KEGG ENZYME: 1.16.3.4

ENZYME: 1.16.3.4

Entry

EC 1.16.3.4                 Enzyme

Name

cuproxidase;
cueO (gene name);
cuprous oxidase;
Cu(I) oxidase;
copper efflux oxidase

Class

Oxidoreductases;
Oxidizing metal ions;
With oxygen as acceptor

Sysname

copper(I):oxygen oxidoreductase

Reaction(IUBMB)

4 Cu+ + 4 H+ + O2 = 4 Cu2+ + 2 H2O [RN:R12925]

Reaction(KEGG)

R12925

Substrate

Cu+ [CPD:C22423];
H+ [CPD:C00080];
O2 [CPD:C00007]

Product

Cu2+ [CPD:C22424];
H2O [CPD:C00001]

Comment

The enzyme, characterized from the bacterium Escherichia coli, is involved in copper tolerance under aerobic conditions. The enzyme contains a substrate binding (type 1) copper site and a trinuclear copper center (consisting of type 2 and type 3 copper sites) in which oxygen binding and reduction takes place. It also contains a methionine rich region that can bind additional copper ions. In vitro, if the substrate binding site is occupied by copper(II), the enzyme can function as a laccase-type quinol oxidase (EC 1.10.3.2). However, in vivo this site is occupied by a copper(I) ion and the enzyme functions as a cuprous oxidase.

History

EC 1.16.3.4 created 2021

Orthology

K14588

cuproxidase

Genes

ECO:	b0123(cueO)

ECJ:	JW0119(cueO)

ECD:	ECDH10B_0103(cueO)

EBW:	BWG_0116(cueO)

ECOK:

ECMDS42_0114(cueO)

ECOC:

C3026_00520

ECE:	Z0133(yacK)

ECS:	ECs_0127(cueO)

ECF:	ECH74115_0130(cueO)

ETW:	ECSP_0124(cueO)

ELX:	CDCO157_0125

EOI:	ECO111_0124(cueO)

EOJ:	ECO26_0125(cueO)

EOH:	ECO103_0123(cueO)

ECOO:

ECRM13514_0125(yacK)

ECOH:

ECRM13516_0128(yacK)

ESL:

O3K_20950

ESO:

O3O_04435

ESM:

O3M_20850

ECK:	EC55989_0116(cueO)

ECG:	E2348C_0126(cueO)

EOK:	G2583_0127(cueO)

ELR:	ECO55CA74_00605

ELH:

ETEC_0119

ECW:	EcE24377A_0125(cueO)

EUN:	UMNK88_121

ECP:

ECP_0130

ENA:	ECNA114_0115(yacK)

ECOS:

EC958_0265(cueO)

ECV:	APECO1_1862(cueO)

ECOA:

APECO78_04055

ECX:	EcHS_A0126(cueO)

ECM:	EcSMS35_0133(cueO)

ECY:

ECSE_0123

ECR:	ECIAI1_0121(cueO)

ECQ:	ECED1_0127(cueO)

EUM:	ECUMN_0120(cueO)

ECT:	ECIAI39_0123(cueO)

EOC:	CE10_0123(cueO)

EBR:	ECB_00122(cueO)

ECOB:

C3029_04365

EBL:	ECD_00122(cueO)

EBE:	B21_00121(cueO)

EBD:

ECBD_3496

ECI:	UTI89_C0136(cueO)

EIH:	ECOK1_0125(cueO)

ECZ:	ECS88_0132(cueO)

ECC:	c0152(yacK)

ELO:	EC042_0122(cueO)

ELN:	NRG857_00640

ESE:

ECSF_0136

ECL:	EcolC_3536

EKO:	EKO11_3793

EKF:	KO11_00590(cueO)

EAB:	ECABU_c01360(cueO)

EDH:	EcDH1_3479

EDJ:	ECDH1ME8569_0117(cueO)

ELU:	UM146_23420

ELW:	ECW_m0120(cueO)

ELL:	WFL_00590(cueO)

ELC:	i14_0139(yacK)

ELD:	i02_0139(yacK)

