRO6) AT5G49740(FRO7) AT5G50160(FRO8)

ALY:	9300115 9301828 9301829 9308155 9310224 9311105 9326612 9328114 9328115

CRB:	17875486 17876579 17881311 17883727 17900195 17900764

CSAT:

104706695 104709065 104711774 104724271 104724294 104725473 104725475 104725524 104736410 104737747 104738638 104741016 104743100 104752049 104754307 104754309 104756660 104758853 104760957 104760958 104761003 104770770 104776424 104778516

EUS:	EUTSA_v10003544mg EUTSA_v10006930mg EUTSA_v10006972mg EUTSA_v10012790mg EUTSA_v10012839mg EUTSA_v10028469mg

BRP:	103836963 103840187 103843795 103843797 103843890 103844661 103854878 103874261

BNA:	106352010 106370060 106377370 106377373 106380097 106395200 106430647 106433706 106434184 106434186 106435186 106437481 106452002 125581332 125593351

BOE:	106293244 106307452 106311524 106314038 106318432 106326287 106343163

RSZ:	108823952 108825073 108829530 108829535 108836493 108842322 108857412 108859245

THJ:	104800318 104809245 104818163 104825852

CPAP:

110810118 110810296 110810297 110820914 110820952

CIT:	102609442 102615568 102620077 102622812 102627420 127901077

CIC:	CICLE_v10000235mg CICLE_v10006989mg CICLE_v10019053mg CICLE_v10019061mg

PVY:	116111940 116111966 116119614 116121373 116121381 116133517 116133535 116134276

MINC:

123210699 123214863 123223339 123225644

TCC:	18586305 18603979 18605617 18605618 18614101

GRA:	105770323 105776367 105798560 105798564 105802725

GHI:	107923096 107930740 107934204 107951153 107951281 107952230 107952477 107957630 121223702

GAB:	108450407 108465693 108469354 108482027 108488086

HSYR:

120130049 120136319 120168740 120172645 120213266

DZI:	111280962 111290129 111305943 111310268 111313883

EGR:	104415402 104418726 104418727 104418729 104418730 104418731 104426230 104434108 104443418 104443420 120291434

RARG:

115729117 115731663 115735758 115745975 115749527

GMX:	100779692 100790114 100794343 100796460 100804994 100814642 100816560 112998154

GSJ:	114367115 114371978 114371979 114388290 114390440 114394224 114395865 114418409

PVU:	137807912 137819512 137825585 137827732 137827733 137832076

VRA:	106753318 106759103 106769936 106773621 106773668 106775835

VAR:	108321581 108324902 108327207 108343239 108346780

VUN:	114166109 114176823 114186059 114188066 114190422 114190579

VUM:	124823382 124838695 124846532 124848644

CCAJ:

109792236 109796177 109800553 109802170 109802667 109803882 109803994

APRC:

113847067 113850265 113853322 113863360 113871806

MTR:	11416672 11419739 11429188 25493725 25500851 25500854

TPRA:

123883024 123883918 123897816 123902338 123902349 123902357 123914186

CAM:	101499003 101499324 101505212 101511261 101513785

PSAT:

127073968 127075938 127075980 127096076 127096645

VVO:	131612667 131616618 131627467 131627551 131627567 131627568 131636457 131642197 131643581 131643582

LJA:	130710470 130718281 130722089 130728284 130746143 130746144

ADU:	107457844 107472727 107483074

AIP:	107609299 107628103 107635065 107638776

AHF:	112702502 112726301 112732410 112741396 112744178 112765774 112796104 112797510

LANG:

109325658 109325664 109334522 109339259 109339264 109356105 109356247 109362491 109362503

PCIN:

129291519 129291538 129306717 129307789

QSA:	O6P43_004271 O6P43_008168 O6P43_012093 O6P43_022664 O6P43_026523 O6P43_027261 O6P43_031421 O6P43_034478

FVE:	101292220 101292511 101307550 101309010 101311281 105353181

AANS:

