KEGG   ENZYME: 1.2.1.96Help
Entry
EC 1.2.1.96                 Enzyme                                 

Name
4-hydroxybenzaldehyde dehydrogenase (NADP+);
p-hydroxybenzaldehyde dehydrogenase (ambiguous);
pchA (gene name)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
4-hydroxybenzaldehyde:NADP+ oxidoreductase
Reaction(IUBMB)
4-hydroxybenzaldehyde + NADP+ + H2O = 4-hydroxybenzoate + NADPH + 2 H+ [RN:R01294]
Reaction(KEGG)
R01294;
(other) R11195
Show
Substrate
4-hydroxybenzaldehyde [CPD:C00633];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
4-hydroxybenzoate [CPD:C00156];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Involved in the aerobic pathway for degradation of toluene, 4-methylphenol, and 2,4-xylenol by several Pseudomonas strains. The enzyme is also active with 4-hydroxy-3-methylbenzaldehyde. cf. EC 1.2.1.64, 4-hydroxybenzaldehyde dehydrogenase (NAD+).
History
EC 1.2.1.96 created 2015
Pathway
ec00623  Toluene degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K20199  4-hydroxybenzaldehyde dehydrogenase (NADP+)
Genes
PCQ: PcP3B5_13480(yfmT_1)
PPUT: L483_22005
PDR: H681_14070
PALK: PSAKL28_20220 PSAKL28_31420
PSOS: POS17_5138(pcuC)
PSET: THL1_648
PSIL: PMA3_18555
OCE: GU3_14325
EBA: ebA3161(pchA)
Taxonomy
Reference
1  [PMID:2019564]
  Authors
Whited GM, Gibson DT.
  Title
Separation and partial characterization of the enzymes of the toluene-4-monooxygenase catabolic pathway in Pseudomonas mendocina KR1.
  Journal
J Bacteriol 173:3017-20 (1991)
DOI:10.1128/JB.173.9.3017-3020.1991
Reference
2  [PMID:23736872]
  Authors
Chen YF, Chao H, Zhou NY
  Title
The catabolism of 2,4-xylenol and p-cresol share the enzymes for the oxidation of para-methyl group in Pseudomonas putida NCIMB 9866.
  Journal
Appl Microbiol Biotechnol 98:1349-56 (2014)
DOI:10.1007/s00253-013-5001-z
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.96
IUBMB Enzyme Nomenclature: 1.2.1.96
ExPASy - ENZYME nomenclature database: 1.2.1.96
BRENDA, the Enzyme Database: 1.2.1.96
CAS: 61229-72-9

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (3)   
   KEGG REACTION (2)   
   KEGG RCLASS (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (11)   
Protein sequence (35)   
   UniProt (34)   
   SWISS-PROT (1)   
DNA sequence (24)   
   GenBank (12)   
   EMBL (12)   
All databases (86)   

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