KEGG   ENZYME: 1.18.1.3Help
Entry
EC 1.18.1.3                 Enzyme                                 

Name
ferredoxin---NAD+ reductase;
ferredoxin-nicotinamide adenine dinucleotide reductase;
ferredoxin reductase (ambiguous);
NAD+-ferredoxin reductase;
NADH-ferredoxin oxidoreductase;
reductase, reduced nicotinamide adenine dinucleotide-ferredoxin;
ferredoxin-NAD+ reductase;
NADH-ferredoxin reductase;
NADH2-ferredoxin oxidoreductase;
NADH flavodoxin oxidoreductase;
NADH-ferredoxin NAP reductase (component of naphthalene dioxygenase multicomponent enzyme system);
ferredoxin-linked NAD+ reductase;
NADH-ferredoxin TOL reductase (component of toluene dioxygenase);
ferredoxin---NAD reductase
Class
Oxidoreductases;
Acting on iron-sulfur proteins as donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
ferredoxin:NAD+ oxidoreductase
Reaction(IUBMB)
(1) 2 reduced [2Fe-2S] ferredoxin + NAD+ + H+ = 2 oxidized [2Fe-2S] ferredoxin + NADH [RN:R05875];
(2) reduced 2[4Fe-4S] ferredoxin + NAD+ + H+ = oxidized 2[4Fe-4S] ferredoxin + NADH
Reaction(KEGG)
R05875;
(other) R02000
Show
Substrate
reduced [2Fe-2S] ferredoxin;
NAD+ [CPD:C00003];
H+ [CPD:C00080];
reduced 2[4Fe-4S] ferredoxin
Product
oxidized [2Fe-2S] ferredoxin;
NADH [CPD:C00004];
oxidized 2[4Fe-4S] ferredoxin
Comment
Contains FAD. Reaction (1) is written for a [2Fe-2S] ferredoxin, which is characteristic of some mono- and dioxygenase systems. The alternative reaction (2) is written for a 2[4Fe-4S] ferredoxin, which transfers two electrons, and occurs in metabolism of anaerobic bacteria.
History
EC 1.18.1.3 created 1976 as EC 1.6.7.3, transferred 1978 to EC 1.18.1.3, modified 2011
Pathway
ec00071  Fatty acid degradation
Orthology
K00529  3-phenylpropionate/trans-cinnamate dioxygenase ferredoxin reductase component
K15758  toluene methyl-monooxygenase electron transfer component
K15765  toluene monooxygenase electron transfer component
K18088  biphenyl 2,3-dioxygenase ferredoxin reductase component
K18090  benzene/toluene/chlorobenzene dioxygenase ferredoxin reductase component
K18227  p-cumate 2,3-dioxygenase ferredoxin reductase component
K18254  phthalate 3,4-dioxygenase ferredoxin reductase component
K18293  p-cymene methyl-monooxygenase electron transfer component
K20809  2-halobenzoate 1,2-dioxygenase electron transfer component
K22362  alkene monooxygenase ferredoxin reductase component
Genes
ECO: b2542(hcaD)
ECJ: JW2526(hcaD)
ECD: ECDH10B_2709(hcaD)
EBW: BWG_2306(hcaD)
ECOK: ECMDS42_2086(hcaD)
ECE: Z3814(hcaD)
ECS: ECs3408
ECF: ECH74115_3774(hcaD)
ETW: ECSP_3486(hcaD)
ELX: CDCO157_3175
EOJ: ECO26_3589(hcaD)
EOI: ECO111_3266(hcaD)
EOH: ECO103_3062(hcaD)
EOK: G2583_3072(hcaD)
ECX: EcHS_A2694(hcaD)
ECW: EcE24377A_2827(hcaD)
ECM: EcSMS35_2695(hcaD)