126793767 126796300 126801656 126801677 126803639

RCN:	112175623 112176184 112179179 112179180 112181549 112181563 112181569 112181578 112182072 112182073 112182596

PPER:

18777125 18786837 18787030 18787637 18788529

PMUM:

103318927 103332089 103333734 103333791 103338170

PAVI:

110745877 110748786 110751835 110765619 110767769

PDUL:

117616267 117618446 117619408 117619666 117626889

MDM:	103428975 103436685 103439801 103439802 103445220 114822770 114826563

MSYL:

126603414 126616447 126618514 126618527 126626985 126629694 126630309 126631579

PXB:	103946433 103953046 103957436 103957437 103958225 103958226 103964313 103964314 103966127 103966184 103967917

PCOX:

137711565 137717509 137719426 137719451 137721251 137721481 137735230 137735231 137736343

ZJU:	107414733 107414747 107418289 107425647 107432941

MNT:	112093424 21387139 21397392 21397674 21404325

CSAV:

115707468 115713941 115716412 133035767

CSV:	101203723 101204544 101211162 101213325

CMO:	103484121 103488760 103493281 103498863

BHJ:	120068478 120070325 120081664 120091586

MCHA:

111007198 111008081 111010173 111011458

CMAX:

111477191 111483082 111483092 111484843 111493542

CMOS:

111430747 111430749 111447866 111458241 111464979

CPEP:

111780704 111802683 111806537 111810074 111810075

RCU:	107260839 8261915 8261916 8262647 8277108 8278296 8286523

MEAN:

126653957 126672463 126673015 126674214 126674468 126674469 126676273 126686249

JCU:	105628625 105639422 105640315 105641611 105642948 105642950 105648431 105648837 105650949

HBR:	110635932 110638052 110642080 110643479 110649451 110658174 110660916 110672321

MESC:

110599944 110614302 110615277 110616522 110616868 110618000

POP:	18106515 18106516 7453800 7458053 7487425 7487426 7491487 7496989

PEU:	105127213 105134209 105135266 105135267 105139193 105139194 105140883 105142058

PALZ:

118030332 118036765 118037153 118037154 118041611 118044809 118057439

PNZ:	133671501 133671502 133675509 133678764 133679853 133699975 133699976

JRE:	108985875 108992652 108996964 109000920 109001751 109010007

CILL:

122281997 122290292 122308858 122310299 122310942 122312134

CAVE:

132175162 132178088 132178712 132186908 132188806

AGLU:

133858304 133858305 133858306 133858307 133863928 133864841 133875982 133881408 133882836

QSU:	111984982 112000009 112000010 112011877 112011887 112011892 112011893 112012273 112013840 112027612 112028646 136069780

QLO:	115959900 115960385 115961249 115962460 115963958 115977685 115977686 115977687 115977688 115987400

TWL:	119981983 119982031 119983193 120004455

VVI:	100241516 100263818

VRI:	117926945 117932593 117934006 117934403

SLY:	101246763 101251223 101266014 101268463 543871(FRO1)

SPEN:

107002501 107008236 107012854 107014546 107019479 107028389

SOT:	102578364 102578945 102579252 102579721 102587336 102589797 102594930 102606355

SSTN:

125843803 125844721 125852362 125852373 125852386 125857692 125860854 125873605 125876473

SDUL:

129884737 129885992 129886543 129893812 129894038 129895709 129900679

CANN:

107839216 107839217 107839219 107839780 107862583 107863218 107866144 107873964

LBB:	132598550 132598554 132598555 132598556 132632598 132632710 132634042 132645551 132645552

NTA:	107760413 107760948 107771783 107776596 107792900 107795235 107795345 107801915 107801919 107804326 107807141 107818188 107818189 107832362

NSY:	104210558 104214974 104231581 104244607 104244859 104246484 104246485

NTO:	104086673 104097932 104102930 104105485 104106813 104113481 108946367 138907085

NAU:	109205126 109206720 109212317 109221287 109223683 109226543

INI:	109171567 109171642 109173121 109177042 109185535

ITR:	115996836 116007127 116013194 116029667 116030260

SIND:

