KEGG   ENZYME: 1.16.1.9Help
Entry
EC 1.16.1.9                 Enzyme                                 

Name
ferric-chelate reductase (NADPH);
ferric chelate reductase (ambiguous);
iron chelate reductase (ambiguous);
NADPH:Fe3+-EDTA reductase;
NADPH-dependent ferric reductase;
yqjH (gene name);
Fe(II):NADP+ oxidoreductase
Class
Oxidoreductases;
Oxidizing metal ions;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
Fe(II)-siderophore:NADP+ oxidoreductase
Reaction(IUBMB)
2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH [RN:R09541]
Reaction(KEGG)
Substrate
Fe(II)-siderophore;
NADP+ [CPD:C00006];
H+ [CPD:C00080]
Product
Fe(III)-siderophore;
NADPH [CPD:C00005]
Comment
Contains FAD. The enzyme, which is widespread among bacteria, catalyses the reduction of ferric iron bound to a variety of iron chelators (siderophores), including ferric triscatecholates and ferric dicitrate, resulting in the release of ferrous iron. The enzyme from the bacterium Escherichia coli has the highest efficiency with the hydrolysed ferric enterobactin complex ferric N-(2,3-dihydroxybenzoyl)-L-serine [3]. cf. EC 1.16.1.7, ferric-chelate reductase (NADH) and EC 1.16.1.10, ferric-chelate reductase [NAD(P)H].
History
EC 1.16.1.9 created 1992 as EC 1.6.99.13, transferred 2002 to EC 1.16.1.7, transferred 2011 to EC 1.16.1.9, modified 2012, modified 2014
Orthology
K07229  ferric-chelate reductase (NADPH)
Genes
ECO: b3070(yqjH)
ECJ: JW3041(yqjH)
ECD: ECDH10B_3245(yqjH)
EBW: BWG_2780(yqjH)
ECOK: ECMDS42_2539(yqjH)
ECE: Z4423(yqjH)
ECS: ECs3952
ECF: ECH74115_4383
ETW: ECSP_4044(yqjH)
ELX: CDCO157_3693
EOJ: ECO26_4171(yqjH)
EOI: ECO111_3892(yqjH)
EOH: ECO103_3815(yqjH)
ECG: E2348C_3363(yqjH)
EOK: G2583_3794(yqjH)
ECC: c3823(yqjH)
ECP: ECP_3160
ECI: UTI89_C3508(yqjH)
ECV: APECO1_3346(yqjH)
ECY: ECSE_3351
ECR: ECIAI1_3217(yqjH)
ECQ: ECED1_3738(yqjH)
ECK: EC55989_3484(yqjH)
ECT: ECIAI39_3566(yqjH)
EOC: CE10_3600(yqjH)
EUM: ECUMN_3553(yqjH)
ECZ: ECS88_3467(yqjH)
ELH: ETEC_3340
ESE: ECSF_2913
ESO: O3O_22040
ESM: O3M_03645
ESL: O3K_03605
EBR: ECB_02939(yqjH)
EBD: ECBD_0672
EKF: KO11_07370(yqjH)
EAB: ECABU_c34900(yqjH)
EDJ: ECDH1ME8569_2965(yqjH)
ENA: ECNA114_3162(ygjH1)
ELW: ECW_m3337(yqjH)
ELL: WFL_16305(yqjH)
ELC: i14_3517(yqjH)
ELD: i02_3517(yqjH)
EBL: ECD_02939(yqjH)
EBE: B21_02889(yqjH)
ELF: LF82_3675(yqjH)
ECOI: ECOPMV1_03388(yqjH)
ECOJ: P423_17345
ECOO: ECRM13514_4030(yqjH)
ECOH: ECRM13516_3833(yqjH)
ECOS: EC958_3475(yqjH)
