Entry |
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Name |
leucoanthocyanidin reductase;
leucocyanidin reductase
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Class |
Oxidoreductases;
Acting on CH or CH2 groups;
With NAD+ or NADP+ as acceptor
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Sysname |
(2R,3S)-catechin:NADP+ 4-oxidoreductase
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Reaction(IUBMB) |
(2R,3S)-catechin + NADP+ + H2O = 2,3-trans-3,4-cis-leucocyanidin + NADPH + H+ [RN: R06532]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
The enzyme catalyses the synthesis of catechin, catechin-4beta-ol (leucocyanidin) and the related flavan-3-ols afzelechin and gallocatechin, which are initiating monomers in the synthesis of plant polymeric proanthocyanidins or condensed tannins. While 2,3-trans-3,4-cis-leucocyanidin is the preferred flavan-3,4-diol substrate, 2,3-trans-3,4-cis-leucodelphinidin and 2,3-trans-3,4-cis-leucopelargonidin can also act as substrates, but more slowly. NADH can replace NADPH but is oxidized more slowly.
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History |
EC 1.17.1.3 created 2003
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Pathway |
ec01110 | Biosynthesis of secondary metabolites |
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Orthology |
K13081 | leucoanthocyanidin reductase |
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Genes |
» show all
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Reference |
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Authors |
Tanner GJ, Kristiansen KN. |
Title |
Synthesis of 3,4-cis-[3H]leucocyanidin and enzymatic reduction to catechin. |
Journal |
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Reference |
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Authors |
Tanner GJ, Francki KT, Abrahams S, Watson JM, Larkin PJ, Ashton AR |
Title |
Proanthocyanidin biosynthesis in plants. Purification of legume leucoanthocyanidin reductase and molecular cloning of its cDNA. |
Journal |
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Sequence |
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Other DBs |
ExplorEnz - The Enzyme Database: | 1.17.1.3 |
ExPASy - ENZYME nomenclature database: | 1.17.1.3 |
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