KEGG   ENZYME: 1.18.1.7Help
Entry
EC 1.18.1.7                 Enzyme                                 

Name
ferredoxin---NAD(P)+ reductase (naphthalene dioxygenase ferredoxin-specific);
NADH-ferredoxin(NAP) reductase
Class
Oxidoreductases;
Acting on iron-sulfur proteins as donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
ferredoxin:NAD(P)+ oxidoreductase
Reaction(IUBMB)
2 reduced [2Fe-2S] ferredoxin + NAD(P)+ + H+ = 2 oxidized [2Fe-2S] ferredoxin + NAD(P)H [RN:R05875 R12422]
Reaction(KEGG)
Substrate
reduced [2Fe-2S] ferredoxin [CPD:C22150];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H+ [CPD:C00080]
Product
oxidized [2Fe-2S] ferredoxin [CPD:C22151];
NADH [CPD:C00004];
NADPH [CPD:C00005]
Comment
The enzyme from the aerobic bacterium Ralstonia sp. U2 donates electrons to both EC 1.14.12.12, naphthalene 1,2-dioxygenase and EC 1.14.13.172, salicylate 5-hydroxylase [1]. The enzyme from Pseudomonas NCIB 9816 is specific for the ferredoxin associated with naphthalene dioxygenase; it contains FAD and a [2Fe-2S] cluster.
History
EC 1.18.1.7 created 2013
Orthology
K14581  naphthalene 1,2-dioxygenase ferredoxin reductase component
Genes
EBT: EBL_c34260(ndoR)
PPI: ND053(nahAa)
PSC: A458_06735
PSTU: UIB01_22615
PBM: CL52_14600
PFK: PFAS1_28600
ALT: ambt_18035
MMW: Mmwyl1_2668
MME: Marme_2403
MPC: Mar181_2356
RSO: RSc1091(nagAa)
RSL: RPSI07_2300(ndoR)
RSM: CMR15_20210(ndoR)
RSE: F504_1062
BMK: DM80_1434(ndoR) DM80_1439(ndoR)
BFN: OI25_3043(ndoR)
PPNO: DA70_21365
PPNM: LV28_08955
PPUL: RO07_03185
PSPU: NA29_24095
PAPI: SG18_03375
AFQ: AFA_02200
POL: Bpro_0980
PNA: Pnap_2489
AAV: Aave_0164
AJS: Ajs_3089
AAA: Acav_0195
LCH: Lcho_0800
THI: THI_2205
AZO: azo2517(nagAa)
AOA: dqs_2674
OAH: DR92_4202
RBM: TEF_01260
SGI: SGRAN_2805(thnY)
TMO: TMO_2240(ndoR)
 » show all
Taxonomy
Reference
1  [PMID:11872705]
  Authors
Zhou NY, Al-Dulayymi J, Baird MS, Williams PA.
  Title
Salicylate 5-hydroxylase from Ralstonia sp. strain U2: a monooxygenase with close relationships to and shared electron transport proteins with naphthalene dioxygenase.
  Journal
J Bacteriol 184:1547-55 (2002)
DOI:10.1128/JB.184.6.1547-1555.2002
  Sequence
Reference
2  [PMID:2294092]
  Authors
Haigler BE, Gibson DT
  Title
Purification and properties of NADH-ferredoxinNAP reductase, a component of naphthalene dioxygenase from Pseudomonas sp. strain NCIB 9816.
  Journal
J Bacteriol 172:457-64 (1990)
DOI:10.1128/JB.172.1.457-464.1990
Other DBs
ExplorEnz - The Enzyme Database: 1.18.1.7
IUBMB Enzyme Nomenclature: 1.18.1.7
ExPASy - ENZYME nomenclature database: 1.18.1.7
BRENDA, the Enzyme Database: 1.18.1.7

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