KEGG ENZYME: 1.18.1.1

ENZYME: 1.18.1.1

Entry

EC 1.18.1.1                 Enzyme

Name

rubredoxin---NAD+ reductase;
rubredoxin reductase;
rubredoxin-nicotinamide adenine dinucleotide reductase;
dihydronicotinamide adenine dinucleotide-rubredoxin reductase;
reduced nicotinamide adenine dinucleotide-rubredoxin reductase;
NADH-rubredoxin reductase;
rubredoxin-NAD reductase;
NADH: rubredoxin oxidoreductase;
DPNH-rubredoxin reductase;
NADH-rubredoxin oxidoreductase

Class

Oxidoreductases;
Acting on iron-sulfur proteins as donors;
With NAD+ or NADP+ as acceptor

Sysname

rubredoxin:NAD+ oxidoreductase

Reaction(IUBMB)

2 reduced rubredoxin + NAD+ + H+ = 2 oxidized rubredoxin + NADH [RN:R02000]

Reaction(KEGG)

R02000

Substrate

reduced rubredoxin [CPD:C00340];
NAD+ [CPD:C00003];
H+ [CPD:C00080]

Product

oxidized rubredoxin [CPD:C00435];
NADH [CPD:C00004]

Comment

Requires FAD. The enzyme from Clostridium acetobutylicum reduces rubredoxin, ferricyanide and dichlorophenolindophenol, but not ferredoxin or flavodoxin. The reaction does not occur when NADPH is substituted for NADH. Contains iron at the redox centre.

History

EC 1.18.1.1 created 1972 as EC 1.6.7.2, transferred 1978 to EC 1.18.1.1, modified 2001

Pathway

ec00071

Fatty acid degradation

Orthology

K05297

rubredoxin---NAD+ reductase

K21738

rubredoxin---NAD+ reductase

K22567

rubredoxin---NAD+ reductase

Genes

XBA:	C7S18_09175

VAG:

N646_3145

VEX:	VEA_001294

VDB:	AL552_01515

VNA:	PN96_15080

VEJ:	VEJY3_23206

VNL:	D3H41_24160

VJP:	NP165_19640

PGH:	FH974_08085

SKS:	FCN78_06135 FCN78_12245

PAE:

PA5349

PAEV:

N297_5529(alkT)

PAEI:

N296_5529(alkT)

PAU:	PA14_70620(rubB)

PAP:	PSPA7_6126

PAG:	PLES_57441

PAF:	PAM18_5469

PNC:	NCGM2_6116(rubB)

PAEB:

NCGM1900_6194(rubB)

PDK:	PADK2_28480

PSG:	G655_28145

PRP:	M062_28170

PAEP:

PA1S_28900

PAER:

PA1R_gp3281

PAEM:

U769_29400

PAEL:

T223_29360

PAES:

SCV20265_6077

PAEU:

BN889_05937

PAEG:

AI22_05090

PAEC:

M802_5527(alkT)

PAEO:

M801_5394(alkT)

PMY:	Pmen_0430 Pmen_4402

PMK:

MDS_4734

PRE:	PCA10_34400 PCA10_55500(rubB)

PPSE:

BN5_4231(rubB)

PFUW:

KF707C_29950 KF707C_55940

PCQ:	PcP3B5_60770(alkT)

PMUI:

G4G71_03845

PNT:	G5B91_04770 G5B91_31530

PPAA:

B7D75_27720

PPU:	PP_5314(alkT) PP_5371

PPF:

Pput_5223

PPG:	PputGB1_5362

PPW:	PputW619_0159

PPT:

PPS_5163

PPB:	PPUBIRD1_5107(rubB)

PPI:

YSA_04864

PPX:	T1E_3940(rubB) T1E_3999

PPUH:

B479_26305

PPUT:

L483_31710

PPUN:

PP4_53750(rubB)

PPUD:

DW66_5733

PFV:	Psefu_0279

PMON:

X969_25520

PMOT:

X970_25155

PPJ:	RK21_04949

PMOL:

CLJ08_13370

PALD:

LU682_029160 LU682_029445

PMOS:

O165_022730

PST:	PSPTO_5473(rubB)

PSB:

Psyr_5028

PSYR:

