Entry |
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Name |
4-hydroxybenzaldehyde dehydrogenase (NADP+);
p-hydroxybenzaldehyde dehydrogenase (ambiguous);
pchA (gene name)
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Class |
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
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Sysname |
4-hydroxybenzaldehyde:NADP+ oxidoreductase
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Reaction(IUBMB) |
4-hydroxybenzaldehyde + NADP+ + H2O = 4-hydroxybenzoate + NADPH + 2 H+ [RN: R01294]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
Involved in the aerobic pathway for degradation of toluene, 4-methylphenol, and 2,4-xylenol by several Pseudomonas strains. The enzyme is also active with 4-hydroxy-3-methylbenzaldehyde. cf. EC 1.2.1.64, 4-hydroxybenzaldehyde dehydrogenase (NAD+).
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History |
EC 1.2.1.96 created 2015
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Pathway |
ec01120 | Microbial metabolism in diverse environments |
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Orthology |
K20199 | 4-hydroxybenzaldehyde dehydrogenase (NADP+) |
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Genes |
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Reference |
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Authors |
Whited GM, Gibson DT. |
Title |
Separation and partial characterization of the enzymes of the toluene-4-monooxygenase catabolic pathway in Pseudomonas mendocina KR1. |
Journal |
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Reference |
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Authors |
Chen YF, Chao H, Zhou NY |
Title |
The catabolism of 2,4-xylenol and p-cresol share the enzymes for the oxidation of para-methyl group in Pseudomonas putida NCIMB 9866. |
Journal |
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Sequence |
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Other DBs |
ExplorEnz - The Enzyme Database: | 1.2.1.96 |
ExPASy - ENZYME nomenclature database: | 1.2.1.96 |
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