KEGG   ENZYME: 1.17.4.4
Entry
EC 1.17.4.4                 Enzyme                                 
Name
vitamin-K-epoxide reductase (warfarin-sensitive);
VKORC1 (gene name);
VKORC1L1 (gene name)
Class
Oxidoreductases;
Acting on CH or CH2 groups;
With a disulfide as acceptor
Sysname
phylloquinone:disulfide oxidoreductase
Reaction(IUBMB)
(1) phylloquinone + a protein with a disulfide bond + H2O = 2,3-epoxyphylloquinone + a protein with reduced L-cysteine residues [RN:R03511];
(2) phylloquinol + a protein with a disulfide bond = phylloquinone + a protein with reduced L-cysteine residues
Reaction(KEGG)
R03511;
(other) R03645 R09992
Substrate
phylloquinone [CPD:C02059];
protein with a disulfide bond;
H2O [CPD:C00001];
phylloquinol [CPD:C03313]
Product
2,3-epoxyphylloquinone [CPD:C05849];
protein with reduced L-cysteine residues;
phylloquinone [CPD:C02059]
Comment
The enzyme catalyses the reduction of vitamin K 2,3-epoxide, which is formed by the activity of EC 4.1.1.90, peptidyl-glutamate 4-carboxylase, back to its phylloquinol active form. The enzyme forms a tight complex with EC 5.3.4.1, protein disulfide-isomerase, which transfers the required electrons from newly-synthesized proteins by catalysing the formation of disulfide bridges. The enzyme acts on the epoxide forms of both phylloquinone (vitamin K1) and menaquinone (vitamin K2). Inhibited strongly by (S)-warfarin and ferulenol.
History
EC 1.17.4.4 created 1989 as EC 1.1.4.1, transferred 2014 to EC 1.17.4.4, modified 2018
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K05357  vitamin-K-epoxide reductase (warfarin-sensitive)
Genes
HSA: 154807(VKORC1L1) 79001(VKORC1)
PTR: 100610370(VKORC1) 472396(VKORC1L1)
PPS: 100979578(VKORC1L1) 103784246(VKORC1)
GGO: 101127117 101145443(VKORC1L1) 129523461(VKORC1)
PON: 100434981(VKORC1) 100458063(VKORC1L1) 112134373
PPYG: 129015781(VKORC1) 129040953(VKORC1L1)
NLE: 100591850(VKORC1) 100601157 100601262(VKORC1L1)
HMH: 116471184(VKORC1) 116811828(VKORC1L1)
SSYN: 129489831(VKORC1L1) 129490691 129493130(VKORC1)
MCC: 114676888 697591(VKORC1L1) 714412(VKORC1)
MCF: 101926368(VKORC1) 102143754(VKORC1L1)
MTHB: 126944258 126946887 126950311
MNI: 105482950(VKORC1)
CSAB: 103231221(VKORC1) 103246568(VKORC1L1) 103246572 103246927
CATY: 105574592 105581545 105593305(VKORC1L1) 105599496(VKORC1)
PANU: 101007749(VKORC1L1) 101025627(VKORC1)
TGE: 112614204(VKORC1) 112620261 112620583
MLEU: 105541466(VKORC1) 105548721 105548733 105548736
RRO: 104661567(VKORC1) 104678399 104678964(VKORC1L1)
RBB: 108529701(VKORC1)
TFN: 117072927(VKORC1L1) 117072933 117073356 117087689(VKORC1)
PTEH: 111525670(VKORC1) 111530454 111535958 113219667
CANG: 105505703(VKORC1) 105518960(VKORC1L1)
CJC: 100386573(VKORC1) 100388998(VKORC1L1)
SBQ: 101041739(VKORC1) 101051522(VKORC1L1)
CIMI: 108290018(VKORC1L1) 108293888(VKORC1) 108296609
ANAN: 105715015(VKORC1L1) 105729284(VKORC1)
CSYR: 103264390(VKORC1)
MMUR: 105871014(VKORC1L1) 105871049(VKORC1)
LCAT: 123632662(VKORC1L1) 123632698(VKORC1)
ERUF: 138394035(VKORC1L1) 138394271(VKORC1)
PCOQ: 105807073(VKORC1L1) 105823161(VKORC1)
OGA: 100947581(VKORC1) 100952951(VKORC1L1)
MMU: 27973(Vkorc1) 69568(Vkorc1l1)
MCAL: 110295344(Vkorc1l1) 110298355(Vkorc1)
MPAH: 110332422(Vkorc1)
RNO: 309004(Vkorc1) 399684(Vkorc1l1)
MCOC: 116068488(Vkorc1l1) 116100916(Vkorc1)
ANU: 117698190(Vkorc1l1) 117702411 117714244(Vkorc1)
ASYL: 127673196(Vkorc1l1) 127679087(Vkorc1)
MUN: 110560966(Vkorc1l1) 110564537(Vkorc1)
CGE: 100755703(Vkorc1) 100757934(Vkorc1l1)
