Entry
Name
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin);
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ambiguous);
(E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:protein-disulfide oxidoreductase (hydrating) (incorrect);
(E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (ambiguous);
gcpE (gene name);
ISPG (gene name);
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase
Class
Oxidoreductases;
Acting on CH or CH2 groups;
With an iron-sulfur protein as acceptor
BRITE hierarchy
Sysname
(E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:oxidized ferredoxin oxidoreductase
Reaction(IUBMB)
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + 2 oxidized ferredoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin [RN:
R08689 ]
Reaction(KEGG)
Substrate
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate [CPD:
C11811 ];
H2O [CPD:
C00001 ];
oxidized ferredoxin [CPD:
C00139 ]
Product
2-C-methyl-D-erythritol 2,4-cyclodiphosphate [CPD:
C11453 ];
reduced ferredoxin [CPD:
C00138 ]
Comment
An iron-sulfur protein found in plant chloroplasts and cyanobacteria that contains a [4Fe-4S] cluster [1]. Forms part of an alternative non-mevalonate pathway for isoprenoid biosynthesis. Bacteria have a similar enzyme that uses flavodoxin rather than ferredoxin (cf. EC
1.17.7.3 ). The enzyme from the plant Arabidopsis thaliana is active with photoreduced 5-deazaflavin but not with flavodoxin [1].
History
EC 1.17.7.1 created 2003 as EC 1.17.4.3, transferred 2009 to EC 1.17.7.1, modified 2014
Pathway
ec00900 Terpenoid backbone biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K03526 (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase
Genes
CSAT : 104726648 104738059 104762167
MINC : 123209347 123226009
LJA : Lj1g3v1049420.1(Lj1g3v1049420.1)
AHF : 112706788 112736519 112769151 112786104
LANG : 109351023 109351646 109358675
PCIN : 129314229 129315466
PMUM : 103325444 103325455 103344199
MSYL : 126590742 126615240
CMAX : 111469429 111493449
CMOS : 111451995 111464881
CPEP : 111783112 111786286 111787829
MESC : 110613793 110626411
CILL : 122292052 122294533
SSPL : 121742365 121745216
APAN : 127244270 127259793
HAN : 110868536 110900233 110904306
CSIN : 114273242 114308174
MING : 122058395 122085654
PSOM : 113309593 113321708
DOSA : Os02t0603800-01(Os02g0603800)
TAES : 123127643 123137401 123144749
PVIR : 120656355 120707671
ZOF : 121982384 121982386 121986275 121986276 121989754 121998706 122042752 122047260 122051563 122056090
SMO : SELMODRAFT_149035 SELMODRAFT_158184
PPP : 112274517 112275376 112296118
CVR : CHLNCDRAFT_144676(HDS)
PMAL : PMUG01_10034000(GcpE)
PREL : PRELSG_0606500(GcpE)
SMIN : v1.2.024904.t1(symbB.v1.2.024904.t1)
