| Entry |
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| Name |
ferredoxin---NADP+ reductase;
ferredoxin-nicotinamide adenine dinucleotide phosphate reductase;
ferredoxin-NADP+ reductase;
TPNH-ferredoxin reductase;
ferredoxin-NADP+ oxidoreductase;
NADP+:ferredoxin oxidoreductase;
ferredoxin-TPN reductase;
ferredoxin-NADP+-oxidoreductase;
NADPH:ferredoxin oxidoreductase;
ferredoxin-nicotinamide-adenine dinucleotide phosphate (oxidized) reductase
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| Class |
Oxidoreductases;
Acting on iron-sulfur proteins as donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
ferredoxin:NADP+ oxidoreductase
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| Reaction(IUBMB) |
2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH [RN: R01195]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
A flavoprotein (FAD). In chloroplasts and cyanobacteria the enzyme acts on plant-type [2Fe-2S] ferredoxins, but in other bacteria it can also reduce bacterial [4Fe-4S] ferredoxins and flavodoxin.
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| History |
EC 1.18.1.2 created 1965 as EC 1.6.99.4, transferred 1972 as EC 1.6.7.1, transferred 1978 to EC 1.18.1.2, part transferred 2012 to EC 1.18.1.6, modified 2012
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| Pathway |
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| Orthology |
| K00528 | ferredoxin/flavodoxin---NADP+ reductase |
| K02641 | ferredoxin--NADP+ reductase |
| K21567 | ferredoxin/flavodoxin---NADP+ reductase |
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| Genes |
» show all
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| Reference |
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| Authors |
SHIN M, TAGAWA K, ARNON DI |
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| Title |
CRYSTALLIZATION OF FERREDOXIN-TPN REDUCTASE AND ITS ROLE IN THE PHOTOSYNTHETIC APPARATUS OF CHLOROPLASTS. |
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| Journal |
Biochem Z 338:84-96 (1963) |
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| Reference |
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| Authors |
Knaff DB, Hirasawa M |
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| Title |
Ferredoxin-dependent chloroplast enzymes. |
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| Journal |
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| Reference |
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| Authors |
Karplus PA, Daniels MJ, Herriott JR |
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| Title |
Atomic structure of ferredoxin-NADP+ reductase: prototype for a structurally novel flavoenzyme family. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Morales R, Charon MH, Kachalova G, Serre L, Medina M, Gomez-Moreno C, Frey M |
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| Title |
A redox-dependent interaction between two electron-transfer partners involved in photosynthesis. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.18.1.2 |
| ExPASy - ENZYME nomenclature database: | 1.18.1.2 |
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