KEGG   ENZYME: 1.2.1.102Help
Entry
EC 1.2.1.102                Enzyme                                 

Name
isopyridoxal dehydrogenase (5-pyridoxate-forming)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
isopyridoxal:NAD+ oxidoreductase (5-pyridoxate-forming)
Reaction(IUBMB)
isopyridoxal + NAD+ + H2O = 5-pyridoxate + NADH + H+ [RN:R12265]
Reaction(KEGG)
Substrate
isopyridoxal [CPD:C06051];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
5-pyridoxate [CPD:C04773];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the bacterium Arthrobacter sp. Cr-7, participates in the degradation of pyridoxine. The enzyme also catalyses the activity of EC 1.1.1.416, isopyridoxal dehydrogenase (5-pyridoxolactone-forming).
History
EC 1.2.1.102 created 2018
Pathway
ec00750  Vitamin B6 metabolism
Reference
1  [PMID:3533936]
  Authors
Lee YC, Nelson MJ, Snell EE.
  Title
Enzymes of vitamin B6 degradation. Purification and properties of isopyridoxal dehydrogenase and 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylic-acid dehydrogenase.
  Journal
J Biol Chem 261:15106-11 (1986)
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.102
IUBMB Enzyme Nomenclature: 1.2.1.102
ExPASy - ENZYME nomenclature database: 1.2.1.102
BRENDA, the Enzyme Database: 1.2.1.102

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