KEGG   ENZYME: 1.2.1.99Help
Entry
EC 1.2.1.99                 Enzyme                                 

Name
4-(gamma-glutamylamino)butanal dehydrogenase;
puuC (gene name)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
4-(gamma-L-glutamylamino)butanal:NAD(P)+ oxidoreductase
Reaction(IUBMB)
4-(gamma-L-glutamylamino)butanal + NAD(P)+ + H2O = 4-(gamma-L-glutamylamino)butanoate + NAD(P)H + H+ [RN:R07417 R07418]
Reaction(KEGG)
Substrate
4-(gamma-L-glutamylamino)butanal;
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
4-(gamma-L-glutamylamino)butanoate [CPD:C15767];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the bacterium Escherichia coli, is involved in a putrescine catabolic pathway. It has a broad substrate range, and can also catalyse the activities of EC 1.2.1.19, aminobutyraldehyde dehydrogenase, and EC 1.2.1.24, succinate-semialdehyde dehydrogenase (NAD+).
History
EC 1.2.1.99 created 2017
Pathway
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
Orthology
K09472  4-(gamma-glutamylamino)butanal dehydrogenase
Genes
ECO: b1300(puuC)
ECJ: JW1293(puuC)
ECD: ECDH10B_1417(puuC)
EBW: BWG_1132(puuC)
ECOK: ECMDS42_1098(puuC)
ECE: Z2488(aldH)
ECS: ECs1877
ECF: ECH74115_1942(puuC)
ETW: ECSP_1825(puuC)
ELX: CDCO157_1797
EOJ: ECO26_1867(puuC)
EOI: ECO111_1683(puuC)
EOH: ECO103_1464(puuC)
ECOO: ECRM13514_1727(aldH)
ECOH: ECRM13516_1691(aldH)
EOK: G2583_1647(puuC)
ESO: O3O_11800
ESM: O3M_13805
ESL: O3K_13830
ECW: EcE24377A_1510(puuC)
ELH: ETEC_1404
EUN: UMNK88_1636(puuC)
ECX: EcHS_A1415(puuC)
ECM: EcSMS35_1822(puuC)
ECY: ECSE_1352
ECR: ECIAI1_1325(puuC)
ECK: EC55989_1462(puuC)
ECT: ECIAI39_1651(puuC)
EUM: ECUMN_1606(puuC)
ELO: EC042_1428(puuC)
EBR: ECB_01277(aldH)
EBD: ECBD_2317
EKF: KO11_16310(puuC)
EDJ: ECDH1ME8569_1242(puuC)
ELW: ECW_m1396(puuC)
ELL: WFL_06805(puuC)
ELP: P12B_c1794(puuC)
EBL: ECD_01277(puuC)
EBE: B21_01288(puuC)
EAL: EAKF1_ch0118c(puuC)
SFL: SF1305(aldH)
SFX: S1387(aldH)
SFV: SFV_1314(aldH)
SFE: SFxv_1478(puuC)
SFN: SFy_1874
SFS: SFyv_1932
SFT: NCTC1_01380(puuC)
SSN: SSON_1840(aldH)
SBO: SBO_1762(aldH)
SBC: SbBS512_E1536(puuC)
ENC: ECL_02229
ESA: ESA_02082
CSK: ES15_2238(puuC)
CTU: CTU_18830(puuC)
KPN: KPN_01018
KPU: KP1_2002
KPP: A79E_3215
KPE: KPK_1801 KPK_3542(puuC)
KPR: KPR_3504(puuC)
KPJ: N559_3269
KPX: PMK1_03358(puuC)
KPNU: LI86_16985
KPNK: BN49_2106(puuC)
KVA: Kvar_3361
KOX: KOX_16920
KOE: A225_2231
KLW: DA718_17655(puuC)
CRO: ROD_03591(puuC)
EBF: D782_2778
SPE: Spro_2065
SRL: SOD_c18770(puuC)
SPLY: Q5A_010385(puuC)
SMW: SMWW4_v1c20840(puuC)
SMAR: SM39_1528(puuC) SM39_1949