105157466 105160697 105169029 105172854 105172876 105173155 105173156 110011863

OEU:	111377055 111391833 111404325 111407634 111409728

EGT:	105960559 105962617 105963835 105963836 105963838 105964044 105965655 105971615 105971931 105975015 105976846

SSPL:

121750337 121754283 121758632 121760990 121779368 121779822 121781819 121783691 121795230 121798793

SMIL:

130999109 131011454 131019704 131020651

SHIS:

125202894 125208499 125209929 125212811 125214691 125214692 125223807

APAN:

127248347 127248424 127254286 127255092 127259694 127261344

HAN:	110864890 110878123 110905122 110908923 110926644 110937641 110941738

ECAD:

122578143 122591142 122592162 122592398 122599846 122603902

LSV:	111888466 111894618 111894637 111904766 111904772 111914006

CCAV:

112500369 112506679 112508676 112514558 112514884 112526800

DCR:	108193054 108194057 108194888 108196555 108204858 108205878 108208697 108210092 108211955 108227088

CSIN:

114268049 114269844 114269847 114270109 114281916 114287471 114298414 114307225 114318559 114319070

RVL:	131298047 131303522 131307408 131319648 131321318 131325436 131333892

AEW:	130750277 130753551 130759378 130767149 130780754 130786613 130792536

DLT:	127794060 127795104 127801964 127801966 127810099

BVG:	104887088 104888387 104894346 104897075

SOE:	110784129 110789161 110789863 110792557

CQI:	110688563 110693851 110693853 110693857 110700333 110714553 110727583 110729606 110731568

ATRI:

130800166 130806900 130811348 130821337 130825961

MOF:	131146613 131156232 131165494 131166126

NNU:	104591492 104596257 104603300 104606707 104611528

MING:

122060673 122066248 122067653 122078813

TSS:	122638247 122644845 122646641 122657865

PSOM:

113274781 113284398 113289994 113304276 113304314 113326458 113344018 113355553

OSA:	4335953(0sFRO1) 4336754

DOSA:

Os04g0444800 Os04g0578600

OBR:

102708713

OGL:	127769605 127771989

BDI:	100826093 100843941

ATS:	109733798 109759862

TDC:	119355256 119355990 119364390 119365126

TAES:

123041749 123045569 123053413 123054105 123185808 123189317

TUA:	125538492 125538495 125539280

LPER:

127334986 127334987 127334988 127336449

LRD:	124675205 124675206 124676603 124677157 124679467

SBI:

8080358

ZMA:

100281526

MFLO:

136495384 136496351

SITA:

101763321

SVS:

117864494

PVIR:

120641121 120681466

PHAI:

112898958

PAUA:

133889780

PDA:	103697168 103715667 103717377 103717378

EGU:	105033551 105043304 105051548

MUS:	135615526 135618188 135618465 135619100 135627965

ZOF:	121967678 121969920 121975026 122008551 122015681 122052921

DCT:	110093167 110097844 110115582

PEQ:	110018408 110020812 110037397

AOF:	109823679 109824604 109839037

MSIN:

131232330 131233862 131236642 131236643 131236644 131236646 131246418 131249094

ACAK:

137934585 137935413 137935414 137935425 137935427 137935428 137935429 137938538 137938541 137938545 137942764 137942871 137945478 137946722 137948186 137948527 137948528 137949945 137950916 137962304

NCOL:

116247808 116248676 116250877 116252931 116253215

ATR:	18424390 18427837 18442059

CJF:	131030319 131032587 131032594 131060210

SMO:	SELMODRAFT_10731 SELMODRAFT_10830 SELMODRAFT_110167 SELMODRAFT_145556 SELMODRAFT_159917 SELMODRAFT_416159 SELMODRAFT_416972 SELMODRAFT_420318 SELMODRAFT_425399 SELMODRAFT_440376 SELMODRAFT_445683 SELMODRAFT_51485

PPP:	112278480 112283332 112286383 112288516 112293012 112294215

CSL:	COCSUDRAFT_64970

CVR:	CHLNCDRAFT_57416

APRO:

F751_3250 F751_3251 F751_3252

MIS:	MICPUN_53877

MPP:	MICPUCDRAFT_46220

GSL:	Gasu_46800

PIC:	PICST_59173(FRE4.1)

LEL:	PVL30_004034(FRP1)

COT:	CORT_0E02920

FVR:	FVEG_13485

FOX:	FOXG_08924 FOXG_14662

NHE:	NECHADRAFT_82244 NECHADRAFT_82537

CFJ:	CFIO01_04872 CFIO01_06133

CHIG:

CH63R_07132

PFY:	PFICI_05751

FFU:	CLAFUR5_00410

CNE:	CNC02670 CND06030 CNG00950

CNB:	CNBD0370 CNBG3850

CNG:	CNAG_03498 CNAG_06524 CNAG_06821 CNAG_07604

CGI:	CGB_G5410C CGB_I0430C

CDEU:

CNBG_2116 CNBG_3298 CNBG_5888

CDEP:

91084729(L203_100513) 91085361(L203_101147)

KMG:	30159949(I203_104922) 30161341(I203_105716) 30166326(I203_102393)

KNE:	92179892(IAR55_002634) 92180592(IAR55_003334)

TMS:	TREMEDRAFT_58976 TREMEDRAFT_74287

TASA:

A1Q1_03144 A1Q1_05173 A1Q1_06677

CCAC:

CcaHIS019_0200280(CcaverHIS019_0200280) CcaHIS019_0401030(CcaverHIS019_0401030) CcaHIS019_0502330(CcaverHIS019_0502330)

PPL:	POSPLDRAFT_104856 POSPLDRAFT_130027 POSPLDRAFT_134646 POSPLDRAFT_134648 POSPLDRAFT_134651 POSPLDRAFT_134771 POSPLDRAFT_134945 POSPLDRAFT_135058 POSPLDRAFT_98469

TVS:	TRAVEDRAFT_162444 TRAVEDRAFT_43274 TRAVEDRAFT_66226 TRAVEDRAFT_69649

DSQ:	DICSQDRAFT_105742 DICSQDRAFT_136693 DICSQDRAFT_170031 DICSQDRAFT_170034

PCO:	PHACADRAFT_108963 PHACADRAFT_259189

SHS:	STEHIDRAFT_123515 STEHIDRAFT_131599 STEHIDRAFT_55077

HIR:	HETIRDRAFT_164205 HETIRDRAFT_313750 HETIRDRAFT_36460 HETIRDRAFT_39263 HETIRDRAFT_39375

PSQ:	PUNSTDRAFT_115913 PUNSTDRAFT_116967 PUNSTDRAFT_119206 PUNSTDRAFT_125114

ADL:	AURDEDRAFT_156793 AURDEDRAFT_158692 AURDEDRAFT_162494 AURDEDRAFT_78658

FME:	FOMMEDRAFT_148974 FOMMEDRAFT_161290 FOMMEDRAFT_74257

GTR:	GLOTRDRAFT_115899 GLOTRDRAFT_132881 GLOTRDRAFT_48566 GLOTRDRAFT_81132

RSX:	RhiXN_05692 RhiXN_07459

LBC:	LACBIDRAFT_304909 LACBIDRAFT_315189

CCI:	CC1G_06499

ABP:	AGABI1DRAFT123369(AGABI1DRAFT_123369) AGABI1DRAFT130257(AGABI1DRAFT_130257) AGABI1DRAFT78089(AGABI1DRAFT_78089) AGABI1DRAFT78091(AGABI1DRAFT_78091)

ABV:	AGABI2DRAFT120020(AGABI2DRAFT_120020) AGABI2DRAFT123337(AGABI2DRAFT_123337) AGABI2DRAFT187504(AGABI2DRAFT_187504)

MRR:	Moror_1019 Moror_11709 Moror_12996 Moror_2446 Moror_4459

E1B28_002786 E1B28_005810 E1B28_007263

SCM:	SCHCO_02603449(SCHCODRAFT_02603449) SCHCO_02643965(SCHCODRAFT_02643965)