PTI : PHATRDRAFT_44955(HDS)
FCY : FRACYDRAFT_259614(HDS)
TPS : THAPSDRAFT_29228(GcpE)
EHX : EMIHUDRAFT_118009 EMIHUDRAFT_442353
ECOO : ECRM13514_3345(ispG)
ECOH : ECRM13516_3201(ispG)
ELR : ECO55CA74_15045(ispG)
ECW : EcE24377A_2799(ispG)
EDJ : ECDH1ME8569_2442(ispG)
SEM : STMDT12_C25410(ispG)
SEEH : SEEH1578_21930(ispG)
SENJ : CFSAN001992_20935(ispG)
REE : electrica_01265(ispG)
RTG : NCTC13098_01758(ispG)
METY : MRY16398_13790(ispG)
PTF : PROFFT_A_06280(ispG)
PSHI : SAMEA2665130_0577(ispG)
PSTS : E05_26680 E05_26690
YPG : YpAngola_A0418(ispG)
YPI : YpsIP31758_1186(ispG)
SMW : SMWW4_v1c37180(ispG)
SERS : SERRSCBI_18095(ispG)
SFJ : SAMEA4384070_3727(ispG)
SOF : NCTC11214_03043(ispG)
RBON : QNM34_05325(ispG) QNM34_12490
PAQU : DMB82_0006210(ispG)
DIC : Dpoa569_000931(ispG)
EHD : ERCIPSTX3056_503(ispG)
BAPF : BUMPF009_CDS00310(ispg)
BAPG : BUMPG002_CDS00311(ispg)
BAPU : BUMPUSDA_CDS00310(ispg)
BAPW : BUMPW106_CDS00310(ispg)
TPTY : NCTC11468_02764(ispG)
PHEI : NCTC12003_01454(ispG)
PRJ : NCTC6933_02503(ispG)
LRI : NCTC12151_00883(ispG)
HIC : NTHIC486_00620(ispG)
HPIT : NCTC13334_02056(ispG)
HHZ : NCTC10839_00960(ispG)
HAEG : NCTC8502_00853(ispG)
PDAG : 4362423_01378(ispG)
ADP : NCTC12871_00005(ispG)
ALIG : NCTC10568_01469(ispG)
ASEG : NCTC10977_00097(ispG)
AVT : NCTC3438_00905(ispG)
RPNE : NCTC8284_01375(ispG)
PAET : NCTC13378_00356(ispG)
XFU : XFF4834R_chr19280(ispG)
XPH : XppCFBP6546_19310(ispG)
XHD : LMG31886_25080(ispG)
LLZ : LYB30171_01012(ispG)
VFU : vfu_A02775 vfu_A02776
VAU : VANGNB10_cI0673(ispG)
VPL : SA104470976_01972(ispG)
PAEB : NCGM1900_1174(ispG)
PVD : CFBP1590__4148(ispG)
PPRC : PFLCHA0_c49380(ispG)
PMUD : NCTC8068_01064(ispG)
PFW : PF1751_v1c45420(ispG)
PPUU : PputUW4_00939(ispG)
PCH : EY04_14490(ispG) EY04_25220
PTRT : HU722_0024145(ispG)
PTW : TUM18999_49420(ispG)
PTAE : NCTC10697_00926(ispG)
PFIT : KJY40_10565(ispG) KJY40_24655(ispG)
MSHE : MAALD49_22090(ispG)
PSYC : DABAL43B_0755(ispG)
MCAT : MC25239_01144(ispG)
MCUN : NCTC10297_01381(ispG)
SCAA : TUM17387_26150(ispG)
SALH : HMF8227_02247(gcpE)
MISZ : MishRS11D_15080(ispG)
MESL : KKZ03_10215(ispG) KKZ03_12095(ispG)
FTR : NE061598_03475(ispG)
TNI : TVNIR_2872(ispG_[H])
GAI : IMCC3135_25150(ispG)
THIC : TspCOW1_17840(ispG)
AEL : NCTC12917_02397(ispG)
CDIZ : CEDIAZO_02647(ispG)
NMM : NMBM01240149_0843(ispG)
NMS : NMBM01240355_1250(ispG)
NMQ : NMBM04240196_0892(ispG)
NMZ : NMBNZ0533_1299(ispG)
NMX : NMA510612_1685(ispG)
NWE : SAMEA3174300_0368(ispG)
NZO : SAMEA4504057_1286(ispG)
NCI : NCTC10296_01601(ispG)
NCZ : NCTC10294_00823(ispG)
NANI : NCTC12227_00994(ispG)
ECOR : SAMEA4412678_0920(ispG)
BMV : BMASAVP1_A1835(ispG)
BML : BMA10229_A0062(ispG)