MAUA: 101836225(Vkorc1l1) 101840628(Vkorc1)
PROB: 127228408(Vkorc1) 127236909(Vkorc1l1)
PLEU: 114693670(Vkorc1l1) 114704396(Vkorc1)
PMAV: 102911037(Vkorc1l1) 102927002(Vkorc1)
MORG: 121446041(Vkorc1l1) 121457867(Vkorc1)
MFOT: 126504211 126515876
AAMP: 119820462(Vkorc1) 119824745(Vkorc1l1)
CNL: 130871901(Vkorc1l1) 130880253(Vkorc1)
NGI: 103726327(Vkorc1) 103738949(Vkorc1l1)
HGL: 101708956(Vkorc1l1) 101712053 101712530(Vkorc1)
CPOC: 100717597(Vkorc1) 100720684(Vkorc1l1)
CCAN: 109682419(Vkorc1)
DORD: 105982096(Vkorc1)
DSP: 122096196(Vkorc1) 122114838(Vkorc1l1)
DMER: 138814941 138825562 138836923(Vkorc1l1)
PLOP: 125338758(Vkorc1l1) 125341148(Vkorc1)
NCAR: 124969992 124970058
MMMA: 107146575(Vkorc1l1) 107146973(Vkorc1)
ITI: 101962475(Vkorc1) 101972389(Vkorc1l1)
OCU: 100348035 100352876
OPI: 101519736(VKORC1L1) 101520237 101524326
OCZ: 121151422(VKORC1L1) 121151522(VKORC1) 121168018
TUP: 102473374(VKORC1L1) 102489609(VKORC1)
GVR: 103600701(VKORC1L1) 103610025(VKORC1)
CFA: 479775(VKORC1) 606915(VKORC1L1)
CLUD: 112640131(VKORC1) 112646081(VKORC1L1)
VVP: 112929263(VKORC1) 112934105(VKORC1L1)
VLG: 121486425(VKORC1L1) 121487294(VKORC1)
NPO: 129519250(VKORC1) 129519602(VKORC1L1)
AML: 100473818(VKORC1L1) 100476494(VKORC1)
UMR: 103657883(VKORC1) 103670242(VKORC1L1)
UAH: 113267716(VKORC1) 113267747(VKORC1L1)
UAR: 123784675(VKORC1) 123784703(VKORC1L1)
ELK: 111146341 111162267
LLV: 125090151 125090200
MPUF: 101677403(VKORC1) 101685820(VKORC1L1)
MNP: 132026663(VKORC1L1) 132026687(VKORC1)
MLK: 131819093(VKORC1) 131819663(VKORC1L1)
NVS: 122895760(VKORC1) 122895982(VKORC1L1)
ORO: 101365518(VKORC1L1) 101379206(VKORC1)
EJU: 114214375(VKORC1L1) 114214419(VKORC1)
ZCA: 113932409(VKORC1) 113933167(VKORC1L1)
MLX: 117999538(VKORC1L1) 117999567(VKORC1)
NSU: 110589734(VKORC1L1) 110589940(VKORC1)
LWW: 102726064(VKORC1) 102742852(VKORC1L1)
FCA: 101085010(VKORC1L1) 101089669(VKORC1)
PYU: 121017459(VKORC1L1) 121022198(VKORC1)
PCOO: 112857064(VKORC1) 112859869(VKORC1L1)
PBG: 122471386(VKORC1L1) 122471420(VKORC1)
PVIV: 125153945(VKORC1) 125154529(VKORC1L1)
LRUF: 124517843 124519158
LGF: 123589547(VKORC1L1) 123589565(VKORC1)
AJU: 106972842 106979129
PTG: 102964464(VKORC1) 102969550(VKORC1L1)
PPAD: 109250658(VKORC1L1) 109259045(VKORC1) 109261808
PUC: 125928111 125928154
PLEZ: 122209428(VKORC1L1) 122209710(VKORC1)
HHV: 120235669(VKORC1L1) 120242261(VKORC1)
BTA: 445422(VKORC1) 506318(VKORC1L1)
BOM: 102273264(VKORC1) 102276117(VKORC1L1)
BIU: 109578500(VKORC1)
BBUB: 102399074(VKORC1L1) 102404250(VKORC1)
BKE: 129638026(VKORC1L1) 129638051(VKORC1)
BBIS: 104986679(VKORC1) 104986777(VKORC1L1)
CHX: 102171296(VKORC1) 102174084(VKORC1L1)
OAS: 101108541(VKORC1L1) 105604738(VKORC1)
BTAX: 128043381(VKORC1) 128069046(VKORC1L1)
CSUM: 138075356(VKORC1) 138075556(VKORC1L1)
ODA: 120860595 120860596 120877656(VKORC1) 120877982(VKORC1L1)
CCAD: 122432710(VKORC1) 122432970(VKORC1L1)
MREE: 136160697(VKORC1) 136160726(VKORC1L1)
OVR: 110125226(VKORC1L1) 110137436(VKORC1)
MBEZ: 129545559(VKORC1) 129545586(VKORC1L1)
SSC: 100518062(VKORC1L1) 100522924(VKORC1)
CFR: 102506472(VKORC1L1) 102515335(VKORC1)
CBAI: 105082780(VKORC1) 105082868(VKORC1L1)
CDK: 105089738(VKORC1L1) 105102715(VKORC1)
VPC: 102530603(VKORC1) 102542192(VKORC1L1)
BACU: 103001696(VKORC1) 103011563(VKORC1L1)
BMUS: 118880606(VKORC1) 118880642(VKORC1L1)
LVE: 103077074(VKORC1) 103091469(VKORC1L1)
OOR: 101271099(VKORC1L1) 101284991(VKORC1)
LALB: 132505099(VKORC1) 132505235(VKORC1L1)
GMF: 115861243(VKORC1) 115861267(VKORC1L1)
