KEGG   ENZYME: 1.18.1.3
Entry
EC 1.18.1.3                 Enzyme                                 

Name
ferredoxin---NAD+ reductase;
ferredoxin-nicotinamide adenine dinucleotide reductase;
ferredoxin reductase (ambiguous);
NAD+-ferredoxin reductase;
NADH-ferredoxin oxidoreductase;
reductase, reduced nicotinamide adenine dinucleotide-ferredoxin;
ferredoxin-NAD+ reductase;
NADH-ferredoxin reductase;
NADH2-ferredoxin oxidoreductase;
NADH flavodoxin oxidoreductase;
NADH-ferredoxin NAP reductase (component of naphthalene dioxygenase multicomponent enzyme system);
ferredoxin-linked NAD+ reductase;
NADH-ferredoxin TOL reductase (component of toluene dioxygenase);
ferredoxin---NAD reductase
Class
Oxidoreductases;
Acting on iron-sulfur proteins as donors;
With NAD+ or NADP+ as acceptor
Sysname
ferredoxin:NAD+ oxidoreductase
Reaction(IUBMB)
(1) 2 reduced [2Fe-2S] ferredoxin + NAD+ + H+ = 2 oxidized [2Fe-2S] ferredoxin + NADH [RN:R05875];
(2) reduced 2[4Fe-4S] ferredoxin + NAD+ + H+ = oxidized 2[4Fe-4S] ferredoxin + NADH
Reaction(KEGG)
R05875;
(other) R02000
Substrate
reduced [2Fe-2S] ferredoxin [CPD:C22150];
NAD+ [CPD:C00003];
H+ [CPD:C00080];
reduced 2[4Fe-4S] ferredoxin
Product
oxidized [2Fe-2S] ferredoxin [CPD:C22151];
NADH [CPD:C00004];
oxidized 2[4Fe-4S] ferredoxin
Comment
Contains FAD. Reaction (1) is written for a [2Fe-2S] ferredoxin, which is characteristic of some mono- and dioxygenase systems. The alternative reaction (2) is written for a 2[4Fe-4S] ferredoxin, which transfers two electrons, and occurs in metabolism of anaerobic bacteria.
History
EC 1.18.1.3 created 1976 as EC 1.6.7.3, transferred 1978 to EC 1.18.1.3, modified 2011
Pathway
ec00071  Fatty acid degradation
Orthology
K00529  3-phenylpropionate/trans-cinnamate dioxygenase ferredoxin reductase component
K15758  toluene methyl-monooxygenase electron transfer component
K15765  toluene monooxygenase electron transfer component
K18088  biphenyl 2,3-dioxygenase ferredoxin reductase component
K18090  benzene/toluene/chlorobenzene dioxygenase ferredoxin reductase component
K18227  p-cumate 2,3-dioxygenase ferredoxin reductase component
K18254  phthalate 3,4-dioxygenase ferredoxin reductase component
K18293  p-cymene methyl-monooxygenase electron transfer component
K20809  2-halobenzoate 1,2-dioxygenase electron transfer component
K22362  alkene monooxygenase ferredoxin reductase component
Genes
MJV: 108388875
OTW: 112242842
PXY: 105397018
ECO: b2542(hcaD)
ECJ: JW2526(hcaD)
ECD: ECDH10B_2709(hcaD)
EBW: BWG_2306(hcaD)
ECOK: ECMDS42_2086(hcaD)
ECE: Z3814(hcaD)
ECS: ECs3408