BPM : BURPS1710b_2355(ispG)
BPL : BURPS1106A_2228(ispG)
BUE : BRPE67_ACDS15940(ispG)
PLG : NCTC10937_01363(ispG)
LMIR : NCTC12852_01741(ispG)
BUO : BRPE64_ACDS15880(ispG)
VTR : MYVALT_F_03750(ispG)
BTRM : SAMEA390648704030(ispG)
AXX : ERS451415_01979(ispG)
VBO : CKY39_20060 CKY39_30065
LIM : L103DPR2_01833(ispG)
LIH : L63ED372_01254(ispG)
URU : DSM104443_02830(ispG)
UPL : DSM104440_02529(ispG)
FPHO : SHINM1_003220(ispG)
ERU : Erum4730(probable_ispG)
ERW : ERWE_CDS_04950(ispG)
ERG : ERGA_CDS_04850(ispG)
RBS : RHODOSMS8_02526(ispG)
SMEL : SM2011_c03888(ispG)
SFD : USDA257_c57050(ispG)
SAME : SAMCFNEI73_Ch3653(ispG)
AGR : AGROH133_09090(ispG)
ALF : CFBP5473_01780(ispG)
AVV : RvVAT039_16120(ispG)
AVF : RvVAR031_03250(ispG)
ASAL : CFBP5507_12410(ispG)
RPUS : CFBP5875_12040(ispG)
ALEG : CFBP4996_12440(ispG)
REC : RHECIAT_CH0004297(gcpE)
REL : REMIM1_CH04106(ispG)
REP : IE4803_CH04395(ispG)
REI : IE4771_CH04345(ispG)
RTR : RTCIAT899_CH18050(ispG)
RGA : RGR602_CH03951(ispG)
RPHA : AMC79_CH04229(ispG)
RLW : RlegWSM1455_20875(ispG)
RBW : RLCC275e_21375(ispG)
NEN : NCHU2750_35470(gcpE)
BSG : IY72_08490(ispG) IY72_14130(ispG)
BIO : BR141012304_10933(ispG)
BRC : BCCGELA001_34990(ispG)
BSEP : HAP48_0017405(ispG)
BCAN : BcanWSM471_36150(ispG)
VGO : GJW-30_1_00428(ispG)
BHS : BM1374165_01582(ispG)
BBK : BARBAKC583_0119(ispG)
BTX : BM1374166_02135(ispG)
BEZ : NCTC12898_01464(ispG)
MAQU : Maq22A_c20290(gcpE)
MMES : MMSR116_10040(ispG)
MTUN : MTUNDRAET4_4136(ispG)
FIL : BN1229_v1_1525(ispG)
FIY : BN1229_v1_1527(ispG)
BVY : NCTC9239_02958(ispG)
TSV : DSM104635_01921(ispG)
RLI : RLO149_c016150(ispG)
PHP : PhaeoP97_02034(ispG)
PPIC : PhaeoP14_01845(ispG)
SINL : DSM14862_01241(ispG)
SPSE : SULPSESMR1_01232(ispG)
RMM : ROSMUCSMR3_00779(ispG)
AHT : ANTHELSMS3_03213(ispG)
LALG : LentiSH36_01570(ispG)
LVS : LOKVESSMR4R_01189(ispG)
AALK : LGT41_0012390(ispG)
SPHU : SPPYR_3068 SPPYR_3069
SBIN : SBA_ch1_05720(ispG)
SFLA : SPHFLASMR4Y_01794(ispG)
ABS : AZOBR_p1110054(ispG)
HPO : HMPREF4655_20974(ispG)
HPX : HMPREF0462_0786(ispG)
HPYA : HPAKL117_02955(ispG)
HPYK : HPAKL86_04515(ispG)
HCL : NCTC13205_00433(gcpE)
HSH : NHP194022_00800(ispG)
HPUL : NCTC13154_01410(gcpE)
CJV : MTVDSCj20_0709(ispG)
CFV : CFVI03293_0774(ispG)
CAMP : CFT03427_0973(ispG)
CCOC : CCON33237_1192(ispG)
CLR : UPTC16701_1160(ispG)
CLM : UPTC16712_1192(ispG)
CAMR : CAQ16704_1202(ispG)
CHV : CHELV3228_0612(ispG)
CPIN : CPIN18020_0789(ispG)
CAMZ : CVIC12175_0968(ispG)
GBN : GEOBRER4_13060(ispG)
PPOR : JCM14722_24770(ispG)
BAZ : BAMTA208_12865(ispG)
BAE : BATR1942_10845(ispG)
BSON : S101395_01841(gcpE)
BTHR : YBT1520_22735(ispG)
BTHU : YBT1518_23835(ispG)
BFD : NCTC4823_01840(ispG)
BACI : B1NLA3E_15965(ispG)
