KEGG ENZYME: 1.2.1.96

ENZYME: 1.2.1.96

Entry

EC 1.2.1.96 Enzyme

Name

4-hydroxybenzaldehyde dehydrogenase (NADP+);
p-hydroxybenzaldehyde dehydrogenase (ambiguous);
pchA (gene name)

Class

Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor

Sysname

4-hydroxybenzaldehyde:NADP+ oxidoreductase

Reaction(IUBMB)

4-hydroxybenzaldehyde + NADP+ + H2O = 4-hydroxybenzoate + NADPH + 2 H+ [RN:R01294]

Reaction(KEGG)

R01294;
(other) R11195

Substrate

4-hydroxybenzaldehyde [CPD:C00633];
NADP+ [CPD:C00006];
H2O [CPD:C00001]

Product

4-hydroxybenzoate [CPD:C00156];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

Involved in the aerobic pathway for degradation of toluene, 4-methylphenol, and 2,4-xylenol by several Pseudomonas strains. The enzyme is also active with 4-hydroxy-3-methylbenzaldehyde. cf. EC 1.2.1.64, 4-hydroxybenzaldehyde dehydrogenase (NAD+).

History

EC 1.2.1.96 created 2015

Pathway

ec00623

Toluene degradation

ec01120

Microbial metabolism in diverse environments

Orthology

K20199

4-hydroxybenzaldehyde dehydrogenase (NADP+)

Genes

PCQ:	PcP3B5_13480(yfmT_1)

PPUT:

L483_22005

PDR:	H681_14070

PALK:

PSAKL28_20220 PSAKL28_31420

PSOS:

POS17_5138(pcuC)

PSET:

THL1_648

PSIL:

PMA3_18555

PUM:	HGP31_12070

OCE:

GU3_14325

EBA:	ebA3161(pchA)

Reference

1 [PMID:2019564]

Authors

Whited GM, Gibson DT.

Title

Separation and partial characterization of the enzymes of the toluene-4-monooxygenase catabolic pathway in Pseudomonas mendocina KR1.

Journal

J Bacteriol 173:3017-20 (1991)
DOI:10.1128/JB.173.9.3017-3020.1991

Reference

2 [PMID:23736872]

Authors

Chen YF, Chao H, Zhou NY

Title

The catabolism of 2,4-xylenol and p-cresol share the enzymes for the oxidation of para-methyl group in Pseudomonas putida NCIMB 9866.

Journal

Appl Microbiol Biotechnol 98:1349-56 (2014)
DOI:10.1007/s00253-013-5001-z

Sequence

[ag:AGO01127]

Other DBs

ExplorEnz - The Enzyme Database:

1.2.1.96

IUBMB Enzyme Nomenclature:

1.2.1.96

ExPASy - ENZYME nomenclature database:

1.2.1.96

BRENDA, the Enzyme Database:

1.2.1.96

CAS:	61229-72-9

DBGET integrated database retrieval system