ELP:	P12B_c0112(cueO)

ELF:	LF82_0383(cueO)

ECOL:

LY180_00595

ECOI:

ECOPMV1_00129(cueO)

ECOJ:

P423_00660

EFE:	EFER_0144(cueO)

EAL:	EAKF1_ch1294c(cueO)

EMA:	C1192_12345

ESZ:	FEM44_15095(cueO)

ERUY:

OSH18_09015(cueO)

STY:	STY0190(yacK)

STT:	t0173(yacK)

SEX:	STBHUCCB_1930

SENT:

TY21A_00890

STM:	STM0168(cueO)

SEO:	STM14_0200(cueO)

SEV:	STMMW_01741

SEY:	SL1344_0169(cueO)

SEM:	STMDT12_C01690

SEJ:	STMUK_0170(cueO)

SEB:	STM474_0177(cueO)

SEF:	UMN798_0187(yacK)

SETU:

STU288_00850

SETC:

CFSAN001921_16570

SENR:

STMDT2_01701(yacK)

SEND:

DT104_01731(yacK)

SENI:

CY43_00845

SEEN:

SE451236_06860

SPT:	SPA0171(yacK)

SEK:

SSPA0167

SPQ:	SPAB_00207

SEI:	SPC_0181(yacK)

SEC:	SCH_0168(cueO)

SEH:	SeHA_C0192

SHB:

SU5_0810

SENH:

CFSAN002069_08340

SEEH:

SEEH1578_09920

SEE:	SNSL254_A0184

SENN:

SN31241_11570

SEW:	SeSA_A0187

SEA:	SeAg_B0200

SENS:

Q786_00890

SED:

SeD_A0183

SEG:	SG0171(cueO)

SEL:	SPUL_0184(cueO)

SEGA:

SPUCDC_0184(cueO)

SET:	SEN0173(cueO)

SENA:

AU38_00860

SENO:

AU37_00860

SENV:

AU39_00860

SENQ:

AU40_01005

SENL:

IY59_00885

SENJ:

CFSAN001992_10155

SEEC:

CFSAN002050_07335

SEEB:

SEEB0189_018500

SEEP:

I137_00820

SENB:

BN855_1810(yacK)

SENE:

IA1_00895

SENC:

SEET0819_07735

SES:	SARI_02826

SBG:	SBG_0160(yacK)

SBZ:

A464_169

SBV:	N643_00765

SALZ:

EOS98_18370(cueO)

SFL:	SF0119(yacK)

SFX:	S0122(yacK)

SFV:	SFV_0113(yacK)

SFE:	SFxv_0125(cueO)

SFN:

SFy_0156

SFS:

SFyv_0160

SFT:	NCTC1_00123(cueO)

SSN:	SSON_0131(yacK)

SBO:	SBO_0112(yacK)

SBC:	SbBS512_E0116(cueO)

SDY:	SDY_0030(yacK)

SDZ:	Asd1617_00035

SHQ:	A0259_04450

ENC:

ECL_00928

ENL:	A3UG_03845

ECLG:

EC036_07550

ECLE:

ECNIH2_04760

ECLN:

ECNIH4_18935

ECLI:

ECNIH5_03845

ECLX:

LI66_03855

ECLY:

LI62_04350

ECLZ:

LI64_03925

ECLO:

ENC_46390

EHM:	AB284_21125

EXF:	BFV63_03815

ECLA:

ECNIH3_03835

ECLC:

ECR091_03815

EAU:	DI57_14750

EKB:	BFV64_03590

ENO:	ECENHK_04055

EEC:	EcWSU1_00740(cueO)

ELG:	BH714_18545

ECAN:

CWI88_18335

ERN:	BFV67_03675

ECLS:

LI67_004820

ECHG:

FY206_04500(cueO)

ESH:	C1N69_03725

EPT:	HWQ17_08730(cueO)

ENT:	Ent638_0671

EAS:	Entas_0725

ENR:	H650_19455

ENX:	NI40_003685

ENF:	AKI40_4158

LNI:	CWR52_08380(cueO)

