KEGG   ENZYME: 1.2.1.59
Entry
EC 1.2.1.59                 Enzyme                                 
Name
glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating);
triosephosphate dehydrogenase (NAD(P));
glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
D-glyceraldehyde 3-phosphate:NAD(P)+ oxidoreductase (phosphorylating)
Reaction(IUBMB)
D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H + H+ [RN:R01061 R01063]
Reaction(KEGG)
R01061 R01063
Substrate
D-glyceraldehyde 3-phosphate [CPD:C00118];
phosphate [CPD:C00009];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
3-phospho-D-glyceroyl phosphate [CPD:C00236];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
NAD+ and NADP+ can be used as cofactors with similar efficiency, unlike EC 1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) and EC 1.2.1.13 glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating), which are NAD+- and NADP+-dependent, respectively.
History
EC 1.2.1.59 created 1999
Pathway
ec00010  Glycolysis / Gluconeogenesis
ec00710  Carbon fixation in photosynthetic organisms
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K00150  glyceraldehyde-3-phosphate dehydrogenase (NAD(P))
Genes
RTHLRK53_00195
PAEUBN889_06934
MARIACP86_11820
MLQASQ50_01600
MARAD0851_08505
HAMHALO1614
AESC2U30_09530
GBIPG2T_06825
AJSAjs_2165 Ajs_2680
ACKC380_06000
ACIDCBP33_07180
ACIPCBP36_07750
ACINCBP34_07080
ACISCBP35_11180
ADKAlide2_2718
HYBQ5W_09960
DAERH9K75_10745
NIINit79A3_0299
DMSE8L03_13200
PBIZLWC08_01530
MESOBSQ44_04110
MESMeso_3884
HOEIMCC20628_04816
RFVRFYW14_04370 RFYW14_04401
CHELAL346_10520
RBMTEF_02830
PZUPHZ_p0131
BDMEQG53_12075
BPONIFE19_05335
OCTFTO60_05960
RMMROSMUCSMR3_04172
ROKRAK1035_4112
NPPPP1Y_AT23129
NPNJI59_04860
SPKCKC8_13855
ALBAEB_P2665
AAYWYH_02517
CNAAB433_14790
CMANA9D14_19235
ERYCP97_05610
TABCIG75_00835 CIG75_00840
CALEFDN13_09895
CLOHMPREF0868_0016
CTHDCDO33_05860
CMQB840_12970(gapB2)
CXEFOB82_06210
CCOECETAM_13710
RBYCEJ39_01370
SGSAVL59_12505
MOYCVS54_03751
ARUASPU41_16435
ARXARZXY2_1270(gap2)
PUEFV140_12360
KFVAS188_15125
KRSEQG70_01390 EQG70_08545
MLUMlut_18410
MICKB1A86_00003170
BRIFDF13_14435
DEMLGT36_011325
RUBGBA63_18820
ATQGH723_02740 GH723_03070 GH723_14930
IAMHC251_18695
SYNsll1342(gap2)
SYZMYO_129570(gap2)
SYYSYNGTS_2929(gap2)
SYTSYNGTI_2928(gap2)
SYSSYNPCCN_2927(gap2)
SYQSYNPCCP_2927(gap2)
SYJD082_08170(gap2)
SYOC7I86_15305(gap)
SYCsyc2349_c(gap2)
SYUM744_07770