DDP: 132438184(VKORC1) 132438204(VKORC1L1)
DLE: 111182082(VKORC1L1) 111182114(VKORC1)
PCAD: 102979206(VKORC1L1) 102984282(VKORC1)
PSIU: 116739769(VKORC1L1) 116740166(VKORC1)
PPHC: 136135085(VKORC1) 136135195(VKORC1L1)
NASI: 112399250(VKORC1L1) 112399311(VKORC1)
ECB: 100063360(VKORC1) 100629446(VKORC1L1)
EPZ: 103547239(VKORC1) 103558037(VKORC1L1)
EAI: 106831834(VKORC1L1) 106831891(VKORC1)
MYB: 102239240 102239782(VKORC1) 102255608(VKORC1L1) 102259131
MYD: 102764792(VKORC1L1) 102771765(VKORC1)
MMYO: 118656148(VKORC1) 118657014(VKORC1L1)
MLF: 102419906(VKORC1L1) 102435302(VKORC1)
MDT: 132228416 132232714(VKORC1) 132233149(VKORC1L1)
MYUM: 139008341(VKORC1) 139008999(VKORC1L1)
PKL: 118702921(VKORC1L1) 118704943(VKORC1)
EFUS: 103286066(VKORC1L1) 103296237(VKORC1)
MNA: 107524390(VKORC1L1) 107540826(VKORC1)
DRO: 112304769(VKORC1) 112314697(VKORC1L1)
SHON: 118976266(VKORC1L1)
AJM: 119041138(VKORC1) 119055020(VKORC1L1)
PDIC: 114496038(VKORC1L1) 114506193(VKORC1)
PHAS: 123806404(VKORC1L1) 123825695(VKORC1)
MMF: 118641647(VKORC1L1) 118641657(VKORC1)
PPAM: 129078015(VKORC1) 129083738(VKORC1L1)
HAI: 109374189(VKORC1) 109376915(VKORC1L1)
RFQ: 117019671(VKORC1) 117025035(VKORC1L1)
PALE: 102880782(VKORC1L1) 102886750(VKORC1)
PGIG: 120591823(VKORC1L1) 120620061(VKORC1)
PVP: 105296731(VKORC1L1) 105304510(VKORC1)
RAY: 107503984(VKORC1) 107507444(VKORC1L1)
MJV: 108385526(VKORC1) 108408939(VKORC1L1)
TOD: 119241467(VKORC1L1) 119241709(VKORC1)
SARA: 101549306(VKORC1) 101549307(VKORC1L1)
SFUM: 130044963(VKORC1) 130044974(VKORC1L1)
SETR: 126030963(VKORC1) 126031275(VKORC1L1)
LAV: 100663455(VKORC1)
TMU: 101346924 101356156
ETF: 101652401(VKORC1L1) 101659528(VKORC1)
DNM: 101442019(VKORC1L1) 101445935(VKORC1)
MDO: 100010095(VKORC1L1) 100019247(VKORC1)
GAS: 123231144(VKORC1) 123244517(VKORC1L1)
SHR: 100914533(VKORC1) 100916214(VKORC1L1)
AFZ: 127558753 127562805
PCW: 110222147(VKORC1L1) 110223223(VKORC1)
TVP: 118856563(VKORC1L1) 118857211(VKORC1)
PBRV: 138158574(VKORC1) 138162414(VKORC1L1)
MLAO: 141488882(VKORC1L1) 141498852(VKORC1)
OAA: 100085063(VKORC1) 103166981(VKORC1L1)
TACU: 119939524(VKORC1L1) 119942068(VKORC1)
GGA: 408253(VKORC1L1)
PCOC: 116228113(VKORC1L1) 116240258
MGP: 100550207(VKORC1L1) 104915861
CJO: 107322449(VKORC1L1)
TPAI: 128083579(VKORC1L1)
LMUT: 125702833(VKORC1L1)
NMEL: 110391899 110407843(VKORC1L1)
APLA: 101798787(VKORC1L1)
AACU: 137842088(VKORC1L1)
ACYG: 106041424(VKORC1L1)
CATA: 118254206(VKORC1L1)
AFUL: 116497308(VKORC1L1)
TGU: 100230928(VKORC1L1)
LSR: 110481996(VKORC1L1) 110483486
SCAN: 103820095(VKORC1L1) 103824717
PMOA: 120507865(VKORC1L1) 120508519
OTC: 121344773 121345750(VKORC1L1)
PRUF: 121352738 121361665(VKORC1L1)
ATRC: 139586187 139600137(VKORC1L1)
GFR: 102033623(VKORC1L1)
FAB: 101810261(VKORC1L1)
OMA: 130260918(VKORC1L1)
PHI: 102104161(VKORC1L1)
PMAJ: 107212753(VKORC1L1)
CCAE: 111922267 111937938(VKORC1L1)
CCW: 104691083(VKORC1L1)
CBRC: 103621523(VKORC1L1)
ACOE: 138101146(VKORC1) 138120690(VKORC1L1)
ETL: 114060508(VKORC1L1)
ZAB: 102075491(VKORC1L1)
ZLE: 135455658(VKORC1L1) 135460768
ACHL: 103805953(VKORC1L1)
SVG: 106853357(VKORC1L1) 106864542
MMEA: 130586015(VKORC1L1) 130586976
HRT: 120761230(VKORC1L1)
SATI: 136370061(VKORC1L1)
CFAI: 136299983(VKORC1L1)
CCIC: 134052493(VKORC1L1) 134055948(VKORC1)
FPG: 101920959(VKORC1L1)
CCRI: 104159049(VKORC1L1)
NNT: 104401361(VKORC1L1)
SHAB: 115602109(VKORC1L1) 115603062
ACUN: 113487087(VKORC1L1)
SURA: 141952636(VKORC1L1)
TALA: 104366804(VKORC1L1)
ACHC: 115338558 115347142(VKORC1L1)