ECY: ECSE_2829
ECK: EC55989_2828(hcaD)
ECT: ECIAI39_2743(hcaD)
EOC: CE10_2974(hcaD)
EUM: ECUMN_2862(hcaD)
ELO: EC042_2746(hcaD)
ELH: ETEC_2699
ESO: O3O_18945
ESM: O3M_06750
ESL: O3K_06705
EBR: ECB_02434(hcaD)
EBD: ECBD_1142
EKF: KO11_10110(hcaD)
EDJ: ECDH1ME8569_2469(hcaD)
ELW: ECW_m2768(hcaD)
ELL: WFL_13555(hcaD)
ELP: P12B_c2642(hcaD)
EBL: ECD_02434(hcaD)
EBE: B21_02398(hcaD)
SFV: SFV_2590(hcaD)
SFE: SFxv_2845(hcaD)
SFN: SFy_3676
SFS: SFyv_3753
SFT: NCTC1_02845(hcaD_1) NCTC1_02846(hcaD_2)
SSN: SSON_2624(hcaD)
ENC: ECL_04260
ECLO: ENC_31820
EEC: EcWSU1_03730(thcD)
ECLX: LI66_18670
ECLY: LI62_20130
ECLZ: LI64_17560
KPN: KPN_03366
KPR: KPR_4631
KPJ: N559_0870
KPNU: LI86_04260
EAE: EAE_03025
EAR: CCG33376
YRO: CH64_1873
SPE: Spro_3963
SRL: SOD_c39190(thcD)
SPLY: Q5A_021000(thcD)
SMAF: D781_3684
SMW: SMWW4_v1c40720(hcaD)
SMAR: SM39_3555
SERF: L085_08140
PLU: plu2209
PAY: PAU_02352(hcaD)
PSI: S70_19015
PSX: DR96_2720
PRG: RB151_039990(andAa)
XCV: XCV2179
XAX: XACM_2265
PPSE: BN5_3604
PCQ: PcP3B5_42510(thcD_2)
PPX: T1E_4244(xylA) T1E_4247(camA) T1E_4269(tobA)
PFS: PFLU_2392
PFE: PSF113_3383(ethA)
PFB: VO64_5562
ACB: A1S_0951
ABY: ABAYE2843
ABN: AB57_1026
ABX: ABK1_0936
ABH: M3Q_1249
ABAD: ABD1_09030
ABAZ: P795_12955
ABAU: IX87_00780
ABAA: IX88_06760
ACC: BDGL_000228(thcD)
ASJ: AsACE_CH00363(hcaD)
PPHE: PP2015_459
PTN: PTRA_a0478(hcaD)
PART: PARC_a2206(hcaD)
MAQ: Maqu_0601
MHC: MARHY2840(ahpH)
MAD: HP15_27
MBS: MRBBS_1308(tmoF)
GPS: C427_3050
CYQ: Q91_2220
GAI: IMCC3135_09320(thcD_1) IMCC3135_19405(thcD_2) IMCC3135_21415(thcD_3)
CSA: Csal_0136
HBE: BEI_0073(hcaD)
ABO: ABO_0203
ADI: B5T_02077
AXE: P40_09940
TBN: TBH_C0920
RSL: RPSI07_2133(hcaD)
RSN: RSPO_c02130(nirB)
RPI: Rpic_4637
REH: H16_A1630(h16_A1630) H16_B0802(h16_B0802)
RME: Rmet_1311
BMA: BMAA1326
BMAL: DM55_4196
BMAE: DM78_3327
BMAQ: DM76_4896
BMAI: DM57_10420
BMAF: DM51_4979
BMAZ: BM44_4160
BMAB: BM45_3282
BPS: BPSS0906
BPM: BURPS1710b_A2504(mopA)
BPSE: BDL_4194
BPSM: BBQ_5231
BPSU: BBN_4365
BPSD: BBX_6034
BPK: BBK_3532
BPSH: DR55_4430
BPSA: BBU_5125
BPSO: X996_4142
BTQ: BTQ_4778
BTJ: BTJ_3410
BTZ: BTL_4258
BTD: BTI_5725
BTV: BTHA_3699
BTHE: BTN_3433
BTHM: BTRA_4184
BTHA: DR62_3506
BTHL: BG87_4234
BOK: DM82_5079
BOC: BG90_5516
BCEW: DM40_4670
BMJ: BMULJ_02643(hcaD)
BUB: BW23_5495
BLAT: WK25_25785
BTEI: WS51_06745
BSEM: WJ12_29335
BPSL: WS57_04795
BSTG: WT74_28375
BGU: KS03_4077
BUL: BW21_5412
BFN: OI25_3033(thcD) OI25_3902(thcD) OI25_5519
PPNM: LV28_03030
PPUL: RO07_21920
PAPI: SG18_20970
BPT: Bpet3741
BHO: D560_1526 D560_1678(thcD)
BHM: D558_1517 D558_1666(thcD)
BHZ: ACR54_01067(camA) ACR54_01699(andAa) ACR54_04420(thcD)
AXX: ERS451415_02891(thcD_2)
AMIM: MIM_c31590
AFQ: AFA_13935 AFA_15115(picB2)
RFR: Rfer_0300
PNA: Pnap_4148
AJS: Ajs_0213
