KEGG   ENZYME: 1.17.5.3
Entry
EC 1.17.5.3                 Enzyme                                 
Name
formate dehydrogenase-N;
Fdh-N;
FdnGHI;
nitrate-inducible formate dehydrogenase;
formate dehydrogenase N;
FDH-N;
nitrate inducible Fdn;
nitrate inducible formate dehydrogenase
Class
Oxidoreductases;
Acting on CH or CH2 groups;
With a quinone or similar compound as acceptor
Sysname
formate:quinone oxidoreductase
Reaction(IUBMB)
formate + a quinone = CO2 + a quinol [RN:R09494]
Reaction(KEGG)
R09494
Substrate
formate [CPD:C00058];
quinone [CPD:C00472]
Product
CO2 [CPD:C00011];
quinol [CPD:C00530]
Comment
The enzyme contains molybdopterin-guanine dinucleotides, five [4Fe-4S] clusters and two heme b groups. Formate dehydrogenase-N oxidizes formate in the periplasm, transferring electrons via the menaquinone pool in the cytoplasmic membrane to a dissimilatory nitrate reductase (EC 1.7.5.1), which transfers electrons to nitrate in the cytoplasm. The system generates proton motive force under anaerobic conditions [3].
History
EC 1.17.5.3 created 2010 as EC 1.1.5.6, transferred 2017 to EC 1.17.5.3
Orthology
K08348  formate dehydrogenase-N, alpha subunit
Genes
ECOb1474(fdnG)
ECJJW1470(fdnG)
ECDECDH10B_1605(fdnG)
EBWBWG_1295(fdnG)
ECOKECMDS42_1186(fdnG)
ECEZ2236(fdnG)
ECSECs_2078(fdnG)
EOIECO111_1864(fdnG)
EOJECO26_2072(fdnG)
EOHECO103_1603(fdnG)
ECOOECRM13514_1928(fdnG)
ECOHECRM13516_1830(fdnG)
ECKEC55989_1605(fdnG)
ECGE2348C_1608(fdnG)
ELRECO55CA74_08985 ECO55CA74_08990
ELHETEC_1545
ECWEcE24377A_1655(fdnG)
EUNUMNK88_1878 UMNK88_1879
ECPECP_1474 ECP_1475
ENAECNA114_3647 ECNA114_36471
ECOSEC958_1738 EC958_1739
ECVAPECO1_609(fdnG)
ECOAAPECO78_11090 APECO78_11095
ECXEcHS_A1557(fdnG)
ECMEcSMS35_1700(fdnG)
ECYECSE_1562 ECSE_1563
ECRECIAI1_1477(fdnG)
ECQECED1_1624(fdnG)
EUMECUMN_1727(fdnG)
ECTECIAI39_1736(fdnG)
EOCCE10_1663(fdnG)
EBRECB_01432(fdnG)
EBLECD_01432(fdnG)
EBEB21_01444(fdnG)
EBDECBD_2165
ECIUTI89_C1689(fdnG)
EIHECOK1_1631(fdnG)
ECZECS88_1566(fdnG)
ECCc5623(fdnG)
ELOEC042_1604(fdnG)
ELNNRG857_07300 NRG857_07305
ESEECSF_1387 ECSF_1388
ECLEcolC_2183
EKOEKO11_2346 EKO11_2347
EABECABU_c17080(fdnG)
EDHEcDH1_2173 EcDH1_2174
EDJECDH1ME8569_1417(fdnG)
ELUUM146_09665 UM146_09670
ELWECW_m1602(fdnG)
ELLWFL_07835(fdnG1)
