KEGG   ENZYME: 1.17.98.3
Entry
EC 1.17.98.3                Enzyme                                 
Name
formate dehydrogenase (coenzyme F420);
coenzyme F420 reducing formate dehydrogenase;
coenzyme F420-dependent formate dehydrogenase
Class
Oxidoreductases;
Acting on CH or CH2 groups;
With other, known, physiological acceptors
Sysname
formate:coenzyme-F420 oxidoreductase
Reaction(IUBMB)
formate + oxidized coenzyme F420 = CO2 + reduced coenzyme F420 [RN:R10797]
Reaction(KEGG)
R10797
Substrate
formate [CPD:C00058];
oxidized coenzyme F420 [CPD:C00876]
Product
CO2 [CPD:C00011];
reduced coenzyme F420 [CPD:C01080]
Comment
The enzyme, characterized from methanogenic archaea, is involved in formate-dependent H2 production. It contains noncovalently bound FAD [1].
History
EC 1.17.98.3 created 2014 as EC 1.2.99.9, transferred 2017 to EC 1.17.98.3
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00125  formate dehydrogenase (coenzyme F420) beta subunit
K22516  formate dehydrogenase (coenzyme F420) alpha subunit
Genes
VNAPN96_21155
VEJVEJY3_20411
PGBH744_1c0419
PGHFH974_23235(fdhF)
PSHPsest_3905
PSTUUIB01_19765
PCHEY04_14750
PSEDDM292_16890
GNIGNIT_2862
TMBThimo_0255
CHIZHQ393_09255
CFONHZU75_11945
SUTTSUTMEG_11560
SUTKFG381_06445
SLACSKTS_06260
CCOCCC13826_0200(fdhH)
CCOCCCON33237_0536(fdhH)
CGRACGRAC_1361(fdhH)
CPINCPIN18020_0262(fdhH)
CGEOCGEO_1649(fdhH)
CMUCCMCT_1635(fdhH)
CSHOCSHOW_0456(fdhH)
SULSSdiek1_1063
SULJSJPD1_1032
AHSAHALO_1025(fdhH)
AMARAMRN_1963(fdhH)
ACAAACAN_2017(fdhH)
CMEDFE773_08405
GSUGSU0088(hdrD)
GSKKN400_0063(hdrD)
GMEGmet_3428(hdrD)
GEMGM21_0027
GEBGM18_0024 GM18_3241
GPIGPICK_06770 GPICK_15705
GAOA2G06_16000
GEFFO488_02625
GBZJZM60_06200 JZM60_10225(fdhF)
GURGura_0147
GEOGeob_0149 Geob_3720(hdrD)
GBMGbem_0028(hdrD)
GBNGEOBRER4_00260(hdrD)
GERKP004_19730
GSUBKP001_16585
GNTKP003_19720
PCAPcar_2701
PPDPpro_2790 Ppro_2799
DVEDESUT3_05340
DFLDFE_0758 DFE_2489
DSDGD606_00175 GD606_07840 GD606_11690
DMADMR_01940
DCBC3Y92_00575
DGGDGI_1052(floxC)
DDEDde_1211 Dde_3528
DMSE8L03_02850
DSADesal_0598
DHYDESAM_21328
DAFDesaf_1864 Desaf_2879
DASDaes_0781
DPIBN4_11862
DEJAWY79_07305
PSELGM415_15615
DDNDND132_1390 DND132_2347
DSXGD604_05900 GD604_12445
DBADbac_2346
DOAAXF15_00785 AXF15_11190
DRTDret_0419
DSFUWK_03159
DMLDmul_02420
DALDalk_5062
DATHRM2_11880(fdhA3) HRM2_14370(fdhA4) HRM2_22080(fdhB5) HRM2_22740(fdhB6)
DTOTOL2_C17890 TOL2_C24200
DOVDSCO28_26720 DSCO28_27580 DSCO28_27830 DSCO28_36090 DSCO28_48980 DSCO28_65560
DWDDSCW_21250 DSCW_47550 DSCW_60930 DSCW_61120
DALKDSCA_54490 DSCA_54710 DSCA_62380(hdrD)