CPUT:

CONPUDRAFT_131705 CONPUDRAFT_85160 CONPUDRAFT_85161

SLA:	SERLADRAFT_401128 SERLADRAFT_442714 SERLADRAFT_442838 SERLADRAFT_478753

WSE:	WALSEDRAFT_44679

WIC:	J056_003456

UMA:	UMAG_11604

PFP:	PFL1_06279

MGL:

MGL_2422

MRT:

MRET_3303

PGR:	PGTG_08247

PTRC:

PtA15_3A573

MLR:	MELLADRAFT_113404 MELLADRAFT_116791 MELLADRAFT_93237

FCY:	FRACYDRAFT_232972(FRO1) FRACYDRAFT_235878 FRACYDRAFT_250055 FRACYDRAFT_252645

PIF:	PITG_01233 PITG_01324 PITG_02771 PITG_03236 PITG_04582

PSOJ:

PHYSODRAFT_264147 PHYSODRAFT_323311 PHYSODRAFT_354556 PHYSODRAFT_474806 PHYSODRAFT_498767 PHYSODRAFT_505264 PHYSODRAFT_506860 PHYSODRAFT_509769 PHYSODRAFT_555131

BLAC:

94349643(CCR75_005898)

SPAR:

SPRG_00043 SPRG_00047 SPRG_02087 SPRG_06468 SPRG_06967 SPRG_10563 SPRG_19396 SPRG_19397

EHX:	EMIHUDRAFT_195350 EMIHUDRAFT_205158 EMIHUDRAFT_215218 EMIHUDRAFT_225553 EMIHUDRAFT_250790

» show all

Reference

Authors

Askerlund P, Larrson C, Widell S.

Title

Localization of donor and acceptor sites of NADH dehydrogenase activities using inside-out and right-side-out plasma membrane vesicles from plants.

Journal

FEBS Lett 239:23-28 (1988)

Reference

Authors

Bruggemann W, Moog PR.

Title

NADH-dependent Fe3+ EDTA and oxygen reduction by plasma membrane vesicles from barley roots.

Journal

Physiol Plant 75:245-254 (1989)

Reference

Authors

Bruggemann W, Moog PR, Nakagawa H, Janiesch P, Kuiper PJC.

Title

Plasma membrane-bound NADH:Fe3+-EDTA reductase and iron deficiency in tomato (Lycopersicon esculentum). Is there a Turbo reductase ?.

Journal

Physiol Plant 79:339-346 (1990)

Reference

Authors

Buckhout TJ, Hrubec TC.

Title

Pyridine nucleotide-dependent ferricyanide reduction associated with isolated plasma membranes of maize (Zea mays L.) roots.

Journal

Protoplasma 135:144-154 (1986)

Reference

Authors

Sandelius AS, Barr R, Crane FL, Morre DJ.

Title

Redox reactions of plasma membranes isolated from soybean hypocotyls by phase partition.

Journal

Plant Sci 48:1-10 (1986)

Reference

6 [PMID:14728682]

Authors

Mazoch J, Tesarik R, Sedlacek V, Kucera I, Turanek J

Title

Isolation and biochemical characterization of two soluble iron(III) reductases from Paracoccus denitrificans.

Journal

Eur J Biochem 271:553-62 (2004)
DOI:10.1046/j.1432-1033.2003.03957.x

Other DBs

ExplorEnz - The Enzyme Database:

1.16.1.7

IUBMB Enzyme Nomenclature:

1.16.1.7

ExPASy - ENZYME nomenclature database:

1.16.1.7

BRENDA, the Enzyme Database:

1.16.1.7

CAS:	120720-17-4

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Gene (770)   
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   RefGene (634)   
Protein sequence (196)   
   UniProt (146)   
   SWISS-PROT (17)   
   RefSeq(pep) (33)   
DNA sequence (225)   
   RefSeq(nuc) (59)   
   GenBank (83)   
   EMBL (83)   
Protein domain (12)   
   InterPro (12)   
All databases (1203)   

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