KEGG   ENZYME: 1.17.99.11
Entry
EC 1.17.99.11               Enzyme                                 
Name
3-oxo-Delta1-steroid hydratase/dehydrogenase;
atcABC (gene names)
Class
Oxidoreductases;
Acting on CH or CH2 groups;
With unknown physiological acceptors
Sysname
3-oxo-Delta1-steroid:acceptor 1-oxidoreductase
Reaction(IUBMB)
a 3-oxo-Delta1-steroid + H2O + acceptor = a steroid 1,3-dione + reduced acceptor (overall reaction) [RN:R12678];
(1a) a 3-oxo-Delta1-steroid + H2O = a 1-hydroxy-3-oxo-steroid [RN:R12679];
(1b) a 1-hydroxy-3-oxo-steroid + acceptor = a steroid 1,3-dione + reduced acceptor [RN:R12680]
Reaction(KEGG)
R12678 R12679 R12680
Substrate
3-oxo-Delta1-steroid [CPD:C02941];
H2O [CPD:C00001];
acceptor [CPD:C00028];
1-hydroxy-3-oxo-steroid [CPD:C22327]
Product
steroid 1,3-dione [CPD:C22326];
reduced acceptor [CPD:C00030];
1-hydroxy-3-oxo-steroid [CPD:C22327]
Comment
A molybdenum enzyme. The enzyme, characterized from the bacterium Steroidobacter denitrificans, is involved in the anaetrobic degradation of steroids. It is specific to 3-oxo-Delta1-steroids such as androsta-1-ene-3,17-dione and Delta1-dihydrotestosterone and does not act on 3-oxo-Delta4-steroids.
History
EC 1.17.99.11 created 2020
Orthology
K24716  3-oxo-Delta1-steroid hydratase/dehydrogenase large subunit
K24717  3-oxo-Delta1-steroid hydratase/dehydrogenase medium subunit
K24718  3-oxo-Delta1-steroid hydratase/dehydrogenase small subunit
Genes
MNY: R50073_37470
SDF: ACG33_03370 ACG33_03375 ACG33_03390
CUPP: CTP10_R76930 CTP10_R76940
BURT: BTHE68_44980
BURM: GJG85_29430 GJG85_29435
POLY: PSHI2_13840(cutL_3)
POLN: PSHI8_13840(cutL_3)
CABK: NK8_48170
BGV: CAL12_00190
DOE: DENOEST_2087 DENOEST_2088 DENOEST_2089(cutS) DENOEST_2108 DENOEST_2110(cutS) DENOEST_2111(cutM) DENOEST_3658
DENI: B9N43_01910 B9N43_01915 B9N43_01920
AZI: AzCIB_1523 AzCIB_1524 AzCIB_1525
AZD: CDA09_10040 CDA09_10045 CDA09_10050
THAG: CKCBHOJB_02409(cutM) CKCBHOJB_02410(cutS) CKCBHOJB_02411(cutL)
RHIZ: QMO80_005747
BCOU: IC761_22640
BROS: QUH67_23240
RHOR: ONR75_23280
RHOL: RBJ75_26640
TARD: RSO67_09080
XDI: EZH22_16710
APOL: K9D25_22075 K9D25_22080
AQI: J5J86_15505
PTAW: DW352_10695 DW352_11645 DW352_11650 DW352_20480
MOG: MMB17_21635 MMB17_21640
RHZ: RHPLAN_65240
RPOP: K1718_24230 K1718_24235
RPEL: N7U68_05680
AALU: ABWI00_03065 ABWI00_03075
TRO: trd_0578
UAM: UABAM_05849
UHL: UABHE_003512
BACA: FAY30_04550
SCIA: HUG15_03265
CMIC: caldi_18810
CASP: NQ535_06900
HHJ: NQ487_25985
EMJ: V1225_12250
SGRF: SGFS_021420
SSOI: I1A49_06670
SLON: LGI35_11520
KBU: Q4V64_29380
SPOF: P8A21_36005
PHRZ: QN084_20570 QN084_20575
JTR: V3C34_03365 V3C34_03370
TED: U5C87_22505
NOCW: ABFU82_21450
NOCA: ncot_10280
NOCL: KM427_13555
SGRG: L0C25_00110 L0C25_23810
ACTQ: OG417_37235 OG417_37245
BBRG: U6N30_28295
AMYB: BKN51_25850
ANW: QP939_28645
AMYE: MJQ72_17250
PPEL: H6H00_25295
PSDS: K1T35_32415
ACTY: OG774_11415 OG774_11420
SBAE: DSM104329_04640(cdhC_2) DSM104329_05421(cutL_5)
DHI: LH044_19345
LEPV: J4558_07570
HLU: LT972_04845
HAYC: NGM10_16050
HAXY: NGM07_22765 NGM07_23620
NAY: HYG81_22920
 » show all
Reference
1  [PMID:26872041]
  Authors
Yang FC, Chen YL, Tang SL, Yu CP, Wang PH, Ismail W, Wang CH, Ding JY, Yang CY, Yang CY, Chiang YR.
  Title
Integrated multi-omics analyses reveal the biochemical mechanisms and phylogenetic relevance of anaerobic androgen biodegradation in the environment.
  Journal
ISME J 10:1967-83 (2016)
DOI:10.1038/ismej.2015.255
  Sequence
[sdf:ACG33_03390 ACG33_03375 ACG33_03370]
Other DBs
ExplorEnz - The Enzyme Database: 1.17.99.11
IUBMB Enzyme Nomenclature: 1.17.99.11
ExPASy - ENZYME nomenclature database: 1.17.99.11
BRENDA, the Enzyme Database: 1.17.99.11

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