HALD: 104324435(VKORC1L1)
HLE: 104835547(VKORC1L1)
AGEN: 126039126
HHAR: 128136019 128149538(VKORC1L1)
BBUT: 142026081(VKORC1) 142033041(VKORC1L1)
GCL: 127024518 127027939
CSTI: 104562308
LDI: 104349763
MNB: 103781915(VKORC1L1)
DPUB: 104302817(VKORC1L1)
PPUS: 135187494(VKORC1L1)
AVIT: 104269803(VKORC1L1)
BRHI: 104489633(VKORC1L1)
NNI: 104016793(VKORC1L1)
PCRI: 104027212(VKORC1L1)
PCAO: 104047897(VKORC1L1)
PADL: 103925608(VKORC1L1)
AFOR: 103905889(VKORC1L1)
FGA: 104072260(VKORC1L1)
CBOR: 142074640 142090624(VKORC1L1)
GSTE: 104255810(VKORC1L1)
CBOY: 140645694(VKORC1) 140661061(VKORC1L1)
MAME: 142404206(VKORC1) 142417510(VKORC1L1)
CLV: 102085852(VKORC1L1)
CNIC: 135995619(VKORC1L1) 136001230(VKORC1)
MUI: 104535578(VKORC1L1)
PGUU: 104462459 104471619
PLET: 104625971(VKORC1L1)
EHS: 104505469(VKORC1L1)
CMAC: 104475505(VKORC1L1)
CUCA: 104057319(VKORC1L1) 128850082(VKORC1)
GAME: 129214933(VKORC1L1)
OHA: 104332795(VKORC1L1)
ACAR: 104522469(VKORC1L1)
CVF: 104286546(VKORC1L1)
RTD: 128903532 128912790(VKORC1L1)
CRID: 134508136(VKORC1) 134518191(VKORC1L1)
LMIC: 141735327(VKORC1) 141746756(VKORC1L1)
NARQ: 141473258(VKORC1L1)
AAM: 106495348(VKORC1L1)
AROW: 112961823 112978587(VKORC1L1)
NPD: 112945368(VKORC1L1)
TGT: 104567832(VKORC1L1)
DNE: 112987420
SCAM: 104144738(VKORC1L1)
ASN: 102373007(VKORC1L1) 112548693(VKORC1)
AMJ: 102575124(VKORC1L1) 102577367
CPOO: 109316933(VKORC1L1)
GGN: 109293442(VKORC1L1)
PSS: 102455189(VKORC1L1) 102455458
CIZ: 142015013(VKORC1) 142022942(VKORC1L1)
CMY: 102931890(VKORC1L1) 102937112
CCAY: 125623802(VKORC1L1) 125638107(VKORC1)
LKP: 140899750(VKORC1L1) 140912336
NDS: 141988501 142000469(VKORC1L1)
DCC: 119844451(VKORC1L1) 119857009
CPIC: 101932287(VKORC1L1) 101952869
TST: 117867437(VKORC1L1) 117888239
CABI: 116815531(VKORC1) 116821334(VKORC1L1)
MRV: 120387374(VKORC1L1) 120403351 120403473
ACS: 100555617(vkorc1)
ASAO: 132763447(VKORC1L1) 132777745(VKORC1)
PVT: 110084532(VKORC1L1) 110086404 110086406
SUND: 121916934(VKORC1L1) 121933336(VKORC1)
PBI: 103052312 103064445(VKORC1L1)
PMUR: 107287076(VKORC1L1) 107294319 107299076
CTIG: 120302294(VKORC1) 120309254(VKORC1L1)
TSR: 106543821(VKORC1L1) 106545499(VKORC1)
PGUT: 117666827(VKORC1) 117667535(VKORC1L1)
PCAE: 139308525(VKORC1L1)
APRI: 131188870(VKORC1L1) 131196866(VKORC1)
PTEX: 113441564(VKORC1L1) 113449986(VKORC1)
NSS: 113414693(VKORC1L1) 113422509(VKORC1)
VKO: 123019596(VKORC1) 123036705(VKORC1L1)
PMUA: 114582862 114582863 114585928(VKORC1L1)
PRAF: 128399366(VKORC1) 128402640(VKORC1L1)
ZVI: 118094680(VKORC1) 118096703(VKORC1L1)
HCG: 128328742(VKORC1) 128335924 128336209
GJA: 107106645(VKORC1) 107112507(VKORC1L1)
STOW: 125444557(VKORC1) 125445465(VKORC1L1)
EMC: 129340535(VKORC1) 129344615(VKORC1L1)
XLA: 108709644(vkorc1l1.S) 398467(vkorc1.S) 733276(vkorc1l1.L)
XTR: 448775(vkorc1) 549523(vkorc1l1)
NPR: 108799191(VKORC1L1) 108800672
RTEM: 120926639(VKORC1L1) 120942978
ACAT: 141128055(VKORC1L1) 141148278
PADS: 140334050(VKORC1L1) 140334864
BBUF: 120995518(VKORC1L1) 121007962
BGAR: 122931659(VKORC1L1) 122945556
DTC: 141050834 141069406(VKORC1L1)
PWL: 138286522(VKORC1L1) 138304276(VKORC1)
MUO: 115456684(VKORC1L1) 115473952
GSH: 117349101(VKORC1L1) 117360752(VKORC1)
DRE: 100000559(vkorc1) 553717(vkorc1l1)
SRX: 107719344 107719575 107734370
SANH: 107654009 107654281(vkorc1l1) 107701846
SGH: 107563435 107598672
CCAR: 109051702(vkorc1) 109058151 122137323
CAUA: 113068058 113070150 113070234 113070775 113112000
CGIB: 127958225 127969284 128014907
PTET: 122344903(vkorc1l1) 122355215 122361710