EBG:	FAI37_02800(cueO)

ENZ:	G0034_03860(cueO)

ENS:	HWQ15_12260(cueO)

ENK:	LOC22_14645(cueO)

EHU:	D5067_0019060(cueO)

EMOR:

L6Y89_03675(cueO)

ENB:	ELK40_04480(cueO)

EQU:	OM418_03765(cueO)

EPU:	QVH39_03735(cueO)

EDY:	F0320_03470(cueO)

ESA:

ESA_03209

CSK:

ES15_3196

CSZ:	CSSP291_14850

CSJ:	CSK29544_00133

CCON:

AFK62_03830

CDM:	AFK67_03815

CSI:	P262_04727

CMJ:	AFK66_015900

CUI:	AFK65_03765

CMW:	AFK63_14795

CTU:	CTU_07620(cueO)

KPN:	KPN_00131(cueO)

KPU:	KP1_0957(cueO)

KPM:	KPHS_08570

KPP:

A79E_4165

KPH:	KPNIH24_04310

KPZ:	KPNIH27_04120

KPV:	KPNIH29_04500

KPW:	KPNIH30_04530

KPY:	KPNIH31_03520

KPG:	KPNIH32_04535

KPC:	KPNIH10_04295

KPQ:	KPR0928_04305

KPT:	VK055_2438

KPO:	KPN2242_03095

KPR:	KPR_1060(cueO)

KPJ:

N559_4288

KPI:	D364_00615

KPA:	KPNJ1_04594

KPS:	KPNJ2_04547

KPX:	PMK1_02439(cueO)

KPB:	FH42_21490

KPNE:

KU54_022215

KPNU:

LI86_22055

KPNK:

BN49_4209(cueO)

KVA:

Kvar_4251

KPE:	KPK_4606(cueO)

KPK:	A593_15065

KVD:	KR75_12445

KVQ:	SP68_19120

KOX:

KOX_11130

KOE:

A225_0935

KOY:	J415_26580

KOM:	HR38_09860

KMI:	VW41_03640

KOK:	KONIH1_04865

KOC:	AB185_31310

KQU:	AVR78_08885

EAE:

EAE_11445

EAR:

CCG31694

KQV:	B8P98_23070

KLL:	BJF97_05405

KLW:	DA718_23575(cueO)

KAR:	LGL98_20780(cueO)

KGR:	JJJ10_23140(cueO)

KPAS:

LUW96_11385(cueO)

KLC:	K7H21_23285(cueO)

KLM:	BWI76_04945

REE:	electrica_04206(cueO)

KLP:	GUC22_22295(cueO)

ROR:	RORB6_14540

RON:	TE10_06395

RPLN:

B1209_22510

RAO:	DSD31_21225

RTG:	NCTC13098_06152(cueO_3)

CRO:	ROD_01341(cueO)

CKO:

CKO_03244

CFD:	CFNIH1_10345

CBRA:

A6J81_12760

CWE:	CO701_17775

CYO:	CD187_19880

CPOT:

FOB25_06990(cueO)

CFQ:	C2U38_03985

CSED:

JY391_17690(cueO)

CAMA:

F384_00690

CAF:	AL524_21805

CIF:	AL515_05410

CFAR:

CI104_05085

CIR:	C2U53_04230

CIE:	AN232_25815

CPAR:

CUC49_00620

CTEL:

GBC03_25170(cueO)

CITZ:

E4Z61_12970(cueO)

CARS:

E1B03_05160(cueO)

CIX:	M4I31_19520(cueO)

CIB:	HF677_019280(cueO)

CENS:

P2W74_18900(cueO)

CITR:

GUC46_19645(cueO)

EBT:	EBL_c32300(cueO)

CNT:	JT31_08630

CEM:	LH23_09095

CEN:	LH86_09150

CLAP:

NCTC11466_03798(cueO)

PGE:	LG71_24435

ESC:	Entcl_3603

KLE:	AO703_03890

KSA:	C813_11130

KOR:	AWR26_20855(cueO)

