KEGG   ENZYME: 1.17.1.10
Entry
EC 1.17.1.10                Enzyme                                 

Name
formate dehydrogenase (NADP+);
NADP+-dependent formate dehydrogenase
Class
Oxidoreductases;
Acting on CH or CH2 groups;
With NAD+ or NADP+ as acceptor
Sysname
formate:NADP+ oxidoreductase
Reaction(IUBMB)
formate + NADP+ = CO2 + NADPH [RN:R00134]
Reaction(KEGG)
R00134
Substrate
formate [CPD:C00058];
NADP+ [CPD:C00006]
Product
CO2 [CPD:C00011];
NADPH [CPD:C00005]
Comment
A tungsten-selenium-iron protein characterized from the bacterium Moorella thermoacetica. It is extremely sensitive to oxygen.
History
EC 1.17.1.10 created 1978 as EC 1.2.1.43, transferred 2017 to EC 1.17.1.10
Pathway
ec00680  Methane metabolism
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K05299  formate dehydrogenase (NADP+) alpha subunit
K15022  formate dehydrogenase (NADP+) beta subunit
Genes
XBA: C7S18_01025
VFU: vfu_A02711
VGA: BSQ33_17050
THT: E2K93_16355
THAP: FNC98_07420
MARA: D0851_18400
SPOI: IMCC21906_01458
ZAL: AZF00_11880
OSG: BST96_15830
HALC: EY643_10615
MCA: MCA0770
MMAI: sS8_1217
TIG: THII_3690
GPB: HDN1F_09540(korC)
LHK: LHK_02330
RFR: Rfer_2800
WSU: WS0477(FDHB)
SUA: Saut_1830
SULC: CVO_01175
SULR: B649_01165
HYO: NNO_1954
NIS: NIS_0293
SUN: SUN_2227
GSU: GSU0509(sfrA) GSU0510(sfrB)
GSK: KN400_0498(sfrA) KN400_0499(sfrB)
GME: Gmet_3022(sfrA) Gmet_3023(sfrB)
GBM: Gbem_0659(sfrB) Gbem_0660(sfrA)
GEO: Geob_1607(sfrB) Geob_1608(sfrA)
PCA: Pcar_2503(sfrB)
DVU: DVU1772
DVL: Dvul_1383
DDS: Ddes_1543
DAS: Daes_1334
DBA: Dbac_0167
DPS: DP0682
DOL: Dole_2825
DML: Dmul_27610(rnfB2)
DAT: HRM2_16890(fdhA6) HRM2_26590(gltD1) HRM2_32120
DTO: TOL2_C10170(rnfB) TOL2_C28850(fdhA2)
ADE: Adeh_2406
SFU: Sfum_1181
BRS: S23_15710
AOL: S58_18190
BRAD: BF49_4910
RPA: RPA0135
RPE: RPE_3861
RPT: Rpal_0138
VGO: GJW-30_1_03563(gltD)
MSL: Msil_2986
BVR: BVIR_2956
BLAG: BLTE_01210
PZU: PHZ_c1698
RHC: RGUI_3847
SWI: Swit_3235
SPHD: HY78_09380
SHUM: STHU_46680
MAGQ: MGMAQ_1747
CSR: Cspa_c47560(nuoG)
DSY: DSY3968(fdhF)
DHD: Dhaf_1398
DAU: Daud_0104
SGY: Sgly_2685
HMO: HM1_1745(fdhA)
CHY: CHY_0733(fdhA)
MTA: Moth_2314
MTHO: MOTHE_c23870(fdhF3) MOTHE_c23890(sfrB2)
MTHZ: MOTHA_c24590(fdhF3) MOTHA_c24610(sfrB2)
TOC: Toce_0785
CAD: Curi_c16640(fdhB)
ACIJ: JS278_02794(sfrB)
DET: DET0123
DEV: DhcVS_131
DMG: GY50_0154
SUS: Acid_3510
GBA: J421_1491
MGOT: MgSA37_01366(gltD_1)
MOX: DAMO_0766
MTH: MTH_1552
MMG: MTBMA_c01380(fdhA1)
METC: MTCT_1417
MTP: Mthe_0915
BARB: AOA66_1514(sudA_1)
 » show all
Reference
1  [PMID:4154039]
  Authors
Andreesen JR, Ljungdahl LG.
  Title
Nicotinamide adenine dinucleotide phosphate-dependent formate dehydrogenase from Clostridium thermoaceticum: purification and properties.
  Journal
J Bacteriol 120:6-14 (1974)
DOI:10.1128/JB.120.1.6-14.1974
Reference
2  [PMID:6822536]
  Authors
Yamamoto I, Saiki T, Liu SM, Ljungdahl LG.
  Title
Purification and properties of NADP-dependent formate dehydrogenase from Clostridium thermoaceticum, a tungsten-selenium-iron protein.
  Journal
J Biol Chem 258:1826-32 (1983)
Other DBs
ExplorEnz - The Enzyme Database: 1.17.1.10
IUBMB Enzyme Nomenclature: 1.17.1.10
ExPASy - ENZYME nomenclature database: 1.17.1.10
BRENDA, the Enzyme Database: 1.17.1.10
CAS: 51377-43-6

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