KEGG   ENZYME: 1.17.1.10
Entry
EC 1.17.1.10                Enzyme                                 
Name
formate dehydrogenase (NADP+);
NADP+-dependent formate dehydrogenase
Class
Oxidoreductases;
Acting on CH or CH2 groups;
With NAD+ or NADP+ as acceptor
Sysname
formate:NADP+ oxidoreductase
Reaction(IUBMB)
formate + NADP+ = CO2 + NADPH [RN:R00134]
Reaction(KEGG)
R00134
Substrate
formate [CPD:C00058];
NADP+ [CPD:C00006]
Product
CO2 [CPD:C00011];
NADPH [CPD:C00005]
Comment
A tungsten-selenium-iron protein characterized from the bacterium Moorella thermoacetica. It is extremely sensitive to oxygen.
History
EC 1.17.1.10 created 1978 as EC 1.2.1.43, transferred 2017 to EC 1.17.1.10
Pathway
ec00680  Methane metabolism
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K05299  formate dehydrogenase (NADP+) alpha subunit
K15022  formate dehydrogenase (NADP+) beta subunit
Genes
VFUvfu_A02711
VGABSQ33_17050
VSRVspart_03926(gltD_2)
TIGTHII_3690
TNITVNIR_2014
TTITHITH_06945
ATYA9R16_007295
LHKLHK_02330
CCAXKZ686_11545(fdhF)
SUTTSUTMEG_16550
SUTKFG381_03580
SWSI6J16_02780
BBAYA4V04_04855
DDZDSYM_19100
RPATX73_000695
RPERPE_3861
RPTRpal_0138
RPXRpdx1_0129
BVRBVIR_2956
BLAGBLTE_01210
RHCRGUI_3847
RAPRHOA_1103
MAGQMGMAQ_1747
HBLXJ32_06675
WSUWS0477(FDHB)
TDNSuden_1824
SUASaut_1830
SULNFJR47_08390
SULGFJR48_10415
SULCCVO_01175
SPALFM071_08755
SSEIFJR45_10385
SBALHUE88_01240
SMASHUE87_10880
SMAXFJR03_09560
SKUSulku_0269
SULRB649_01165
HYONNO_1954
HTMRZR91_01580
HCJHCR_15980(sfrB)
NSANitsa_0162
SUNSUN_2227
SLHYH65_00465
SINUIMZ28_01145
SMABLN246_12055
NISNIS_0293
GSUGSU0509(sfrA) GSU0510(sfrB)
GSKKN400_0498(sfrA) KN400_0499(sfrB)
GMEGmet_3022(sfrA) Gmet_3023(sfrB)
GPIGPICK_13835 GPICK_13840
GBZJZM60_03195 JZM60_03200
GEMGM21_0672 GM21_0673
GEBGM18_3695 GM18_3696
GEFFO488_01565
GURGura_3639 Gura_3640
GEOGeob_1607(sfrB) Geob_1608(sfrA)
GLOGlov_0660 Glov_0661
TAMMGEAMG1_0198(sfrA) GEAMG1_0199(sfrB)
GBMGbem_0659(sfrB) Gbem_0660(sfrA)
GBNGEOBRER4_06660(sfrB) GEOBRER4_06670(sfrA) GEOBRER4_30170
GERKP004_02570 KP004_02575
GSUBKP001_12875 KP001_12880
GNTKP003_02205 KP003_02210
GPLM1B72_18390 M1B72_18395
GSBGSUB_01595 GSUB_01600
PCAPcar_2503(sfrB)
DEUDBW_0666 DBW_0667
DVEDESUT3_04340(sfrB) DESUT3_04350(sfrA)
DEPAOP6_2711(sfrA) AOP6_2712(sfrB)
DESDSOUD_3426 DSOUD_3427
DDSDdes_1543
DEFCNY67_05260
PSYFN1030_00160(fdhF)
DSADesal_0925 Desal_1735
DHYDESAM_22464 DESAM_23223
DAFDesaf_1699
DASDaes_1334
DPIBN4_10151 BN4_10592
DEJAWY79_10930 AWY79_17585
PPRFDPRO_0175 DPRO_0998
PSELGM415_12865
DDNDND132_0178 DND132_0691 DND132_2868
PSEFPSDVSF_06760
PPORJCM14722_04400 JCM14722_09200
PNWSYK_05490 SYK_08600 SYK_15590
DVUDVU_1772
DVLDvul_1383
DVGDeval_1526
DBADbac_0167
DESUNLA06_12110(fdhF)
DPSDP0682
DBKDGMP_17720
DDUGF1_09750
DOLDole_2825
DALDalk_0215 Dalk_2557 Dalk_2596 Dalk_2597
DATHRM2_16890(fdhA6) HRM2_26590(gltD1) HRM2_32120
DTOTOL2_C10170(rnfB) TOL2_C28850(fdhA2)
DOVDSCO28_46070 DSCO28_50930(sfrB) DSCO28_53000 DSCO28_60770