DMMdnm_011400 dnm_084970
DEKDSLASN_12960
DTIDesti_4266
SFUSfum_0822 Sfum_1972
DAXFDQ92_05250 FDQ92_10770
DBRDeba_2134
BLAGBLTE_14910
EFSEFS1_1216
ENEENT_08450
CSQCSCA_0253
CEUA7L45_12260
CDRKB9W14_17240
CTHDCDO33_09930
RCHRUM_11000
RUMCK1_05080
SMANC12CBH8_20570
BYLA4V09_16705
BPROPMF13cell1_01674
BLABEYS05_14060
SWOSwol_0400
SALQSYNTR_0266
DSYDSY1990
DHDDhaf_3153
DDHDesde_2607
SGYSgly_1898
DORDesor_0108 Desor_2815 Desor_3508
DAIDesaci_2628
DMIDesmer_2224
DCADesca_0132 Desca_0138 Desca_0819
PTHPTH_1407(RnfC)
DRMDred_0139 Dred_0146 Dred_1330
DRUDesru_0208 Desru_0215 Desru_2695
DFGB0537_01500 B0537_01535 B0537_06305 B0537_08745
DAEDtox_1279 Dtox_1355
DKUDesku_0190 Desku_1432 Desku_1482
DAUDaud_0567
TFRBR63_02785 BR63_09665
FWADCMF_10300 DCMF_16640 DCMF_24650
TJRTherJR_0939 TherJR_1951 TherJR_2471
DGIDesgi_0611 Desgi_0612 Desgi_2044
HMOHM1_2010
HCVFTV88_1706
CTHMCFE_1626
CMIUB1H56_01495
CHYCHY_0932
ADGAdeg_1331
MASMahau_0897
NTHNther_2660
AARAcear_0635
SFISFUL_466
NOABKM31_20845
ABATCFX1CAM_1232
PSUBPelsub_P0987
BPITBPIT_11130
TBETrebr_2032
FVAFV113G1_17800
FULC4N20_13335
IPOIlyop_2562
CPORBED41_00295
TTKTST_1517 TST_1524
DTEDester_1341
TIDThein_2071
TAVG4V39_00755 G4V39_00795
MJAMJ_0005 MJ_0006
MFEMefer_0653 Mefer_0654 Mefer_1009
MVUMetvu_0710 Metvu_0711 Metvu_1163
MFSMFS40622_0206 MFS40622_0207 MFS40622_0235 MFS40622_0236
MJHJH146_0247 JH146_0280 JH146_0281
MESGMLAUSG7_0307 MLAUSG7_0837(fdhB) MLAUSG7_0838
MESAMLASG1_0357 MLASG1_0358(fdhB) MLASG1_1372
MIGMetig_0762 Metig_1191 Metig_1192
MMPMMP0138(fdhA) MMP0139(fdhB) MMP1297(fdhB) MMP1298(fdhA)
MMQMmarC5_0295 MmarC5_0296 MmarC5_1537 MmarC5_1538
MMXMmarC6_0813 MmarC6_0814 MmarC6_1376 MmarC6_1377
MMZMmarC7_0542 MmarC7_0543 MmarC7_1137 MmarC7_1138
MMDGYY_00710 GYY_07320
MMAKMMKA1_01430(fdhA) MMKA1_01440(fdhB) MMKA1_15220(fdhB) MMKA1_15230(fdhA)
MMAOMMOS7_01690(fdhA) MMOS7_01700(fdhB) MMOS7_14040(fdhB) MMOS7_14050(fdhA)
MMADMMJJ_09460 MMJJ_09470(fdhF_2) MMJJ_15440(fdhA2) MMJJ_15460(fdhB1)
MAEMaeo_0577 Maeo_0578
MVNMevan_0607 Mevan_0608 Mevan_1144
MVOMvol_0702 Mvol_0703 Mvol_0818 Mvol_0819
MOKMetok_0188 Metok_0189 Metok_1223 Metok_1224
MTHMTH_1139 MTH_1140
MMGMTBMA_c15220(fdhB) MTBMA_c15230(fdhA2)
METCMTCT_1032 MTCT_1033 MTCT_1438 MTCT_1439
MWOMWSIV6_0697(fdhA5) MWSIV6_0698(fdhB1) MWSIV6_1531(fdhB3) MWSIV6_1532
METEtca_01095 tca_01096
METKFVF72_05885 FVF72_05890
MTHMFZP57_03345 FZP57_03350 FZP57_07330 FZP57_07335
METJFZP68_03340 FZP68_03345
MSTMsp_0639(fdhB) Msp_0640(fdhA)
METBAW729_02755 AW729_02760
MRUmru_0333(fdhA1) mru_0334(fdhB1) mru_2074(fdhA2) mru_2075(fdhB2)
