KEGG   ENZYME: 1.2.1.107
Entry
EC 1.2.1.107                Enzyme                                 
Name
glyceraldehyde-3-phosphate dehydrogenase (arsenate-transferring)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (arsenate-transferring)
Reaction(IUBMB)
D-glyceraldehyde 3-phosphate + arsenate + NAD+ = 1-arsono-3-phospho-D-glycerate + NADH + H+ [RN:R12785]
Reaction(KEGG)
R12785
Substrate
D-glyceraldehyde 3-phosphate [CPD:C00118];
arsenate [CPD:C11215];
NAD+ [CPD:C00003]
Product
1-arsono-3-phospho-D-glycerate [CPD:C22393];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, discovered in bacteria, is very similar to EC 1.2.1.12, glyceraldehyde-3-phosphate dehydrogenase (phosphorylating). However, the gene encoding it is located in arsenic resistance islands in the chromosome, next to a gene (arsJ) that encodes a transporter that removes the product, 1-arsono-3-phosphoglycerate, from the cell. Together the two proteins form an arsenic detoxification system.
History
EC 1.2.1.107 created 2021
Orthology
K25224  glyceraldehyde-3-phosphate dehydrogenase (arsenate-transferring)
Genes
PMEXH4W19_14340
LYJFKV23_06175
LCICINQ41_06995
VCHVC_1069
VCFIR04_10685
VCSMS6_0861
VCEVch1786_I0573(gap)
VCQEN18_08680
VCJVCD_003271
VCIO3Y_04975
VCOVC0395_A0587(gap)
VCRVC395_1084(gap)
VCMVCM66_1025(gap)
VCLVCLMA_A0925
VCXVAA049_2667(gap)
VCZVAB027_1753(gap)
VVUVV1_1141(gap)
VVYVV0100
VVMVVMO6_00116
VVLVV93_v1c00900
VPAVP2970
VPBVPBB_2807
VPKM636_22425
VPFM634_01370
VPHVPUCM_3054
VHAVIBHAR_00296
VCAM892_11210
VAGN646_2065
VEXVEA_002126
VDBAL552_23895(gap)
VHRAL538_09055(gap)
VNAPN96_13945
VOWA9237_08805
VROBSZ04_23935
VSPVS_3033
VEJVEJY3_14990
VFUvfu_A00452
VNIVIBNI_A3753(gap3)
VANVAA_00950
LAGN175_15935
VAUVANGNB10_cII0816c(gap)
VCYIX92_00795
VCTJV59_40055
VTUIX91_14635
VEUIXK98_23305
VSIMTO69_12865
VFLAL536_20840(gap)
VMIAL543_14595(gap)
VBRA6E01_00400
VSCVSVS12_00027(gapA)
VSHBSZ05_03940
VQICCZ37_14565(gap)
VTAA3390(gap)
VAFD1115_00505
VNLD3H41_16110
VCCFAZ90_00480
VASGT360_00815
VAQFIV01_13870(gap1)
VKABTD91_06880
VZIG5S32_14275
VNVIF132_05275
VGIMID13_14995
VSLLTQ54_09285
VPLSA104470976_00821(gap)
VFIVF_2360(gapA2)
VFMVFMJ11_2481(gap_2)
VSAVSAL_I2818(gap)
AWDAWOD_I_0238(gap)
PPRPBPRA2208(PRO1577)
PGBH744_2c2424
PDSCAY62_05655
PGHFH974_09465
GHOAL542_02630(gap)
SALYE8E00_09190
SKSFCN78_04285
SCOTHBA18_04510
PDKPADK2_28140
