EC                 Enzyme                                 

[methionine synthase] reductase;
methionine synthase cob(II)alamin reductase (methylating);
methionine synthase reductase;
[methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing);
[methionine synthase]-methylcob(I)alamin,S-adenosylhomocysteine:NADP+ oxidoreductase
Oxidizing metal ions;
With NAD+ or NADP+ as acceptor
[methionine synthase]-methylcob(III)alamin,S-adenosyl-L-homocysteine:NADP+ oxidoreductase
2 [methionine synthase]-methylcob(III)alamin + 2 S-adenosyl-L-homocysteine + NADP+ = 2 [methionine synthase]-cob(II)alamin + NADPH + H+ + 2 S-adenosyl-L-methionine [RN:R05182]
[methionine synthase]-methylcob(III)alamin;
S-adenosyl-L-homocysteine [CPD:C00021];
NADP+ [CPD:C00006]
[methionine synthase]-cob(II)alamin [CPD:C06409];
NADPH [CPD:C00005];
H+ [CPD:C00080];
S-adenosyl-L-methionine [CPD:C00019]
In humans, the enzyme is a flavoprotein containing FAD and FMN. The substrate of the enzyme is the inactivated cobalt(II) form of EC, methionine synthase. Electrons are transferred from NADPH to FAD to FMN. Defects in this enzyme lead to hereditary hyperhomocysteinemia.
EC created 1999 as EC, transferred 2003 to EC, modified 2020
K00597  methionine synthase reductase
HSA: 4552(MTRR)
PTR: 461717(MTRR)
PPS: 100990677(MTRR)
GGO: 101138335(MTRR)
PON: 100174319(MTRR)
NLE: 100605425(MTRR)
MCC: 100430789(MTRR)
MCF: 101925754(MTRR)
CSAB: 103214983(MTRR)
RRO: 104674086(MTRR)
RBB: 108536959(MTRR)
CJC: 100389974(MTRR)
SBQ: 101042701(MTRR)
MMU: 210009(Mtrr)
MCAL: 110307972(Mtrr)
MPAH: 110329102(Mtrr)
RNO: 290947(Mtrr)
MUN: 110550967(Mtrr)
CGE: 100773236(Mtrr)
NGI: 103735353(Mtrr)
HGL: 101720530(Mtrr)
CCAN: 109688199(Mtrr)
OCU: 100350605(MTRR)
TUP: 102491380(MTRR)
CFA: 478623(MTRR)
VVP: 112934268(MTRR)
AML: 100484655(MTRR)
UMR: 103662251(MTRR)
UAH: 113260809(MTRR)
ORO: 101366274(MTRR)
ELK: 111153446
FCA: 101098359(MTRR)
PTG: 102949230(MTRR)
PPAD: 109267828(MTRR)
AJU: 106971266(MTRR)
BTA: 507991(MTRR)
BOM: 102272980(MTRR)
BIU: 109574962(MTRR)
BBUB: 102411193(MTRR)
CHX: 102171193(MTRR)
OAS: 101123409(MTRR)
SSC: 100516580(MTRR)
CFR: 102511463(MTRR)
CDK: 105094043(MTRR)
BACU: 103019188(MTRR)
LVE: 103085843(MTRR)
OOR: 101285453(MTRR)
DLE: 111178558(MTRR)
PCAD: 102990472(MTRR)
ECB: 100071310(MTRR)
EPZ: 103540506(MTRR)
EAI: 106823000(MTRR)
MYB: 102241177(MTRR)
MYD: 102763596(MTRR)
MNA: 107540559(MTRR)
DRO: 112321035(MTRR)
PALE: 102892778(MTRR)
RAY: 107502702(MTRR)
MJV: 108384628(MTRR)
LAV: 100654114(MTRR)
TMU: 101359820
MDO: 100013254(MTRR)
SHR: 100923220(MTRR)
PCW: 110220385(MTRR)
OAA: 100089744(MTRR)
GGA: 428502(MTRR)
MGP: 100540427(MTRR)
CJO: 107309523(MTRR)
NMEL: 110393327(MTRR)
APLA: 101802959(MTRR)
ACYG: 106036580(MTRR)
TGU: 100228556(MTRR)
LSR: 110479512(MTRR)
SCAN: 103822476(MTRR)
GFR: 102038689(MTRR)
FAB: 101807366(MTRR)
PHI: 102113343(MTRR)
PMAJ: 107200311(MTRR)
CCAE: 111925671(MTRR)
CCW: 104685872(MTRR)
ETL: 114055131(MTRR)
FPG: 101910301(MTRR)
FCH: 102047448(MTRR)
CLV: 102096989(MTRR)