SMAC: SMDB11_1338(puuC)
SERF: L085_18345
SQU: E4343_05890(puuC)
TPTY: NCTC11468_02302(puuC_2)
PSI: S70_20145
PSX: DR96_2928
PRG: RB151_020650(puuC)
PHEI: NCTC12003_02199(puuC)
XAL: XALC_2105
SML: Smlt1571(aldH)
SMT: Smal_1330
VPA: VP1777
VPB: VPBB_1634
VAG: N646_0405
PAU: PA14_02680(aldH) PA14_09710(aldH)
PNC: NCGM2_0225(aldH) NCGM2_5393(aldH)
PAEB: NCGM1900_0210(aldH) NCGM1900_0765(aldH)
PCQ: PcP3B5_01250(puuC_1) PcP3B5_28650(puuC_2)
PPU: PP_2589
PPF: Pput_3127
PPI: YSA_00386
PPX: T1E_0370(puuC)
PPUT: L483_10470
PPUD: DW66_2399
PMON: X969_09030
PMOT: X970_08690
PFL: PFL_3523
PPRC: PFLCHA0_c35640(puuC2)
PPRO: PPC_3677
PFB: VO64_0192
PMAN: OU5_4250
PEN: PSEEN2886
PSTT: CH92_04415
PPUU: PputUW4_04746(puuC2)
PKC: PKB_0176(puuc1)
PSEM: TO66_17050
PSEC: CCOS191_2333(puuC1) CCOS191_3971(puuC2)
PSOS: POS17_3661
PALI: A3K91_1186
SON: SO_3496(gabD)
SDN: Sden_3034
SFR: Sfri_3021
SAZ: Sama_2648
SBL: Sbal_1093
SLO: Shew_0967
SSE: Ssed_1045
SPL: Spea_0937
SHL: Shal_0987
SWD: Swoo_1115
SWP: swp_4177
SPSW: Sps_02564
CPS: CPS_2053
MAD: HP15_943
FBL: Fbal_1146
GAI: IMCC3135_02520(puuC_1) IMCC3135_09185(puuC_2) IMCC3135_30570(puuC_3)
HCH: HCH_03162
CSA: Csal_1187
HEL: HELO_1453(puuC3) HELO_3918(puuC2)
HAM: HALO4281
AHA: AHA_0243
ASA: ASA_4155
LHK: LHK_02213
RSO: RSc2110(aldH)
RSC: RCFBP_10754(betB)
RSM: CMR15_11262(betB)
RSE: F504_2063
CNC: CNE_BB1p01420(puuC)
RME: Rmet_1623(puuC)
CTI: RALTA_A1429(puuC)
CGD: CR3_3236(putA)
BPS: BPSS0473
BPSE: BDL_3700
BPSM: BBQ_5722
BPSU: BBN_3874
BPSD: BBX_5537
BPK: BBK_5679
BPSH: DR55_4878
BPSA: BBU_5573
BPSO: X996_4628
BUT: X994_4146
BTQ: BTQ_5225
BTJ: BTJ_3856
BTZ: BTL_4710
BTD: BTI_4309
BTV: BTHA_5517
BTHE: BTN_4349
BTHM: BTRA_4615
BTHA: DR62_4398
BTHL: BG87_4682
BOK: DM82_4572
BOC: BG90_6020
BVE: AK36_924
BCN: Bcen_2376
BCJ: BCAL0603(puuC)
BCEW: DM40_587
BCEO: I35_3065(puuC) I35_7818
BMU: Bmul_2984
BMJ: BMULJ_00248(puuC)
BMK: DM80_1933
BCED: DM42_2019
BDL: AK34_119
BUB: BW23_1895
BLAT: WK25_14475
BTEI: WS51_25265
BSTG: WT74_15765
BGU: KS03_3283
BGO: BM43_295
BUK: MYA_2743
BGP: BGL_1c26770(puuC)
BFN: OI25_6720
PLG: NCTC10937_02140(puuC_2)
BPE: BP2303
BPC: BPTD_2262
BPER: BN118_0765
BPET: B1917_2211
BPEU: Q425_16080
BPA: BPP1569(aldH) BPP2426
BPAR: BN117_1752
BBR: BB1875 BB2647(aldH)
BPT: Bpet2339(aldH)
BAV: BAV2204(aldH)
BHM: D558_3570
BHZ: ACR54_02294(puuC_1) ACR54_02961(puuC_3)
BTRM: SAMEA390648703042(aldH)
AXY: AXYL_03090(puuC)
AXX: ERS451415_02058(puuC_1)
PUT: PT7_0371
AFQ: AFA_03990
RFR: Rfer_0356
LIH: L63ED372_01614(puuC_1)
CBAA: SRAA_2187
MPT: Mpe_A1909
