KEGG   ENZYME: 1.17.8.1
Entry
EC 1.17.8.1                 Enzyme                                 
Name
hydroxysqualene dehydroxylase;
hpnE (gene name)
Class
Oxidoreductases;
Acting on CH or CH2 groups;
With a flavin as acceptor
Sysname
squalene:FAD oxidoreductase (hydroxylating)
Reaction(IUBMB)
squalene + FAD + H2O = hydroxysqualene + FADH2 [RN:R11401]
Reaction(KEGG)
R11401
Substrate
squalene [CPD:C00751];
FAD [CPD:C00016];
H2O [CPD:C00001]
Product
hydroxysqualene [CPD:C21116];
FADH2 [CPD:C01352]
Comment
This enzyme, isolated from the bacteria Rhodopseudomonas palustris and Zymomonas mobilis, participates, along with EC 2.5.1.103, presqualene diphosphate synthase, and EC 4.2.3.156, hydroxysqualene synthase, in the conversion of all-trans-farnesyl diphosphate to squalene. Eukaryotes achieve the same goal in a single step, catalysed by EC 2.5.1.21, squalene synthase.
History
EC 1.17.8.1 created 2016
Orthology
K21677  hydroxysqualene dehydroxylase
Genes
MEJQ7A_576
MECQ7C_2166
TEETel_08420
HHCM911_10420
EBSECTOBSL9_3060
TGRTgr7_1523
TKMTK90_1513
TNITVNIR_1518
TTITHITH_09115
TVRTVD_07365
APRSBI364_06315
TTCFOKN1_2198
SVASVA_2085
REVHUE57_10320
NELNELON_09780
NWESAMEA3174300_0491
NSIA6J88_08335
NMJNM96_03015
NEIBG910_02825
NEKCGZ77_10440
NFVFAH67_06635
NSFFAH66_06620
NZLD0T92_06755
NAQD0T90_10260
NBLGJV52_09745
NZOSAMEA4504057_1349
NCINCTC10296_01518
NCZNCTC10294_00762(pds)
NANINCTC12227_01024
NBCH3L91_02765
NWDH3L96_11675
NSGH3L94_07260
NMUSH7A79_0561
NDNH3L92_05740
KKIKKKWG1_1300
KOAH3L93_07795
VFFVITFI_CDS2493
VITADP71_05650
ECORSAMEA4412678_1366
EEXEZJ17_01775
SMURBWP33_07955
AFFH3L97_09340
CSTEH3L98_08445
CVICV_2977
CVCBKX93_05580
CHROCXB49_06645
CHRIDK842_21885
CHRBDK843_04625
CRZD1345_13640
CHRMFYK34_09110
CHAECH06BL_28880
IODEJO50_08485
IFLC1H71_16080
LHKLHK_02042
PSENH8B_3077
JEUBJP62_15965
AQLBXU06_08210
AMAHDLM_0808
AQSDKK66_01300
DEEHQN60_02630
CHIZHQ393_00385
CFONHZU75_03600
VOGLCH97_01545(hpnE)
CGDCR3_1544
BVIBcep1808_3807
BVEAK36_4902
BURBcep18194_B0018
BCNBcen_5179
BCHBcen2424_5680
BCMBcenmc03_4555
BCJBCAM2832
BCENDM39_5012
BCEWDM40_3397
BAMBamb_4952
BACBamMC406_5505
BMJBMULJ_05350
BMUBmul_3174
BMKDM80_4552
BMULNP80_3380
BCTGEM_5580
BCEDDM42_5156
BCEPAPZ15_24780
BDLAK34_4973
BPYRABD05_21480
BCONNL30_18010
BUBBW23_4002
BDFWI26_26720
BLATWK25_29565
BTEIWS51_10750
BSEMWJ12_34025
BPSLWS57_00080
BMECWJ16_32500
BSTGWT74_32865
BSTLBBJ41_27935
BANNJFN94_18180
BUGBC1001_4760
BGFBC1003_4524
BYIBYI23_B013710
BUKMYA_3464
BUEBRPE67_BCDS00670
BUQAC233_26245
BUMAXG89_19295
BUIAX768_29060
BURKDM992_25925
BXEBxe_B0011
BXBDR64_5375
BPHBphy_4138
BGEBC1002_5087
BPXBUPH_01325
BPYBphyt_7028
BUZAYM40_35480
BFNOI25_5473
BCAIK788_0000710
PSPWBJG93_21550(hpnE)
PARABTO02_22400
