| Entry |
|
|---|
| Name |
CDP-4-dehydro-6-deoxyglucose reductase;
CDP-4-keto-6-deoxyglucose reductase;
cytidine diphospho-4-keto-6-deoxy-D-glucose reductase;
cytidine diphosphate 4-keto-6-deoxy-D-glucose-3-dehydrogenase;
CDP-4-keto-deoxy-glucose reductase;
CDP-4-keto-6-deoxy-D-glucose-3-dehydrogenase system;
NAD(P)H:CDP-4-keto-6-deoxy-D-glucose oxidoreductase
|
|---|
| Class |
Oxidoreductases;
Acting on CH or CH2 groups;
With NAD+ or NADP+ as acceptor
|
|---|
| Sysname |
CDP-4-dehydro-3,6-dideoxy-D-glucose:NAD(P)+ 3-oxidoreductase
|
|---|
| Reaction(IUBMB) |
CDP-4-dehydro-3,6-dideoxy-D-glucose + NAD(P)+ + H2O = CDP-4-dehydro-6-deoxy-D-glucose + NAD(P)H + H+ [RN: R03391 R03392]
|
|---|
| Reaction(KEGG) |
|
|---|
| Substrate |
|
|---|
| Product |
|
|---|
| Comment |
The enzyme consists of two proteins. One forms an enzyme-bound adduct of the CDP-4-dehydro-6-deoxyglucose with pyridoxamine phosphate, in which the 3-hydroxy group has been removed. The second catalyses the reduction of this adduct by NAD(P)H and release of the CDP-4-dehydro-3,6-dideoxy-D-glucose and pyridoxamine phosphate.
|
|---|
| History |
EC 1.17.1.1 created 1972, modified 2005
|
|---|
| Pathway |
| ec00520 | Amino sugar and nucleotide sugar metabolism |
| ec00541 | O-Antigen nucleotide sugar biosynthesis |
|
|---|
| Orthology |
| K00523 | CDP-4-dehydro-6-deoxyglucose reductase, E3 |
| K12452 | CDP-4-dehydro-6-deoxyglucose reductase, E1 |
|
|---|
| Genes |
» show all
|
|---|
| Reference |
|
|---|
| Authors |
Pape H, Strominger JL. |
|---|
| Title |
Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. V. Partial purification of the two protein components required for introduction of the 3-deoxy group. |
|---|
| Journal |
J Biol Chem 244:3598-604 (1969) |
|---|
| Reference |
|
|---|
| Authors |
Rubenstein PA, Strominger JL. |
|---|
| Title |
Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. 8. Mechanistic roles of enzyme E-1 and pyridoxamine 5'-phosphate in the formation of cytidine diphosphate-4-keto-3,6-dideoxy-D-glucose from cytidine diphosphate-4-keto-6-deoxy-D-glucose. |
|---|
| Journal |
J Biol Chem 249:3776-81 (1974) |
|---|
| Reference |
|
|---|
| Authors |
Liu HW, Thorson JS. |
|---|
| Title |
Pathways and mechanisms in the biogenesis of novel deoxysugars by bacteria. |
|---|
| Journal |
|
|---|
| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.17.1.1 |
| ExPASy - ENZYME nomenclature database: | 1.17.1.1 |
|
|---|