KRD:	A3780_02885

KCO:	BWI95_01675

KOT:	EH164_18400(cueO)

KPSE:

IP581_03910(cueO)

KOB:	HF650_04405(cueO)

KOO:	O9K67_20505(cueO)

KOU:	C0557_03280

KIE:	NCTC12125_02910(cueO)

KAS:	KATP_37500

KLU:	K7B04_00800(cueO)

KCY:	RIN60_18785(cueO)

LAX:	APT61_18440

LEI:	C2U54_08905

LEH:	C3F35_07855

LEE:	DVA44_19975

LER:	GNG29_04125(cueO)

LEA:	GNG26_03615(cueO)

LPNU:

KQ929_17015(cueO)

LAZ:	A8A57_03830

LEF:	LJPFL01_0760

LEW:	DAI21_00575

BUF:	D8682_11360(cueO)

BAGE:

BADSM9389_34220

BFT:	MNO13_20025(cueO)

BSEL:

RHD99_19910(cueO)

AHN:	NCTC12129_00920(cueO)

ASUB:

NLZ15_18170(cueO)

YRE:	HEC60_21810(cueO)

SGOE:

A8O29_018935(cueO)

KIN:	AB182_21095

PDZ:	HHA33_23645(cueO)

METY:

MRY16398_46930(cueO)

IZH:	FEM41_09815(cueO)

PSHI:

SAMEA2665130_0426(cueO)

PSGC:

G163CM_27760(cueO)

SCOL:

KFZ77_03670(cueO)

PVJ:	LMA04_08425(cueO)

SUPE:

P0H77_04805(cueO)

TOE:	QMG90_17565(cueO)

EBF:

D782_3741

EBC:	C2U52_02745

EBU:	CUC76_10975

EBB:	F652_2538(cueO)

PSTS:

E05_02520

YPE:	YPO3409(yacK)

YPK:

y0777

YPH:	YPC_3739(cueO)

YPA:

YPA_2911

YPN:

YPN_0679

YPM:	YP_0276(sufI1)

YPP:	YPDSF_2946

YPG:	YpAngola_A1021(cueO)

YPZ:

YPZ3_3006

YPT:	A1122_08860

YPD:

YPD4_2993

YPX:

YPD8_2993

YPW:

CH59_2639

YPJ:

CH55_1990

YPV:

BZ15_113

YPL:

CH46_1681

YPS:	YPTB0722(yacK)

YPO:

BZ17_1833

YPI:	YpsIP31758_3352(cueO)

YPY:

YPK_3480

YPB:

YPTS_0753

YPQ:	DJ40_1650(cueO)

YPU:

BZ21_4106

YPR:

BZ20_1363

YPC:

BZ23_199

YPF:

BZ19_72

YEN:	YE0712(yacK)

YEP:	YE105_C0827

YEY:

Y11_39441

YEW:	CH47_2773(cueO)

YET:

CH48_895

YEF:	FORC2_3386

YEE:	YE5303_26271(yacK)

YSI:	BF17_11895

YAL:

AT01_3237

YFR:	AW19_4049(cueO)

YIN:	CH53_984(cueO)

YKR:

CH54_1741

YRO:

CH64_3333

YRU:	BD65_2590(cueO)

YRB:	UGYR_13330

YAK:	ACZ76_12675

YMA:	DA391_18475

YHI:	D5F51_04420(cueO)

YEL:	LC20_04449

YCA:	F0T03_02120(cueO) F0T03_04145(cueO)

YMO:	HRD69_09310(cueO)

YAS:	N0H69_03810(cueO)

YKI:	HRD70_06535(cueO) HRD70_08460(cueO)

YEG:	PL78_14170

SMAR:

SM39_3597(cueO)

SMAC:

SMDB11_3411(cueO)

SMW:	SMWW4_v1c41080(cueO)

SPE:

Spro_3999

SRR:	SerAS9_4206

SRL:	SOD_c39520(cueO)

SRY:	M621_21220

SPLY:

Q5A_021185(cueO)

SRS:	SerAS12_4207

SRA:	SerAS13_4207

SMAF:

D781_3724

SLQ:	M495_20865

SERF:

L085_07965

SERS:

SERRSCBI_19975

SFW:	WN53_02785

SFG:	AV650_25515

SRZ:	AXX16_1363

SERM:

CLM71_19435

SQU:	E4343_20380(cueO)

SFJ:	SAMEA4384070_4119(cueO)

SOF:	NCTC11214_02620(cueO_1)

SSUR:

ATE40_017260

SURI:

J0X03_03365(cueO)

SRHZ:

FO014_14715(cueO)

SENP:

KHA73_20100(cueO)

SNEM:

NLX84_20860(cueO)

SNEV:

OI978_10830(cueO)

SGRI:

SGBXF1_04098(cueO)

SSAR:

SSARUM_004000(cueO)

SFO:	Z042_07180

RAH:	Rahaq_3685

RACE:

JHW33_12625(cueO)

RAQ:	Rahaq2_3779

RAA:

Q7S_18765

ROX:	BV494_13260

RVC:	J9880_03975(cueO)

RBON:

QNM34_18745(cueO)

RIU:	I2123_03925(cueO) I2123_20025(cueO)

GQU:	AWC35_15960

EAME:

GXP68_17275(cueO)

RBAD:

H2866_11330(cueO)

RCB:	O1V66_14210(cueO)

NIG:	C1N62_14080

SERA:

Ser39006_015515

SERQ:

CWC46_15510

DDD:	Dda3937_00009(cueO)

DZE:	Dd1591_2296

DDC:	Dd586_2229

DZC:	W909_08850

DSO:	A4U42_18850

CED:	LH89_02470

DFN:	CVE23_10310

DDQ:

DDI_1766

DAQ:	DAQ1742_02125(cueO)

DIC:	Dpoa569_002062(cueO)

DLC:	O1Q98_00995(cueO)

DDA:	Dd703_2196

EAM:	EAMY_2803(yacK)

EAY:	EAM_0777(cueO)

ETA:	ETA_08330(cueO)

EPY:	EpC_08230(cueO)

EPR:	EPYR_00868(yacK)

EBI:	EbC_07740(cueO)

ERJ:	EJP617_02700(yacK)

EPE:	CI789_14625

ERWI:

GN242_17370(cueO)

ETP:	LU633_04840(cueO)

ERP:	LJN55_19060(cueO)

EPI:	Q3V30_17480(cueO)

ETO:	RIN69_04380(cueO)

EGE:	EM595_0771(cueO)

PAM:	PANA_0758(cueO)

PLF:	PANA5342_3549(cueO)

PAJ:	PAJ_0106(cueO)

PAQ:	PAGR_g3440

PVA:	Pvag_0170(yacK)

PAGG:

AL522_07790

PAO:	Pat9b_0716

KLN:	LH22_18665

PANT:

PSNIH1_08540

PANP:

PSNIH2_14210

PAGC:

BEE12_10520

PALH:

B1H58_03260

PANS:

FCN45_03610(cueO)

PEY:	EE896_15750(cueO)

PDIS:

D8B20_03475(cueO)

PER:	LAC65_02730(cueO)

PJI:	KTJ90_15610(cueO)

PANO:

OJ965_17495(cueO)

KPIE:

N5580_14990(cueO)

PALF:

K6R05_15340(cueO)

PPHO:

CTZ24_03710

PDIP:

KFZ74_16355(cueO)

PGZ:	C2E15_04545

PCD:	C2E16_04475

MINT:

C7M51_00088(cueO)

MTHI:

C7M52_02628(cueO)

MHAN:

K6958_04215(cueO)

TCI:	A7K98_16035

TPTY:

NCTC11468_03055(cueO)

TATU:

EFZ10_11745(cueO)

PMAK:

PMPD1_0911

PLU:	plu0845(cueO)

PLUM:

A4R40_04225

PAY:	PAU_00797(cueO)

PAKH:

B0X70_04650

PLUI:

CE143_04580

PMR:	PMI0159(cueO)

PMIB:

BB2000_0323(cueO)