N018_25385

PSP:	PSPPH_5110(rubB)

PSAV:

PSA3335_00955

PAMG:

BKM19_029100

PCI:	PCH70_50780

PAVL:

BKM03_29340

PVD:	CFBP1590__5340(alkT)

PCAB:

JGS08_26175

PCOF:

POR16_24730

PTRE:

I9H09_00720

PSYI:

MME58_25730

PAST:

N015_01305

PLIJ:

KQP88_24490

PFL:	PFL_6103(rubB)

PPRC:

PFLCHA0_c60620(alkT)

PPRO:

PPC_6056

PFE:	PSF113_0127(rubB)

PFN:	HZ99_17075

PFO:	Pfl01_5601(norW)

PFS:

PFLU_6033

PFC:	PflA506_5316(rubB)

PPZ:	H045_20525

PFB:

VO64_2925

PMAN:

OU5_0014 OU5_3562

PTV:	AA957_14975

PCG:	AXG94_14840

PVR:	PverR02_30860

PAZO:

AYR47_06325

POI:	BOP93_25835

PRX:	HRH33_00370

PMED:

E3Z27_27880

PKR:	AYO71_00595

PMUD:

NCTC8068_05313(alkT)

PTOL:

I7845_28450

PFW:	PF1751_v1c54440(rubB)

PFF:	PFLUOLIPICF708775

PFX:	A7318_26865

PEN:	PSEEN5459(rubB)

PLUL:

FOB45_24075

PBA:	PSEBR_a133

PBC:	CD58_29280

PPUU:

PputUW4_05349

PDR:	H681_24300

PSV:	PVLB_25165

PSK:	U771_31185

PKC:	PKB_5680(alkT)

PCH:	EY04_30105

PCZ:	PCL1606_01050

PCP:	JM49_00810

PCHP:

C4K32_6185

PFZ:	AV641_00595

PLQ:	AA042_09715

PALK:

PSAKL28_51800

PRH:	LT40_07120 LT40_07165

PPV:	NJ69_19510

PSEM:

TO66_31050

PSEC:

CCOS191_5209(alkT)

PPSY:

AOC04_20770

PSOS:

POS17_6064

PFK:	PFAS1_11625

PANR:

A7J50_5768

PSET:

THL1_5641

PSIL:

PMA3_29615

PYM:	AK972_6044

PKE:	DLD99_12320 DLD99_28440

PALL:

UYA_14270 UYA_23590

PUM:	HGP31_00235 HGP31_12865

POJ:	PtoMrB4_01360(alkT)

PGG:	FX982_01593

PPSH:

G5J76_03830

PGY:	AWU82_06970

PLAL:

FXN65_27290

PSEJ:

HNQ25_02610 HNQ25_11295

PVK:	EPZ47_29380

PEZ:	HWQ56_28230

PBZ:	GN234_17540

PKH:	JLK41_24180

PTY:	JWV26_09015 JWV26_11725

PMAO:

PMYSY11_2129 PMYSY11_4365(alkT)

PATA:

JWU58_01130

PDW:

BV82_2204

PZE:	HU754_000465

PMOE:

HV782_000465

PSEP:

C4K39_3558

PVW:	HU752_000445

PTRT:

HU722_0000355

PXA:	KSS93_02420

PSAM:

HU731_015475

PTZ:	HU718_000460

PQI:	KH389_26700

PSHH:

HU773_000385

PXN:	HU772_024485

PHV:	HU739_018255

PPRG:

HU725_022420

PANH:

HU763_024160

PASG:

KSS96_00365

PFAK:

KSS94_23085 KSS94_26660

PMUY:

KSS95_03505

PMAM:

KSS90_25035

PAZE:

KSS91_00225

PALV:

KSS97_00410

PORY:

EJA05_27650

PWZ:	J7655_00040 J7655_09485 J7655_20695

PTK:	EXN22_01055

PTW:	TUM18999_01360(alkT)

PZA:	HU749_001555

PIE:	HU724_000460

PWY:	HU734_001290

PTAE:

NCTC10697_00117(alkT_1) NCTC10697_02146(alkT_2)

PGF:	J0G10_00420

PCAV:

D3880_21885

PJU:	L1P09_24800

PHF:	NLY38_24255

PPHN:

HU825_03005

PIZ:	LAB08_R20720 LAB08_R59490

PPEG:

KUA23_29510

PSII:

NF676_27000

PSIH:

LOY51_26455

PCAS:

LOY40_28715

PFIT:

KJY40_00400

PASI:

LG197_04420

PKM:	PZ739_27330

PNB:	NK667_28020

PSOA:

PSm6_21530

PTAI:

ICN73_06850

PKK:	QQ992_27585

PKJ:	Q1W70_10815

PHYG:

JTY93_26840

PHOM:

KJF94_26055

PSA:	PST_0438(rubB)

PSZ:	PSTAB_0469(rubB)

PSR:	PSTAA_0491(rubB)

PSC:	A458_19190

PSJ:	PSJM300_17460

PSH:	Psest_3834

PSTT:

CH92_01830

PSTU:

UIB01_19410

PSED:

DM292_16510

PCHL:

LLJ08_18425

PBM:	CL52_02025

PKG:	LW136_20055

SDEG:

GOM96_08385

PZD:	KQ248_01995

PBB:	AKN87_09625

HPEG:

EAO82_00380 EAO82_02465

HAES:

LO767_16015

PDEN:

F1C79_23470

HARR:

HV822_09140

PNN:	KEM63_16445

PPHA:

BVH74_05160

MAQ:	Maqu_0442 Maqu_3591

MHC:	MARHY2849(alkT) MARHY3494(rubB)

MAD:

HP15_3349

MBS:	MRBBS_3587(alkT)

MSR:	AU15_01845 AU15_22050

MSX:	AU14_08110

MPQ:	ABA45_16830

MARI:

ACP86_07285 ACP86_20395

MLQ:	ASQ50_08875 ASQ50_10975 ASQ50_12490

MSQ:	BKP64_16950

MARA:

D0851_01590 D0851_10745

MARJ:

MARI_17880(alkT_1) MARI_30590(alkT_2)

MALL:

PBN92_01975 PBN92_18175

MSHE:

MAALD49_20300 MAALD49_35730 MAALD49_40670(norW)

MANP:

EHN06_18440 EHN06_20790

KAK:	Kalk_12615

PAR:

Psyc_0307

PCR:	Pcryo_0338

PRW:	PsycPRwf_2061

PSO:	PSYCG_01945

PUR:	AOC03_08170

PALI:

A3K91_0387 A3K91_2007

PSPG:

AK823_01985

PSYG:

AK825_01940

PSYC:

DABAL43B_0397(rubB)

PSYA:

AOT82_1414

PSYY:

DLE54_09830

PSYP:

E5677_03375 E5677_11510

PKY:	PKHYL_05480

PCIA:

Q6344_02005

ACB:

A1S_0994

ABM:	ABSDF2404(rubB)

ABY:	ABAYE1067 ABAYE2799(rubB)

ABC:	ACICU_00955 ACICU_02608

ABN:	AB57_1073 AB57_2839

ABB:	ABBFA_02593(rubB)

ABX:	ABK1_0980 ABK1_2728

ABZ:	ABZJ_01098 ABZJ_02802

ABR:	ABTJ_01105 ABTJ_02817

ABD:	ABTW07_1084 ABTW07_2856

ABH:	M3Q_1292 M3Q_2875

ABAD:

ABD1_09470(rubB)

ABJ:	BJAB07104_01092 BJAB07104_02766

ABAB:

BJAB0715_01106

ABAJ:

BJAB0868_01106 BJAB0868_02648

ABAZ:

P795_12740

ABK:	LX00_05015

ABAU:

IX87_00560

ABAA:

IX88_06985

ABW:	BL01_04850 BL01_11680

ABAL:

ABLAC_17630

ACC:	BDGL_000275(rubB)

ANO:	RR32_13185

ALC:	OTEC02_13900

ACAL:

BUM88_04805

ASEI:

I8T81_14050

ACD:	AOLE_14370

ACI:	ACIAD1065(rubB)

ATT:	AMQ28_03830

AEI:	AOY20_14255

AJO:	RZ95_11825

ACW:	A0J50_12465

ACV:	AMD27_04170

AHL:	AHTJS_05070

AJN:	BVL33_07215

ASOL:

BEN76_08380

ALA:	BFG52_04590

ASJ:	AsACE_CH00799(rubB)

AID:	CTZ23_04340

ADV:	DJ533_13635

ARJ:	DOM24_10215

AWU:	BEN71_13890

ACUM:

C9E88_008150

AGU:	AS4_32640(rubB)

AUG:

URS_2062

ALW:	FOB21_14340

ADS:	FPL17_01335

ABER:

BSR55_15775

ATN:	FM020_04025 FM020_10750

ACHI:

CDG60_13200

ALJ:	G8D99_11510

AWG:	GFH30_03760

ASHA:

G8E00_04535

ATG:	J4G44_06275

AVB:	RYU24_22120(rubB)

ABOU:

ACBO_23310(rubB)

AGYL:

FPL18_12830 FPL18_15235

ACIU:

A3K93_03400

AVZ:	HWI77_11430

APOT:

MZO21_03975

ATZ:	M5E07_04735(rubB)

ACOI:

NQU59_09440(rubB)

AVIV:

LF296_04970 LF296_13025(rubB)

MCT:

MCR_0041

MCS:

DR90_38

MCAT:

MC25239_00086(norW)

MOI:	MOVS_09940

MOS:	AXE82_01245

MBL:	AAX09_09510

MBOI:

DQF64_13375

MCUN:

NCTC10297_00560(norW)

MNN:	I6G26_02565

MNS:	LU293_05425

MNC:	LU297_05325

MNJ:	LU290_00590

MBAH:

HYN46_07845

SDN:

Sden_3466

SINV:

K8B83_21315

SACH:

K0H61_17355

THT:	E2K93_08950

PART:

PARC_a1586

HMI:	soil367_16035

ALKM:

NKI27_00235 NKI27_16700

ASEM:

NNL22_13175 NNL22_18310

CELL:

CBR65_18765

SAGA:

M5M_15220

ZAL:	AZF00_18220

OSG:	BST96_07165

MTHD:

A3224_04565

MICC:

AUP74_00095(rubB_1) AUP74_02936(rubB_2)

MAGA:

Mag101_09900 Mag101_11295 Mag101_12995

MII:	BTJ40_17590

MICT:

FIU95_16400(rubB)

MHYD:

GTQ55_10320 GTQ55_12815

MCEL:

LPW13_10270

MICZ:

GL2_22400

MVB:	MJO52_16715

MPAF:

R5R33_01810 R5R33_14665

HJA:	BST95_03215

HALC:

EY643_19265

KIM:	G3T16_09300

AFUS:

EYZ66_14005

CBU:

CBU_0276

CBS:	COXBURSA331_A0379

CBD:

CBUD_1816

CBG:

CbuG_1731

CBC:

CbuK_0471

CEY:	CleRT_13210

TCX:

Tcr_0037

HTR:	EPV75_00365 EPV75_09705

TAO:	THIAE_07020

THIO:

AYJ59_00365

TMH:	JX580_05455

TXA:	HQN79_11560

TLH:	NR989_00890

TSE:	THMIRHAS_04100(rubB)

TZO:	THMIRHAT_15060(norW)

TIG:

THII_3133

TSB:	HMY34_01370

TANI:

J8380_15820

AEH:

Mlg_0757

HHC:	M911_00990

EBS:	ECTOBSL9_1078

TGR:

Tgr7_0681

TKM:

TK90_0972

TVR:

TVD_08070

SPIU:

SPICUR_05485

SROS:

BBH56_03120

SPIZ:

GJ672_05460

NAX:	HC341_07615 HC341_16180

HNA:	Hneap_2210

HAZ:	A9404_11330

GHL:	GM160_04545

HCH:

HCH_00777

HAHE:

ENC22_03160

HAHH:

O5O45_22240

CSA:

Csal_3250

HEL:	HELO_4414(rubB)

HCS:	FF32_05815

HAK:	KO116_00116

HAM:

HALO0041

HHU:	AR456_20455

HCO:	LOKO_02284(alkT)

HSI:	BOX17_06760 BOX17_07650

HALO:

BWR19_18640

HHH:	CLM76_06090

HBE:	BEI_1545 BEI_3745

HAG:	BB497_04250

HAF:	C8233_11455

HALK:

