Entry
Name
glyceraldehyde-3-phosphate dehydrogenase (arsenate-transferring)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (arsenate-transferring)
Reaction(IUBMB)
D-glyceraldehyde 3-phosphate + arsenate + NAD+ = 1-arsono-3-phospho-D-glycerate + NADH + H+ [RN:
R12785 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme, discovered in bacteria, is very similar to EC
1.2.1.12 , glyceraldehyde-3-phosphate dehydrogenase (phosphorylating). However, the gene encoding it is located in arsenic resistance islands in the chromosome, next to a gene (arsJ) that encodes a transporter that removes the product, 1-arsono-3-phosphoglycerate, from the cell. Together the two proteins form an arsenic detoxification system.
History
EC 1.2.1.107 created 2021
Orthology
K25224 glyceraldehyde-3-phosphate dehydrogenase (arsenate-transferring)
Genes
VAU : VANGNB10_cII0816c(gap)
VPL : SA104470976_00821(gap)
PALK : PSAKL28_24870 PSAKL28_44790
PFK : PFAS1_21910 PFAS1_22250
PSIL : PMA3_09450 PMA3_10125
PALV : KSS97_13915 KSS97_14025
PAGR : E2H98_00015 E2H98_00075 E2H98_13890
MSHE : MAALD49_36230(gapA)
SPC : Sputcn32_1223 Sputcn32_3815
SHN : Shewana3_0534 Shewana3_2330
SCAA : TUM17387_05290(gapA_1)
PTD : PTET_a2754(gapA) PTET_b0264(gapA)
PMAZ : R5H13_18605 R5H13_20115
PSMM : PspMM1_33230(gapA_2)
HMI : soil367_17190 soil367_18705
CEG : D0C16_08085 D0C16_17535
THIO : AYJ59_02830 AYJ59_03800
MTHA : VSX76_01010 VSX76_12620
TIB : THMIRHAM_00500(gapA)
TWN : L2Y54_01965 L2Y54_10245
RHEI : ATY27_05185 ATY27_11765
TFRI : Thiofri_01882(gap3_1) Thiofri_03859(gap3_2)
TWG : Thiowin_02026(gap3_2)
GAI : IMCC3135_14690(gap3)
HAXI : HAALTHF_44610n(gapA)
HAAH : HALA3H3_130047(gap) HALA3H3_790132(gap) HALA3H3_p30002(gap)
MPON : MACH16_02770(gapA_1)
LIH : L63ED372_02115(gap3)
HYN : F9K07_10600 F9K07_29730
SNIV : SFSGTM_17030(gapA_1)
THAG : CKCBHOJB_01921(gap3)
ANC : GBB76_17110 GBB76_17345
RLI : RLO149_c016870(gapA2)
OAT : OAN307_c26680(gapA1)
SINL : DSM14862_02658(gap3)
SPSE : SULPSESMR1_03895(gap3)
RMM : ROSMUCSMR3_03688(gap3)
HAT : RC74_02030 RC74_20775
PALX : GQA70_03945 GQA70_07130
RMAI : MACH21_33940(gapA-1)
RCP : RCAP_rcc02071(gap2) RCAP_rcp00086(gap4)
PSAP : JHX88_09035 JHX88_18645
LVS : LOKVESSMR4R_01967(gap3)
NSM : JO391_00525 JO391_20315
SYR : SynRCC307_0428(gap3)
SYX : SynWH7803_1460(gap3)
SYH : Syncc8109_0834(gap3)
SYNW : SynWH8103_00910(gap3)
LET : O77CONTIG1_03975(gap3)
MDP : NIES3275_06440(gap3)
NSPH : BDGGKGIB_01144(gap3)
OBG : Verru16b_00790(gap3)
» show all
Taxonomy
Reference
Authors
Chen J, Yoshinaga M, Garbinski LD, Rosen BP.
Title
Synergistic interaction of glyceraldehydes-3-phosphate dehydrogenase and ArsJ, a novel organoarsenical efflux permease, confers arsenate resistance.
Journal
Sequence
Reference
Authors
Wu S, Wang L, Gan R, Tong T, Bian H, Li Z, Du S, Deng Z, Chen S
Title
Signature Arsenic Detoxification Pathways in Halomonas sp. Strain GFAJ-1.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 1.2.1.107