PMYPmen_1522
PREPCA10_35760(gap)
PPSEBN5_2711
PFUWKF707C_31510
PALCA0T30_16095
PPWPputW619_5150
PPTPPS_2278 PPS_5217
PPIYSA_00655
PPUHB479_11705
PPUTL483_15980(gapA)
PPUDDW66_2537
PMONX969_09735
PMOTX970_09395
PMOSO165_023275
PPJRK21_02550
PMOLCLJ08_12895(gap)
PFEPSF113_2059
PMANOU5_5709
PCGAXG94_00340
PMEDE3Z27_12625
PBAPSEBR_a3680
PSVPVLB_14275
PKCPKB_2804(gap3)
PALKPSAKL28_24870 PSAKL28_44790
PPVNJ69_19050
PSEMTO66_30585
PFKPFAS1_21910 PFAS1_22250
PSETTHL1_2592
PSILPMA3_09450 PMA3_10125
PALLUYA_22530
PUMHGP31_10225
PLALFXN65_17015
PVKEPZ47_10995
PKHJLK41_13070
PTYJWV26_18885
PCAMHNE05_11305
PNNKEM63_02405
PALVKSS97_13915 KSS97_14025
PPHABVH74_05110
PWZJ7655_11005
PZAHU749_019490
PCAVD3880_10995
PJUL1P09_25335
PSAPST_2100
PSZPSTAB_1991
PSRPSTAA_2132
PSCA458_10245
PSHPsest_2243
PSTUUIB01_11455
PSTTCH92_11005
PSEDDM292_08860
PCHLLLJ08_10680
PBMCL52_20340
PKGLW136_11870
SDEGGOM96_01895
AVNAvin_25890(gapA)
AVLAvCA_25890(gapA)
AVDAvCA6_25890(gapA)
ACXAchr_21250(gapA)
PAGRE2H98_00015 E2H98_00075 E2H98_13890
HPEGEAO82_19125
HAESLO767_16200
MAQMaqu_3637
MHCMARHY3543(gapA)
MADHP15_3399
MSRAU15_01630
MSXAU14_15695
MARIACP86_07520
MLQASQ50_12270
MSQBKP64_16725
MARAD0851_10975
MARJMARI_30250(gap3)
PKYPKHYL_38240
SONSO_0538(gapA)
SDNSden_3551
SFRSfri_4002
SAZSama_0494
SBLSbal_0494
SBMShew185_3830
SBNSbal195_3956
SBPSbal223_3774
SBTSbal678_3987
SBSSbal117_0596
SBBSbal175_3752
SLOShew_0419
SPCSputcn32_1223 Sputcn32_3815
SHPSput200_1232
SSESsed_0576
SPLSpea_3736
SHEShewmr4_0536
SHMShewmr7_3495
SHNShewana3_0534 Shewana3_2330
SHWSputw3181_2923
SHLShal_3821
SWDSwoo_4385
SWPswp_0526
SVOSVI_0320(gapA-1)
SHFCEQ32_13435
SJASJ2017_3539
SPSWSps_05321
SBJCF168_18175(gap)
SMAVCFF01_02060(gap)
SHEWCKQ84_05925(gap)
SALGBS332_10065
SLJEGC82_00725
SMAIEXU30_06395
SPOLFH971_19580
SBKSHEWBE_0970(gap)
SKHSTH12_03076(gap3)
SAESHBH39_17360
SLITJQC75_02370
SDKKHX94_06480
SCAATUM17387_05290(gapA_1)
SPSHFM037_02015
SEURFM038_022430
SYKKDN34_02020
SCYPJYB88_15765
SAVIJYB87_16705
SSEMJYB85_16255
SGLAFJ709_15845
SINVK8B83_01650
SXMMKD32_18315
SVMKDH10_003122
ILOIL2126
ILIK734_10710
IPICEW91_02520(gap)
IDICWC33_08020(gap)
IDTC5610_08780
IABK5X84_10000
CPSCPS_3355(gap3)
COMCMT41_14315
COZA3Q34_14465
COLWA3Q33_14315
COLADBO93_12950
COVEKO29_06105
CBERB5D82_14455(gap)
LSDEMK97_17065
THTE2K93_07740
THAPFNC98_13430
THABLP316_12900
PHAPSHAb0182(gapB)