LROH: 127165280(vkorc1l1) 127173911(vkorc1)
GRF: 141298171(vkorc1) 141335422 141335512 141335807
OMC: 131540844(vkorc1l1) 131551078(vkorc1)
PPRM: 120468976(vkorc1) 120471681(vkorc1l1)
RKG: 130077417(vkorc1l1) 130080594(vkorc1)
MAMB: 125255907(vkorc1) 125266285(vkorc1l1)
CIDE: 127513116 127523718
CERY: 137008017(vkorc1) 137034527(vkorc1l1)
MASI: 127422809 127423721 127433467
TROS: 130545486(vkorc1l1)
TDW: 130419180(vkorc1l1)
MANU: 129439534(vkorc1l1)
PDAB: 135732787(vkorc1l1)
IPU: 100528488(vkorc1) 108259877
IFU: 128603894(vkorc1l1) 128616923(vkorc1)
PHYP: 113527539 113531399(vkorc1l1)
SMEO: 124378900(vkorc1l1) 124389036(vkorc1)
TFD: 113637233(vkorc1l1) 113653535(vkorc1)
TVC: 132841253 132841313(vkorc1l1) 132860245
CGAR: 128512491(vkorc1l1) 128541166(vkorc1)
NGRA: 132875838(vkorc1l1) 132898049(vkorc1)
TRN: 134303215(vkorc1l1) 134321645(vkorc1)
AMEX: 103029702(vkorc1) 103037761(vkorc1l1)
CMAO: 118809730(vkorc1) 118814753(vkorc1l1)
EEE: 113577552(vkorc1l1) 113591952
CHAR: 105892714(vkorc1) 105896063(vkorc1l1)
SPIL: 134070400(vkorc1) 134080025(vkorc1l1)
ASAD: 121699802(vkorc1) 121708821(vkorc1l1)
TRU: 115248692 446034(vkorc1) 446035(vkorc1l1)
TFS: 130522464(vkorc1) 130538001(vkorc1l1)
TNG: GSTEN00016275G001 GSTEN00028302G001
LCO: 104928769(vkorc1l1) 104935549
NCC: 104956341(vkorc1l1) 104967444
TBEN: 117469002(vkorc1l1) 117473349(vkorc1)
CGOB: 115018980(vkorc1l1) 115025109
PGEO: 117458239(vkorc1l1) 117464884(vkorc1)
GACU: 117544946(vkorc1) 117557292(vkorc1l1)
EMAC: 134871219(vkorc1) 134872442(vkorc1l1)
ELY: 117246706(vkorc1) 117267407(vkorc1l1)
EFO: 125880841(vkorc1) 125897940(vkorc1l1)
PLEP: 121952702(vkorc1l1) 121958389(vkorc1)
SLUC: 116058102(vkorc1l1) 116061570(vkorc1)
ECRA: 117937341(vkorc1) 117956082(vkorc1l1)
ESP: 116671110 116700533(vkorc1l1)
PFLV: 114548348 114566835(vkorc1l1)
GAT: 120819142(vkorc1) 120821346(vkorc1l1)
PPUG: 119212699(vkorc1) 119215732(vkorc1l1)
AFB: 129091359(vkorc1) 129113972(vkorc1l1)
CLUM: 117742435(vkorc1l1) 117748831(vkorc1)
PSWI: 130203808(vkorc1) 130212434(vkorc1l1)
CANA: 137789787(vkorc1) 137802641(vkorc1l1)
CVE: 137886819(vkorc1l1)
MSAM: 119894921(vkorc1l1) 119915941(vkorc1)
SCHU: 122867176(vkorc1) 122888441(vkorc1l1)
CUD: 121518681(vkorc1l1) 121527885(vkorc1)
SPUL: 138593345(vkorc1) 138601881(vkorc1l1)
LMIX: 132955394(vkorc1) 132988678(vkorc1l1)
HTC: 141785334(vkorc1) 141791679(vkorc1l1)
ALAT: 119009859(vkorc1) 119031576(vkorc1l1)
ASTR: 137588781(vkorc1) 137605781(vkorc1l1)
MZE: 101466626 101476827(vkorc1l1)
ONL: 100705457(vkorc1l1) 100706346
OAU: 116321898(vkorc1) 116324375(vkorc1l1)
OLA: 101166326(vkorc1l1) 101175272(vkorc1)
OML: 112142385(vkorc1l1) 112154204(vkorc1)
CSAI: 133419509(vkorc1) 133459815(vkorc1l1)
XMA: 102224968 102236035(vkorc1l1)
XCO: 114150296 114152577(vkorc1l1)
XHE: 116727136 116728597(vkorc1l1)
PRET: 103476055(vkorc1l1) 103481412
PFOR: 103133842(vkorc1l1) 103156839
PLAI: 106939030 106956650(vkorc1l1)
PMEI: 106908662 106934299(vkorc1l1)
GAF: 122823577(vkorc1) 122845224(vkorc1l1)
PPRL: 129368672(vkorc1l1) 129377672(vkorc1)
CVG: 107090350(vkorc1l1) 107097194
CTUL: 119775639(vkorc1l1) 119796754(vkorc1)
GMU: 124874787(vkorc1) 124876281(vkorc1l1)
NFU: 107387049(vkorc1l1) 107387978
KMR: 108233845(vkorc1l1) 108237265(vkorc1)
ALIM: 106521363 106525412(vkorc1)
NWH: 119420067(vkorc1l1) 119423595(vkorc1)
AOCE: 111572720(vkorc1l1) 111581582(vkorc1)
EJA: 138196656(vkorc1l1) 138202023(vkorc1)
BFRE: 138616974(vkorc1) 138622128(vkorc1l1)
MCEP: 125021070(vkorc1l1) 125022023(vkorc1)