SYFSynpcc7942_1742
SYDSyncc9605_0030
SYESyncc9902_0026
SYGsync_0029(gap-1)
SYRSynRCC307_0028(gap1)
SYXSynWH7803_0029(gap1)
SYPSYNPCC7002_A0106(gap)
CYACYA_0325(gap-2)
CYBCYB_1704(gap-2)
SYNESyn6312_3152
SYNPSyn7502_02294
SYNKKR100_00955(gapA)
SYNRKR49_09050(gapA)
SYNDKR52_02330(gapA)
SYHSyncc8109_0030(gap2)
SYNWSynWH8103_00029(gap2)
SYVAWQ23_00670
SYLAWQ21_00535
SYNCCB0101_08410(gap)
DSLDacsa_1284
SYWSYNW0030(gap2)
CGCCyagr_2332
CYICBM981_2391(gap)
PMAPro_0023(gap2)
PMMPMM0023(gap2)
PMTPMT_0028
PMNPMN2A_1350
PMIPMT9312_0023
PMBA9601_00221(gap2)
PMCP9515_00221(gap2)
PMFP9303_00271(gap2)
PMGP9301_00221(gap2)
PMHP9215_00221(gap2)
PMJP9211_00231(gap2)
PMENATL1_00221(gap2)
PRCEW14_0023
PRMEW15_0024
CMPCha6605_3592
AMRAM1_4369(gapA)
TVNNIES2134_101900
TELtll1466
THNNK55_02785(gap2)
THECFFX45_10850
LEPLepto7376_0133
LENLEP3755_20840
LETO77CONTIG1_02614(gap2)
LBOLBWT_1060
KOVK9N68_28790
LSCKIK02_14375
LSKJ5X98_19790
HHGXM38_038250(gap2)
PSEUPse7367_0081
PSERABRG53_3610(gap2)
THEUHPC62_02625
GLPGlo7428_3592
GENGM3709_2641
GEEGM3708_2476
CHONNIES4102_22850
MARMAE_25030
MPKVL20_4417
MIQB5D77_14075
MVZmyaer102_01830
CANCyan10605_3072
CSNCyast_1687
CYLAA637_07255(gap2)
HAOPCC7418_0720
ENNFRE64_10595
CWACwatDRAFT_0980
CYPPCC8801_2557
CYHCyan8802_3549
CYCPCC7424_2221
CYJCyan7822_4638
CYNCyan7425_0946
TERTery_4030
ARPNIES39_C00270(gap)
PAGHNIES204_17160
OXYHCG48_22255
MVAGD0A34_01280
LFSHFV01_12805
MICMic7113_2091
GEIGEI7407_2652
OACOscil6304_0603
ONIOsc7112_4898
MPROBJP34_06935
PHORJWS08_01090
CEPCri9333_2336
GVIglr0530(gap1)
GLJGKIL_1218(gap2)
GMLISF26_16420
ANAall5062(gap2)
NPUNpun_R0444
NOSNos7107_2266
NOPNos7524_5283
NONNOS3756_28700
NFLCOO91_05459
NOECLI64_04785(gap)
NSHGXM_00760
NEDHUN01_22660
AVAAva_2318
NAZAazo_0813
ANBANA_C12497
ACYAnacy_0265
AWAAA650_19390
ANNEH233_22995
CSGCylst_5376
RSINB6N60_04277
CALOCal7507_0037
CALTCal6303_4016
CALHIJ00_23650
RIVRiv7116_0750
FISFIS3754_36610
DOUBMF77_04217(gap2)
DFSHGD76_19170
CCURIAR63_07465
AFLOHEQ12_07585
TOQHCG51_06105
NCNBZZ01_26190
CTHEChro_4726
PLPPle7327_4413
SCSSta7437_0238
STANSTA3757_01250
CERRGRSB_1341
DLYDehly_0804
DFODform_01359(gap2)
PSUBPelsub_P0893
ABAOBEQ56_08940
PMETG4Y79_01775 G4Y79_01975
MTAIMtai_v1c29420
TPITREPR_0394
SSMSpirs_0990
SCCSpico_0086
SGPSpiGrapes_3134
BHCJFL75_19805
MCOSGM418_19695
CMRCycma_4563 Cycma_4565
EVIEchvi_3157
PACTCA264_20790
MTTFtrac_2076
GFLGRFL_3040
GRSC7S20_15660
ZPRZPR_3400
MARBCJ263_11960