EGZ: 104126205(MTRR)
NNI: 104018869(MTRR)
ACUN: 113476799(MTRR)
PADL: 103915149(MTRR)
AAM: 106492684(MTRR)
ASN: 102383326(MTRR)
AMJ: 102561574(MTRR)
PSS: 102457990(MTRR)
CMY: 102929534(MTRR)
CPIC: 101951331(MTRR)
ACS: 100563923(mtrr)
PVT: 110089599(MTRR)
PBI: 103055371(MTRR)
PMUR: 107297701(MTRR)
PMUA: 114601218(MTRR)
GJA: 107108830(MTRR)
XLA: 108719055(mtrr.L)
XTR: 733716(mtrr)
NPR: 108802102(MTRR)
DRE: 560667(mtrr)
SANH: 107686717(mtrr) 107695375
SGH: 107549192 107595114(mtrr)
IPU: 108256395(mtrr)
PHYP: 113541137(mtrr)
AMEX: 103046907(mtrr)
EEE: 113588751(mtrr)
TRU: 101070210(mtrr)
LCO: 104921714(mtrr)
NCC: 104954888(mtrr)
MZE: 101481719(mtrr)
ONL: 100709326(mtrr)
OLA: 101167253(mtrr)
XMA: 102232227(mtrr)
XCO: 114136999(mtrr)
PRET: 103482452(mtrr)
CVG: 107096083(mtrr)
NFU: 107382941(mtrr)
KMR: 108243160(mtrr)
ALIM: 106513500(mtrr)
AOCE: 111581030(mtrr)
CSEM: 103377015(mtrr)
POV: 109629723(mtrr)
LCF: 108902055(mtrr)
SDU: 111237220(mtrr)
SLAL: 111662991(mtrr)
HCQ: 109511817(mtrr)
BPEC: 110160921(mtrr)
MALB: 109965535(mtrr)
ELS: 105019455(mtrr)
SFM: 108935528(mtrr)
PKI: 111849508(mtrr)
LCM: 102351804(MTRR)
CMK: 103186339(mtrr)
RTP: 109935699(mtrr)
BFO: 118403551
CIN: 100182690
SPU: 581957
APLC: 110975926
SKO: 100371498
DME: Dmel_CG14882(CG14882)
DER: 6553357
DSE: 6616881
DSI: Dsimw501_GD19100(Dsim_GD19100)
DSR: 110177283
DPE: 6592026
DMN: 108155099
DWI: 6651662
DAZ: 108608773
DNV: 108653072
DHE: 111604956
MDE: 101896273
LCQ: 111676765
TCA: 655238
DPA: 109546268
ATD: 109594433
NVL: 108558885
BMOR: 101743356
BMAN: 114248178
PMAC: 106717667
HAW: 110376093
TNL: 113505823
CLEC: 106670593
ZNE: 110830537
FCD: 110845930
PVM: 113810127
TUT: 107363566
DPTE: 113789801
CSCU: 111614502
PTEP: 107450790
CEL: CELE_C01G6.6(mtrr-1)
CBR: CBG00882(Cbr-tag-165)
BMY: Bm1_35655
TSP: Tsp_01287
PCAN: 112556068
CRG: 105333103
MYI: 110450395
OBI: 106882104
SHX: MS3_02917
EGL: EGR_00462
NVE: 5511985
EPA: 110247156
ADF: 107342874
AMIL: 114954870
PDAM: 113682435
SPIS: 111320968
DGT: 114526309
HMG: 100207049
AQU: 100635303
SPAR: SPRG_03729
 » show all
1  [PMID:9501215]
Leclerc D, Wilson A, Dumas R, Gafuik C, Song D, Watkins D, Heng HH, Rommens JM, Scherer SW, Rosenblatt DS, Gravel RA
Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria.
Proc Natl Acad Sci U S A 95:3059-64 (1998)
2  [PMID:11466310]
Olteanu H, Banerjee R.
Human methionine synthase reductase, a soluble P-450 reductase-like dual flavoprotein, is sufficient for NADPH-dependent methionine synthase activation.
J Biol Chem 276:35558-63 (2001)
3  [PMID:12416982]
Olteanu H, Munson T, Banerjee R.
Differences in the efficiency of reductive activation of methionine synthase and exogenous electron acceptors between the common polymorphic variants of human methionine synthase reductase.
Biochemistry 41:13378-85 (2002)
Other DBs
ExplorEnz - The Enzyme Database:
IUBMB Enzyme Nomenclature:
ExPASy - ENZYME nomenclature database:
BRENDA, the Enzyme Database:
CAS: 207004-87-3

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