KEGG   ENZYME: 1.17.8.1Help
Entry
EC 1.17.8.1                 Enzyme                                 

Name
hydroxysqualene dehydroxylase;
hpnE (gene name)
Class
Oxidoreductases;
Acting on CH or CH2 groups;
With a flavin as acceptor
BRITE hierarchy
Sysname
squalene:FAD oxidoreductase (hydroxylating)
Reaction(IUBMB)
squalene + FAD + H2O = hydroxysqualene + FADH2 [RN:R11401]
Reaction(KEGG)
Substrate
squalene [CPD:C00751];
FAD [CPD:C00016];
H2O [CPD:C00001]
Product
hydroxysqualene [CPD:C21116];
FADH2 [CPD:C01352]
Comment
This enzyme, isolated from the bacteria Rhodopseudomonas palustris and Zymomonas mobilis, participates, along with EC 2.5.1.103, presqualene diphosphate synthase, and EC 4.2.3.156, hydroxysqualene synthase, in the conversion of all-trans-farnesyl diphosphate to squalene. Eukaryotes achieve the same goal in a single step, catalysed by EC 2.5.1.21, squalene synthase.
History
EC 1.17.8.1 created 2016
Orthology
K21677  hydroxysqualene dehydroxylase
Genes
BVI: Bcep1808_3807
BVE: AK36_4902
BUR: Bcep18194_B0018
BCN: Bcen_5179
BCH: Bcen2424_5680
BCM: Bcenmc03_4555
BCJ: BCAM2832
BCEN: DM39_5012
BCEW: DM40_3397
BCEO: I35_6712
BAM: Bamb_4952
BMU: Bmul_3174
BMK: DM80_4552
BMUL: NP80_3380
BCT: GEM_5580
BCED: DM42_5156
BDL: AK34_4973
BCON: NL30_18010
BUB: BW23_4002
BLAT: WK25_29565
BTEI: WS51_10750
BSEM: WJ12_34025
BPSL: WS57_00080
BMEC: WJ16_32500
BSTG: WT74_32865
BUK: MYA_3464
BXE: Bxe_B0011
BXB: DR64_5375
BPH: Bphy_4138
BFN: OI25_5473
PPNO: DA70_09095
PPNM: LV28_21710
PPUL: RO07_16100
PSPU: NA29_21050
PAPI: SG18_00200
BJA: blr3003
BRA: BRADO2629
BBT: BBta_2968
BRS: S23_49940(hpnD)
AOL: S58_49900
BRAD: BF49_1689
RPA: RPA3741
RPB: RPB_1725
RPC: RPC_1719
RPD: RPD_3574
RPE: RPE_1813
RPT: Rpal_4262
NWI: Nwi_2270
NHA: Nham_2683
OCA: OCAR_6672(hpnE)
MEX: Mext_1943
MDI: METDI2704
MCH: Mchl_2219
MPO: Mpop_1834
MET: M446_6348
MNO: Mnod_7145
MOR: MOC_6000
META: Y590_09035
BID: Bind_3155
MSL: Msil_3242
HDN: Hden_0476
RVA: Rvan_3018
MSC: BN69_1679
RBM: TEF_04815
ZMO: ZMO0871
ZMN: Za10_0421
ZMM: Zmob_0426
ZMB: ZZ6_0424
ZMI: ZCP4_0440
SPHM: G432_09185
GOX: GOX2259
GOH: B932_2743
ACR: Acry_0117
GDI: GDI1621
GDJ: Gdia_1826
GXY: GLX_17340
GXL: H845_3228
KEU: S101446_02250(crtQ)
KSC: CD178_01160(pds)
ASZ: ASN_2209(hpnE)
ABG: Asbog_02595(hpnE)
RRU: Rru_A0063
RRF: F11_00320
RCE: RC1_1043(y4aB)
MAG: amb2510
MGRY: MSR1_10390
MAGX: XM1_3270
MAGN: WV31_06940
TMO: TMO_1551
TXI: TH3_09565
MAGQ: MGMAQ_1493
LFC: LFE_1961
 » show all
Taxonomy
Reference
1  [PMID:26258173]
  Authors
Pan JJ, Solbiati JO, Ramamoorthy G, Hillerich BS, Seidel RD, Cronan JE, Almo SC, Poulter CD
  Title
Biosynthesis of Squalene from Farnesyl Diphosphate in Bacteria: Three Steps Catalyzed by Three Enzymes.
  Journal
ACS Cent Sci 1:77-82 (2015)
DOI:10.1021/acscentsci.5b00115
Other DBs
ExplorEnz - The Enzyme Database: 1.17.8.1
IUBMB Enzyme Nomenclature: 1.17.8.1
ExPASy - ENZYME nomenclature database: 1.17.8.1
BRENDA, the Enzyme Database: 1.17.8.1

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