MUTGVT53_06155 GVT53_12320
MAQILDL77_01660
AICJK629_07220
LULLPB138_11440
SALTAO058_13725
SMISLDL76_13055
AALGAREALGSMS7_02355
KANIMCC3317_19460
EMARD1013_07590
AFLAFHG64_12925
ANPFK178_05205
OCIFEZ18_08560
BIAGMA17_05940
EGMAYC65_17730
ELZFCS00_02350
CCAUEG346_07265
CLACEG342_04495
CCASEIB73_11960
KHIEG338_04420
KOLKole_0996
KPFIX53_05910
CAQAMICH65_0245
MJAMJ_1146
MFEMefer_0809
MVUMetvu_0390
MFSMFS40622_0779
MIFMetin_0953
MJHJH146_0701
MESGMLAUSG7_1031(gap)
MESAMLASG1_0746(gap)
MIGMetig_1019
MMPMMP0325
MMQMmarC5_1348
MMXMmarC6_0626
MMZMmarC7_1327
MMDGYY_01675
MMAKMMKA1_03330(gap)
MMAOMMOS7_03600(gap)
MMADMMJJ_07330
MAEMaeo_0627
MVNMevan_1336
MVOMvol_1211
MOKMetok_0880
METFCFE53_02475
MTHMTH_1009
MMGMTBMA_c13910(gap)
METCMTCT_0917
MWOMWSIV6_1395(gap)
METEtca_00970
METZMETMT2_1035
METKFVF72_06565
MTHMFZP57_06665
METJFZP68_03995
MSTMsp_1346(gap)
METBAW729_08800
MRUmru_1856(gap)
MSIMsm_0962
MEBAbm4_1478(gap)
MMILsm9_1923(gap)
MEYETL18_09080
MOLYLM1_1311
MAROMarbSA_16210
MELMetbo_1751 Metbo_2379
MEWMSWAN_0266
METHMBMB1_0326(gap)
MFCBRM9_1942(gap)
MFIDSM1535_0130(gap)
MCUBMCBB_0298(gap)
MSUBBK009_11810
METNBK008_07445
METTCIT01_02770
METOCIT02_05215
MEMEHYG87_04475
MFVMfer_0276
MKAMK0618(gapA)
AFUAF_1732
AFGAFULGI_00019830
APOArcpr_0732
AVEArcve_0098
ASTAsulf_01633
FPLFerp_1302
GACGACE_0477
GAHGAH_01734
PFUPF1874
PFIPFC_09215
PHOPH1830(PH1830)
PABPAB0257(gap)
PYNPNA2_0429
PYAPYCH_00860
PYSPy04_1761
PYCTQ32_07585
TKOTK0765
TONTON_0639
TGATGAM_1667(gap)
TSITSIB_0949
TBATERMP_00454
THEGQS_01790
THATAM4_1537
THMCL1_0086
TLTOCC_07249
THSTES1_0542
TNUBD01_0756
TEUTEU_08915
TGYX802_01260
THVADU37_CDS06300
TCHCHITON_2116
TPEPA0127_01245
TPIEA7C91_09215
TGGA3K92_02135
TCEA3L02_04215
TBSA3L01_03935
THHCDI07_03850
TSLA3L11_07910
TTDA3L14_05775
TPRFA3L09_07370
TRLA3L10_02640
TPAFA3L08_07140
THYA3L12_05115
TICFH039_07480
TCQTIRI35C_1030(gap)
THEMFPV09_01960
PPACPAP_02855
MBAMbar_A2189 Mbar_A3564
MBYMSBRM_1921 MSBRM_2242
MBWMSBRW_1171 MSBRW_2552
MBARMSBR2_0167 MSBR2_0489
MBAKMSBR3_1050 MSBR3_1146
MACMA_1018(gap) MA_3345(gap)
MMAMM_2782
MMAZMmTuc01_2831
MMJMSMAS_1945
MMACMSMAC_1180
MVCMSVAZ_2027
MEKMSKOL_2005
MLSMSLAZ_1558
METMMSMTP_1360
MEFMSWH1_1524
MEQMSWHS_1783
MSJMSSAC_2557 MSSAC_3452
MSZMSSIH_2160 MSSIH_2980
MSWMSSIT_2267 MSSIT_3037
MTHRMSTHT_0429
MTHEMSTHC_0292
MHORMSHOH_1621 MSHOH_2523
MFZAOB57_000070
MBUMbur_0851
MMETMCMEM_0983
MELOJ7W08_02765
MMHMmah_1159
MHAZBHR79_07740
MEVMetev_0436