MSIMsm_1404 Msm_1405 Msm_1462 Msm_1463
MEBAbm4_0131(fdhA) Abm4_0132(fdhB) Abm4_0854(fdhB2) Abm4_0855(fdhA2)
MMILsm9_1349(flpB) sm9_1350(flpA) sm9_2182(fdhB) sm9_2183(fdhA)
MEYETL18_00925 TL18_01670 TL18_01675
MOLYLM1_0030 YLM1_0031 YLM1_1105 YLM1_1106 YLM1_1539 YLM1_1540
MAROMarbSA_13560 MarbSA_13570
MEWMSWAN_0113 MSWAN_0115 MSWAN_0116
METHMBMB1_0103(fdhB) MBMB1_0104(fdhA)
MFCBRM9_0167(fdhB) BRM9_0168(fdhA)
MFIDSM1535_1485(fdhB) DSM1535_1486(fdhA)
MCUBMCBB_2028(fdhA) MCBB_2029(fdhB1) MCBB_2031(fdhB3)
MSUBBK009_10240 BK009_10250 BK009_10255
METNBK008_05865 BK008_05875 BK008_05880
METTCIT01_01075 CIT01_01080
METOCIT02_06500 CIT02_06505
MFVMfer_0694 Mfer_0695 Mfer_0725 Mfer_0726
MKAMK0321 MK0322
AVEArcve_2107
ASTAsulf_01818
FPLFerp_0094
PYNPNA2_1925
PYAPYCH_11030
PYSPy04_1234
PYCTQ32_09760 TQ32_10390
TKOTK2076
TONTON_0539 TON_1563
TGATGAM_0065(mhy2A) TGAM_0631(fdhA)
TSITSIB_0067
TBATERMP_00460
THEGQS_02455 GQS_05815
THATAM4_610
THMCL1_0794 CL1_1148
TLTOCC_06696 OCC_12236
THSTES1_1496
TNUBD01_1760 BD01_1899
TEUTEU_00760
THVADU37_CDS22830
TCHCHITON_1559
TPIEA7C91_04320 A7C91_08750
TCEA3L02_01395
TBSA3L01_00065
THHCDI07_00115
TSLA3L11_03805
TTDA3L14_01350
TPRFA3L09_08935
TRLA3L10_09785
TPAFA3L08_06500
THYA3L12_01285
TICFH039_02070 FH039_05990
TCQTIRI35C_0225(fdhA)
THEMFPV09_03360 FPV09_07205
PPACPAP_03230
MBAMbar_A1561 Mbar_A1562
MBYMSBRM_2895 MSBRM_2896
MBWMSBRW_3168 MSBRW_3169
MBARMSBR2_2854 MSBR2_2855
MMACMSMAC_2581 MSMAC_2582
METMMSMTP_1177
MEFMSWH1_2086
MEQMSWHS_3009
MHORMSHOH_1794 MSHOH_1795
MPYMpsy_2943 Mpsy_2944
MTPMthe_1339
MCJMCON_2237(fdhA)
MHIMhar_0324 Mhar_0325 Mhar_1282 Mhar_1628 Mhar_1941
MHUMhun_1813 Mhun_1814 Mhun_1832 Mhun_1833 Mhun_2020 Mhun_2021 Mhun_2022 Mhun_2023 Mhun_3237 Mhun_3238
MRTJKHC33_00530(fdhF) KHC33_00535 KHC33_05240(fdhF) KHC33_05245 KHC33_05335 KHC33_05340(fdhF) KHC33_10635 KHC33_10640(fdhF) KHC33_14310(fdhF) KHC33_14315 KHC33_14320(fdhF) KHC33_14325
MLAMlab_0462 Mlab_0463 Mlab_1057 Mlab_1058
MEMMemar_1044 Memar_1045 Memar_1378 Memar_1379 Memar_1380 Memar_1381 Memar_1623 Memar_1624
MBGBN140_0841(fdhB) BN140_0842(fdhA) BN140_1327(fdhA1) BN140_1328(fdhB1) BN140_1329(fdhA2) BN140_1330(fdhB2) BN140_2197(fdhB3) BN140_2198(fdhA3)
MEMAMMAB1_1105(fdhB) MMAB1_1106(fdhA) MMAB1_1689(fdhA) MMAB1_1690(fdhB) MMAB1_2913(fdhB) MMAB1_2914(fdhA)
MCHKMchiMG62_11690 MchiMG62_11700 MchiMG62_15750 MchiMG62_15760 MchiMG62_15770 MchiMG62_15780 MchiMG62_17900 MchiMG62_17910
MPIMpet_1035 Mpet_1036 Mpet_1047 Mpet_1048 Mpet_1627 Mpet_1628
MBNMboo_0923 Mboo_0924