PVL:	AOB99_03610

PVG:	CRN77_00410

PHAU:

PH4a_10830

PROT:

BTA34_02510

PCOL:

F1325_03770(cueO)

PCIB:

F9282_03590(cueO)

PPEE:

I6G31_05705(cueO)

PAPP:

QQS39_03995(cueO)

PSI:

S70_05215

PSX:	DR96_155(cueO)

PSTA:

BGK56_08090

PTHA:

OI982_18580(cueO)

PRG:	RB151_034280(cueO)

PALA:

CO695_09185

PHEI:

NCTC12003_01021(cueO)

PRQ:	CYG50_21330(cueO)

PRJ:	NCTC6933_03024(cueO)

PVC:	G3341_05000(cueO)

PMAG:

JI723_05350(cueO)

PHAG:

PZ638_04985(cueO)

PZJ:	QS795_013215(cueO)

MMK:

MU9_1116

ANS:	ArsFIN_36830(cueO_2)

AET:	LDL57_03220(cueO)

AAPC:

QG404_11850(cueO)

HAV:	AT03_17850

HPAR:

AL518_08650

OPO:	DSM2777_07395

MII:	BTJ40_18080

MICT:

FIU95_16880(cueO)

MVB:	MJO52_17190(cueO)

AHA:

AHA_3589

AHY:	AHML_18985

AHD:	AI20_01415

AHR:	V428_19735

AHP:	V429_19765

AHJ:	V469_03545

AHH:	RY45_18430

AHI:	VU14_03750

AAJ:	BOQ57_18735

ADH:	CK627_22375

SALV:

SALWKB2_1479

PEW:	KZJ38_34310(cueO)

AMIM:

MIM_c31520(cueO)

BME:

BMEII0580

BMEL:

DK63_2666(cueO)

BMI:	BMEA_B0678

BMZ:	BM28_B0672

BMG:	BM590_B0671

BMW:	BMNI_II0655

BMEE:

DK62_2736(cueO)

BMF:

BAB2_0534

BMB:	BruAb2_0526

BMC:	BAbS19_II05050

BAA:	BAA13334_II01075

BABO:

DK55_2514(cueO)

BABR:

DO74_2929(cueO)

BABT:

DK49_2725(cueO)

BABB:

DK48_2177(cueO)

BABU:

DK53_2517(cueO)

BABS:

DK51_3101(cueO)

BABC:

DO78_2541(cueO)

BMS:

BRA0704

BSI:	BS1330_II0697

BSF:	BSS2_II0669

BSUI:

BSSP1_II0645

BSUP:

BSPT1_II0642

BSUV:

BSPT2_II0645

BSUC:

BSSP2_II0654

BMT:	BSUIS_B0689

BSZ:	DK67_2669(cueO)

BSV:	BSVBI22_B0696

BSW:	IY71_14550

BSG:	IY72_14505

BOV:

BOV_A0660

BCS:	BCAN_B0707

BSK:	BCA52141_II0227

BOL:	BCOUA_II0704

BCAR:

DK60_2404(cueO)

BCAS:

DA85_13840

BMR:

BMI_II698

BPP:

BPI_II758

BPV:	DK65_2933(cueO)

BCET:

V910_200565

BCEE:

V568_200645

BVL:	BF3285c2_0235

BRU:	BFS01_12930

BRJ:	BKD03_03210

OIN:	IAR37_17165(cueO)

BIO:	BR141012304_20323

OAN:

Oant_3828

OAH:	DR92_2663(cueO)

OPS:	A8A54_14650

BPSN:

NIK97_19885(cueO)

BRUC:

LJ361_14365(cueO)

OCR:	HGK82_21610(cueO)

OCL:	GTN27_16285(cueO)

OCC:	KMS41_15530(cueO)

OCH:	CES85_4087

PSCQ:

KHQ08_02520(cueO)

PSXF:

LDL70_00545(cueO)

MSL:

Msil_2277

THD:	BHV28_08930

GYJ:	AADW23_06855

DEX:	HWD60_14670(cueO)

DOG:	HP555_08250(cueO)

» show all

Reference

1 [PMID:11466290]

Authors

Kim C, Lorenz WW, Hoopes JT, Dean JF

Title

Oxidation of phenolate siderophores by the multicopper oxidase encoded by the Escherichia coli yacK gene.