MZHMzhil_1145
MPYMpsy_2902
MZIHWN40_08190
MHZMetho_0889
MTPMthe_0701
MCJMCON_2908
MHIMhar_1240
MHUMhun_2462
MRTJKHC33_16945
MLAMlab_1723
MEMMemar_2497
MBGBN140_2174(gapA) BN140_2612(gap)
MEMAMMAB1_3505(gap)
MCHKMchiMG62_02060
MPIMpet_2779
MBNMboo_1283 Mboo_2454
MFOMetfor_0186
MPLMpal_2790
MPDMCP_1270(gap-1) MCP_2688(gap-2)
MEZMtc_0299(gap)
RCIRCIX551(gap)
HALVNG_0095G(gapB) VNG_1297C
HSLOE_1154F(gap)
HDLHALDL1_03425
HHBHhub_1290(gap)
HAGSJT689_01830
HABOJRZ79_00320
HNOLT974_01205
HLULT972_12455
HANRLJ422_00440
HJEHacjB3_14555
HALHHTSR_0246(gapB)
HHSRHSR6_0233(gapB)
HSUHLASF_0350(gapB)
HSFHLASA_0349(gapB)
SALRFQU85_03300
HALREFA46_004935
HARAAArcS_0753(gapA)
HAADMW046_10245
HALXM0R89_08955
HMArrnAC2262(gapB)
HHIHAH_2730(gapA1)
HHNHISP_13880
HABSG26_06160
HTABVU17_13275
HALJG9465_04740
HSINKDQ40_15705
NPHNP_0012A(gap)
NMONmlp_1502(gap)
NHOHWV23_12045
NSALHWV07_09535
HMUHmuk_0529
HALZE5139_05775
HALLLC1Hm_3010(gapA)
HAZPGBQ70_05770
HALIBV210_06795
HRRHZS55_21670
HPELHZS54_25145
HLTI7X12_14950
HDOMUK72_04055
HWAHQ_1360A(gap1) HQ_2025A(gap3)
HWCHqrw_1421(gap1)
HVOHVO_0478(gap1)
HMEHFX_0444(gapA)
HGIABY42_02215
HALEG3A49_02475
HBOHbor_26990
HAQDU484_02720 DU484_18510
HAJDU500_01365 DU500_03125
HAERDU502_00920 DU502_16895
HRAEI982_12355 EI982_14035
HLMDV707_12960
HALMFCF25_09235
HLAHlac_1672
HALPDOS48_08135
HALBEKH57_01770
HEZZEO776_10940
HALQHrr1229_013600
HSSJ7656_06735
HSAIHPS36_12190
HAZZKI388_07820
SRUBC2R22_02160
HAEhalTADL_0684 halTADL_1211
HALNB4589_013915
HALGHUG10_00195
HALUHUG12_17725
HMPK6T50_13470
HREK6T36_13390
HRMK6T25_03305
HACBHbl1158_05285
HDFAArcSl_1168(gap2)
HAHHalar_3698
HTUHtur_0284
HDABB347_12400
HJTDVR14_08280
HALYHYG82_15175
HSALJMJ58_07805
HLOJ0X27_07560
HAKZJ0X25_07830
NMGNmag_2141(gap1)
HXAHalxa_1641
NATNJ7G_0220
NPENatpe_3640
NVRFEJ81_17405
NPLFGF80_16250
NAYHYG81_11655
NGENatgr_1664
HRUHalru_0450
NOUNatoc_0189
SALIL593_02145
SAIMK0C01_00965 K0C01_09710
HLRHALLA_06130
HLCCHINAEXTREME03235
NAJB1756_06065
NAGAArcMg_3369
NANAArc1_3275
NBGDV706_07920
NASGCU68_04815
NACAQV86_01560
MELUMTLP_05710
MEAMMU439_03870
TACTa1103
TVOTVG0444310(TVG0444310)
PTOPTO0742
FACFACI_IFERC01G1571
FAIFAD_0549
CDIVCPM_0301
TARTALC_01406
MAXMMALV_15110
MERMMINT_02260
MEARMpt1_c00900(gap)
MARCAR505_0154
ABIAboo_0431
ACFAciM339_0618
APEAPE_0171.1
ACJACAM_0134
SMRSmar_0241
SHCShell_0576
IHOIgni_1001
IISEYM_03900
DKADKAM_0185
DFDDesfe_0262
DMUDesmu_0845
TAGTagg_0301
THGTCELL_1375