ELPP12B_c1654(fdnG) P12B_c1655(fdnG)
ELFLF82_0630(fdnG)
ECOLLY180_07640 LY180_07645
ECOJP423_08190 P423_08195
EFEEFER_1489(fdnG)
EALEAKF1_ch0027c EAKF1_ch0028c
EMAC1192_04735 C1192_04740(fdnG)
ESZFEM44_22465(fdnG)
SEXSTBHUCCB_15800
SENTTY21A_07540
STMSTM1570(fdnG)
SEOSTM14_1894(fdnG)
SEVSTMMW_15651
SEYSL1344_1500(fdnG)
SEMSTMDT12_C15890
SEBSTM474_1583(fdnG)
SEFUMN798_1644(fdnG) UMN798_1645(fdnG)
SETCCFSAN001921_09250 CFSAN001921_09255
SENRSTMDT2_14931(fdnG)
SENICY43_08015 CY43_08020
SEENSE451236_13755 SE451236_13760
SPTSPA1298(fdnG)
SEKSSPA1206
SENHCFSAN002069_01115 CFSAN002069_01120
SENNSN31241_26440 SN31241_26450
SEGSG1557(fdnG)
SETSEN1485(fdnG)
SENAAU38_07665 AU38_07670
SENOAU37_07665 AU37_07670
SENVAU39_07675 AU39_07680
SENQAU40_08610 AU40_08615
SENLIY59_07860 IY59_07865
SEECCFSAN002050_14245 CFSAN002050_14250
SEEBSEEB0189_011660 SEEB0189_011665
SENBBN855_16160(fdnG)
SENEIA1_07770 IA1_07775
SENCSEET0819_14540 SEET0819_14545
SBZA464_1593 A464_1595
SBVN643_06690 N643_06695
SALZEOS98_11545 EOS98_11550(fdnG)
SFLSF1751(fdnG)
SFXS1884(fdnG)
SFVSFV_1747(fdnG)
SFNSFy_2508 SFy_2509
SFSSFyv_2563 SFyv_2564
SSNSSON_1650(fdnG)
SBOSBO_1583(fdnG)
SDZAsd1617_02149 Asd1617_02150 Asd1617_02152 Asd1617_02153
SHQA0259_11415 A0259_11420
ENCECL_01901 ECL_01902
ENLA3UG_11755 A3UG_11760
ECLGEC036_22400 EC036_22410
ECLEECNIH2_11870 ECNIH2_11875
ECLNECNIH4_11325 ECNIH4_11330
ECLIECNIH5_10795 ECNIH5_10800
ECLXLI66_11170 LI66_11175
ECLYLI62_13315 LI62_13320
ECLZLI64_10985 LI64_10990
ECLOENC_09820
EHMAB284_13745 AB284_13750
EXFBFV63_11425 BFV63_11430
ECLAECNIH3_11020 ECNIH3_11025
ECLCECR091_10960 ECR091_10965
EAUDI57_07230 DI57_07235
EKBBFV64_11795 BFV64_11800
ENOECENHK_11435 ECENHK_11440
EECEcWSU1_02353(fdnG) EcWSU1_02354(fdnG)
ELGBH714_07740 BH714_07745
ECANCWI88_11350 CWI88_11355(fdnG)
ERNBFV67_11215 BFV67_11220
ECLSLI67_014150
ECHGFY206_12940(fdnG)
ESHC1N69_11665(fdnG)
ENTEnt638_1750 Ent638_2054 Ent638_2055
EASEntas_1974 Entas_2221 Entas_2222
ENRH650_02770 H650_02775 H650_03170
ENXNI40_011650 NI40_011655
ENFAKI40_3158(fdnG) AKI40_3159
LNICWR52_00620 CWR52_00625(fdnG)
EBGFAI37_17690(fdnG)
ENDA4308_16115 A4308_16120
ENZG0034_11585(fdnG)
ENSHWQ15_19890(fdnG)
ENKLOC22_21610(fdnG)
KPNKPN_01867(fdnG)
KPUKP1_2931(fdnG)