PARG : PspKH34_10630(ispG)
BLEN : NCTC4824_01688(ispG)
SDP : NCTC12225_01454(ispG)
SSTE : SAMEA4384403_1211(ispG)
MCAK : MCCS_14880(ispG_1) MCCS_15270(ispG_2)
LMOC : LMOSLCC5850_1501(ispG)
LMW : LMOSLCC2755_1446(ispG)
LMX : LMOSLCC2372_1503(ispG)
LMZ : LMOSLCC2482_1496(ispG)
LMOS : LMOSLCC7179_1413(ispG)
LMOO : LMOSLCC2378_1457(ispG)
LMOY : LMOSLCC2479_1502(ispG)
LMOT : LMOSLCC2540_1520(ispG)
LMOA : LMOATCC19117_1450(ispG)
BAYD : BSPP4475_09095(ispG)
PPQ : PPSQR21_039310(gcpE)
COHN : KCTCHS21_19070(ispG)
CCOH : SAMEA4530647_1087(ispG)
CGEL : psyc5s11_41010(ispG)
CTAG : LL095_14220(ispG) LL095_23440(ispG)
OCW : OW730_14105(ispG) OW730_20390(ispG)
CLO : HMPREF0868_0937(ispG)
SMAN : C12CBH8_06760(ispG)
PFAA : MM59RIKEN_28890(ispG)
VFA : MM35RIKEN_02080(ispG)
VCOP : MM50RIKEN_05930(ispG)
BPRO : PMF13cell1_02140(ispG)
BLUI : Blut17040_07220(ispG)
CSCI : HDCHBGLK_02342(ispG)
CHYL : CE91St63_10740(ispG)
ACEL : acsn021_29960(ispG)
ACHT : bsdcttw_32890(ispG)
PDF : CD630DERM_21280(ispG)
FAA : HMPREF0389_00113(ispG)
PHX : KGNDJEFE_01420(ispG)
CBAR : PATL70BA_0425(ispG)
AMIC : Ami3637_13340(ispG)
ABUT : Ami103574_06710(ispG)
ETM : CE91St48_16050(ispG)
CDIA : CaldiYA01_07230(ispG)
PHAR : NCTC13077_00844(ispG)
PIV : NCTC13079_00797(ispG)
VRM : 44547418_00881(ispG)
VDN : NCTC11831_01080(ispG)
DHO : Dia5BBH33_10570(ispG)
MANA : MAMMFC1_03853(ispG)
PFAC : PFJ30894_01560(ispG)
AARG : Aargi30884_04890(ispG)
ABSI : A9CBEGH2_06260(ispG)
FIT : Fi14EGH31_17750(ispG)
SCR : SCHRY_v1c04270(ispG)
SSYR : SSYRP_v1c04310(ispG)
SDI : SDIMI_v3c02320(ispG)
STAI : STAIW_v1c02780(ispG)
SAPI : SAPIS_v1c02830(ispG)
SCQ : SCULI_v1c03020(ispG)
SSAB : SSABA_v1c02290(ispG)
SATR : SATRI_v1c06980(ispG)
SERI : SERIO_v1c06690(ispG)
SLL : SLITO_v1c08480(ispG)
SCJ : SCANT_v1c02460(ispG)
SHJ : SHELI_v1c02390(ispG)
SFZ : SFLOR_v1c03040(ispG)
SCOU : SCORR_v1c08160(ispG)
SCLA : SCLARK_001551(ispG)
SPRN : S100390_v1c04800(ispG)
SPIT : STU14_v1c04800(ispG)
STAB : STABA_v1c03390(ispG)
SMOO : SMONO_v1c02260(ispG)
SALX : SALLE_v1c07760(ispG)
SGQ : SGLAD_v1c02880(ispG)
SCHI : SCHIN_v1c04000(ispG)
MGN : HFMG06NCA_2217(ispG)
MGS : HFMG95NCA_2262(ispG)
MGT : HFMG01NYA_2276(ispG)
MGV : HFMG94VAA_2335(ispG)
MGW : HFMG01WIA_2210(ispG)
MGAC : HFMG06CAA_2215(ispG)
MGAN : HFMG08NCA_2218(ispG)
MGNC : HFMG96NCA_2261(ispG)
PCAT : Pcatena_08190(ispG)
RTS : CE91St31_08670(ispG)
MBO : BQ2027_MB2893C(gcpE)
MMI : MMAR_0275(gcpE_2) MMAR_1838(ispG)
MMAE : MMARE11_17680(ispG)
MLI : MULP_00245(gcpE) MULP_02002(ispG)
MPSE : MPSD_18410(ispG_1) MPSD_53270(ispG_2)
MBAI : MB901379_01658(ispG)
MHEK : JMUB5695_03255(ispG)
MKY : IWGMT90018_39790(ispG)
MPHL : MPHLCCUG_02208(ispG)
MTHN : 4412656_01667(ispG)
MAUU : NCTC10437_02119(ispG)