KEGG   ENZYME: 1.2.1.77
Entry
EC 1.2.1.77                 Enzyme                                 
Name
3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP+);
BoxD;
3,4-dehydroadipyl-CoA semialdehyde dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
3,4-didehydroadipyl-CoA semialdehyde:NADP+ oxidoreductase
Reaction(IUBMB)
3,4-didehydroadipyl-CoA semialdehyde + NADP+ + H2O = 3,4-didehydroadipyl-CoA + NADPH + H+ [RN:R09554]
Reaction(KEGG)
R09554
Substrate
3,4-didehydroadipyl-CoA semialdehyde [CPD:C19683];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
3,4-didehydroadipyl-CoA [CPD:C19682];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
This enzyme catalyses a step in the aerobic benzoyl-coenzyme A catabolic pathway in Azoarcus evansii and Burkholderia xenovorans.
History
EC 1.2.1.77 created 2010
Pathway
ec00362  Benzoate degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K15514  3,4-dehydroadipyl-CoA semialdehyde dehydrogenase
Genes
THISHZT40_02660
VFFVITFI_CDS1598
RPJN234_31300
REHH16_B1917(h16_B1917)
CNCCNE_2c18770(boxD)
CUHBJN34_32115
CTIRALTA_B1616
CBWRR42_s3015
CGDCR3_3377(putA)
CCUPBKK81_26765
CUPBKK80_29550
CUUBKK79_35505
COXE0W60_03190
BUGBC1001_2394
BGFBC1003_1064
BUQAC233_12260
BXEBxe_A1420 Bxe_C0895
BXBDR64_3583(paaN) DR64_7555(paaN)
BPXBUPH_02970
BPYBphyt_2699
BFNOI25_2712(paaN)
PARBCJU94_11380
PGPCUJ91_12160
PCJCUJ87_05110
PCAFDSC91_004076
PGISI6I06_01080
PACSFAZ98_17240
PDIOPDMSB3_3015(boxD)
PPKU875_25545
PPNODA70_23840
PPNMLV28_06870
PRBX636_02810
PPULRO07_00955
PSPUNA29_10710
PAPISG18_01130
PVEUC34_17210
POXMB84_21985
PTXABW99_07640
PFGAB870_04250
PNRAT302_14890
PANDDRB87_15910
PFIBPI93_010775
BPTBpet3573(paaZ2)
BHOD560_2017(boxD)
BHMD558_2002(boxD)
BHZACR54_04088(boxD)
BPDZBBN53_02650
BGMCAL15_08685
PUDG9Q38_06755
CDNBN940_14771
PIGEGT29_17310
RFRRfer_0217
RHFEUB48_04935
POLBpro_1625
PNAPnap_2947
ACKC380_20145
VAPVapar_0090
VPEVarpa_0103
VPDVAPA_1c00920(paaN)
VBOCKY39_00525
VAMC4F17_18575
CTTCtCNB1_0098
CTESO987_00470
LIHL63ED372_02249(boxD)
HYRBSY239_632(boxD)
HYBQ5W_16400
HYLLPB072_05875
HPSEHPF_06690(boxD)
HYNF9K07_05865
HTNKI616_07610
DRGH9K76_04155
CBAASRAA_0582
LCHLcho_3656
THITHI_0471
SNNEWH46_00430
ATERMW290_08075
EBAebA2759(boxZ)
ABREpbN1_17380(boxD)
APETToN1_26690(boxD)
AZOazo3054
AOAdqs_3188
AZAAZKH_4516(boxZ)
AZIAzCIB_4634
AZDCDA09_22725
AZRCJ010_18895(paaN)
TCLTchl_1105
TAKTharo_1136
SCLsce3620(paaZ)
SCUSCE1572_21885
CCROCMC5_025740(aldA)
SAMYDB32_005327
LLUAKJ09_05635
MRMA7982_02498
HOHHoch_4944
KMNHW532_10720
ABAWD5400_06455
PSINCAK95_08375
MAGamb0173
MAGXXM1_1068(maoC)
MAGNWV31_13515
 » show all
Reference
1  [PMID:16585753]
  Authors
Gescher J, Ismail W, Olgeschlager E, Eisenreich W, Worth J, Fuchs G
  Title
Aerobic benzoyl-coenzyme A (CoA) catabolic pathway in Azoarcus evansii: conversion of ring cleavage product by 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase.
  Journal
J Bacteriol 188:2919-27 (2006)
DOI:10.1128/JB.188.8.2919-2927.2006
  Sequence
Reference
2  [PMID:18462753]
  Authors
Bains J, Boulanger MJ
  Title
Structural and biochemical characterization of a novel aldehyde dehydrogenase encoded by the benzoate oxidation pathway in Burkholderia xenovorans LB400.
  Journal
J Mol Biol 379:597-608 (2008)
DOI:10.1016/j.jmb.2008.04.031
  Sequence
[bxe:Bxe_A1420]
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.77
IUBMB Enzyme Nomenclature: 1.2.1.77
ExPASy - ENZYME nomenclature database: 1.2.1.77
UM-BBD (Biocatalysis/Biodegradation Database): 1.2.1.77
BRENDA, the Enzyme Database: 1.2.1.77

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