KPMKPHS_28360 KPHS_28370
KPPA79E_2378
KPHKPNIH24_14220 KPNIH24_14225
KPZKPNIH27_13555 KPNIH27_13560
KPVKPNIH29_14225 KPNIH29_14230
KPWKPNIH30_14490 KPNIH30_14495
KPYKPNIH31_13505 KPNIH31_13510
KPGKPNIH32_14385 KPNIH32_14390
KPCKPNIH10_14025 KPNIH10_14030
KPQKPR0928_14005 KPR0928_14010
KPTVK055_0616 VK055_0617
KPOKPN2242_12250 KPN2242_12255
KPRKPR_2929(fdnG)
KPID364_09570 D364_09575
KPAKPNJ1_02610 KPNJ1_02611
KPSKPNJ2_02566 KPNJ2_02567
KPXPMK1_04207(fdnG_1) PMK1_04208(fdnG_2)
KPBFH42_05405 FH42_05410
KPNEKU54_012125 KU54_012130
KPNULI86_12060 LI86_12065
KPNKBN49_2967(fdnG)
KVAKvar_2437 Kvar_2438
KPEKPK_2489(fdnG)
KPKA593_24195 A593_24200
KVDKR75_22130 KR75_22135
KVQSP68_02875 SP68_02880
KOXKOX_20025 KOX_20030
KOEA225_2876
KOYJ415_17595 J415_17600
KOMHR38_18355 HR38_18360
KMIVW41_05125 VW41_05130
KOKKONIH1_14090 KONIH1_14095
KOCAB185_22250 AB185_22255
KQUAVR78_18365 AVR78_18370
EAEEAE_19865 EAE_19870
EARCCG29906 CCG29907
KQVB8P98_13170 B8P98_13175(fdnG)
KLLBJF97_14255 BJF97_14260
KLWDA718_14030 DA718_14035(fdnG)
KARLGL98_11665(fdnG)
KGRJJJ10_09175(fdnG) JJJ10_14625(fdnG)
RORRORB6_06740 RORB6_06745
RONTE10_13840 TE10_13845
RPLNB1209_13840 B1209_13845
RAODSD31_13360(fdnG)
RTGNCTC13098_06023(fdnG_1)
REEelectrica_02598(fdnG_1) electrica_02600(fdnG_2) electrica_04112(fdnG_3)
CROROD_15621(fdnG)
CFDCFNIH1_17935 CFNIH1_17940
CBRAA6J81_04390(fdnG) A6J81_04780(fdnG)
CWECO701_10300 CO701_10305(fdnG)
CYOCD187_11765 CD187_11770(fdnG)
CFQC2U38_12040 C2U38_12045(fdnG)
CSEDJY391_11140(fdnG)
CAMAF384_07195 F384_07200
CAFAL524_15110 AL524_15115(fdnG)
CIFAL515_12255(fdnG)
CFARCI104_13145(fdnG)
CIRC2U53_22215(fdnG)
CIEAN232_17870 AN232_17875(fdnG)
CPARCUC49_07970(fdnG)
CTELGBC03_13400(fdnG) GBC03_17345(fdnG)
CITZE4Z61_05145(fdnG)
CARSE1B03_13415(fdnG)
EBTEBL_c27500 EBL_c27510
CNTJT31_07180 JT31_07185
CEMLH23_10550 LH23_10555
CENLH86_10570 LH86_10575
PGELG71_17210 LG71_17215
ESCEntcl_2349 Entcl_2350
KLEAO703_10480 AO703_10485
KSAC813_03400 C813_03775 C813_24500
KORAWR26_12790(fdnG)
KRDA3780_11255 A3780_11260
KCOBWI95_16120 BWI95_16125
KOTEH164_11525(fdnG) EH164_11845(fdnG)
KPSEIP581_11315(fdnG)
KASKATP_22420 KATP_22430
LAXAPT61_11090 APT61_11095
LEIC2U54_16530(fdnG)
LEHC3F35_00250 C3F35_00255(fdnG)
LEEDVA44_11955
