KEGG   ENZYME: 1.16.3.3
Entry
EC 1.16.3.3                 Enzyme                                 

Name
manganese oxidase;
mnxG (gene name);
mofA (gene name);
moxA (gene name);
cotA (gene name)
Class
Oxidoreductases;
Oxidizing metal ions;
With oxygen as acceptor
Sysname
manganese(II):oxygen oxidoreductase
Reaction(IUBMB)
4 Mn2+ + 2 O2 + 4 H2O = 4 MnIVO2 + 8 H+ (overall reaction) [RN:R11880];
(1a) 4 Mn2+ + O2 + 4 H+ = 4 Mn3+ + 2 H2O [RN:R11881];
(1b) 4 Mn3+ + O2 + 6 H2O = 4 MnIVO2 + 12 H+ [RN:R11882]
Reaction(KEGG)
Substrate
Mn2+ [CPD:C19610];
O2 [CPD:C00007];
H2O [CPD:C00001];
H+ [CPD:C00080];
Mn3+ [CPD:C19611]
Product
MnIVO2;
H+ [CPD:C00080];
Mn3+ [CPD:C19611];
H2O [CPD:C00001]
Comment
The enzyme, which belongs to the multicopper oxidase family, is found in many bacterial strains. It oxidizes soluble manganese(II) to insoluble manganese(IV) oxides. Since the enzyme is localized to the outer surface of the cell, its activity usually results in encrustation of the cells by the oxides. The physiological function of bacterial manganese(II) oxidation remains unclear.
History
EC 1.16.3.3 created 2017
Orthology
K06324  spore coat protein A, manganese oxidase
K22348  manganese oxidase
K22349  manganese oxidase
K22350  manganese oxidase
Genes
LEM: LEN_2383
XBC: ELE36_01670 ELE36_05975 ELE36_10370 ELE36_19270
FAU: Fraau_0525
DJI: CH75_03055 CH75_20015
DJA: HY57_03710 HY57_09055
DYE: EO087_09865
DCS: ISN74_20235
LRZ: BJI69_06120 BJI69_12425
LPY: FIV34_01270 FIV34_05415
XBA: C7S18_08345 C7S18_19260 C7S18_21215
PMY: Pmen_2656
PMK: MDS_2051
PPSE: BN5_2406
PPU: PP_3184(mcoA) PP_3490(mnxG)
PSET: THL1_5006
PALL: UYA_10400
CJA: CJA_2027
MICT: FIU95_01625(cotA) FIU95_09710(copA2)
NOC: Noc_1542
NWA: Nwat_1595
AEH: Mlg_0496
TGR: Tgr7_1204
TKM: TK90_2224
TNI: TVNIR_1106(pcoA_[H])
TVR: TVD_02065
GAI: IMCC3135_18160(copA_1)
APAC: S7S_01900
SVA: SVA_0804
SALN: SALB1_3145
RSY: RSUY_37470(mco)
RPI: Rpic_3912
BPS: BPSS0456
BPM: BURPS1710b_A2009(copA)
BPSE: BDL_3684
BPSM: BBQ_5738
BPSU: BBN_3858
BPSD: BBX_5521
BPK: BBK_5663
BPSH: DR55_4894
BPSA: BBU_5589
BPSO: X996_4644
BUT: X994_4162
BTQ: BTQ_5241
BTJ: BTJ_3873
BTZ: BTL_4726
BTV: BTHA_5500
BTHE: BTN_4366
BTHM: BTRA_4632
BTHA: DR62_4415
BTHL: BG87_4699
BOK: DM82_4551
BOC: BG90_6041
BVE: AK36_4736
BCN: Bcen_4753
BCJ: BCAM0447
BCEO: I35_4350
BAM: Bamb_5190
BMU: Bmul_6291
BMK: DM80_5892
BCT: GEM_5275
BCED: DM42_4708
BCON: NL30_23710
BUB: BW23_4217
BTEI: WS51_01060
BSEM: WJ12_22265
BSTG: WT74_17625
BUK: MYA_3646
BXE: Bxe_B2294
BXB: DR64_4626
BPH: Bphy_2040