ACK: C380_15960(bphA4)
DAC: Daci_2353
LIM: L103DPR2_00189(carAd)
HYR: BSY239_2683(thcD)
CBAA: SRAA_1072
CBAB: SMCB_0826
MPT: Mpe_A0819(tbuC) Mpe_A0921(msmD) Mpe_B0597
CFU: CFU_0345(mocF)
LCH: Lcho_3288
DAR: Daro_3815
AZO: azo2529(camA)
AOA: dqs_2686
AMIH: CO731_00487(thcD_1) CO731_02242(andAa)
PLA: Plav_0127
ATU: Atu1013
ARA: Arad_1563 Arad_9582(mocFe)
RET: RHE_CH01347 RHE_CH02643(mocFch) RHE_PE00444(mocFe)
RIR: BN877_I1000(thcD)
RHL: LPU83_1320 LPU83_2621(mocF1) LPU83_3868(mocF3)
RHT: NT26_0971(thcD)
BME: BMEII0557
BMEL: DK63_2689(thcD)
BMEE: DK62_2713(thcD)
BMF: BAB2_0511
BABO: DK55_2491(thcD)
BABR: DO74_2906(thcD)
BABT: DK49_2748(thcD)
BABB: DK48_2200(thcD)
BABU: DK53_2494(thcD)
BABS: DK51_3078(thcD)
BABC: DO78_2564(thcD)
BMS: BRA0729
BSZ: DK67_2693(thcD)
BOV: BOV_A0683
BCS: BCAN_B0736(thcD)
BCAR: DK60_2428(thcD)
BCAS: DA85_13955
BMR: BMI_II722
BPP: BPI_II782
BPV: DK65_2909(thcD)
OAN: Oant_3868
OAH: DR92_4393(thcD)
OCH: CES85_4051(thcD) CES85_5687(fdr)
BRS: S23_51680
BRAD: BF49_1851
RPA: RPA3782
RPB: RPB_3656
RPC: RPC_1647
RPD: RPD_1802
RPE: RPE_1676
RPT: Rpal_4303
NWI: Nwi_2287
NHA: Nham_2703
OCA: OCAR_6789
BOS: BSY19_593
VGO: GJW-30_1_00441(thcD)
SNO: Snov_0477
MEX: Mext_0977
MDI: METDI1124
MCH: Mchl_0941
MET: M446_2274
MPO: Mpop_0917
MOR: MOC_4083
META: Y590_03895
MAQU: Maq22A_c07385(hcaD)
BVR: BVIR_2618
MMED: Mame_03831(thcD)
HDI: HDIA_0861(thcD) HDIA_1414(andAa) HDIA_4247(carAd)
RBM: TEF_10365
CCR: CC_3525
PZU: PHZ_c0214
SIL: SPO3737
RSP: RSP_0900
RCP: RCAP_rcc03412(thcD)
JAN: Jann_0440
RDE: RD1_0947
DSH: Dshi_0114
KVU: EIO_0493
KVL: KVU_0054
KRO: BVG79_00317(hcaD)
PSF: PSE_0031
PGA: PGA1_c29270(thcD)
PGL: PGA2_c27200(thcD)
PGD: Gal_00503
PHP: PhaeoP97_00578(thcD)
PPIC: PhaeoP14_02699(thcD)
OTM: OSB_01410(fdr)
PTP: RCA23_c03430(thcD)
MALG: MALG_03090
RSU: NHU_03901
RHC: RGUI_2695
RMM: ROSMUCSMR3_02975(thcD)
HNE: HNE_1888
SAL: Sala_1971
SMAZ: LH19_16785
SGI: SGRAN_1201(camA) SGRAN_1587(fdr) SGRAN_2775(camA2) SGRAN_2803(thnA4) SGRAN_3240(camA3)
SPHM: G432_00945
STAX: MC45_14140
SSAN: NX02_11185
SPKC: KC8_02110
SPMI: K663_06390
SPHB: EP837_00486(hcaD)
SINB: SIDU_01545
SFLA: SPHFLASMR4Y_00997(fdr)
BLAS: BSY18_317
ELI: ELI_12420
AAY: WYH_02138(fdr)
ANH: A6F65_00548(fdr)
ADO: A6F68_00373(fdr)
KEU: S101446_03116(hcaD)
ASZ: ASN_576
TMO: TMO_a0555(thcD) TMO_b0125(thcD) TMO_c0277(thcD)
MAGQ: MGMAQ_2659
BTS: Btus_2064
MTU: Rv1869c
MTC: MT1918
MRA: MRA_1880
MTUR: CFBS_1961
MTD: UDA_1869c
MTUC: J113_12960
MTUE: J114_09960
MTUL: TBHG_01824
MTUT: HKBT1_1958
MTUU: HKBT2_1966
MBB: BCG_1905c
MBT: JTY_1889
MBX: BCGT_1702
MAF: MAF_18910
MMIC: RN08_2074
MPA: MAP_1579c
MAO: MAP4_2260
MAVI: RC58_11240
MAVU: RE97_11250
MAV: MAV_2849
MAVD: NF84_12705
MAVR: LA63_12860
MAVA: LA64_12850
MIA: OCU_26650
MID: MIP_03989
MYO: OEM_25310