LERGNG29_11045(fdnG)
LEAGNG26_11310(fdnG)
LAZA8A57_11095
LEFLJPFL01_1786 LJPFL01_2133 LJPFL01_2134
LEWDAI21_15460 DAI21_15465(fdnG)
BAGEBADSM9389_30600 BADSM9389_30610
METYMRY16398_24300(fdnG) MRY16398_29020 MRY16398_29030
AHNNCTC12129_00262(fdnG_2) NCTC12129_03677(fdnG_3)
YREHEC60_05625(fdnG)
KINAB182_10840 AB182_12330 AB182_12335
PDZHHA33_13540(fdnG) HHA33_15130(fdnG)
IZHFEM41_12715(fdnG)
PSGCG163CM_11680(fdnG_2)
EBFD782_2135 D782_2136
EBCC2U52_21525(fdnG) C2U52_23225(fdnG)
EBUCUC76_01790 CUC76_01795(fdnG)
SFWWN53_07410 WN53_07415
SFGAV650_03405 AV650_03410
SERASer39006_010700(fdnG)
SERQCWC46_10695(fdnG)
SFOZ042_26160
RAHRahaq_0044
RACEJHW33_16845(fdnG)
RAQRahaq2_0050
RAAQ7S_00210
ROXBV494_16450
RVCJ9880_08000(fdnG)
GQUAWC35_19195
ECAECA1408(fdnG)
PATREV46_07130
PATOGZ59_14450(fdnG)
PCTPC1_1286
PCCPCC21_013180
PCVBCS7_06600
PWAPecwa_3045
PPARA8F97_03470
PECW5S_3034
PWSA7983_15605
PPOABJK05_01640
PBRAB5S52_15075
PPUJE2566_07135(fdnG)
PARII2D83_15565(fdnG)
PAQUDMB82_0013955(fdnG)
PVZOA04_14900(fdnG)
PPAVLOZ86_06980(fdnG)
DDDDda3937_02963(fdnG)
DZEDd1591_1427 Dd1591_2662
DDCDd586_2558
DZCW909_07530
DSOA4U42_01755 A4U42_16865
CEDLH89_04310 LH89_19930
DFNCVE23_08490(fdnG)
DDQDDI_1292
DAQDAQ1742_01388(fdoG) DAQ1742_01538(fdnG)
DICDpoa569_002332(fdnG)
DDADd703_1335
BGJAWC36_11695
PAJPAJ_0232(FdnG)
PVAPvag_3327(fdnG)
PAGGAL522_04785(fdnG)
PANPPSNIH2_17870
PAGCBEE12_07160
PALHB1H58_06955
PCDC2E16_00880(fdnG)
MINTC7M51_03641(fdnG)
MTHIC7M52_03392(fdnG)
PAYPAU_00744(fdnG)
PTTVY86_04090
PAKHB0X70_04425
PLUICE143_04355(fdnG)
PVGCRN77_04695(fdnG)
PHAUPH4a_06470(fdnG)
PROTBTA34_16235
PCOLF1325_18505(fdnG)
PCIBF9282_19075(fdnG)
PSIS70_17650 S70_17655
PSXDR96_2483 DR96_2484
PSTABGK56_19885 BGK56_19890
PRGRB151_014060(fdnG_1) RB151_014070(fdnG_2)
PALACO695_16965(fdnG)
PHEINCTC12003_00220(fdnG)
PRQCYG50_09120(fdnG)
PVCG3341_13440(fdnG)
MMKMU9_1138 MU9_1139
MWIMNY66_13670(fdnG)
EICNT01EI_3713 NT01EI_3714
ETRETAE_3337 ETAE_3338
ETDETAF_3025 ETAF_3338
ETCETAC_15930 ETAC_15935
HAVAT03_04270 AT03_04275
HPARAL518_01330(fdnG)
OPODSM2777_21905 DSM2777_21910
LPVHYN51_13205(fdnG)
PFQQQ39_17380
PRAGEKN56_03610(fdnG)
HSEML3077_05220(fdnG)
ADPNCTC12871_00141(fdnG)
PDSCAY62_02595 CAY62_02600
PMKMDS_4225
PPRCPFLCHA0_c32650(fdoG)
PPROPPC_3259
