KEGG   ENZYME: 1.2.1.101Help
Entry
EC 1.2.1.101                Enzyme                                 

Name
L-tyrosine reductase;
lnaA (gene name);
lnbA (gene name)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(2S)-2-amino-3-(4-hydroxyphenyl)propanal:NADP+ oxidoreductase (ATP-forming)
Reaction(IUBMB)
L-tyrosinal + NADP+ + AMP + diphosphate = L-tyrosine + NADPH + H+ + ATP [RN:R12235]
Reaction(KEGG)
Substrate
L-tyrosinal [CPD:C22021];
NADP+ [CPD:C00006];
AMP [CPD:C00020];
diphosphate [CPD:C00013]
Product
L-tyrosine [CPD:C00082];
NADPH [CPD:C00005];
H+ [CPD:C00080];
ATP [CPD:C00002]
Comment
The enzyme, characterized from the ascomycete fungus Aspergillus flavus, is specific for L-tyrosine. It contains three domains - an adenylation domain, a peptidyl-carrier protein (PCP) domain, and a reductase domain, and requires activation by attachment of a phosphopantetheinyl group. The enzyme activates its substrate to an adenylate form, followed by a transfer to the PCP domain. The resulting thioester is subsequently transferred to the reductase domain, where it is reduced to the aldehyde.
History
EC 1.2.1.101 created 2018
Orthology
K00155  L-tyrosine reductase
Genes
MAJ: MAA_08272
PLJ: VFPFJ_10289
ANI: AN8105.2
AFM: AFUA_8G01640
AOR: AO090020000240
ANG: ANI_1_1360144(An16g00600)
AFV: AFLA_101700 AFLA_121520
NFI: NFIA_045590
PCS: Pc06g01540
PBL: PAAG_01545
ABE: ARB_02573
TVE: TRV_05503
 » show all
Taxonomy
Reference
1  [PMID:23281040]
  Authors
Forseth RR, Amaike S, Schwenk D, Affeldt KJ, Hoffmeister D, Schroeder FC, Keller NP
  Title
Homologous NRPS-like gene clusters mediate redundant small-molecule biosynthesis  in Aspergillus flavus.
  Journal
Angew Chem Int Ed Engl 52:1590-4 (2013)
DOI:10.1002/anie.201207456
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.101
IUBMB Enzyme Nomenclature: 1.2.1.101
ExPASy - ENZYME nomenclature database: 1.2.1.101
BRENDA, the Enzyme Database: 1.2.1.101
CAS: 9074-94-6

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