ECF: ECH74115_3774(hcaD)
ETW: ECSP_3486(hcaD)
EOI: ECO111_3266(hcaD)
EOJ: ECO26_3589(hcaD)
EOH: ECO103_3062(hcaD)
ESL: O3K_06705
ESO: O3O_18945
ESM: O3M_06750
ECK: EC55989_2828(hcaD)
EOK: G2583_3072(hcaD)
ELH: ETEC_2699
ECW: EcE24377A_2827(hcaD)
ECX: EcHS_A2694(hcaD)
ECM: EcSMS35_2695(hcaD)
ECY: ECSE_2829
EUM: ECUMN_2862(hcaD)
ECT: ECIAI39_2743(hcaD)
EOC: CE10_2974(hcaD)
EBR: ECB_02434(hcaD)
EBL: ECD_02434(hcaD)
EBE: B21_02398(hcaD)
EBD: ECBD_1142
ELO: EC042_2746(hcaD)
EKF: KO11_10110(hcaD)
EDJ: ECDH1ME8569_2469(hcaD)
ELW: ECW_m2768(hcaD)
ELL: WFL_13555(hcaD)
ELP: P12B_c2642(hcaD)
SFV: SFV_2590(hcaD)
SFE: SFxv_2845(hcaD)
SFN: SFy_3676
SFS: SFyv_3753
SFT: NCTC1_02846(hcaD_2)
SSN: SSON_2624(hcaD)
ENC: ECL_04260
ECLO: ENC_31820
ECLX: LI66_18670
ECLY: LI62_20130
ECLZ: LI64_17560
EEC: EcWSU1_03730(thcD)
KPN: KPN_03366
KPR: KPR_4631
KPJ: N559_0870
KPNU: LI86_04260
EAE: EAE_03025
EAR: CCG33376
RTG: NCTC13098_01028(andAa)
REE: electrica_01229(hcaD)
YRO: CH64_1873
SMAR: SM39_3555
SMW: SMWW4_v1c40720(hcaD)
SPE: Spro_3963
SRL: SOD_c39190(thcD)
SPLY: Q5A_021000(thcD)
SMAF: D781_3684
SERF: L085_08140
SFJ: SAMEA4384070_4078(thcD_3)
SOF: NCTC11214_02663(hcaD)
MINT: C7M51_02647(andAa)
MTHI: C7M52_00210(andAa)
PLU: plu2209
PAY: PAU_02352(hcaD)
PSI: S70_19015
PSX: DR96_2720
PRG: RB151_039990(andAa)
LRI: NCTC12151_03199(hcaD)
XCV: XCV2179
XAX: XACM_2265
PPSE: BN5_3604
PCQ: PcP3B5_42510(thcD_2)
PPX: T1E_4244(xylA) T1E_4247(camA) T1E_4269(tobA)
PFS: PFLU_2392
PFE: PSF113_3383(ethA)
PFB: VO64_5562
ACB: A1S_0951
ABY: ABAYE2843
ABN: AB57_1026
ABB: ABBFA_02637(thcD)
ABX: ABK1_0936
ABH: M3Q_1249
ABAD: ABD1_09030
ABAZ: P795_12955
ABAU: IX87_00780
ABAA: IX88_06760
ACC: BDGL_000228(thcD)
ASJ: AsACE_CH00363(hcaD)
AUG: URS_1863
PAT: Patl_2303
PPHE: PP2015_459
PTN: PTRA_a0478(hcaD)
PART: PARC_a2206(hcaD)
PAGA: PAGA_a1709(hcaD)
MAQ: Maqu_0601
MHC: MARHY2840(ahpH)
MAD: HP15_27
MBS: MRBBS_1308(tmoF)
MARJ: MARI_17960(camA)
GPS: C427_3050
MCA: MCA2776
MMAI: sS8_0833
FTL: FTL_0635
FTS: F92_03475
FTC: DA46_45
FTV: CH67_951
FTZ: CH68_685
CYQ: Q91_2220
GAI: IMCC3135_09320(thcD_1) IMCC3135_19405(thcD_2) IMCC3135_21415(thcD_3)
CSA: Csal_0136
HBE: BEI_0073(hcaD)
ABO: ABO_0203
ADI: B5T_02077
AXE: P40_09940
SVA: SVA_3652
SALN: SALB1_2724
TBN: TBH_C0920
RSL: RPSI07_2133(hcaD)
RSN: RSPO_c02130(nirB)
RPI: Rpic_4637
REH: H16_A1630(h16_A1630) H16_B0802(h16_B0802)
RME: Rmet_1311
BMA: BMAA1326
BMAL: DM55_4196
BMAE: DM78_3327
BMAQ: DM76_4896
BMAI: DM57_10420
BMAF: DM51_4979
BMAZ: BM44_4160
BMAB: BM45_3282
BPS: BPSS0906
BPM: BURPS1710b_A2504(mopA)
BPSE: BDL_4194
BPSM: BBQ_5231
BPSU: BBN_4365
BPSD: BBX_6034