CUU95_06275

HVN:	EI420_19945

HOL:	HORIV_72020(rubB)

HSR:	HSBAA_65910(alkT)

HMD:	CTT34_17815

HAXI:

HAALTHF_10940n

HTT:	HZS52_04950

HCAM:

I4484_20475

HPIZ:

GYM47_17425

HSX:	HNO51_20560

HSV:	HNO53_21145

HTX:	EKK97_23065

HPRO:

LMS44_23495

HQD:	K1Y77_16655

HBH:	E4T21_20715

HBP:	HPTD01_1226

HALF:

QEN58_18970

HHAO:

QWG60_16450

HASO:

B2G49_18585

HALW:

B6N23_10125

CMAI:

BFX80_00155

CAMH:

LCW13_17085

COBE:

CLAM6_34370(rubB)

PAUR:

FGL86_04005

SAJS:

QO259_18280

ABO:	ABO_0162(rubB)

ALN:	AS19_01670

ADI:	B5T_02839 B5T_04348(rubB)

AXE:

P40_21175

APAC:

S7S_17715

TOL:

TOL_0163

TOR:	R615_00815

TWAN:

HUF19_17630

OAI:	OLEAN_C38720(rubB)

MARS:

A8C75_00675

MGEO:

CFI10_04725

MRZ:	KDW95_15455

BSAN:

CHH28_04755

BMAR:

HF888_00555

VCW:	GJQ55_00595

BACZ:

KFF03_15760

GSN:	YC6258_00905

RFO:	REIFOR_00121

OME:	OLMES_3725 OLMES_4764

OCE:

GU3_07995

OPE:	PU634_04610

ZDF:	AN401_10800

SOK:	D0B54_23360

SALN:

SALB1_1968

SEDS:

AAY24_18110

PTES:

JQU52_04805

IOD:	EJO50_07550

IFL:	C1H71_18115

JEU:	BJP62_03405

JES:	JHS3_13970(rubB)

DTK:	K4H28_08660

CHIZ:

HQ393_07450

CFON:

HZU75_13670

CHIC:

N8I74_13165

CARI:

FNU76_22145

CKS:	H9L41_13160

LHK:

LHK_03088

AQL:	BXU06_11265

CBW:	RR42_m0808

BUR:	Bcep18194_B0789

BCON:

NL30_16215

BSTL:

BBJ41_24250

BARI:

NLX30_26700

BUM:	AXG89_24015 AXG89_28675

PCAF:

DSC91_006346

PBRY:

NDK50_05015

PKF:	RW095_04520

PNU:

Pnuc_1378

PDQ:	CL55_00012780

PTRP:

DCO17_07235

PANI:

DCO16_07150

PCOS:

C2747_06545

PYT:	PKF023_06440

PTX:	ABW99_20085

PAND:

DRB87_07250

PLG:	NCTC10937_05175(alkT)

CABA:

SBC2_52550(norW)

CABK:

NK8_77980

LIMN:

HKT17_05715

AMIM:

MIM_c34090

RFR:

Rfer_0092

RSB:	RS694_19990

RHF:	EUB48_00230

RHG:	EXZ61_16925

POL:	Bpro_4853 Bpro_4857

ACK:	C380_02900

VPD:	VAPA_1c22320

HYR:	BSY239_3842

HYB:

Q5W_21975

HTN:	KI616_01040

HCZ:	G9Q37_17830

MPT:

Mpe_A3669

METP:

C1M51_08230

HAR:

HEAR0644

MMS:	mma_0610(rubB)

JAG:	GJA_3183(alkT) GJA_559(rubB)

JAB:	VN23_07460

CFU:	CFU_0845(rubB)

CARE:

LT85_0937

CPRA:

CPter91_0986(alkT)

MUM:	FCL38_01385

TMJ:	P0M04_30610

UPV:	EJN92_15700

UPI:	EJG51_017975

UND:	UNDKW_1903(rubB)

NOK:	FAY22_12385

GLC:	JQN73_12535

RGU:	A4W93_27285

AON:	DEH84_13885

NEU:

NE1420

NET:

Neut_1534

NIT:	NAL212_0762

NII:	Nit79A3_0576

NCO:	AAW31_15800

NUR:	ATY38_02115

NST:	Nstercoris_01532

NMU:	Nmul_A0171

NLC:	EBAPG3_001890

NIZ:	NNRS527_00136

DOE:	DENOEST_0186(rubB)

TBD:

Tbd_2315

MFA:

Mfla_2173

GCA:

Galf_2385

FAM:	OYT1_ch0139

SEME:

MIZ01_0210

SDR:	SCD_n02163

SULF:

CAP31_00410

SPLB:

SFPGR_33950(alkT)

SNIV:

SFSGTM_00780

SLAC:

SKTS_14210(rubB)

AIQ:	Azoinq_07040

EBA:	ebA2965(norW) ebA6036

ABRE:

pbN1_18290 pbN1_36310(rubB)

APET:

ToN1_01030(rubB) ToN1_24900

AOA:

dqs_2624

AZA:	AZKH_0051(norW) AZKH_2404(rubB)

AZI:	AzCIB_2199

AZD:	CDA09_00240 CDA09_07180

ACOM:

CEW83_06500 CEW83_14970

ATW:	C0099_01440

BPRC:

D521_1162

MEA:	Mex_1p0921

MDI:

METDI1722

MEX:

Mext_1149

MCH:

Mchl_1308

MPO:

Mpop_4666

MZA:	B2G69_13015

MOR:

MOC_5231

META:

Y590_04930

MPHY:

MCBMB27_04073

METX:

A3862_08585

HMC:	HYPMC_3983

SPSE:

SULPSESMR1_04189(alkT)

MON:	G8E03_03690

NRE:	BES08_26535

SPKC:

KC8_06485

SECH:

B18_09050

SBIN:

SBA_ch2_0580

SYB:	TZ53_18270

SBD:	ATN00_17680

SPHT:

K426_24049

SHYD:

CJD35_15685

SUFL:

FIL70_06640

SPHY:

CHN51_00400

BLAS:

BSY18_2508

CMAN:

A9D14_14625

KOI:	LV478_14640

ASZ:

ASN_3251

ATO:	CIW82_15195

MAG:

amb3427

MAGX:

XM1_4310(rubB)

MAGN:

WV31_00580

MAGQ:

MGMAQ_0418(rubB)

VSU:	P3M64_01580

MGM:

Mmc1_3270

ECOG:

FIV45_05045 FIV45_16800

PARH:

I5S86_01510

CAC:

CA_C2448

CAE:

SMB_G2483

CAY:

CEA_G2462

CRW:	CROST_030910(nroR)

CFB:	CLFE_030830(nroR)

CAUN:

CLAUR_045420(nroR)

EEL:	EUBELI_20024

» show all

Reference

1 [PMID:4294330]

Authors

Peterson JA, Kusunose M, Kusunose E, Coon MJ.

Title

Enzymatic omega-oxidation. II. Function of rubredoxin as the electron carrier in omega-hydroxylation.

Journal

J Biol Chem 242:4334-40 (1967)

Reference

2 [PMID:4335861]

Authors

Enzymatic -oxidation. VI. Isolation of homogeneous reduced diphosphopyridine nucleotide-rubredoxin reductase.

Title

J Biol Chem 247:2109-16 (1972)

Reference

3 [PMID:4403503]

Authors

Ueda T, Coon MJ.

Title

Enzymatic oxidation. VII. Reduced diphosphopyridine nucleotide-rubredoxin reductase: properties and function as an electron carrier in hydroxylation.

Journal

J Biol Chem 247:5010-6 (1972)

Reference

4 [PMID:526302]

Authors

Petitdemange H, Marczak R, Blusson H, Gay R.

Title

Isolation and properties of reduced nicotinamide adenine dinucleotiderubredoxin oxidoreductase of Clostridium acetobutylicum.

Journal

Biochem Biophys Res Commun 91:1258-65 (1979)
DOI:10.1016/0006-291X(79)91202-6

Other DBs

ExplorEnz - The Enzyme Database:

1.18.1.1

IUBMB Enzyme Nomenclature:

1.18.1.1

ExPASy - ENZYME nomenclature database:

1.18.1.1

BRENDA, the Enzyme Database:

1.18.1.1

CAS:

9032-27-3

DBGET integrated database retrieval system