MFOMetfor_0647 Metfor_0648 Metfor_0650 Metfor_0651 Metfor_0677 Metfor_0678
MPLMpal_0195 Mpal_0196 Mpal_0577 Mpal_0578
MPDMCP_1569(fdhB-1) MCP_1570(fdhA-1) MCP_2406(fdhB-2) MCP_2407(fdhA-2)
MEZMtc_2124(fdhB) Mtc_2125(fdhA)
RCIRCIX1628(fdhA-1) RCIX1630(fdhB-1) RCIX2372(fdhB-2) RCIX2373(fdhA-2) RCIX2376(fdhB-3) RCIX2378(fdhA-3) RRC251(fdhA-4) RRC252(fdhB-4)
HHBHhub_2705(fdhA)
HNOLT974_10300(fdhF)
HJEHacjB3_08400
HALHHTSR_1736(fdhA) HTSR_1740(fdhA2)
HHSRHSR6_1802(fdoG2) HSR6_1806(fdoG3)
HARAAArcS_1771(yjgC)
HHIHAH_5041(fdhA)
HHNHISP_18370
HABSG26_17860
NMONmlp_2714(fdhA)
HALIBV210_11270
HAQDU484_02900 DU484_17375
HAJDU500_00415 DU500_03330
HAERDU502_01085 DU502_15800
HRAEI982_15430
HLMDV707_15380
HLAHlac_1238
HALPDOS48_05995
HALBEKH57_00640 EKH57_15440
HEZZEO776_02790
HALQHrr1229_013155(fdhF)
HSSJ7656_05930(fdhF) J7656_13980(fdhF)
HSAIHPS36_11145(fdhF)
HAZZKI388_08835(fdhF)
SRUBC2R22_06085
HALUHUG12_20610(fdhF)
HRMK6T25_13375(fdhF)
HDFAArcSl_0465(fdoG) AArcSl_1489(fdoG2)
HTUHtur_0685
HJTDVR14_04645
HALYHYG82_00570(fdhF)
HSALJMJ58_05665(fdhF)
HXAHalxa_0835
NPENatpe_2904
NAYHYG81_16490(fdhF)
NGENatgr_0651 Natgr_2918
NOUNatoc_1422
HLCCHINAEXTREME08970
NAJB1756_07310 B1756_16645
NAGAArcMg_0491
NANAArc1_0503
NBGDV706_17960
NASGCU68_09540
TACTa0045
TVOTVG0003442(TVG0003442)
FACFACI_IFERC01G0549
FAIFAD_1471
ABIAboo_0808 Aboo_0980
ACFAciM339_1138
SHCShell_0724
IHOIgni_1101
IISEYM_07315
PFMPyrfu_0745
AHOAhos_2012
AAMBD1866_05085
VDIVdis_2449
TPETpen_0190
FFOFFONT_1292
LOKILokiarch_00320(fdhB) Lokiarch_42530
PSYTDSAG12_02784(fdhB_1) DSAG12_03719(fdhB_2)
 » show all
Reference
1  [PMID:6874636]
  Authors
Schauer NL, Ferry JG
  Title
FAD requirement for the reduction of coenzyme F420 by formate dehydrogenase from  Methanobacterium formicicum.
  Journal
J Bacteriol 155:467-72 (1983)
DOI:10.1128/JB.155.2.467-472.1983
Reference
2  [PMID:3944055]
  Authors
Schauer NL, Ferry JG
  Title
Composition of the coenzyme F420-dependent formate dehydrogenase from Methanobacterium formicicum.
  Journal
J Bacteriol 165:405-11 (1986)
DOI:10.1128/JB.165.2.405-411.1986
Reference
3  [PMID:18791018]
  Authors
Lupa B, Hendrickson EL, Leigh JA, Whitman WB
  Title
Formate-dependent H2 production by the mesophilic methanogen Methanococcus maripaludis.
  Journal
Appl Environ Microbiol 74:6584-90 (2008)
DOI:10.1128/AEM.01455-08
Other DBs
ExplorEnz - The Enzyme Database: 1.17.98.3
IUBMB Enzyme Nomenclature: 1.17.98.3
ExPASy - ENZYME nomenclature database: 1.17.98.3
BRENDA, the Enzyme Database: 1.17.98.3

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