KEGG ENZYME: 1.2.1.4

ENZYME: 1.2.1.4

Entry

EC 1.2.1.4 Enzyme

Name

aldehyde dehydrogenase (NADP+);
NADP-acetaldehyde dehydrogenase;
NADP-dependent aldehyde dehydrogenase;
aldehyde dehydrogenase (NADP)

Class

Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor

Sysname

aldehyde:NADP+ oxidoreductase

Reaction(IUBMB)

an aldehyde + NADP+ + H2O = a carboxylate + NADPH + H+ [RN:R00634]

Reaction(KEGG)

R00634 > R00711 R05099

Substrate

aldehyde [CPD:C00071];
NADP+ [CPD:C00006];
H2O [CPD:C00001]

Product

carboxylate [CPD:C00060];
NADPH [CPD:C00005];
H+ [CPD:C00080]

History

EC 1.2.1.4 created 1961

Pathway

ec00930

Caprolactam degradation

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K14519

NADP-dependent aldehyde dehydrogenase

Genes

POL:

AAV:

AAA:

PDE:

HBA:

MGO:	AFA91_18385

NBR:	O3I_014410

RHA:	RHA1_ro02898 RHA1_ro08151

REB:	XU06_29340

ROP:	ROP_04960 ROP_33690

ROA:	Pd630_LPD07647

GPO:	GPOL_c08310

SCO:	SCO1871(SCI39.18c)

SALB:

XNR_4954

SMA:	SAVERM_6389

SGR:	SGR_1630 SGR_5625

SGB:

WQO_07195

SCB:	SCAB_70651

SSX:	SACTE_1304

SVL:	Strvi_6068 Strvi_6961

SCT:	SCAT_1069(aldH)

SCY:	SCATT_10640

SFA:

Sfla_4940

SBH:

SBI_08125

SHY:

SHJG_3333

SHO:	SHJGH_3098

SVE:

SVEN_1516

SDV:	BN159_6637

SALS:

SLNWT_3889 SLNWT_5169

STRP:

F750_1741

SFI:

SFUL_1445

SCI:	B446_09735

SRC:	M271_36920 M271_42100

SALU:

DC74_2375

SALL:

SAZ_13230

SLV:	SLIV_28360

SGU:	SGLAU_08360

SVT:	SVTN_09040

STRE:

GZL_06632

SCW:	TU94_07955

SXI:	SXIM_08460

STRM:

M444_09735

STRC:

AA958_05410

SAMB:

SAM23877_1946(aldH)

SPRI:

SPRI_6598

SCZ:	ABE83_05080 ABE83_28580

SCX:	AS200_33840

SRW:	TUE45_02355(aldH)

STRF:

ASR50_09120

SLE:	sle_52630(sle_52630)

SRN:	A4G23_01098(aldH)

SNR:	SNOUR_30860

CMI:

CMM_0812

CMS:

CMS0069

MCW:	A8L33_01720

MPAL:

BO218_08130 BO218_12285

AGY:	ATC03_04975 ATC03_15645

ART:

Arth_3335

ARR:	ARUE_c34530(aldH)

ARM:

ART_2596

ARE:	AL755_00525

AAQ:	AOC05_16125

ARW:	MB46_17645

ARZ:	AUT26_15885

ARI:	UM93_13775

AAU:	AAur_3317(aldH)

ACH:

Achl_3135

APN:	Asphe3_32640

PSUL:

AU252_14625

RSA:	RSal33209_1814

BCV:

Bcav_0786

LMOI:

VV02_11040

MPH:	MLP_07890 MLP_19760

NCA:

KFL:

TFU:

NDA:

NAL:

SRO:

FRE:	Franean1_4676

GOB:

Gobs_2395

SEN:	SACE_1997 SACE_2783

AMD:

AMN:

AMM:

AMZ:

AOI:	AORI_3623(aldH) AORI_4998(aldH)

AJA:	AJAP_14530 AJAP_21020

AMQ:	AMETH_6878

PDX:

Psed_4281

PHH:	AFB00_20980

AMI:	Amir_1484 Amir_4721

KAL:

KALB_6874

KPHY:

AOZ06_14455

LED:	BBK82_01545 BBK82_46985

AHM:	TL08_12515

ACTI:

UA75_13535

ACAD:

UA74_13450

AMS:	AMIS_59920

CAI:

Caci_7805

SNA:

Snas_4113

TBI:	Tbis_1086 Tbis_1743

CWO:

Cwoe_3952

RBA:

RB1887

FTE:	Fluta_2463

» show all

Reference

Authors

Adachi, O., Matsushita, K., Shinagawa, E. and Ameyama, M.

Title

Crystallization and properties of NADP-dependent aldehyde dehydrogenase from Gluconobacter melanogenus.

Journal

Agric Biol Chem 44:155-164 (1980)

Reference

Authors

Jakoby, W.B.

Title

Aldehyde dehydrogenases.

Journal

In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 203-221.

Reference

Authors

Nakayama, T.

Title

Acetic acid bacteria. II. Intracellular distribution of enzymes related to acetic acid fermentation, and some properties of a highly purified triphosphopyridine nucleotide (TPN)-dependent aldehyde dehydrogenase.

Journal

J Biochem (Tokyo) 48:812-830 (1960)

Reference

4 [PMID:13061400]

Authors

SEEGMILLER JE.

Title

Triphosphopyridine nucleotide-linked aldehyde dehydrogenase from yeast.

Journal

J Biol Chem 201:629-37 (1953)

Other DBs

ExplorEnz - The Enzyme Database:

1.2.1.4

IUBMB Enzyme Nomenclature:

1.2.1.4

ExPASy - ENZYME nomenclature database:

1.2.1.4

BRENDA, the Enzyme Database:

1.2.1.4

CAS:

9028-87-9

DBGET integrated database retrieval system