PARBCJU94_28540
PHSC2L64_18370
PTERC2L65_16205
PGPCUJ91_29995
PCJCUJ87_28075
PTSCUJ90_23650
PCAFDSC91_003032
PMEGFNZ07_04855
PTROG5S35_20785
PGISI6I06_28035
PACPFAZ97_23540
PACSFAZ98_18975
PEWKZJ38_24045(hpnE)
PDIOPDMSB3_3366.1(hpnE)
PPKU875_17025
PPNODA70_09095
PPNMLV28_21710
PRBX636_17395
PPULRO07_16100
PSPUNA29_21050
PAPISG18_00200
PVEUC34_07355
POXMB84_11690
PFGAB870_18050
PNRAT302_26705
PANDDRB87_06620
PFIBPI93_020485
LMIRNCTC12852_01853(pds)
CABASBC2_70710(hpnE)
BUOBRPE64_BCDS00800
CARIFNU76_18440
BPEBP1218
BPCBPTD_1209
BPERBN118_1184
BPETB1917_2637
BPEUQ425_26880
BPARBN117_3027
BPABPP1832
BBHBN112_1076
BBRBB3274
BBMBN115_1877
BBXBBS798_3106
BPTBpet3165(crtD)
BAVBAV2419
BHOD560_2907
BHMD558_2883
BHZACR54_01344
BTRMSAMEA390648704111(pds)
BBROBAU06_17130
BFZBAU07_09040
BPDZBBN53_15035
BOHAKI39_16470
BGMCAL15_10620
BOJCBF45_11160
AXYAXYL_04187
AXONH44784_056831
AXNAX27061_3941
AXXERS451415_03964(crtN)
ADTAPT56_18425
AISBUW96_10160
ASWCVS48_22635
ACHRC2U31_24610
ACHBDVB37_16915
ADYHLG70_03080(hpnE)
PUTPT7_0477
PUSCKA81_07845
PUDG9Q38_12720
AKATKWG_15595
AMIMMIM_c14980
CDNBN940_12466
AFQAFA_05275
AAQUD3M96_06820
AAMMFE795_05415
PHNPAEH1_12675
ODIODI_R1605
BOZDBV39_01535
PIGEGT29_15370
PACRFXN63_09585
KGYEHF36_11405
PARKLSG25_08395(hpnE)
RFRRfer_1548
RSBRS694_08085
RACRA876_07080
RHYRD110_09925
RHFEUB48_08300
RHGEXZ61_07450
POLBpro_2016
PNAPnap_2965
POSDT070_19925
POOF7R28_10635
PVACHC248_02480(hpnE)
AAVAave_1455
AJSAjs_1201
AAAAcav_1494
ACKC380_16115
ACRABSY15_70
ACIDCBP33_06830
ACIPCBP36_07400
ACINCBP34_06725
ACIOEAG14_07705
AMONH9L24_00420
AANTHUK68_06665
ARADKI609_15300(hpnE)
VEIVeis_0071
DACDaci_2571
DELDelCs14_4082
DTSBI380_11410
DHKBO996_12115
DLAI6G47_11345
VAPVapar_2504
VPEVarpa_3430
VPDVAPA_1c30530(hpnE)
VAAAX767_18360
VBOCKY39_15550
VAMC4F17_07385
CTTCtCNB1_1245
CTESO987_06860
CKEB5M06_16655
COFFOZ74_15300
CAQTKAQ61_10035(hpnE)
CODOLAD35_15960(hpnE)
ADNAlide_2995
ADKAlide2_1452
RTARta_15720
CBXCenrod_1403
OTOADJ79_09810
OTKC6570_14535
LIML103DPR2_02183
HYRBSY239_1274
HYBQ5W_07520
HYLLPB072_13510
HYCE5678_02945
HPSEHPF_15125
HYNF9K07_18635
HTNKI616_10770(hpnE)
DPYBA022_08200
DIHG7047_03015
DAERH9K75_19345
DRGH9K76_16455
DIADtpsy_1120
SIMPC6571_15270
MELMC7H73_06770
MELAC6568_02450
MJELVC68_10630(hpnE)
CBAASRAA_0595
CBABSMCB_1453
PBHAAW51_1821
KIAG8A07_19845
MPTMpe_A1286
METPC1M51_01840
HARHEAR1757
MMSmma_1527
JAGGJA_2380
JABVN23_03935
JAZYQ44_13185
JALBZG29_14345
JSVCNX70_14760
JAJEKL02_09535
JASFJQ89_03905
JLVG3257_15235
HSEHsero_2593(hpnE)
HSZACP92_12975
HHTF506_12040
HRBHrubri_2676(hpnE)
HEEhmeg3_10380
HHFE2K99_13810
CFUCFU_2448
CARELT85_2172
CPRACPter91_3186
MNRACZ75_06170
MASWAM586_14375
MASSCR152_24260
MASZC9I28_15765
MTIMDIR46_01180
MASYDPH57_06050
