KEGG   ENZYME: 1.2.1.58Help
Entry
EC 1.2.1.58                 Enzyme                                 

Name
phenylglyoxylate dehydrogenase (acylating)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
phenylglyoxylate:NAD+ oxidoreductase
Reaction(IUBMB)
phenylglyoxylate + NAD+ + CoA = benzoyl-S-CoA + CO2 + NADH [RN:R02450]
Reaction(KEGG)
Substrate
phenylglyoxylate [CPD:C02137];
NAD+ [CPD:C00003];
CoA [CPD:C00010]
Product
benzoyl-S-CoA;
CO2 [CPD:C00011];
NADH [CPD:C00004]
Comment
Requires thiamine diphosphate as cofactor. The enzyme from the denitrifying bacterium Azoarcus evansii is specific for phenylglyoxylate. 2-Oxoisovalerate is oxidized at 15% of the rate for phenylglyoxylate. Also reduces viologen dyes. Contains iron-sulfur centres and FAD.
History
EC 1.2.1.58 created 1999
Pathway
ec00360  Phenylalanine metabolism
ec01100  Metabolic pathways
Orthology
K18355  phenylglyoxylate dehydrogenase alpha subunit
K18356  phenylglyoxylate dehydrogenase beta subunit
K18357  phenylglyoxylate dehydrogenase gamma subunit
K18358  phenylglyoxylate dehydrogenase delta subunit
K18359  phenylglyoxylate dehydrogenase epsilon subunit
Genes
SHD: SUTH_01625(padE) SUTH_01626(padF) SUTH_01627(padG) SUTH_01628(padH) SUTH_01629(padI)
EBA: ebA5397(padE) ebA5399(padG) ebA5400(padH) ebA5401(padI) ebB191(padF)
AZA: AZKH_2897(padI) AZKH_2898(padH) AZKH_2899(padG) AZKH_2900(padF) AZKH_2901(padE)
AZI: AzCIB_2838 AzCIB_2839 AzCIB_2840 AzCIB_2841 AzCIB_2842
AZD: CDA09_15475 CDA09_15480 CDA09_15485 CDA09_15490 CDA09_15495
TMZ: Tmz1t_2962 Tmz1t_2963 Tmz1t_2964 Tmz1t_2965 Tmz1t_2966
TCL: Tchl_2132 Tchl_2133 Tchl_2134 Tchl_2135 Tchl_2136
TAK: Tharo_1290 Tharo_1291 Tharo_1292 Tharo_1293 Tharo_1294
DTO: TOL2_C41570(padE2) TOL2_C41580(padF2) TOL2_C41590(padG2) TOL2_C41600(padH2) TOL2_C41610(padI2)
RPD: RPD_1510 RPD_1511 RPD_1512 RPD_1513 RPD_1514
MAGX: XM1_3886(padI) XM1_3887(padH) XM1_3888(padG) XM1_3889 XM1_3890(padE)
 » show all
Taxonomy
Reference
1  [PMID:9490067]
  Authors
Hirsch W, Schagger H, Fuchs G.
  Title
Phenylglyoxylate:NAD+ oxidoreductase (CoA benzoylating), a new enzyme of anaerobic phenylalanine metabolism in the denitrifying bacterium Azoarcus evansii.
  Journal
Eur J Biochem 251:907-15 (1998)
DOI:10.1046/j.1432-1327.1998.2510907.x
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.58
IUBMB Enzyme Nomenclature: 1.2.1.58
ExPASy - ENZYME nomenclature database: 1.2.1.58
BRENDA, the Enzyme Database: 1.2.1.58
CAS: 205510-78-7

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