BPK: BBK_3532
BPSH: DR55_4430
BPSA: BBU_5125
BPSO: X996_4142
BTQ: BTQ_4778
BTJ: BTJ_3410
BTZ: BTL_4258
BTD: BTI_5725
BTV: BTHA_3699
BTHE: BTN_3433
BTHM: BTRA_4184
BTHA: DR62_3506
BTHL: BG87_4234
BOK: DM82_5079
BOC: BG90_5516
BCEW: DM40_4670
BMJ: BMULJ_02643(hcaD)
BUB: BW23_5495
BLAT: WK25_25785
BTEI: WS51_06745
BSEM: WJ12_29335
BPSL: WS57_04795
BSTG: WT74_28375
BGU: KS03_4077
BUL: BW21_5412
BFN: OI25_3033(thcD) OI25_3902(thcD) OI25_5519
PPNM: LV28_03030
PPUL: RO07_21920
PAPI: SG18_20970
CABA: SBC2_40130(andAa_1) SBC2_53620(andAa_2) SBC2_81290(cmtAa)
BPAR: BN117_1343
BPT: Bpet3741
BHO: D560_1526 D560_1678(thcD)
BHM: D558_1517 D558_1666(thcD)
BHZ: ACR54_01067(camA) ACR54_01699(andAa) ACR54_04420(thcD)
AXX: ERS451415_02891(thcD_2)
AMIM: MIM_c31590
AFQ: AFA_13935 AFA_15115(picB2)
RFR: Rfer_0300
PNA: Pnap_4148
ACK: C380_15960(bphA4)
VEI: Veis_4603
DAC: Daci_2353
LIM: L103DPR2_00189(carAd)
HYR: BSY239_2683(thcD)
HPSE: HPF_01780(tmoF)
CBAA: SRAA_1072
CBAB: SMCB_0826
MPT: Mpe_A0819(tbuC) Mpe_A0921(msmD) Mpe_B0597
CFU: CFU_0345(mocF)
LCH: Lcho_3288
SLT: Slit_2276
NIM: W01_11750
DAR: Daro_3815
AZO: azo2529(camA)
AOA: dqs_2686
ADE: Adeh_0941
AMIH: CO731_00487(thcD_1) CO731_02242(andAa)
PLA: Plav_0127
RBS: RHODOSMS8_03330(camA)
ATU: Atu1013
ARA: Arad_1563 Arad_9582(mocFe)
RET: RHE_CH01347 RHE_CH02643(mocFch) RHE_PE00444(mocFe)
RIR: BN877_I1000(thcD)
RHL: LPU83_1320 LPU83_2621(mocF1) LPU83_3868(mocF3)
RHT: NT26_0971(thcD)
BME: BMEII0557
BMEL: DK63_2689(thcD)
BMEE: DK62_2713(thcD)
BMF: BAB2_0511
BABO: DK55_2491(thcD)
BABR: DO74_2906(thcD)
BABT: DK49_2748(thcD)
BABB: DK48_2200(thcD)
BABU: DK53_2494(thcD)
BABS: DK51_3078(thcD)
BABC: DO78_2564(thcD)
BMS: BRA0729
BSZ: DK67_2693(thcD)
BOV: BOV_A0683
BCS: BCAN_B0736(thcD)
BCAR: DK60_2428(thcD)
BCAS: DA85_13955
BMR: BMI_II722
BPP: BPI_II782
BPV: DK65_2909(thcD)
OAN: Oant_3868
OAH: DR92_4393(thcD)
OCH: CES85_4051(thcD) CES85_5687(fdr)
BRA: BRADO2491
BRS: S23_51680
BRAD: BF49_1851
RPA: RPA3782
RPB: RPB_3656
RPC: RPC_1647
RPD: RPD_1802
RPE: RPE_1676
RPT: Rpal_4303
NWI: Nwi_2287
OCA: OCAR_6789
BOS: BSY19_593
VGO: GJW-30_1_00441(thcD)
SNO: Snov_0477
MDI: METDI1124
MEX: Mext_0977
MCH: Mchl_0941
MPO: Mpop_0917
MET: M446_2274
META: Y590_03895
MAQU: Maq22A_c07385(hcaD)
MTUN: MTUNDRAET4_0896(camA)
BVR: BVIR_2618
BLAG: BLTE_22930
PLEO: OHA_2_00071(hcaD2)
MMED: Mame_03831(thcD)
HDI: HDIA_0861(thcD) HDIA_4247(carAd)
RBM: TEF_10365
CCR: CC_3525
PZU: PHZ_c0214
SIL: SPO3737
RUT: FIU92_15365(fdr)
RSP: RSP_0900
RCP: RCAP_rcc03412(thcD)
JAN: Jann_0440
RDE: RD1_0947
DSH: Dshi_0114
KVL: KVU_0054
KVU: EIO_0493
KRO: BVG79_00317(hcaD)
