KEGG   ENZYME: 1.2.1.100Help
Entry
EC 1.2.1.100                Enzyme                                 

Name
5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase;
mlr6793 (locus name)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate:NAD+ 5-oxidoreductase
Reaction(IUBMB)
5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + NAD+ + H2O = 3-hydroxy-2-methylpyridine-4,5-dicarboxylate + NADH + H+ [RN:R04524]
Reaction(KEGG)
Substrate
5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate [CPD:C06050];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
3-hydroxy-2-methylpyridine-4,5-dicarboxylate [CPD:C04604];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the bacteria Pseudomonas sp. MA-1 and Mesorhizobium loti, participates in the degradation of pyridoxine (vitamin B6).
History
EC 1.2.1.100 created 2018
Pathway
ec00750  Vitamin B6 metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K18612  5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase
Genes
PHD: 102334275
MLO: mlr6793
MLN: A9174_14045
MCI: Mesci_2021
MAM: Mesau_02085
MESW: A9K65_010545
MEY: TM49_03795
MMED: Mame_00129(mmgB_1)
Taxonomy
Reference
1  [PMID:3533936]
  Authors
Lee YC, Nelson MJ, Snell EE.
  Title
Enzymes of vitamin B6 degradation. Purification and properties of isopyridoxal dehydrogenase and 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylic-acid dehydrogenase.
  Journal
J Biol Chem 261:15106-11 (1986)
Reference
2  [PMID:19218190]
  Authors
Yokochi N, Yoshikane Y, Matsumoto S, Fujisawa M, Ohnishi K, Yagi T.
  Title
Gene identification and characterization of 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase, an NAD+-dependent dismutase.
  Journal
J Biochem 145:493-503 (2009)
DOI:10.1093/jb/mvp007
  Sequence
[mlo:mlr6793]
Reference
3  [PMID:25446130]
  Authors
Mugo AN, Kobayashi J, Mikami B, Yoshikane Y, Yagi T, Ohnishi K
  Title
Crystal structure of 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase, an NAD(+)-dependent dismutase from Mesorhizobium loti.
  Journal
Biochem Biophys Res Commun 456:35-40 (2015)
DOI:10.1016/j.bbrc.2014.11.028
  Sequence
[mlo:mlr6793]
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.100
IUBMB Enzyme Nomenclature: 1.2.1.100
ExPASy - ENZYME nomenclature database: 1.2.1.100
BRENDA, the Enzyme Database: 1.2.1.100

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