MALIEYF70_12560
MUMFCL38_06520
MFLAGO485_01465
MPLIE1742_03225
DUGHH213_25140
OFOBRW83_1188
UPVEJN92_01315
UPIEJG51_005450
NOKFAY22_07315
GLCJQN73_00850
LCHLcho_2550
RGERGE_28000
RBNRBXJA2T_19166
RDPRD2015_1448
PKTAT984_04170
MIUABE85_14160
RGUA4W93_10800
SNNEWH46_05295
XYKGT347_23445
TTWLCC91_06915(hpnE)
IDCLRM40_11280(hpnE)
SHDSUTH_02461
METRBSY238_462
DOEDENOEST_1303
MFAMfla_1470
MMBMmol_1178
MEHM301_1429
MEIMsip34_1421
MEPMPQ_1495
MBACBN1209_0788
MEUACJ67_06060
MPAUZMTM_12440
SLTSlit_1435
GCAGalf_1735
FAMOYT1_ch0653
NIMW01_00780
FKUFGKAn22_15060
SEMEMIZ01_1239
SDRSCD_n01778
SULFCAP31_08150
SPLBSFPGR_20000
SNIVSFSGTM_17710
SLACSKTS_24330
URUDSM104443_02757(hpnE)
UPLDSM104440_02480(hpnE)
DSUDsui_2191
ARESIWH25_14355
AIQAzoinq_12675
RBUPG1C_08560
OTROTERR_11830
NIVJY500_13220
EBAebA6811
ABREpbN1_35050(hpnE)
APETToN1_08520(hpnE)
ATWC0099_08790
RBHB4966_07850
DARDaro_2707
DEYHYN24_06440
QAUKI612_10925(hpnE)
FLEKI610_10050(hpnE)
AZOazo1885
AOAdqs_2040
AZAAZKH_2220
AZIAzCIB_2652
ACOMCEW83_04345
AZDCDA09_14450
AZRCJ010_12390
TMZTmz1t_2159
THUAC731_005010
TCLTchl_2745
THKCCZ27_08620
TAKTharo_2032
AZQG3580_09175
ZPAC3497_07430
FPHOSHINM1_007670
APPCAP2UW1_3260
DDZDSYM_17480
BEBAEM42_08770
BEBABWI17_12865
PMOBHG718_04900
KMNHW532_17950
RHINGR_a00450
SINOSS05631_a45180
ESJSJ05684_a40280
BJAblr3003(blr3003)
BJUBJ6T_67640
BJPRN69_32805
BRABRADO2629
BBTBBta_2968
BRSS23_49940(hpnD)
AOLS58_49900
BRCBCCGELA001_13470
BRADBF49_1689
BICLMTR13_28335
BROBRAD285_4712
BRKCWS35_18220
BOTCIT37_38580
BRQCIT40_09515
BGQX265_25985
BGZXH91_24125
BSYMCIT39_08635
BBETF8237_05030
BARHWN72_16445
BVZBRAD3257_5707
BELBE61_70450
BDGLPJ38_18015(hpnE)
BSEPHAP48_0030895(hpnE)
BQBJ4P68_0032155(hpnE)
RPARPA3741
RPBRPB_1725
RPCRPC_1719
RPDRPD_3574
RPERPE_1813
RPTRpal_4262
RPXRpdx1_1604
RBKE0H22_09835
NWINwi_2270
NHANham_2683
OCAOCAR_6672(hpnE)
OCGOCA5_c13960
OCOOCA4_c13960
VGOGJW-30_1_02141
TRBHB776_13760
STARG3545_15485
MEAMex_1p1817
MDIMETDI2704 METDI4481
MEXMext_1943
MCHMchl_2219 Mchl_5461
MPOMpop_1834
MZAB2G69_17175
MRDMrad2831_5425
METM446_6348
MNOMnod_7145
MORMOC_6000
METAY590_09035
MAQUMaq22A_c25250
MPHYMCBMB27_04726
MEEDA075_06150
METDC0214_10790
METXA3862_03550
METSDK389_19260
METIDK427_04655 DK427_24630
MMESMMSR116_24430
MTEADK419_24985
MINDmvi_55620
MOGMMB17_13745(hpnE)
MOCBB934_38315
MICOGDR74_17430
BIDBind_3155
MSLMsil_3242
MLGCWB41_01840
BBARRHAL1_00133
HDNHden_0476
HDTHYPDE_24883
HMCHYPMC_3772
RVARvan_3018
RHZRHPLAN_23300
MSCBN69_1679
MBRYB1812_10040
MROSEHO51_00875
MHEYH2LOC_015880
MPARF7D14_11070
MTWCQW49_11730
PSINCAK95_04480
TSOIZ6_27200
RBMTEF_04815
LIZLGH83_10470(hpnE)
CAULKCG34_23150(hpnE)
PALWPSAL_001900(hpnE)
ZMOZMO0871
ZMNZa10_0421
ZMMZmob_0426
ZMBZZ6_0424
ZMIZCP4_0440
ZMCA265_00435