DWDDSCW_19530 DSCW_24100 DSCW_39410
DALKDSCA_31580 DSCA_39350 DSCA_49620 DSCA_51850 DSCA_56540
DMLDmul_27610(rnfB2)
DMMdnm_034450 dnm_072420(rnfB2) dnm_095740
DEKDSLASN_10670
DAODesac_1071 Desac_2111
DTIDesti_0863 Desti_2930 Desti_2931
SFUSfum_1181
DAXFDQ92_14530 FDQ92_14660
DBRDeba_0487 Deba_0488 Deba_1743
TAVG4V39_01635
TMAIFVE67_00210
ADEAdeh_2406
DHRLGS26_01895(fdhF)
CLJCLJU_c08690
CAHCAETHG_2963
CDRKB9W14_11420
CMICcaldi_03270
DSYDSY3968(fdhF)
DHDDhaf_1398
DDHDesde_1318
DDLDesdi_1184
SGYSgly_2685
DORDesor_0661 Desor_4477
DAIDesaci_0777
DMIDesmer_0214 Desmer_0713
DEDDHBDCA_p1614
DECDCF50_p1622
DRSDEHRE_11885
DCADesca_2053
DAEDtox_3503 Dtox_3507
DAUDaud_0104
FWADCMF_14065
AACXDEACI_1377
TJRTherJR_0670 TherJR_0942
DGIDesgi_2136 Desgi_3847
HMOHM1_1745(fdhA)
AWICHL1_000121(fdhF)
CTHMCFE_2215
CHYCHY_0733(fdhA)
ADGAdeg_0156 Adeg_0334
MTAMoth_2312(fdhA) Moth_2314
MTHOMOTHE_c23870(fdhF3) MOTHE_c23890(sfrB2)
MTHZMOTHA_c24590(fdhF3) MOTHA_c24610(sfrB2)
TOCToce_0785
NTHNther_0100
AARAcear_2299
CADCuri_c16640(fdhB)
KPARJL105_10655(fdhF)
DETDET0123
DEVDhcVS_131
DMGGY50_0154
DMXX792_00790
DMYX793_00645
DUCUCH007_01080
DLYDehly_0151 Dehly_0227 Dehly_1357
DEWDGWBC_1766
DFODform_02183
DETHHX448_07080(fdhF)
KBBccbrp13_10910
ULIETAA1_06170
KSTKSMBR1_3796
BROCIPI25_00230 IPI25_04935 IPI25_07710(fdhF) IPI25_08630(fdhF) IPI25_10400
BPITBPIT_05580 BPIT_26950
JETL3J17_07505 L3J17_14530(fdhF)
ADINH7849_06915(nuoG)
SUSAcid_3510
PFERIRI77_15560
ARAMKAR29_00265(fdhF)
CSACSIO70_24310
ASACATHSA_0203
DDFDEFDS_1613
DAPDacet_2494
GTLEP073_00480
CNICalni_1870
FSIFlexsi_0433
MSCHN508_001026(sfrA) N508_001027(sfrB)
DTPJZK55_05530(nuoG-1_1) JZK55_11790 JZK55_19460(fdhA)
NKFNkreftii_003503 Nkreftii_004097
NTIDNFV4_00402 DNFV4_00911
NALLPP769_05445 PP769_08770(nuoG)
NNEOPQG83_16650 PQG83_19995(nuoG)
NLIG3M70_15040
MOXDAMO_0766
MTHMTH_1552
MMGMTBMA_c01380(fdhA1)
MTEEMTTB_15350
METCMTCT_1417
METEtca_01501(fdhF_2)
METZMETMT2_0015
METKFVF72_03860
METJFZP68_05395
MELMetbo_2515
METTCIT01_06250
MEMEHYG87_07080(fdhF)
MFEGGCM10025860_09010
MTPMthe_0915
BARBAOA66_1514(sudA_1)
LOBNEF87_003197
 » show all
Reference
1  [PMID:4154039]
  Authors
Andreesen JR, Ljungdahl LG.
  Title
Nicotinamide adenine dinucleotide phosphate-dependent formate dehydrogenase from Clostridium thermoaceticum: purification and properties.
  Journal
J Bacteriol 120:6-14 (1974)
DOI:10.1128/JB.120.1.6-14.1974
Reference
2  [PMID:6822536]
  Authors
Yamamoto I, Saiki T, Liu SM, Ljungdahl LG
  Title
Purification and properties of NADP-dependent formate dehydrogenase from Clostridium thermoaceticum, a tungsten-selenium-iron protein.
  Journal
J Biol Chem 258:1826-32 (1983)
Other DBs
ExplorEnz - The Enzyme Database: 1.17.1.10
IUBMB Enzyme Nomenclature: 1.17.1.10
ExPASy - ENZYME nomenclature database: 1.17.1.10
BRENDA, the Enzyme Database: 1.17.1.10
CAS: 51377-43-6

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