CSEM: 103382040 103394913(vkorc1l1)
POV: 109628628(vkorc1l1) 109646209
SSEN: 122762756(vkorc1) 122780047(vkorc1l1)
SSOE: 131448949(vkorc1) 131458770(vkorc1l1)
HHIP: 117752784(vkorc1) 117774060(vkorc1l1)
HSP: 118101059(vkorc1) 118121755(vkorc1l1)
PPLT: 128426297(vkorc1) 128457297(vkorc1l1)
SMAU: 118287274(vkorc1) 118300400(vkorc1l1)
LCF: 108884459 108893410
SDU: 111220323 111222156(vkorc1l1)
SLAL: 111658706 111663852(vkorc1l1)
XGL: 120794874(vkorc1) 120802311(vkorc1l1)
HCQ: 109508799(vkorc1l1) 109524007
SSCV: 125982417(vkorc1l1) 125990938(vkorc1)
SBIA: 133491556(vkorc1l1) 133496041(vkorc1)
PEE: 133416473(vkorc1l1) 133418010(vkorc1)
PTAO: 133466975(vkorc1l1) 133469701(vkorc1)
BPEC: 110159643 110165064(vkorc1l1)
ENY: 140361049(vkorc1l1) 140368893(vkorc1)
MALB: 109960444(vkorc1l1) 109963618
BSPL: 114845530(vkorc1) 114869075(vkorc1l1)
SJO: 128371141(vkorc1l1) 128381314(vkorc1)
SSCO: 133994614(vkorc1l1) 134003092(vkorc1)
TTY: 137171643(vkorc1) 137195279(vkorc1l1)
GMH: 115531201 115547332(vkorc1l1)
SASA: 106567394(vkorc1l1) 106577046
STRU: 115148425(vkorc1l1) 115193702
OTW: 112253079(vkorc1) 112258348 121841387
OMY: 110529490(vkorc1) 110537845 118966696
OGO: 123999324 124014982 124040746(vkorc1)
ONE: 115105380 115136237 115136328
OKI: 109873325 109888802 109893037
OKE: 118369922(vkorc1) 118389754 118390998
OMM: 135511068(vkorc1) 135548756(vkorc1l1) 135549430
OCLA: 139412003 139417953 139420876
SALP: 111951604 111963498 111980926
SNH: 120017939(vkorc1) 120032726 120056816
SFON: 129822215 129836397(vkorc1) 129868000
CCLU: 121553508(vkorc1) 121574101 121579132(vkorc1l1) 123482454
ELS: 105007720 105008282(vkorc1l1)
OEP: 134030881(vkorc1) 134040131(vkorc1l1)
SFM: 108921596(vkorc1l1) 108938295 108941679
PKI: 111836830 111854712(vkorc1l1) 111859697
AANG: 118209798 118220282(vkorc1) 118235633(vkorc1l1)
AROT: 135235785 135249242(vkorc1) 135263821(vkorc1l1)
CCOG: 133107955 133114125(vkorc1) 133132404(vkorc1l1)
LOC: 102693652(vkorc1l1) 102696686
PSPA: 121305140 121308568(vkorc1l1)
ARUT: 117398336 117429891 117430605
PSEX: 120519621(vkorc1) 120531418(vkorc1l1)
LCM: 102345266(VKORC1L1) 102357927
CMK: 103180624(vkorc1l1)
RTP: 109928519(vkorc1l1)
CPLA: 122542369 122564075(vkorc1l1)
CPUN: 140491425(vkorc1l1)
HOC: 132808900 132830528(vkorc1l1)
SCAU: 119974830
LERI: 129710805(vkorc1l1)
HAKA: 140719048 140731769(vkorc1l1)
PMRN: 116936876 116939185
BFO: 118425571 118426307
BBEL: 109463634 109466245
CIN: 100178185 780870(vkor)
CLEP: 143447004
SPU: 763699
LPIC: 129254799
LVG: 121408957
AJJ: 139981145
APLC: 110988312
ARUN: 117290786
AAMU: 139939095
AFIL: 140136639
AJC: 117116267
SKO: 100376428 102805472
PFLL: 139145698 139145699
DME: Dmel_CG33544(Vkor)
DER: 6548496
DSE: 6609493
DSI: Dsimw501_GD11216(Dsim_GD11216)
DYA: Dyak_GE11817
DSR: 110180445
DPO: 6899093
DPE: 6601584
DMN: 108158370 117192983
DWI: 6640946
DGR: 6571186
DMO: Dmoj_GI21152
DNV: 108653874
DHE: 111594945
CCAT: 101455423
BOD: 106617881
BDR: 105226676
RZE: 108368062
AOQ: 129245533
ALUD: 128867507
TDA: 119683711
MDE: 101888998
SCAC: 106088686
LCQ: 111682432
LSQ: 119607419
CVJ: 135961154(Vkor)
GFS: 119636317
ECOE: 129947933
CLON: 129605458
HIS: 119657085
AGA: 1271615
ACOZ: 120956807
AARA: 120906674
AMER: 121597631
ASTE: 118511958
AMAP: 126560948
AFUN: 125767986
AMOU: 128307181
AMRS: 128712263
AALI: 118460223
ADAR: 125949956
ACOS: 131269043
AAG: 5574649
AALB: 109415799 109431186
ASUA: 134217338
CQU: CpipJ_CPIJ003816
CPII: 120430280
CBRI: 134835385
CNS: 116344816
BCOO: 119083430
PPAP: 129806448