PTNPTRA_b0254(gapA)
PSMPSM_B0195(gapB)
PSEOOM33_14525
PIAPI2015_3249
PPHEPP2015_1728
PBWD172_017475
PRRAT705_01090
PLZS4054249_13960
PALNB0W48_02750
PPISB1L02_19625(gap)
PEAPESP_b0312(gapA)
PSPOPSPO_a2458(gapA)
PARTPARC_b0223(gapA)
PTUPTUN_a0478(gapA)
PNGPNIG_b0268(gapA)
PTDPTET_a2754(gapA) PTET_b0264(gapA)
PSENPNC201_18440(gap3)
PDJD0907_19425
PAGAPAGA_b0289(gapA)
PCARPC2016_3669
PXIJ5O05_01265
PVBJ5X90_13455
PSAZPA25_15960(gapA_1)
PDVFFU37_18525
PSYMJ1N51_03055
CATEC2869_09270
HMIsoil367_17190 soil367_18705
AGZM0C34_15430
PINPing_3636
FBLFbal_0390
FESHER31_17690
MVSMVIS_2897
MYAMORIYA_1495(gap)
MMAAFR932_10355
CEBB0D95_14250
CELLCBR65_04455
CEKD0B88_04160
CEGD0C16_08085 D0C16_17535
SAGAM5M_16345
MARQMARGE09_P3368
MICCAUP74_02497(gap3)
MIIBTJ40_11950
MICTFIU95_10310(gap2)
MICZGL2_34920(gapA)
KIMG3T16_03735
MEINmethR_P1154
TCXTcr_1867 Tcr_1868
HTREPV75_10325(gap)
HMARHVMH_1993(gapA)
TCYThicy_0308
TAOTHIAE_08725
THIOAYJ59_02830 AYJ59_03800
TMHJX580_04360
MEJQ7A_2139(gap)
MECQ7C_2108
MPINLGT42_010235
CYQQ91_1343
CZACYCME_1125(gapA)
CYYCPC19_06105(gap)
THIGFE785_03215
TXAHQN79_10445
TIBTHMIRHAM_00500(gapA)
TSETHMIRHAS_05380
TZOTHMIRHAT_03350
TUNJ9260_08150
TLOJ9253_01055
TSBHMY34_11490
TANIJ8380_01465
TWNL2Y54_01965 L2Y54_10245
TEETel_01685
RHHE0Z06_07830
THIPN838_06715
THIMKFB96_22385
TBOGLT988_18255
TGRTgr7_1924
TKMTK90_1347
TTITHITH_16745
TVRTVD_05450
HNAHneap_1533
HAZA9404_02940
WEZIC757_10875
GAIIMCC3135_14690(gap3)
GHLGM160_06165
HCHHCH_04653(gap4)
HAHEENC22_09525
CSACsal_1482
HELHELO_2131(gapA2)
HCSFF32_12320
HAKKO116_01731
HAMHALO1895
HCOLOKO_02572(gap3)
HSIBOX17_13430
HALOBWR19_13355
HHHCLM76_12940(gap)
HBEBEI_2262
HAGBB497_14790
HAFC8233_00960
HALKCUU95_17825(gap)
HVNEI420_06750
HOLHORIV_43390(gapA)
HSRHSBAA_41170
HMDCTT34_06715(gap)
HAXIHAALTHF_44610n(gapA)
HTTHZS52_14025
HCAMI4484_10170
HPIZGYM47_06430
HSXHNO51_09875
HSVHNO53_11005
HTXEKK97_11095
HPROLMS44_14230
CMAIBFX80_07735
CAMHLCW13_09985
KAKKalk_16070(gap)
MMWMmwyl1_1850
MMEMarme_0762
MPRIMP3633_2277
MARDIBG28_03225
MFOIJSY38_02240
MPRFJ8N69_04610
MARSA8C75_01070
MGEOCFI10_07020(gap)
MSECLN244_05615
MARLHH196_02150
NCUF0U83_11665
NJPNEJAP_2629
NIKF5I99_18185
BMARHF888_03620
AJPAMJAP_1249
VCWGJQ55_01410
RFOREIFOR_01776
OMEOLMES_4632
ENWMJO57_21760
AEOO23A_p2946
AMEDB224_4163
ARVC7N77_08970
OCEGU3_02295
ZDFAN401_06245
KGETQ33_1171
KSDKS2013_1220