PPNO: DA70_14500
PPNM: LV28_16185
PPUL: RO07_10310
PSPU: NA29_06125
PAPI: SG18_25770
POL: Bpro_3485
AAV: Aave_1810
AAA: Acav_1747
DAC: Daci_2910
CTES: O987_09230
RTA: Rta_22160
LIM: L103DPR2_02312(copA_2)
LIH: L63ED372_00294(mco)
HPSE: HPF_08390(mco) HPF_13850(copA3)
CBAA: SRAA_1797
CBAB: SMCB_1768
MPT: Mpe_A0495(copA2) Mpe_A1634
HAR: HEAR1582
HSE: Hsero_1601(copA)
HRB: Hrubri_1492(copA)
CFU: CFU_2966(copA)
CARE: LT85_1610
TIN: Tint_0764
THI: THI_1002
NEU: NE0315(mnxG)
METR: BSY238_658
MEH: M301_1603
MEP: MPQ_0417(sufI)
NIM: W01_10400
DSU: Dsui_2641
AZO: azo2950
BPRC: D521_1661
SULR: B649_09545
GSU: GSU1252
DMA: DMR_38070(copA)
DBA: Dbac_0735
CCX: COCOR_04360(copA)
SCL: sce0503(copA) sce2138
CCRO: CMC5_017630(yacK) CMC5_072120(yacK)
HOH: Hoch_4297
SMX: SM11_chr0212(copA)
SMER: DU99_03080
SMD: Smed_5029
ATU: Atu3991(copA)
ARA: Arad_7553
ATF: Ach5_37760(copA)
AVI: Avi_9850(copA)
RLE: RL2434(copA)
RHT: NT26_0637
KAI: K32_47200
BJA: bll2210(copA)
BRA: BRADO1520
BRS: S23_58120(copA)
BRAD: BF49_2719
BARH: WN72_41105
BVZ: BRAD3257_1450(copA)
RPD: RPD_4268
RPT: Rpal_1091
OCA: OCAR_7632
MDI: METDI1364
MCH: Mchl_1031
MNO: Mnod_7874
MAQU: Maq22A_1p35505(sufI)
BID: Bind_0315
MSC: BN69_0178
HDI: HDIA_4282(copA_3)
PAMN: pAMV3p0537
PGD: Gal_04041
LAQU: R2C4_15580
CID: P73_4727
SPSE: SULPSESMR1_00730(copA)
RID: RIdsm_05698(copA_1)
ROH: FIU89_21625(copA4)
MARU: FIU81_00895(copA1)
MALU: KU6B_01520 KU6B_58800(copA)
SHUM: STHU_17160
BSU: BSU06300(cotA)
BSL: A7A1_0020
BSH: BSU6051_06300(cotA)
BSUT: BSUB_00698(cotA)
BSUL: BSUA_00698(cotA)
BSUS: Q433_03560
BSO: BSNT_07002(cotA)
BSQ: B657_06300(cotA)
BSX: C663_0649(cotA)
BSS: BSUW23_03195(cotA)
BLI: BL01190(cotA)
BLD: BLi00679(cotA)
BLH: BaLi_c07680(cotA)
BAQ: BACAU_0641(cotA)
BYA: BANAU_0580(cotA)
BAMP: B938_03070
BAML: BAM5036_0590(cotA)
BAMA: RBAU_0647(cotA)
BAMN: BASU_0618(cotA)
BAMB: BAPNAU_0589(cotA)
BAMT: AJ82_03720
BAMY: V529_05960(cotA)
BMP: NG74_00650(cotA)
BAO: BAMF_0622(cotA)
BAZ: BAMTA208_02905(cotA)
BQL: LL3_00666(cotA)
BXH: BAXH7_00610(cotA)
BQY: MUS_0636(cotA)
BAMI: KSO_016420
BAMC: U471_06420
BAMF: U722_03325
BMOJ: HC660_06650(cotA)
BTEQ: G4P54_03420(cotA)
BMYC: DJ92_3652(cotA)
BPU: BPUM_0542
BPUM: BW16_03155
BPUS: UP12_03240
BJS: MY9_0702
BMET: BMMGA3_09095(cotA)
BACW: QR42_03100
BACP: SB24_06525
BACB: OY17_05960
BACY: QF06_02065
BACL: BS34A_07230(cotA)
BALM: BsLM_0658
BGY: BGLY_0705(cotA)
BFD: NCTC4823_02221(cotA_1) NCTC4823_03222(cotA_2)
BEO: BEH_10335
BCK: BCO26_2380(cotA)
BAG: Bcoa_2041
BCOA: BF29_1522(cotA)
BCL: ABC2649(cotA)
OIH: OB1346(cotA)