TIN: Tint_0186
THI: THI_0208(puuC)
DDS: Ddes_1689
MES: Meso_0566
SAME: SAMCFNEI73_Ch3112(ald)
ATU: Atu3959(dhaL)
ARA: Arad_4300(dhaL) Arad_8144(dhaL)
AVI: Avi_7257(dhaL)
RET: RHE_PF00397(dhaL)
REC: RHECIAT_PC0000578(dhaL)
RLE: pRL120529
RLG: Rleg_4835
RHL: LPU83_1791(dhaL)
NEN: NCHU2750_34000(puuC)
BMEL: DK63_3120
BMEE: DK62_2279
BMF: BAB2_1130
BABO: DK55_3078
BABR: DO74_2475
BABT: DK49_3174
BABB: DK48_2719
BABU: DK53_3163
BABS: DK51_2645
BABC: DO78_2994
BMS: BRA1171
BSZ: DK67_3119
BOV: BOV_A1074
BCS: BCAN_B1202(aldA)
BCAR: DK60_2856
BCAS: DA85_16140
BPV: DK65_2487
RPD: RPD_0049
XAU: Xaut_2725
MET: M446_3859
HDN: Hden_0974
HMC: HYPMC_2755(puuC) HYPMC_3960(puuC)
PLEO: OHA_1_02861(puuC)
CCR: CC_3141
CAK: Caul_3955
CSE: Cseg_0813
RSP: RSP_3533 RSP_4003(dhaL)
RCP: RCAP_rcc02448(aldH2)
JAN: Jann_3507
PDE: Pden_4752
PGA: PGA1_c32250(puuC)
PGL: PGA2_c00450(puuC)
PGD: Gal_00023
PHP: PhaeoP97_03886(puuC)
PPIC: PhaeoP14_00023(puuC)
OTM: OSB_15690(puuC)
MALG: MALG_01149
SPSE: SULPSESMR1_00275(puuC)
LVS: LOKVESSMR4R_00429(puuC)
SPHD: HY78_18020
SPHM: G432_10310
SPKC: KC8_12730
RRU: Rru_A0298
RRF: F11_01505
RCE: RC1_1452(puuC)
TMO: TMO_1026(puuC) TMO_b0414(puuC)
MVQ: MYVA_5916(aldH)
TPR: Tpau_0386
SHY: SHJG_1780
SDV: BN159_0468(puuC)
SFK: KY5_2591
AUW: AURUGA1_01419(puuC)
AAU: AAur_0650
MPH: MLP_24600
PSIM: KR76_16015
AMD: AMED_6208(puuC)
AMN: RAM_31850
AMM: AMES_6118(puuC)
AMZ: B737_6118(puuC)
KAL: KALB_2084
TBI: Tbis_1741
 » show all
Taxonomy
Reference
1  [PMID:15590624]
  Authors
Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H.
  Title
A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12.
  Journal
J Biol Chem 280:4602-8 (2005)
DOI:10.1074/jbc.M411114200
  Sequence
[eco:b1300]
Reference
2  [PMID:18668238]
  Authors
Jo JE, Mohan Raj S, Rathnasingh C, Selvakumar E, Jung WC, Park S
  Title
Cloning, expression, and characterization of an aldehyde dehydrogenase from Escherichia coli K-12 that utilizes 3-Hydroxypropionaldehyde as a substrate.
  Journal
Appl Microbiol Biotechnol 81:51-60 (2008)
DOI:10.1007/s00253-008-1608-x
  Sequence
[eco:b1300]
Reference
3  [PMID:22636776]
  Authors
Schneider BL, Reitzer L
  Title
Pathway and enzyme redundancy in putrescine catabolism in Escherichia coli.
  Journal
J Bacteriol 194:4080-8 (2012)
DOI:10.1128/JB.05063-11
  Sequence
[eco:b1300]
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.99
IUBMB Enzyme Nomenclature: 1.2.1.99
ExPASy - ENZYME nomenclature database: 1.2.1.99
BRENDA, the Enzyme Database: 1.2.1.99

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