MMI: MMAR_3153
MMM: W7S_13005
MHAD: B586_11635
MPHL: MPHLCCUG_01328(thcD)
MVQ: MYVA_1135
MSTE: MSTE_04054
MTER: 4434518_01908(andAa) 4434518_03871(camA)
CDR: CDHC03_1954(hcaD)
CVA: CVAR_0135
CTER: A606_11495
CMV: CMUST_15090(hcaD)
CAMG: CAMM_10640
NFA: NFA_12150
RFA: A3L23_01169(thcD_1) A3L23_05141(camA)
RHS: A3Q41_00445(camA) A3Q41_02200(thcD_1)
SGB: WQO_10105
SCT: SCAT_1535
SFA: Sfla_4382
SBH: SBI_00328 SBI_07356(fprD)
SHY: SHJG_3945
SVE: SVEN_2257
SALB: XNR_4478
STRP: F750_2319
SFI: SFUL_2016
STRE: GZL_05962
SRW: TUE45_03065(camA)
SLE: sle_47430(sle_47430)
SRN: A4G23_01569(andAa)
SALJ: SMD11_4667
SLX: SLAV_25040(thcD2)
AMIN: AUMI_19500
LMOI: VV02_12055
IDO: I598_2943(thcD)
CFI: Celf_2109
DCO: SAMEA4475696_0460(bedA)
NDK: I601_1173(thcD) I601_3166(camA_2)
SRO: Sros_1897
FAL: FRAAL3171 FRAAL4010(fprC)
ACE: Acel_0803
NML: Namu_3641
SEN: SACE_2839(fprC) SACE_3145(fprC) SACE_3433 SACE_4511(fprC) SACE_5609(padAd2)
AMD: AMED_0391(hcaD) AMED_4383
AMM: AMES_0391(hcaD) AMES_4329
AMZ: B737_0392(hcaD) B737_4329
AOI: AORI_0410(hcaD) AORI_3258(hcaD) AORI_6047
AJA: AJAP_22905(andAa) AJAP_37605(thcD)
PSEA: WY02_20120
SESP: BN6_12600
KAL: KALB_1398
ALL: CRK55028
AFS: AFR_27755
CAI: Caci_2641
RXY: Rxyl_2822
AVA: Ava_2874
TRO: trd_A0924
FLM: MY04_2083
MARM: YQ22_01785
CBAL: M667_11695
CBAT: M666_11740
HMA: rrnAC0717
NPH: NP_4516A
 » show all
Taxonomy
Reference
1  [PMID:4147457]
  Authors
Jungermann K, Thauer RK, Leimenstoll G, Decker K.
  Title
Function of reduced pyridine nucleotide-ferredoxin oxidoreductases in saccharolytic Clostridia.
  Journal
Biochim Biophys Acta 305:268-80 (1973)
DOI:10.1016/0005-2728(73)90175-8
Reference
2  [PMID:2294092]
  Authors
Haigler BE, Gibson DT
  Title
Purification and properties of NADH-ferredoxinNAP reductase, a component of naphthalene dioxygenase from Pseudomonas sp. strain NCIB 9816.
  Journal
J Bacteriol 172:457-64 (1990)
DOI:10.1128/JB.172.1.457-464.1990
Reference
3  [PMID:1938912]
  Authors
Ramachandra M, Seetharam R, Emptage MH, Sariaslani FS
  Title
Purification and characterization of a soybean flour-inducible ferredoxin reductase of Streptomyces griseus.
  Journal
J Bacteriol 173:7106-12 (1991)
DOI:10.1128/JB.173.22.7106-7112.1991
Reference
4  [PMID:1327782]
  Authors
Shaw JP, Harayama S
  Title
Purification and characterisation of the NADH:acceptor reductase component of xylene monooxygenase encoded by the TOL plasmid pWW0 of Pseudomonas putida mt-2.
  Journal
Eur J Biochem 209:51-61 (1992)
DOI:10.1111/j.1432-1033.1992.tb17260.x
Other DBs
ExplorEnz - The Enzyme Database: 1.18.1.3
IUBMB Enzyme Nomenclature: 1.18.1.3
ExPASy - ENZYME nomenclature database: 1.18.1.3
BRENDA, the Enzyme Database: 1.18.1.3
CAS: 39369-37-4

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