KEGG   ENZYME: 1.2.1.78
Entry
EC 1.2.1.78                 Enzyme                                 

Name
2-formylbenzoate dehydrogenase;
2-carboxybenzaldehyde dehydrogenase;
2CBAL dehydrogenase;
PhdK
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
2-formylbenzoate:NAD+ oxidoreductase
Reaction(IUBMB)
2-formylbenzoate + NAD+ + H2O = o-phthalic acid + NADH + H+ [RN:R05643]
Reaction(KEGG)
R05643
Substrate
2-formylbenzoate [CPD:C03057];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
o-phthalic acid [CPD:C01606];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme is involved in phenanthrene degradation.
History
EC 1.2.1.78 created 2010
Pathway
ec00624  Polycyclic aromatic hydrocarbon degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K18275  2-formylbenzoate dehydrogenase
Genes
NKI: KW403_13540
MMAN: MMAN_42220(gbsA)
MMC: Mmcs_1663
MKM: Mkms_1687 Mkms_5636
MJL: Mjls_1636
MYE: AB431_15525
MGAU: MGALJ_00300
MPAE: K0O64_27450
MVA: Mvan_0522
MGI: Mflv_0643
MTY: MTOK_55630(dhaS)
MGAD: MGAD_31960(betB)
 » show all
Reference
1  [PMID:9335300]
  Authors
Iwabuchi T, Harayama S
  Title
Biochemical and genetic characterization of 2-carboxybenzaldehyde dehydrogenase, an enzyme involved in phenanthrene degradation by Nocardioides sp. strain KP7.
  Journal
J Bacteriol 179:6488-94 (1997)
DOI:10.1128/JB.179.20.6488-6494.1997
  Sequence
Reference
2
  Authors
Kiyohara, H., Nagao, K. and Yano, K.
  Title
Isolation and some properties of NAD-linked 2-carboxybenzaldehyde dehydrogenase in Alcaligenes faecalis AFK 2 grown on phenanthrene.
  Journal
J Gen Appl Microbiol 27:443-455 (1981)
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.78
IUBMB Enzyme Nomenclature: 1.2.1.78
ExPASy - ENZYME nomenclature database: 1.2.1.78
BRENDA, the Enzyme Database: 1.2.1.78

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