PLQAA042_20910
PALKPSAKL28_29570
PSWLK03_16505
AVLAvCA_03810(fdhA)
AVDAvCA6_03810(fdhA)
ACXAchr_37960(fdhA)
SONSO_0101(fdnG)
SBMShew185_0099
SBPSbal223_0104
SBTSbal678_0108
SPLSpea_0437
SHMShewmr7_0097
SHNShewana3_2089
SHLShal_0492
SBJCF168_00535 CF168_00540(fdnG) CF168_10260(fdnG)
SHEWCKQ84_08700 CKQ84_08705(fdnG)
SALGBS332_04165
SDKKHX94_11780(fdnG)
SCAATUM17387_33350(fdnG)
SEURFM038_021825(fdnG)
KUSB9G99_04270
NEIBG910_02450(fdnG)
NBLGJV52_02430(fdnG)
VFFVITFI_CDS0376
AQLBXU06_10390
RPJN234_10235
CNCCNE_2c14340(fdoG)
CUHBJN34_31335
CTIRALTA_B1681(fdnG)
COXE0W60_02610(fdnG)
AFAUZ73_04120
ODIODI_R1009
CKEB5M06_15395
SWSI6J16_07240
QAUKI612_01395(fdnG)
HETBBW65_03215
CJUC8J_1415
CJNICDCCJ07001_1438
CJMCJM1_1456(fdhA)
CJQUC78_1444(fdnG)
ABTABED_1396
NAPC3L23_06860
GSKKN400_0757(fdnG)
GEMGM21_1955
GEBGM18_1962
GURGura_3388
GEOGeob_1634(fdnG-1)
GBMGbem_2267(fdnG-1)
GBNGEOBRER4_21210(fdnG)
APKAPA386B_352(fdnG)
ASZASN_3403(fdoG)
APERA0U91_00725
APOMCPF11_12735(fdnG)
ATOCIW82_14445(fdnG)
ACETDS739_07695(fdnG)
NEHE3E11_02405(fdnG)
SWFE3E12_02660(fdnG)
AZMDM194_14325(fdnG)
BDAFSZ17_22305(fdnG)
NMKCHR53_27385(fdnG)
AIAAWH56_013365(fdnG)
BBEVBBEV_0717(fdhA-1)
BSEBsel_1218
SALQSYNTR_0512
ATLAthai_16180
 » show all
Reference
1  [PMID:1099093]
  Authors
Enoch HG, Lester RL
  Title
The purification and properties of formate dehydrogenase and nitrate reductase from Escherichia coli.
  Journal
J Biol Chem 250:6693-705 (1975)
  Sequence
Reference
2  [PMID:11884747]
  Authors
Jormakka M, Tornroth S, Byrne B, Iwata S
  Title
Molecular basis of proton motive force generation: structure of formate dehydrogenase-N.
  Journal
Science 295:1863-8 (2002)
DOI:10.1126/science.1068186
  Sequence
Reference
3  [PMID:11752799]
  Authors
Jormakka M, Tornroth S, Abramson J, Byrne B, Iwata S
  Title
Purification and crystallization of the respiratory complex formate dehydrogenase-N from Escherichia coli.
  Journal
Acta Crystallogr D Biol Crystallogr 58:160-2 (2002)
DOI:10.1107/S0907444901017723
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.17.5.3
IUBMB Enzyme Nomenclature: 1.17.5.3
ExPASy - ENZYME nomenclature database: 1.17.5.3
BRENDA, the Enzyme Database: 1.17.5.3

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