AME: 724791
ACER: 107995061
ALAB: 122718185
ADR: 102677293
AFLR: 100872042
BIM: 100746180
BBIF: 117207068
BVK: 117237317
BVAN: 117160893
BHUN: 126864325
BTER: 100647907
BAFF: 126917871
BPYO: 122572804
BPAS: 132907303
FVI: 122532552
CCAL: 108622863
OBB: 114878863
MGEN: 117229918
NMEA: 116428177
CGIG: 122404484
SOC: 105199915
MPHA: 105838573
AEC: 105148077
ACEP: 105624125
ACOC: 108694970
MZT: 108723320(Vkor)
CCOA: 108780284
TCZ: 108758015
TSEP: 108755715
PBAR: 105423896
VEM: 105565949
COBS: 139109686(Vkor)
TLN: 139808900(Vkor)
HST: 105189853
DQU: 106741085
CFO: 105256425
FEX: 115240480
PMEC: 138943243(Vkor)
LHU: 105671028(Vkor)
PGC: 109856097
OBO: 105284994
PCF: 106790230
PFUC: 122513406
VPS: 122637170
VCRB: 124431200
VVE: 124957148
NVI: 100121150
CSOL: 105364056
TPRE: 106654656
LHT: 122510351
LBD: 127283293
MDL: 103578951
CGLO: 123271579
CTYP: 141529997(Vkor)
FAS: 105264909
DAM: 107043343
AGIF: 122851518
VCAN: 122407524
CCIN: 107272607
DSM: 124407860
NPT: 124217205(Vkor)
NFB: 124180621
NLO: 107218685
NVG: 124303227
AROA: 105688833
TCA: 103315249
DPA: 109544649
ESIM: 136416831(Vkor)
EFOR: 136347318(Vkor)
SOY: 115879210
RFG: 143205155(Vkor)
AGRG: 126737622
ATD: 109609280
CSET: 123317026
HAXR: 123682489
AGB: 108912240
DVV: 114328066
NVL: 108562475
APLN: 112906499
PPYR: 116177948
OTU: 111426474
BMOR: 101746818
BMAN: 114252611
MSEX: 115456116
DPL: KGM_206433
BANY: 112044458
MJU: 123872599
NIQ: 126773741
VCD: 124534157
MCIX: 123656458
PMAC: 106717878
PPOT: 106108589
PXU: 106115825
BPHI: 137933523(Vkor)
PRAP: 111003414
PBX: 123709376
PNAP: 125048649
ZCE: 119830629
CCRC: 123695995
LSIN: 126977427
AAGE: 121733311
HAW: 110374796
HZE: 124637883
TNL: 113498914
SLIU: 111347859
OFU: 114360700
ONU: 135075095
ATRA: 106132107
GMW: 113520658
PXY: 105381639
PGW: 126372056
LGLY: 125230495
CSTB: 134746095
CFUM: 141437059(Vkor)
CFEL: 113376005 113386337
CCRN: 123292839
API: 100573656 103309105
DNX: 107161956
AGS: 114121307
RMD: 113554155
ACOO: 126840747
DVT: 126893585
BTAB: 109041108
DCI: 103511493 103511494
CLEC: 106663678
HHAL: 106689846(Vkor)
NLU: 111046624 120355860
LDA: 142323882(Vkor)
HVI: 124367190 124367217
PHU: Phum_PHUM098450
FOC: 113207895
TPAL: 117645287
ZNE: 110831183
CSEC: 111873453
PAME: 138714847(Vkor)
SGRE: 126284065
BROR: 134530118
IEL: 124157570
HAMR: 139690279(Vkor)
FCD: 110856806
DPX: DAPPUDRAFT_304442
DMK: 123471513
DPZ: 124336485
AFRA: 136033765
PVM: 113823507(Vkor)
PJA: 122260330
PCHN: 125025702
PMOO: 119577042
HAME: 121875687
PCLA: 123764994 138369789
PTRU: 123518769
ESN: 126987733
MNZ: 135220824
MRJ: 136832576(Vkor)
PORN: 139760531(Vkor)
HAZT: 108676735
EAF: 111699917
LSM: 121122276(Vkor)
TCF: 131880885
DSV: 119446301
DALB: 135900709(Vkor)
RSAN: 119389877
RMP: 119175932
VDE: 111251999
VJA: 111260006
GOE: 100905438 108865163
TUT: 107362817
DPTE: 113792512
DFR: 124497101
CSCU: 111629235
CVS: 136970546(Vkor)
PTEP: 107451341
ABRU: 129969131
SDM: 118196454
LPOL: 106465429
PMEO: 129595072
BMY: BM_BM605(Bm605)
LOA: LOAG_06369
HRO: HELRODRAFT_88258
LGI: LOTGIDRAFT_114833 LOTGIDRAFT_115113
PVUL: 126823478 126823479
PCAN: 112561177 112562931
LSAX: 138975184 138975468
BARL: 143274762 143302211
BGT: 106056179 106056190
GAE: 121369461 121390761
HRF: 124147730 124147731
HRJ: 124286966 124286967
HASI: 137282123 137282140
HCRA: 139455696 139456424
CRG: 105338127
CANU: 128188912
CVN: 111136434
OED: 125674842
MYI: 110460140
PMAX: 117333684
AIRR: 138331094
YBA: 132548050
MCAF: 127710581
MMER: 123535186
RPHI: 132715536
MAEA: 128230163