EFE: EFER_3022(yqjH)
STY: STY3392
STT: t3134
STM: STM3214(yqjH)
SEO: STM14_3891(yqjH)
SEY: SL1344_3187(yqjH)
SEJ: STMUK_3203(yqjH)
SEB: STM474_3368(yqjH)
SENI: CY43_16755
SPT: SPA3082(yqjH)
SEK: SSPA2878
SEI: SPC_3289(yqjH)
SEC: SCH_3160(yqjH)
SHB: SU5_03709
SENS: Q786_15675
SED: SeD_A3570
SEG: SG3110(yqjH)
SEL: SPUL_3226
SET: SEN3056(yqjH)
SENA: AU38_15555
SENO: AU37_15755
SENV: AU39_15755
SENQ: AU40_17530
SENL: IY59_16160
SEEP: I137_15395
SENE: IA1_15545
SBG: SBG_2849
SBZ: A464_3290
SFT: NCTC1_03369(yqjH_1) NCTC1_03370(yqjH_2)
SSN: SSON_3208(yqjH)
SBO: SBO_2929(yqjH)
SDY: SDY_3254(yqjH)
ENC: ECL_04454
ECLO: ENC_33180
EEC: EcWSU1_03884(yqjH)
ECLX: LI66_19470
ECLY: LI62_21430
ECLZ: LI64_18610
ESA: ESA_03485
CSK: ES15_3444
CTU: CTU_04810(yqjH)
KPN: KPN_03499(yqjH)
KPU: KP1_4796(yqjH)
KPP: A79E_0618
KPE: KPK_0613
KPR: KPR_4703
KPJ: N559_0673
KPX: PMK1_01017(yqjH)
KPNU: LI86_03260
KPNK: BN49_0608
KVA: Kvar_0601
KOX: KOX_03200
KOE: A225_5090
EAE: EAE_03870
EAR: CCG33218
CKO: CKO_04480
CRO: ROD_48101
EBT: EBL_c04730(yqjH)
EBF: D782_0610
PSTS: E05_39570
RAA: Q7S_24696
SOD: Sant_3532
ETA: ETA_13670(yqjH)
EBI: EbC_22530(viuB)
EGE: EM595_2950(yqjH)
PAM: PANA_3242(yqjH)
PLF: PANA5342_0831(yqjH)
PAJ: PAJ_2467(yqjH)
PVA: Pvag_2587(yqjH)
PSTW: DSJ_21015
PSPO: PSPO_a3286
 » show all
Taxonomy
Reference
1  [PMID:18765906]
  Authors
Bamford VA, Armour M, Mitchell SA, Cartron M, Andrews SC, Watson KA
  Title
Preliminary X-ray diffraction analysis of YqjH from Escherichia coli: a putative  cytoplasmic ferri-siderophore reductase.
  Journal
Acta Crystallogr Sect F Struct Biol Cryst Commun 64:792-6 (2008)
DOI:10.1107/S174430910802352X
  Sequence
[eco:b3070]
Reference
2  [PMID:21097627]
  Authors
Wang S, Wu Y, Outten FW
  Title
Fur and the novel regulator YqjI control transcription of the ferric reductase gene yqjH in Escherichia coli.
  Journal
J Bacteriol 193:563-74 (2011)
DOI:10.1128/JB.01062-10
  Sequence
[eco:b3070]
Reference
3  [PMID:22098718]
  Authors
Miethke M, Hou J, Marahiel MA
  Title
The siderophore-interacting protein YqjH acts as a ferric reductase in different  iron assimilation pathways of Escherichia coli.
  Journal
Biochemistry 50:10951-64 (2011)
DOI:10.1021/bi201517h
Other DBs
ExplorEnz - The Enzyme Database: 1.16.1.9
IUBMB Enzyme Nomenclature: 1.16.1.9
ExPASy - ENZYME nomenclature database: 1.16.1.9
BRENDA, the Enzyme Database: 1.16.1.9
CAS: 120720-17-4

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