Journal

J Bacteriol 183:4866-75 (2001)
DOI:10.1128/JB.183.16.4866-4875.2001

Reference

2 [PMID:11527384]

Authors

Grass G, Rensing C.

Title

CueO is a multi-copper oxidase that confers copper tolerance in Escherichia coli.

Journal

Biochem Biophys Res Commun 286:902-8 (2001)
DOI:10.1006/bbrc.2001.5474

Sequence

[eco:b0123]

Reference

3 [PMID:11399769]

Authors

Outten FW, Huffman DL, Hale JA, O'Halloran TV

Title

The independent cue and cus systems confer copper tolerance during aerobic and anaerobic growth in Escherichia coli.

Journal

J Biol Chem 276:30670-7 (2001)
DOI:10.1074/jbc.M104122200

Reference

4 [PMID:11867755]

Authors

Roberts SA, Weichsel A, Grass G, Thakali K, Hazzard JT, Tollin G, Rensing C, Montfort WR.

Title

Crystal structure and electron transfer kinetics of CueO, a multicopper oxidase required for copper homeostasis in Escherichia coli.

Journal

Proc Natl Acad Sci U S A 99:2766-71 (2002)
DOI:10.1073/pnas.052710499

Sequence

[eco:b0123]

Reference

5 [PMID:12794077]

Authors

Roberts SA, Wildner GF, Grass G, Weichsel A, Ambrus A, Rensing C, Montfort WR.

Title

A labile regulatory copper ion lies near the T1 copper site in the multicopper oxidase CueO.

Journal

J Biol Chem 278:31958-63 (2003)
DOI:10.1074/jbc.M302963200

Sequence

[eco:b0123]

Reference

6 [PMID:15516598]

Authors

Singh SK, Grass G, Rensing C, Montfort WR.

Title

Cuprous oxidase activity of CueO from Escherichia coli.

Journal

J Bacteriol 186:7815-7 (2004)
DOI:10.1128/JB.186.22.7815-7817.2004

Reference

7 [PMID:14648285]

Authors

Galli I, Musci G, Bonaccorsi di Patti MC.

Title

Sequential reconstitution of copper sites in the multicopper oxidase CueO.

Journal

J Biol Inorg Chem 9:90-5 (2004)
DOI:10.1007/s00775-003-0501-4

Reference

8 [PMID:20088522]

Authors

Djoko KY, Chong LX, Wedd AG, Xiao Z.

Title

Reaction mechanisms of the multicopper oxidase CueO from Escherichia coli support its functional role as a cuprous oxidase.

Journal

J Am Chem Soc 132:2005-15 (2010)
DOI:10.1021/ja9091903

Sequence

[eco:b0123]

Reference

9 [PMID:21903583]

Authors

Singh SK, Roberts SA, McDevitt SF, Weichsel A, Wildner GF, Grass GB, Rensing C, Montfort WR.

Title

Crystal structures of multicopper oxidase CueO bound to copper(I) and silver(I): functional role of a methionine-rich sequence.

Journal

J Biol Chem 286:37849-57 (2011)
DOI:10.1074/jbc.M111.293589

Sequence

[eco:b0123]

Reference

10 [PMID:25679350]

Authors

Cortes L, Wedd AG, Xiao Z.

Title

The functional roles of the three copper sites associated with the methionine-rich insert in the multicopper oxidase CueO from E. coli.

Journal

Metallomics 7:776-85 (2015)
DOI:10.1039/c5mt00001g

Sequence

[eco:b0123]

Other DBs

ExplorEnz - The Enzyme Database:

1.16.3.4

IUBMB Enzyme Nomenclature:

1.16.3.4

ExPASy - ENZYME nomenclature database:

1.16.3.4

BRENDA, the Enzyme Database:

1.16.3.4

DBGET integrated database retrieval system