Entry
Name
rubredoxin---NAD(P)+ reductase;
rubredoxin-nicotinamide adenine dinucleotide (phosphate) reductase;
rubredoxin-nicotinamide adenine;
dinucleotide phosphate reductase;
NAD(P)+-rubredoxin oxidoreductase;
NAD(P)H-rubredoxin oxidoreductase
Class
Oxidoreductases;
Acting on iron-sulfur proteins as donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
rubredoxin:NAD(P)+ oxidoreductase
Reaction(IUBMB)
2 reduced rubredoxin + NAD(P)+ + H+ = 2 oxidized rubredoxin + NAD(P)H [RN:
R02000 R02002 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme from Pyrococcus furiosus requires FAD. It reduces a number of electron carriers, including benzyl viologen, menadione and 2,6-dichloroindophenol, but rubredoxin is the most efficient. Ferredoxin is not utilized.
History
EC 1.18.1.4 created 1984, modified 2001, modified 2011
Pathway
Reference
Authors
Petitdemange H, Blusson H, Gay R.
Title
Detection of NAD(P)H--rubredoxin oxidoreductases in Clostridia.
Journal
Reference
Authors
Ma K, Adams MW.
Title
A hyperactive NAD(P)H:Rubredoxin oxidoreductase from the hyperthermophilic archaeon Pyrococcus furiosus.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 1.18.1.4
ExPASy - ENZYME nomenclature database: 1.18.1.4