HBUHbut_0939
PFMPyrfu_1285
PDLPyrde_1673
STOSTK_13560(gap)
SOHD1869_07630
SSOSSO0528(gap)
SOLSsol_1613
SSOASULA_1640
SSOLSULB_1641
SSOFSULC_1639
SSHIJ5U23_02852
SCASSACC_04390
SAISaci_1356
SACNSacN8_06615
SACRSacRon12I_06605
SACSSUSAZ_06485
SISLS215_1689
SIAM1425_1581
SIMM1627_1697
SIDM164_1578
SIYYG5714_1585
SINYN1551_1251
SIILD85_1789
SIHSiH_1548
SIRSiRe_1456
SICSiL_1458
SULABFU36_04430
SULEGFS03_08975
SULOGFS33_00760
SULLEWF20_08810
MSEMsed_1652
MCNMcup_0577
MHKDFR87_10480
MPRUDFR88_10010
MTENGWK48_01855
MJNMjAS7_2768
AHOAhos_1308
AMANB6F84_10980
ABRIDFR85_10240
ASULDFR86_09320
AAMBD1866_01455
ACIHHS5_27090
SACDHS1genome_0997
SAZOD1868_04885
CSTYKN1_25840
STEPIC006_1046
PAIPAE1740
PISPisl_1710
PCLPcal_0632
PASPars_0743
PYRP186_0070
POGPogu_1600
TNETneu_0730
PYWPYWP30_00779
CMACmaq_1790
TTNTTX_1534(gap)
TUZTUZN_2003
VDIVdis_1977
VMOVMUT_0389
TPETpen_0757 Tpen_1765
THELIG193_01405
ASCASAC_0892
ACIASE86_05130
CLGCalag_0739
FFOFFONT_0242
NMRNmar_0831
NKRNKOR_04585
NIDNPIRD3C_1371
NINNADRNF5_1235
NIWNisw_00595
NCLC5F47_04710
NOXC5F49_04620
NUEC5F50_06235
NIPNsoK4_03970
NCTNMSP_0789(gap)
NICDSQ20_04935
CSYCENSYa_0972
NGANgar_c16720(gap)
NVNNVIE_005380(gap)
NEVNTE_01905
TAANMY3_03314
NFNNFRAN_0723
NCVNCAV_1503(gap)
CSUCSUB_C1460
NBVT478_0731
TAHSU86_001980
NIUDSQ19_04860
NDVNDEV_1047(gap)
CCAINAS2_1284
KCRKcr_0230
BARCAOA65_1541(gap)
FLTSv326_0301
NCONLC1Nh_0135(gap)
 » show all
Reference
1
  Authors
Valverde, F., Losada, M. and Serrano, A.
  Title
Cloning by functional complementation in E. coli of the gap2 gene of Synechocystis PCC 6803 supports an amphibolic role for cyanobacterial NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase.
  Journal
In: P. Mathis (Ed.), Photosynthesis: From Light to Biosphere, vol. 1, Kluwer Academic Publishers, 1995, p. 959-962.
Reference
2  [PMID:9226260]
  Authors
Valverde F, Losada M, Serrano A
  Title
Functional complementation of an Escherichia coli gap mutant supports an amphibolic role for NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase of Synechocystis sp. strain PCC 6803.
  Journal
J Bacteriol 179:4513-22 (1997)
DOI:10.1128/JB.179.14.4513-4522.1997
  Sequence
[syn:sll1342]
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.59
IUBMB Enzyme Nomenclature: 1.2.1.59
ExPASy - ENZYME nomenclature database: 1.2.1.59
BRENDA, the Enzyme Database: 1.2.1.59
CAS: 39369-25-0

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