ZMRA254_00435
ZMPZymop_0394
NORFA702_05040
SPHMG432_09185
SPANAWL63_21315
SARIH5J25_10645
POQKZX46_17580(hpnE)
GOXGOX2259
GOHB932_2743
GOYGLS_c24020
GALA0U94_06165
GTIFXF46_13820
GSPIGS75_12760
GFAMKW11_14250(hpnE)
GBEGbCGDNIH1_2106
GBHGbCGDNIH2_2106
GBCGbCGDNIH3_2106
GBSGbCGDNIH4_2106
ACRAcry_0117
AMVACMV_01420
GDIGDI1621
GDJGdia_1826
GXYGLX_17340
GXLH845_3228
KNAB0W47_08875
KEUS101446_02250(crtQ)
KSCCD178_01160(pds)
KREGWK63_14320
APTAPA01_01960
APWAPA42C_01960
APFAPA03_01960
APUAPA07_01960
APGAPA12_01960
APQAPA22_01960
APXAPA26_01960
APZAPA32_01960
APKAPA386B_1684
ASZASN_2209(hpnE)
ASVWG31_01020
AACEA0U92_11675
APERA0U91_06970
APOMCPF11_06320
ATOCIW82_01585
AASCA4S02_11560
ACETDS739_01120
AOTAcetOri_orf02405
AOYEOV40_001045
ACEKFLP30_07005
ABGAsbog_02595(hpnE)
KBAA0U89_01835
RGIRGI145_09725
ROSCTJ15_07695
RMUCFOB66_09720
RMTIAI58_18590
NCHA0U93_11940
COQD9V35_08225
COMMGN303_08025
NTND5366_10595
NEHE3E11_07660
SSAME3D00_09660
SWFE3E12_06925
BOBGN304_03815
BOMBGT348_03340
EBLAJGUZn3_04100(hpnE)
LCKHN018_00145
KHAIFJ82_01380
PARZDTQ13_08070
SHUMSTHU_32390
SVCSTVA_19150
STELSTAQ_29090
AZLAZL_014570
ALIAZOLI_1389
ABSAZOBR_p120092
ABFAMK58_16900
ATIAL072_11955
AHUA6A40_04995
AZTTSH58p_22400
AZMDM194_04390
AZZDEW08_02160
AOZHUE56_17250
NAOY958_22675
NCBC0V82_03555
SKTIGS68_10420
SMUCJL100_016815(hpnE)
SROEJL101_015665(hpnE)
RRURru_A0063
RRFF11_00320
RCERC1_1043(y4aB)
RPMRSPPHO_00432
MAGamb2510
MGYMGMSRv2__1220
MGRYMSR1_10390
MAGXXM1_3270
MAGNWV31_06940
TMOTMO_1551
HJOAY555_08485
HTQFRZ44_04160
HADHFRZ61_04430
TXITH3_09565
TIIDY252_12215
MAGQMGMAQ_1493
MGMMmc1_0307
MAESGa0123461_1323
AACAaci_2440
AADTC41_2730(crtQ)
NTPCRH09_23895
NWLNWFMUON74_15120
ACTWF7P10_06035
AGRAAGRA3207_001322
NOWGBF35_34745
FRAFrancci3_0821
FREFranean1_5715
FRIFraEuI1c_5919
FSYFsymDg_1168
BSDBLASA_0213(hopC)
SACGFDZ84_33300
SVISvir_23100
SACCEYD13_12865(pds)
AMQAMETH_4079(hopC)
AMYCCU254_13930
PDXPsed_3678
KALKALB_4046
PMADBAY61_14050
PLKCIK06_14735
PLABC6361_04785
PLATC6W10_01310
PFLAPflav_027720
PSUUPsuf_090680
ATLAthai_51140
ASERAsera_23700
CAICaci_6666
AEYCDG81_09435
BSOLFSW04_24300
MROMROS_2827
LFCLFE_1961
LFILFML04_2159
LFPY981_11070
LEGABH19_11640
 » show all
Reference
1  [PMID:26258173]
  Authors
Pan JJ, Solbiati JO, Ramamoorthy G, Hillerich BS, Seidel RD, Cronan JE, Almo SC, Poulter CD
  Title
Biosynthesis of Squalene from Farnesyl Diphosphate in Bacteria: Three Steps Catalyzed by Three Enzymes.
  Journal
ACS Cent Sci 1:77-82 (2015)
DOI:10.1021/acscentsci.5b00115
Other DBs
ExplorEnz - The Enzyme Database: 1.17.8.1
IUBMB Enzyme Nomenclature: 1.17.8.1
ExPASy - ENZYME nomenclature database: 1.17.8.1
BRENDA, the Enzyme Database: 1.17.8.1

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