PSF: PSE_0031
PGA: PGA1_c29270(thcD)
PGL: PGA2_c27200(thcD)
PGD: Gal_00503
PHP: PhaeoP97_00578(thcD)
PPIC: PhaeoP14_02699(thcD)
OTM: OSB_01410(fdr)
LAQU: R2C4_15210
PTP: RCA23_c03430(thcD)
RSU: NHU_03901
RHC: RGUI_2695
LABT: FIU93_08995(thcD)
RMM: ROSMUCSMR3_02975(thcD)
RID: RIdsm_04573(fdr)
ROH: FIU89_01605(fdr)
MARU: FIU81_00045(thcD)
ROT: FIV09_15880(fdr)
HNE: HNE_1888
GAK: X907_2626
SAL: Sala_1971
SMAZ: LH19_16785
SGI: SGRAN_1201(camA) SGRAN_1587(fdr) SGRAN_2775(camA2) SGRAN_2803(thnA4) SGRAN_3240(camA3)
SPHU: SPPYR_0680(fdr) SPPYR_0815(fdr) SPPYR_1398(fdr)
SPHM: G432_00945
STAX: MC45_14140
SSAN: NX02_11185
SPKC: KC8_02110
SSY: SLG_18830
SPMI: K663_06390
SPHB: EP837_00486(hcaD)
SINB: SIDU_01545
SFLA: SPHFLASMR4Y_00997(fdr)
BLAS: BSY18_317
SMIC: SmB9_27880
ELI: ELI_12420
ERF: FIU90_02990(fdr)
AAY: WYH_02138(fdr)
ANH: A6F65_00548(fdr)
ADO: A6F68_00373(fdr)
ALB: AEB_P0367
KEU: S101446_03116(hcaD)
ASZ: ASN_576
SHUM: STHU_47130
TMO: TMO_a0555(thcD) TMO_b0125(thcD) TMO_c0277(thcD)
MAGQ: MGMAQ_2659
AFR: AFE_0859
ACU: Atc_1941
LGZ: NCTC10812_00971(andAa)
PPOL: X809_40900
BTS: Btus_2064
CRN: CAR_c20790(camA)
CARC: NY10_1481
TMR: Tmar_1434
SAY: TPY_1591(hcaD)
LPIL: LIP_1091
MTU: Rv1869c
MTC: MT1918
MTUH: I917_04905
MBB: BCG_1905c
MLP: MLM_2286
MUL: MUL_0769
MPHL: MPHLCCUG_01328(thcD)
MTHN: 4412656_00897(thcD)
MHAS: MHAS_00215(fdr)
MABB: MASS_3850
MSAL: DSM43276_03632(fdr)
MTER: 4434518_00685(thcD_1) 4434518_01908(andAa) 4434518_03871(camA) 4434518_03948(thcD_2)
CGL: NCgl2615(Cgl2709)
CEF: CE0557
CDR: CDHC03_1954(hcaD)
CTER: A606_11495
CMV: CMUST_15090(hcaD)
CAMG: CAMM_10640
RFA: A3L23_01169(thcD_1) A3L23_01317(bedA) A3L23_03552(thcD_2) A3L23_05141(camA)
RHS: A3Q41_00445(camA) A3Q41_02050(bedA) A3Q41_02200(thcD_1) A3Q41_04674(thcD_2)
RHU: A3Q40_00741(andAa) A3Q40_03722(bedA)
RRT: 4535765_00396(thcD_1) 4535765_01806(andAa) 4535765_03586(thcD_2)
GRU: GCWB2_12280(camA1) GCWB2_19215(fdr) GCWB2_21195(camA2) GCWB2_21445(camA3) GCWB2_23000(thcD4)
GOM: D7316_03163(andAa) D7316_03239(thcD_2) D7316_03417(thcD_3) D7316_05153(thcD_4)
SCO: SCO2106(SC2C1A.02c) SCO2469(SC7A8.08c)
SMA: SAVERM_5675(fprD) SAVERM_6097(fprE)
SCT: SCAT_1228(fprE) SCAT_1535
SRW: TUE45_02637(thcD_2) TUE45_03065(camA)
SLE: sle_47430(sle_47430) sle_50330(sle_50330)
SRN: A4G23_01296(thcD) A4G23_01569(andAa)
SLX: SLAV_25040(thcD2) SLAV_26690(thcD3)
SGE: DWG14_00347(thcD_1) DWG14_00652(thcD_2) DWG14_00852(bedA_1) DWG14_05723(camA) DWG14_06224(thcD_3)
KSK: KSE_18230
MTS: MTES_1347
MOO: BWL13_00818(camA)
AUW: AURUGA1_00408(thcD_1) AURUGA1_01407(thcD_2)
ACH: Achl_1302
JDE: Jden_0679