TBNTBH_C1974
SEDSAAY24_13205
PSPIPS2015_2706
REVHUE57_09825
EPSL0Y14_05450
IODEJO50_11115
IFLC1H71_10990(gap)
DEEHQN60_15315
CHIZHQ393_10445
CFONHZU75_13725
VOGLCH97_15965
BOZDBV39_18050(gap)
ACIDCBP33_14595
ACIPCBP36_15000
ACINCBP34_15350
OTKC6570_08720(gap)
LIHL63ED372_02115(gap3)
HYRBSY239_1570(gap)
HYNF9K07_10600 F9K07_29730
HTNKI616_13795
MPTMpe_A1586(gapA)
JABVN23_14290
SNIVSFSGTM_17030(gapA_1)
TMZTmz1t_1850
THUAC731_002435
APPCAP2UW1_2669
GSBGSUB_11235
PEFA7E78_12505
DVEDESUT3_07660
ABAWD5400_02215(gap)
RPBRPB_1642
BOSBSY19_2004
BVVBHK69_17250
BOFFQV39_32130
XAUXaut_3960
SNOSnov_1293
ANCGBB76_17110 GBB76_17345
PHRC6569_16915
ACUTMRB58_21880
CSECseg_2582
SILSPO3878(gap-4)
SITTM1040_0525
RUAD1823_15265(gap)
RUTFIU92_15955(gap2)
RDERD1_2398(gap)
RLIRLO149_c016870(gapA2)
RPONG3256_11755
DSHDshi_1254
OATOAN307_c26680(gapA1)
OAROA238_c39200(gapA1)
OTMOSB_25320(gap3)
OCTFTO60_02255
REDroselon_03462
CIDP73_3782
CMARIMCC12053_2242
CEHCEW89_18775(gap)
MALGMALG_02770
CONTQ29_07585
YPACCEW88_05290(gap)
YANAYJ57_18520
TPROGa0080559_TMP2420
PABYGa0080574_TMP3037
SUAMBOO69_02315
SULIC1J05_17385(gap)
SULDB5M07_03330
SPOTG6548_08640
SINLDSM14862_02658(gap3)
SPSESULPSESMR1_03895(gap3)
TOMBWR18_10320
RMMROSMUCSMR3_03688(gap3)
ROKRAK1035_2512
ROHFIU89_01470(gap3)
AHTANTHELSMS3_02528
SAGUCDO87_17825(gap)
OCDFHY55_04150
MARUFIU81_06485(gap3)
ROTFIV09_03305(gap1)
RMHLVO79_07830
MALUKU6B_33300(gapA-1)
TGLHFZ77_15800
HATRC74_02030 RC74_20775
PALXGQA70_03945 GQA70_07130
RSPRSP_4211(gapA-1)
RSQRsph17025_1411
CAZTLV780_06370
RCPRCAP_rcc02071(gap2) RCAP_rcp00086(gap4)
RHPLPB142_09785
PYEA6J80_11150(gap)
PCONB0A89_02340
PZHCX676_16540(gap)
PARSDRW48_14855(gap)
PARREOJ32_12445(gap)
PLIAE4191_17855
PMAUCP157_01235(gap3)
RHCRGUI_1997
RMBK529_010930
DAAAKL17_2948
DONBSK21_08110
THWBMG03_11920
TECAKL02_011455
LVSLOKVESSMR4R_01967(gap3)
RBGBG454_04280(gap)
GEHHYN69_14375(gap)
GFUKM031_09575
TAWEI545_16715(gap)
HMLHmaOT1_01285
LITFPZ52_12820
PSHQF3W81_16325
POZI0K15_03775
PALWPSAL_035130(gap3)
CACTHZ995_00985
RBZB9057_05230
CMAGCBW24_12885
FAPGR316_12310
GCEKYE46_05240
NSMJO391_00525 JO391_20315
ACROK3J57_15645
FAQG5B39_15615
AMAQGO499_14750
SRFLHU95_09215
SHUMSTHU_01220
SVCSTVA_47070
STELSTAQ_10940
SKTIGS68_08840
SMUCJL100_018540
SROEJL101_017245
TMOTMO_a0483(gap3)
TXITH3_01475
TIIDY252_20165(gap)
THAIIT893_01365
MAGQMGMAQ_0092(gap)