OBI: 106870276 106877249
OSN: 115222593 115224536
LJP: 135476909 135477254
LAK: 106150415 106150416
LLON: 135500352
NVE: 5506957 5515586
EPA: 110250868
ATEN: 116292045 116293954
ADF: 107340505
AMIL: 114960653
MCAZ: 138035559 138047126
MFOO: 137975205
PDAM: 113676685
SPIS: 111331307
DGT: 114520441
XEN: 124433813
HMG: 101235337
HSY: 130645204
RES: 135683730
TAD: TRIADDRAFT_6927
AQU: 100633778
MBR: MONBRDRAFT_29821
SRE: PTSG_04186
TGO: TGME49_203720 TGME49_249760
BBES: BESB_003870 BESB_065570
FCY: FRACYDRAFT_267199
PSOJ: PHYSODRAFT_472863
TBR: Tb927.2.4840
TBG: TbgDal_II2880
TCR: 504741.190
LMA: LMJF_27_2190
LIF: LINJ_27_2110
LDO: LDBPK_272110
LMI: LMXM_27_2190
LMAT: 92513619(LSCM1_03572)
LBZ: LBRM_27_2370
LPAN: LPMP_272190
LOI: 92360220(LSCM4_04299)
LEIS: 94180124(GH5_04700)
LENR: 94170940(CUR178_03700)
LEIN: 94187850(JIQ42_04187)
PHET: 94289478(JKF63_03398)
EHX: EMIHUDRAFT_361809 EMIHUDRAFT_440728
GTT: GUITHDRAFT_106868
 » show all
Reference
1  [PMID:646989]
  Authors
Whitlon DS, Sadowski JA, Suttie JW.
  Title
Mechanism of coumarin action: significance of vitamin K epoxide reductase inhibition.
  Journal
Biochemistry 17:1371-7 (1978)
DOI:10.1021/bi00601a003
Reference
2  [PMID:6733086]
  Authors
Lee JJ, Fasco MJ.
  Title
Metabolism of vitamin K and vitamin K 2,3-epoxide via interaction with a common disulfide.
  Journal
Biochemistry 23:2246-52 (1984)
DOI:10.1021/bi00305a024
Reference
3  [PMID:3857611]
  Authors
Mukharji I, Silverman RB.
  Title
Purification of a vitamin K epoxide reductase that catalyzes conversion of vitamin K 2,3-epoxide to 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone.
  Journal
Proc Natl Acad Sci U S A 82:2713-7 (1985)
DOI:10.1073/pnas.82.9.2713
Reference
4  [PMID:14765195]
  Authors
Li T, Chang CY, Jin DY, Lin PJ, Khvorova A, Stafford DW
  Title
Identification of the gene for vitamin K epoxide reductase.
  Journal
Nature 427:541-4 (2004)
DOI:10.1038/nature02254
Reference
5  [PMID:17124179]
  Authors
Wajih N, Hutson SM, Wallin R
  Title
Disulfide-dependent protein folding is linked to operation of the vitamin K cycle in the endoplasmic reticulum. A protein disulfide isomerase-VKORC1 redox enzyme complex appears to be responsible for vitamin K1 2,3-epoxide reduction.
  Journal
J Biol Chem 282:2626-35 (2007)
DOI:10.1074/jbc.M608954200
Reference
6  [PMID:19492146]
  Authors
Spohn G, Kleinridders A, Wunderlich FT, Watzka M, Zaucke F, Blumbach K, Geisen C, Seifried E, Muller C, Paulsson M, Bruning JC, Oldenburg J
  Title
VKORC1 deficiency in mice causes early postnatal lethality due to severe bleeding.
  Journal
Thromb Haemost 101:1044-50 (2009)
Reference
7  [PMID:20696932]
  Authors
Schulman S, Wang B, Li W, Rapoport TA
  Title
Vitamin K epoxide reductase prefers ER membrane-anchored thioredoxin-like redox partners.
  Journal
Proc Natl Acad Sci U S A 107:15027-32 (2010)
DOI:10.1073/pnas.1009972107
Other DBs
ExplorEnz - The Enzyme Database: 1.17.4.4
IUBMB Enzyme Nomenclature: 1.17.4.4
ExPASy - ENZYME nomenclature database: 1.17.4.4
BRENDA, the Enzyme Database: 1.17.4.4
CAS: 55963-40-1

  All links  
Gene (3069)   
   MGENES (299)   
   RefGene (2770)   
Protein sequence (2803)   
   UniProt (2273)   
   SWISS-PROT (8)   
   RefSeq(pep) (511)   
   PDBSTR (11)   
DNA sequence (1653)   
   RefSeq(nuc) (1431)   
   GenBank (112)   
   EMBL (110)   
3D Structure (9)   
   PDB (9)   
Protein domain (3)   
   InterPro (3)   
All databases (7537)   

Download RDF
DBGET integrated database retrieval system