KEGG   ENZYME: 1.17.1.11Help
Entry
EC 1.17.1.11                Enzyme                                 

Name
formate dehydrogenase (NAD+, ferredoxin);
electron-bifurcating formate dehydrogenase
Class
Oxidoreductases;
Acting on CH or CH2 groups;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
formate:NAD+, ferredoxin oxidoreductase
Reaction(IUBMB)
2 formate + NAD+ + 2 oxidized ferredoxin [iron-sulfur] cluster = 2 CO2 + NADH + H+ + 2 reduced ferredoxin [iron-sulfur] cluster [RN:R11818]
Reaction(KEGG)
Substrate
formate [CPD:C00058];
NAD+ [CPD:C00003];
oxidized ferredoxin [iron-sulfur] cluster [CPD:C00139]
Product
CO2 [CPD:C00011];
NADH [CPD:C00004];
H+ [CPD:C00080];
reduced ferredoxin [iron-sulfur] cluster [CPD:C00138]
Comment
The enzyme complex, isolated from the bacterium Gottschalkia acidurici, couples the reduction of NAD+ and the reduction of ferredoxin with formate via flavin-based electron bifurcation.
History
EC 1.17.1.11 created 2015 as EC 1.2.1.93, transferred 2017 to EC 1.17.1.11
Orthology
K22338  formate dehydrogenase (NAD+, ferredoxin) subunit A
K22339  formate dehydrogenase (NAD+, ferredoxin) subunit B
K22340  formate dehydrogenase (NAD+, ferredoxin) subunit C
K22341  formate dehydrogenase (NAD+, ferredoxin) subunit
Genes
CACE: CACET_c32690(fdhA) CACET_c35730(nuoF2) CACET_c35750(nuoE2)
CFM: BJL90_01750 BJL90_01760 BJL90_01770 BJL90_01775
AMT: Amet_4108 Amet_4110
AOE: Clos_2249 Clos_2250 Clos_2251 Clos_2252
GFE: Gferi_20690 Gferi_20700
EAC: EAL2_c04290(hymA) EAL2_c04300(hymB) EAL2_c04330(fdhB1) EAL2_c04340(fdhA1)
AAR: Acear_2300
FMA: FMG_1154
CAD: Curi_c29380(fdhF2) Curi_c29390(hydA1) Curi_c29400(hydB) Curi_c29410(hydC)
Taxonomy
Reference
1  [PMID:23872566]
  Authors
Wang S, Huang H, Kahnt J, Thauer RK
  Title
Clostridium acidurici electron-bifurcating formate dehydrogenase.
  Journal
Appl Environ Microbiol 79:6176-9 (2013)
DOI:10.1128/AEM.02015-13
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.17.1.11
IUBMB Enzyme Nomenclature: 1.17.1.11
ExPASy - ENZYME nomenclature database: 1.17.1.11
BRENDA, the Enzyme Database: 1.17.1.11

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