KEGG   ENZYME: 1.2.1.30Help
Entry
EC 1.2.1.30                 Enzyme                                 

Name
carboxylate reductase (NADP+);
aromatic acid reductase;
aryl-aldehyde dehydrogenase (NADP+)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
aryl-aldehyde:NADP+ oxidoreductase (ATP-forming)
Reaction(IUBMB)
an aromatic aldehyde + NADP+ + AMP + diphosphate = an aromatic acid + NADPH + H+ + ATP [RN:R01490]
Reaction(KEGG)
Substrate
aromatic aldehyde [CPD:C00193];
NADP+ [CPD:C00006];
AMP [CPD:C00020];
diphosphate [CPD:C00013]
Product
aromatic acid [CPD:C00539];
NADPH [CPD:C00005];
H+ [CPD:C00080];
ATP [CPD:C00002]
Comment
The enzyme contains an adenylation domain, a phosphopantetheinyl binding domain, and a reductase domain, and requires activation by attachment of a phosphopantetheinyl group. The enzyme activates its substrate to an adenylate form, followed by a transfer to the phosphopantetheinyl binding domain. The resulting thioester is subsequently transferred to the reductase domain, where it is reduced to an aldehyde and released.
History
EC 1.2.1.30 created 1972, modified 2019
Reference
1  [PMID:4389863]
  Authors
Gross GG, Zenk MH.
  Title
[Reduction of aromatic acids to aldehydes and alcohols in the cell-free system. 1. Purification and properties of aryl-aldehyde: NADP-oxidoreductase from Neurospora crassa]
  Journal
Eur J Biochem 8:413-9 (1969)
DOI:10.1111/j.1432-1033.1969.tb00543.x
Reference
2  [PMID:4405494]
  Authors
Gross GG.
  Title
Formation and reduction of intermediate acyladenylate by aryl-aldehyde. NADP oxidoreductase from Neurospora crassa.
  Journal
Eur J Biochem 31:585-92 (1972)
DOI:10.1111/j.1432-1033.1972.tb02569.x
Reference
3  [PMID:17102130]
  Authors
Venkitasubramanian P, Daniels L, Rosazza JP
  Title
Reduction of carboxylic acids by Nocardia aldehyde oxidoreductase requires a phosphopantetheinylated enzyme.
  Journal
J Biol Chem 282:478-85 (2007)
Reference
4  [PMID:28223183]
  Authors
Stolterfoht H, Schwendenwein D, Sensen CW, Rudroff F, Winkler M
  Title
Four distinct types of E.C. 1.2.1.30 enzymes can catalyze the reduction of carboxylic acids to aldehydes.
  Journal
J Biotechnol 257:222-232 (2017)
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.30
IUBMB Enzyme Nomenclature: 1.2.1.30
ExPASy - ENZYME nomenclature database: 1.2.1.30
BRENDA, the Enzyme Database: 1.2.1.30
CAS: 9074-94-6

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