LSP: Bsph_2070
VPN: A21D_00749(cotA)
BLEN: NCTC4824_00656(cotA)
BLR: BRLA_c023320(cotA_2)
PBK: Back11_32270(cotA)
SIV: SSIL_0583
CBO: CBO0890(cotA)
CBA: CLB_0928
CBH: CLC_0942
CBN: CbC4_0596
CSR: Cspa_c44000(cotA)
CSQ: CSCA_1212
CLD: CLSPO_c08700(cotA)
ACEL: acsn021_14610(cotA)
TOC: Toce_1552
PUF: UFO1_3386
MBAI: MB901379_02378(cotA)
NSP: BMF81_00691(cotA)
DFC: DFI_16155
PNL: PNK_0990(copa7)
PUV: PUV_15560
RUL: UC8_32690(mco_1) UC8_38730(mco_2)
MFF: MFFC18_19230(mco)
AHEL: Q31a_43410(mco)
LCRE: Pla8534_06340(mco)
PND: Pla175_29360(mco)
FMR: Fuma_06120(mco)
GMR: GmarT_50920(copA)
GPN: Pan110_52650(mco)
MRI: Mal4_44650(copA)
SDYN: Mal52_29880(mco)
PLON: Pla110_00060(mco)
KST: KSMBR1_0316(sufI)
PCOR: KS4_34100(mco)
ALUS: STSP2_01286(copA)
ABAS: ACPOL_2083
GAU: GAU_1323
HTU: Htur_4294
 » show all
Reference
1
  Authors
Corstjens, P.L.A.M., de Vrind, J.P.M., Goosen, T. and de Vrind-de Jong, E.W.
  Title
Identification and molecular analysis of the Leptothrix discophora SS-1 mofA gene, a gene putatively encoding a manganese-oxidizing protein with copper domains.
  Journal
Geomicrobiol J 14:91-108 (1997)
Reference
2  [PMID:12420165]
  Authors
Francis CA, Casciotti KL, Tebo BM
  Title
Localization of Mn(II)-oxidizing activity and the putative multicopper oxidase, MnxG, to the exosporium of the marine Bacillus sp. strain SG-1.
  Journal
Arch Microbiol 178:450-6 (2002)
DOI:10.1007/s00203-002-0472-9
Reference
3  [PMID:17359266]
  Authors
Ridge JP, Lin M, Larsen EI, Fegan M, McEwan AG, Sly LI
  Title
A multicopper oxidase is essential for manganese oxidation and laccase-like activity in Pedomicrobium sp. ACM 3067.
  Journal
Environ Microbiol 9:944-53 (2007)
DOI:10.1111/j.1462-2920.2006.01216.x
  Sequence
Reference
4  [PMID:23124227]
  Authors
Geszvain K, McCarthy JK, Tebo BM
  Title
Elimination of manganese(II,III) oxidation in Pseudomonas putida GB-1 by a double knockout of two putative multicopper oxidase genes.
  Journal
Appl Environ Microbiol 79:357-66 (2013)
DOI:10.1128/AEM.01850-12
  Sequence
Reference
5  [PMID:23577125]
  Authors
Su J, Bao P, Bai T, Deng L, Wu H, Liu F, He J
  Title
CotA, a multicopper oxidase from Bacillus pumilus WH4, exhibits manganese-oxidase activity.
  Journal
PLoS One 8:e60573 (2013)
DOI:10.1371/journal.pone.0060573
  Sequence
[bpum:BW16_03155]
Other DBs
ExplorEnz - The Enzyme Database: 1.16.3.3
IUBMB Enzyme Nomenclature: 1.16.3.3
ExPASy - ENZYME nomenclature database: 1.16.3.3
BRENDA, the Enzyme Database: 1.16.3.3

DBGET integrated database retrieval system