KEGG ENZYME: 1.2.1.4

ENZYME: 1.2.1.4

Entry

EC 1.2.1.4                  Enzyme

Name

aldehyde dehydrogenase (NADP+);
NADP-acetaldehyde dehydrogenase;
NADP-dependent aldehyde dehydrogenase;
aldehyde dehydrogenase (NADP)

Class

Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor

Sysname

aldehyde:NADP+ oxidoreductase

Reaction(IUBMB)

an aldehyde + NADP+ + H2O = a carboxylate + NADPH + H+ [RN:R00634]

Reaction(KEGG)

R00634 > R00711 R05099

Substrate

aldehyde [CPD:C00071];
NADP+ [CPD:C00006];
H2O [CPD:C00001]

Product

carboxylate [CPD:C00060];
NADPH [CPD:C00005];
H+ [CPD:C00080]

History

EC 1.2.1.4 created 1961

Pathway

ec00930

Caprolactam degradation

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K14519

NADP-dependent aldehyde dehydrogenase

Genes

POL:

Bpro_2298

AAV:

Aave_0115

PDE:

Pden_3264

HBA:

Hbal_2501

MGO:	AFA91_18385

MMAG:

MMAD_17910

MTY:	MTOK_16350

MMAT:

MMAGJ_18140

CSUR:

N24_0341(aldH)

CCYC:

SCMU_32610

NBR:	O3I_014410

NOZ:	DMB37_12025

NAH:	F5544_03970 F5544_18980

NIE:	KV110_32105

RHA:	RHA1_ro02898 RHA1_ro08151

REB:	XU06_29340

ROP:	ROP_04960 ROP_33690

ROA:	Pd630_LPD01864 Pd630_LPD07647

RPY:	Y013_12795

RKO:	JWS14_15360 JWS14_29370

GPO:	GPOL_c08310

GAM:	GII34_11230

SCO:	SCO1871(SCI39.18c)

SALB:

XNR_4954

SMA:	SAVERM_6389

SGR:

SGR_5625

SGB:

WQO_07195

SCB:	SCAB_70651

SSX:	SACTE_1304

SVL:	Strvi_6068 Strvi_6961

SHY:

SHJG_3333

SHO:	SHJGH_3098

SRC:	M271_36920 M271_42100

SMAL:

SMALA_1828

SSOI:

I1A49_12290

SCT:	SCAT_1069(aldH)

SCY:	SCATT_10640

SFA:

Sfla_4940

SBH:

SBI_08125

SVE:

SVEN_1516

SDV:	BN159_6637

SALS:

SLNWT_3889 SLNWT_5169

STRP:

F750_1741

SFI:

SFUL_1445

SCI:	B446_09735

SALU:

DC74_2375

SALL:

SAZ_13230

SLV:	SLIV_28360

SGU:	SGLAU_08360

SVT:	SVTN_09040

STRE:

GZL_06632

SCW:	TU94_07955

SXI:	SXIM_08460

STRM:

M444_09735

STRC:

AA958_05410

SAMB:

SAM23877_1946(aldH)

SPRI:

SPRI_5639 SPRI_6598

SCZ:	ABE83_05080 ABE83_28580

SCX:	AS200_33840

SRW:	TUE45_02355(aldH)

STRF:

ASR50_09120

SLE:	sle_52630(sle_52630)

SRN:	A4G23_01098(aldH)

SPAV:

Spa2297_07475

STRT:

A8713_06920

SGS:	AVL59_36200

STSI:

A4E84_09445

SKY:	D0C37_26780

SALW:

CP975_07930

SGM:	GCM10017557_63870

SCAD:

DN051_29150

SLS:	SLINC_2143

SNR:	SNOUR_30860

SPLU:

LK06_006345

STRD:

NI25_29855

SNW:	BBN63_27130

SAUO:

BV401_12610

SSIA:

A7J05_27570

SPUN:

BFF78_31920

SALF:

SMD44_02024(aldH)

SLX:	SLAV_28055(aldH)

SFK:

KY5_1790c

SNZ:	DC008_07595

SGE:	DWG14_06529(aldH)

SLK:	SLUN_09055

SDX:	C4B68_30950

SGD:	ELQ87_30185

SCYA:

EJ357_10760

SAST:

CD934_26295

SNQ:	CP978_09035

SKA:	CP970_33710

SGZ:	C0216_22605

SVN:	CP980_25430

SNK:	CP967_26925

SHAW:

CEB94_09900

SFIC:

EIZ62_25730

SGAL:

CP966_08010

SPAD:

DVK44_05385

SFY:	GFH48_30745

SAQU:

EJC51_12510

SGF:	HEP81_07415

SCAV:

CVT27_06070

SSEO:

D0Z67_06320

SBY:	H7H31_27955

SRIM:

CP984_31595

SSUB:

CP968_25250

SPHV:

F9278_09390 F9278_41905

SCIN:

CP977_08425

SFUG:

CNQ36_08105

SPAC:

B1H29_28125

SCHA:

CP983_33330

SGX:	H4W23_09490

SCOE:

CP976_10630

SBAT:

G4Z16_27200 G4Z16_31395

SSPB:

CP982_11050

SNF:	JYK04_02543(aldH)

SPLA:

CP981_09390

SBRO:

GQF42_12225

STUI:

GCM10017668_14690

SATA:

C5746_10310

SCHF:

IPT68_08685

SHUN:

DWB77_05847(aldH)

SHAR:

HUT13_04790

SCYG:

S1361_10270(aldH)

SFEU:

IM697_12885

SLIA:

HA039_26585

SDW:	K7C20_08905

SVD:	CP969_10400 CP969_21185

SAUH:

SU9_007405

SFB:	CP974_05695

SPRA:

CP972_08485

SROI:

IAG44_31050

SXN:	IAG42_27470

SGJ:	IAG43_06880

SHK:	J2N69_07750

SANU:

K7396_27430

SDD:	D9753_27385

SACT:

DMT42_08595

SMAO:

CAG99_10430 CAG99_23505

SINE:

KI385_12000

SLF:	JEQ17_35575

SDEC:

L3078_10880

SAOV:

G3H79_29000

KAB:	B7C62_06205

YIA:	LO772_29230

LEIF:

HF024_03025 HF024_15475 HF024_15560

LSE:	F1C12_02900

CMI:

CMM_0812

CMS:

CMS0069

CMC:

CMN_00768

CMH:	VO01_12315

CZH:	H9X71_03675

CPHA:

FGI33_09290

MCW:	A8L33_01720

MPAL:

BO218_08130 BO218_12285

MPRT:

ET475_03200

MCHN:

HCR76_14865

MICS:

C1N74_02830 C1N74_14770

AGY:	ATC03_04975 ATC03_15645

AARC:

G127AT_04820

AMAU:

DSM26151_06040 DSM26151_17850(aldH)

ASOI:

MTP13_01615

LEB:	G7066_05385

LDN:	H9L06_03900

LVI:	G7068_14510 G7068_14680

LLUT:

K1X41_04820

HEA:	HL652_16540 HL652_20135

GLN:	F1C58_00235

GSD:	M3M28_01495

ART:

Arth_3335

ARR:	ARUE_c34530(aldH)

ARM:

ART_2596

ARE:	AL755_00525

AAQ:	AOC05_16125

ARW:	MB46_17645

ARZ:	AUT26_15885

ARI:	UM93_13775

AAU:	AAur_3317(aldH)

PUE:	FV140_17450

PNV:	JMY29_15825

ACH:

Achl_3135

APN:	Asphe3_32640

PSUL:

AU252_14625

GMY:

XH9_10795

RSA:	RSal33209_1814

BCV:

Bcav_0786

LMOI:

VV02_11040

HALT:

IM660_17765

RHAL:

LQF10_17490

RSUA:

LQF12_15025

NCA:

Noca_0086

MUZ:	H4N58_00735

KFL:

Kfla_6632

KQI:	F1D05_17890

TFU:

Tfu_1706

THAO:

NI17_003845

TALX:

FOF52_07935

NDA:

Ndas_5346

NAL:

B005_1809

NFE:	HUT17_01055

NEX:	NE857_16965 NE857_33615

SAIU:

J4H86_15000

SRO:

Sros_1486

NCX:	Nocox_10180(aldH)

NGN:	LCN96_11480

TBI:	Tbis_1086 Tbis_1743

FRE:	Franean1_4676

GOB:

Gobs_2395

BSD:	BLASA_1682(aldH)

SEN:	SACE_1997 SACE_2783

SACG:

FDZ84_03090

AMD:

AMED_5971

AMN:

RAM_30625

AMM:

AMES_5887

AMZ:

B737_5887

AOI:	AORI_3623(aldH) AORI_4998(aldH)

AJA:	AJAP_14530 AJAP_21020

AMQ:	AMETH_6878

AMYB:

BKN51_17445

AORI:

SD37_24610

AACD:

LWP59_12210 LWP59_13140 LWP59_13260

APRT:

MUY14_06015

PHH:	AFB00_20980

AMI:	Amir_1484 Amir_4721

KAL:

KALB_6874

KPHY:

AOZ06_14455

LED:	BBK82_01545 BBK82_46985

AHM:	TL08_12515

ACTI:

UA75_13535

ACAD:

UA74_13450

ACTU:

Actkin_02660(aldH)

AMS:	AMIS_59920

AIH:	Aiant_90370

ATL:	Athai_51790

ASER:

Asera_23020

PRY:	Prubr_70620

NHY:	JQS43_03115 JQS43_13575

CAI:

Caci_7805

SNA:

Snas_4113

NAV:	JQS30_15595

JTL:	M6D93_07025

CWO:

Cwoe_3952

RBA:

RB1887

» show all

Reference

Authors

Adachi, O., Matsushita, K., Shinagawa, E. and Ameyama, M.

Title

Crystallization and properties of NADP-dependent aldehyde dehydrogenase from Gluconobacter melanogenus.

Journal

Agric Biol Chem 44:155-164 (1980)

Reference

Authors

Jakoby, W.B.

Title

Aldehyde dehydrogenases.

Journal

In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 203-221.

Reference

Authors

Nakayama, T.

Title

Acetic acid bacteria. II. Intracellular distribution of enzymes related to acetic acid fermentation, and some properties of a highly purified triphosphopyridine nucleotide (TPN)-dependent aldehyde dehydrogenase.

Journal

J Biochem (Tokyo) 48:812-830 (1960)

Reference

4 [PMID:13061400]

Authors

SEEGMILLER JE.

Title

Triphosphopyridine nucleotide-linked aldehyde dehydrogenase from yeast.

Journal

J Biol Chem 201:629-37 (1953)

Other DBs

ExplorEnz - The Enzyme Database:

1.2.1.4

IUBMB Enzyme Nomenclature:

1.2.1.4

ExPASy - ENZYME nomenclature database:

1.2.1.4

BRENDA, the Enzyme Database:

1.2.1.4

CAS:

9028-87-9

DBGET integrated database retrieval system