KEGG   ENZYME: 1.2.1.75
Entry
EC 1.2.1.75                 Enzyme                                 
Name
malonyl-CoA reductase (malonate semialdehyde-forming);
NADP-dependent malonyl CoA reductase;
malonyl CoA reductase (NADP);
malonyl CoA reductase (malonate semialdehyde-forming)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
malonate semialdehyde:NADP+ oxidoreductase (malonate semialdehyde-forming)
Reaction(IUBMB)
malonate semialdehyde + CoA + NADP+ = malonyl-CoA + NADPH + H+ [RN:R00740]
Reaction(KEGG)
R00740
Substrate
malonate semialdehyde [CPD:C00222];
CoA [CPD:C00010];
NADP+ [CPD:C00006]
Product
malonyl-CoA [CPD:C00083];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Requires Mg2+. Catalyses the reduction of malonyl-CoA to malonate semialdehyde, a key step in the 3-hydroxypropanoate and the 3-hydroxypropanoate/4-hydroxybutanoate cycles, autotrophic CO2 fixation pathways found in some green non-sulfur phototrophic bacteria and some thermoacidophilic archaea, respectively [1,2]. The enzyme from Sulfolobus tokodaii has been purified, and found to contain one RNA molecule per two subunits [3]. The enzyme from Chloroflexus aurantiacus is bifunctional, and also catalyses the next reaction in the pathway, EC 1.1.1.298 [3-hydroxypropionate dehydrogenase (NADP+)] [4].
History
EC 1.2.1.75 created 2009
Pathway
ec00640  Propanoate metabolism
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
Orthology
K14468  malonyl-CoA reductase / 3-hydroxypropionate dehydrogenase (NADP+)
K15017  malonyl-CoA/succinyl-CoA reductase (NADPH)
Genes
PALGHFP57_16700
SANDH3309_14805
POQKZX46_11630
RRSRoseRS_3201
RCARcas_2929
CAUCaur_2614
CHLChy400_2826
CAGCagg_1256
CTMCabther_B0159
CVLJ8C06_14250
CHLOJ8C02_13405
GGRHKW67_05060
STOSTK_21710(mcr_scr)
SOHD1869_11875(asd)
SSOSSO2178(asd-2)
SOLSsol_2908
SSOASULA_2921(asd)
SSOLSULB_2921(asd)
SSOFSULC_2918(asd)
SSHIJ5U23_00989
SCASSACC_21720
SAISaci_2147 Saci_2370
SACNSacN8_10450 SacN8_11535
SACRSacRon12I_10705 SacRon12I_11780
SACSSUSAZ_09800 SUSAZ_11160
SISLS215_2961
SIAM1425_2796
SIMM1627_2848
SIDM164_2777
SIYYG5714_2976
SINYN1551_3167
SIILD85_3126
SIHSiH_2755
SIRSiRe_2691
SICSiL_2637
SULABFU36_10310
SULEGFS03_01510(asd)
SULOGFS33_06710(asd)
SULLEWF20_13035(asd)
MSEMsed_0709
MCNMcup_1427
MHKDFR87_03300(asd)
MPRUDFR88_03035(asd)
MTENGWK48_08305(asd)
MJNMjAS7_1475
AHOAhos_2348
AMANB6F84_02355
ABRIDFR85_01565(asd)
ASULDFR86_02340(asd)
AAMBD1866_06835(asd)
ACIHHS5_12500
SAZOD1868_09095(asd)
CSTYKN1_05910
STEPIC006_0038
 » show all
Reference
1  [PMID:8354269]
  Authors
Strauss G, Fuchs G
  Title
Enzymes of a novel autotrophic CO2 fixation pathway in the phototrophic bacterium Chloroflexus aurantiacus, the 3-hydroxypropionate cycle.
  Journal
Eur J Biochem 215:633-43 (1993)
DOI:10.1111/j.1432-1033.1993.tb18074.x
Reference
2  [PMID:18079405]
  Authors
Berg IA, Kockelkorn D, Buckel W, Fuchs G
  Title
A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea.
  Journal
Science 318:1782-6 (2007)
DOI:10.1126/science.1149976
  Sequence
[mse:Msed_0709]
Reference
3  [PMID:17041055]
  Authors
Alber B, Olinger M, Rieder A, Kockelkorn D, Jobst B, Hugler M, Fuchs G
  Title
Malonyl-coenzyme A reductase in the modified 3-hydroxypropionate cycle for autotrophic carbon fixation in archaeal Metallosphaera and Sulfolobus spp.
  Journal
J Bacteriol 188:8551-9 (2006)
DOI:10.1128/JB.00987-06
  Sequence
[mse:Msed_0709] [sto:STK_21710]
Reference
4  [PMID:11948153]
  Authors
Hugler M, Menendez C, Schagger H, Fuchs G
  Title
Malonyl-coenzyme A reductase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO(2) fixation.
  Journal
J Bacteriol 184:2404-10 (2002)
DOI:10.1128/JB.184.9.2404-2410.2002
  Sequence
[cau:Caur_2614]
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.75
IUBMB Enzyme Nomenclature: 1.2.1.75
ExPASy - ENZYME nomenclature database: 1.2.1.75
BRENDA, the Enzyme Database: 1.2.1.75

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