KEGG   ENZYME: 1.2.1.96Help
Entry
EC 1.2.1.96                 Enzyme                                 

Name
4-hydroxybenzaldehyde dehydrogenase (NADP+);
p-hydroxybenzaldehyde dehydrogenase (ambiguous);
pchA (gene name)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
4-hydroxybenzaldehyde:NADP+ oxidoreductase
Reaction(IUBMB)
4-hydroxybenzaldehyde + NADP+ + H2O = 4-hydroxybenzoate + NADPH + 2 H+ [RN:R01294]
Reaction(KEGG)
R01294;
(other) R11195
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Substrate
4-hydroxybenzaldehyde [CPD:C00633];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
4-hydroxybenzoate [CPD:C00156];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Involved in the aerobic pathway for degradation of toluene, 4-methylphenol, and 2,4-xylenol by several Pseudomonas strains. The enzyme is also active with 4-hydroxy-3-methylbenzaldehyde. cf. EC 1.2.1.64, 4-hydroxybenzaldehyde dehydrogenase (NAD+).
History
EC 1.2.1.96 created 2015
Pathway
ec00623  Toluene degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K20199  4-hydroxybenzaldehyde dehydrogenase (NADP+)
Genes
PCQ: PcP3B5_13480(yfmT_1)
PPUT: L483_22005
PDR: H681_14070
PALK: PSAKL28_20220 PSAKL28_31420
PSOS: POS17_5138(pcuC)
PSET: THL1_648
PSIL: PMA3_18555
OCE: GU3_14325
EBA: ebA3161(pchA)
Taxonomy
Reference
1  [PMID:2019564]
  Authors
Whited GM, Gibson DT.
  Title
Separation and partial characterization of the enzymes of the toluene-4-monooxygenase catabolic pathway in Pseudomonas mendocina KR1.
  Journal
J Bacteriol 173:3017-20 (1991)
DOI:10.1128/JB.173.9.3017-3020.1991
Reference
2  [PMID:23736872]
  Authors
Chen YF, Chao H, Zhou NY
  Title
The catabolism of 2,4-xylenol and p-cresol share the enzymes for the oxidation of para-methyl group in Pseudomonas putida NCIMB 9866.
  Journal
Appl Microbiol Biotechnol 98:1349-56 (2014)
DOI:10.1007/s00253-013-5001-z
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.96
IUBMB Enzyme Nomenclature: 1.2.1.96
ExPASy - ENZYME nomenclature database: 1.2.1.96
BRENDA, the Enzyme Database: 1.2.1.96
CAS: 61229-72-9

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