ELIOKO353_00280
NACINUH88_09955
MGMMmc1_2970
ECOGFIV45_12600
SNEANBZ79_16445
MAESGa0123461_2431
MFNGa0123462_2232
PARHI5S86_00495
BSOLFSW04_09750
PARNNBH00_16735
AYMYM304_06820
SYCsyc2155_c(gap1)
SYUM744_06730
SYFSynpcc7942_1939
SYDSyncc9605_1846
SYRSynRCC307_0428(gap3)
SYXSynWH7803_1460(gap3)
CYACYA_2179(gap-3)
CYBCYB_2306(gap-3)
SYNESyn6312_2449
SYNPSyn7502_00085
SYNRKR49_04380
SYNDKR52_07105
SYHSyncc8109_0834(gap3)
SYNWSynWH8103_00910(gap3)
SYNCCB0101_01150
SYNYBM449_08220
SYWSYNW0799(gap3)
CGCCyagr_1440
CYICBM981_1542(gap)
PMAPro_1577(gap3)
PMMPMM0713(gap1)
PMTPMT_1000
PMNPMN2A_0445
PMIPMT9312_0725
PMFP9303_11051(gap3)
PMGP9301_12361(gap3)
PMENATL1_11571(gap3)
PRCEW14_1292
PRMEW15_1164 EW15_1470
CMPCha6605_3999
SLWBRW62_07355
THNNK55_06405(gap)
THECFFX45_03525
LETO77CONTIG1_03975(gap3)
LBOLBWT_7080
KOVK9N68_37080
LSCKIK02_21190
LSKJ5X98_01755
PSERABRG53_3495(gap3)
THEUHPC62_11055
GENGM3709_1018
GEEGM3708_3028
CANCyan10605_0608
CSNCyast_0739
CYLAA637_12150(gapA)
CYNCyan7425_0669
TERTery_3274
ANAalr1095(gap3)
NOPNos7524_1610
NOECLI64_20610(gap)
NSHGXM_05961
NEDHUN01_18280
AVAAva_3715
ANBANA_C13129(gap)
ACYAnacy_5045
AWAAA650_12815
ANNEH233_29050
CALOCal7507_1012
CALTCal6303_5003
CALHIJ00_10890
NSPBMF81_03610(gapA)
NSPHBDGGKGIB_01144(gap3)
DOUBMF77_03708(gap3)
DFSHGD76_23330
CCURIAR63_16740
CRKL3I90_08945
AFLOHEQ12_11085
CTHEChro_2847
RRSRoseRS_1226
RCARcas_2314
CAUCaur_0010
CHLChy400_0011
CAGCagg_3678
HAUHaur_3331
OBGVerru16b_00790(gap3)
VBHCMV30_05700(gap)
SOAG3M56_008415
SPEREW093_01455
CDESC0J27_01295
 » show all
Reference
1  [PMID:26991003]
  Authors
Chen J, Yoshinaga M, Garbinski LD, Rosen BP.
  Title
Synergistic interaction of glyceraldehydes-3-phosphate dehydrogenase and ArsJ, a novel organoarsenical efflux permease, confers arsenate resistance.
  Journal
Mol Microbiol 100:945-53 (2016)
DOI:10.1111/mmi.13371
  Sequence
Reference
2  [PMID:29717010]
  Authors
Wu S, Wang L, Gan R, Tong T, Bian H, Li Z, Du S, Deng Z, Chen S
  Title
Signature Arsenic Detoxification Pathways in Halomonas sp. Strain GFAJ-1.
  Journal
mBio 9:e00515-18 (2018)
DOI:10.1128/mBio.00515-18
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.107
IUBMB Enzyme Nomenclature: 1.2.1.107
ExPASy - ENZYME nomenclature database: 1.2.1.107
BRENDA, the Enzyme Database: 1.2.1.107

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