LMOI: VV02_12055
IDO: I598_2943(thcD)
CFL: Cfla_2531
DCO: SAMEA4475696_0460(bedA)
ACIJ: JS278_00284(andAa) JS278_00518(camA)
MPH: MLP_03520
NDK: I601_1173(thcD) I601_1935(camA_1) I601_3166(camA_2)
STRR: EKD16_09280(thcD1)
TCU: Tcur_3032
FAL: FRAAL3171
ACE: Acel_0803
SEN: SACE_2839(fprC) SACE_3145(fprC) SACE_3433 SACE_4041(fprD) SACE_4511(fprC) SACE_5609(padAd2)
SACC: EYD13_07995(thcD1)
AOI: AORI_0410(hcaD) AORI_3258(hcaD) AORI_6047 AORI_6806(hcaD)
AJA: AJAP_09195 AJAP_22905(andAa) AJAP_37605(thcD)
AMYY: YIM_10650(thcD1) YIM_22020(thcD3) YIM_25620(bedA) YIM_36765(thcD6)
PSEA: WY02_20120
PSEE: FRP1_20320
PAUT: Pdca_14150(hcaD) Pdca_38410
AMI: Amir_2893
ALO: CRK55028
AFS: AFR_27755
SNA: Snas_2828
RXY: Rxyl_2822
AFO: Afer_0564
STI: Sthe_3232
TTR: Tter_1295
OTE: Oter_2142
MKC: kam1_1275
SUS: Acid_3685
FLM: MY04_2083
GFL: GRFL_1778
ZPR: ZPR_4195
CBAL: M667_11695
CBAT: M666_11740
NDO: DDD_1840
HHB: Hhub_3040
HALH: HTSR_0303
HHSR: HSR6_0289
HMA: rrnAC0717
HUT: Huta_1813
HWA: HQ_3319A
HWC: Hqrw_3848
HLA: Hlac_1947
HDF: AArcSl_0005(hcaD)
STO: STK_00920
SOL: Ssol_2188
SSOA: SULA_2223
SSOL: SULB_2224
SSOF: SULC_2221
SIC: SiL_0316
MSE: Msed_0487
MCN: Mcup_1613
 » show all
Reference
1  [PMID:4147457]
  Authors
Jungermann K, Thauer RK, Leimenstoll G, Decker K.
  Title
Function of reduced pyridine nucleotide-ferredoxin oxidoreductases in saccharolytic Clostridia.
  Journal
Biochim Biophys Acta 305:268-80 (1973)
DOI:10.1016/0005-2728(73)90175-8
Reference
2  [PMID:2294092]
  Authors
Haigler BE, Gibson DT
  Title
Purification and properties of NADH-ferredoxinNAP reductase, a component of naphthalene dioxygenase from Pseudomonas sp. strain NCIB 9816.
  Journal
J Bacteriol 172:457-64 (1990)
DOI:10.1128/JB.172.1.457-464.1990
Reference
3  [PMID:1938912]
  Authors
Ramachandra M, Seetharam R, Emptage MH, Sariaslani FS
  Title
Purification and characterization of a soybean flour-inducible ferredoxin reductase of Streptomyces griseus.
  Journal
J Bacteriol 173:7106-12 (1991)
DOI:10.1128/JB.173.22.7106-7112.1991
Reference
4  [PMID:1327782]
  Authors
Shaw JP, Harayama S
  Title
Purification and characterisation of the NADH:acceptor reductase component of xylene monooxygenase encoded by the TOL plasmid pWW0 of Pseudomonas putida mt-2.
  Journal
Eur J Biochem 209:51-61 (1992)
DOI:10.1111/j.1432-1033.1992.tb17260.x
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.18.1.3
IUBMB Enzyme Nomenclature: 1.18.1.3
ExPASy - ENZYME nomenclature database: 1.18.1.3
BRENDA, the Enzyme Database: 1.18.1.3
CAS: 39369-37-4

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