KEGG   ENZYME: 1.17.3.3
Entry
EC 1.17.3.3                 Enzyme                                 
Name
6-hydroxynicotinate dehydrogenase;
6-hydroxynicotinic acid hydroxylase;
6-hydroxynicotinic acid dehydrogenase;
6-hydroxynicotinate hydroxylase;
6-hydroxynicotinate:O2 oxidoreductase
Class
Oxidoreductases;
Acting on CH or CH2 groups;
With oxygen as acceptor
Sysname
6-hydroxynicotinate:oxygen oxidoreductase
Reaction(IUBMB)
6-hydroxynicotinate + H2O + O2 = 2,6-dihydroxynicotinate + H2O2 [RN:R07221]
Reaction(KEGG)
R07221
Substrate
6-hydroxynicotinate [CPD:C01020];
H2O [CPD:C00001];
O2 [CPD:C00007]
Product
2,6-dihydroxynicotinate [CPD:C15523];
H2O2 [CPD:C00027]
Comment
Contains [2Fe-2S] iron-sulfur centres, FAD and molybdenum. It also has a catalytically essential, labile selenium that can be removed by reaction with cyanide. In Bacillus niacini, this enzyme is required for growth on nicotinic acid.
History
EC 1.17.3.3 created 2004
Pathway
ec00760  Nicotinate and nicotinamide metabolism
Reference
1
  Authors
Nagel M, Andreesen JR.
  Title
Molybdenum-dependent degradation of nicotinic acid by Bacillus sp. DSM 2923.
  Journal
FEMS Microbiol Lett 59:147-152 (1989)
Reference
2
  Authors
Nagel M, Andreesen JR.
  Title
Purification and characterization of the molybdoenzymes nicotinate dehydrogenase and 6-hydroxynicotinate dehydrogenase from Bacillus niacini.
  Journal
Arch Microbiol 154:605-613 (1990)
Other DBs
ExplorEnz - The Enzyme Database: 1.17.3.3
IUBMB Enzyme Nomenclature: 1.17.3.3
ExPASy - ENZYME nomenclature database: 1.17.3.3
BRENDA, the Enzyme Database: 1.17.3.3
CAS: 122191-32-6

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