KEGG ENZYME: 1.2.2.4

ENZYME: 1.2.2.4

Entry

EC 1.2.2.4 Enzyme

Name

carbon-monoxide dehydrogenase (cytochrome b-561);
carbon monoxide oxidase;
carbon monoxide oxygenase (cytochrome b-561);
carbon monoxide:methylene blue oxidoreductase;
CO dehydrogenase;
carbon-monoxide dehydrogenase

Class

Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With a cytochrome as acceptor

Sysname

carbon monoxide,water:cytochrome b-561 oxidoreductase

Reaction(IUBMB)

CO + H2O + 2 ferricytochrome b-561 = CO2 + 2 H+ + 2 ferrocytochrome b-561 [RN:R04698]

Reaction(KEGG)

R04698;
(other) R00276

Substrate

CO [CPD:C00237];
H2O [CPD:C00001];
ferricytochrome b-561 [CPD:C05305]

Product

CO2 [CPD:C00011];
H+ [CPD:C00080];
ferrocytochrome b-561 [CPD:C05183]

Comment

Contains molybdopterin cytosine dinucleotide, FAD and [2Fe-2S]-clusters. Oxygen, methylene blue and iodonitrotetrazolium chloride can act as nonphysiological electron acceptors.

History

EC 1.2.2.4 created 1999 (EC 1.2.3.10 created 1990, incorporated 2003), modified 2003

Reference

Authors

Meyer, O., Jacobitz, S. and Kruger, B.

Title

Biochemistry and physiology of aerobic carbon monoxide-utilizing bacteria.

Journal

FEMS Microbiol Rev 39:161-179 (1986)

Reference

2 [PMID:2808305]

Authors

Jacobitz S, Meyer O.

Title

Removal of CO dehydrogenase from Pseudomonas carboxydovorans cytoplasmic membranes, rebinding of CO dehydrogenase to depleted membranes, and restoration of respiratory activities.

Journal

J Bacteriol 171:6294-9 (1989)
DOI:10.1128/JB.171.11.6294-6299.1989

Reference

3 [PMID:7354006]

Authors

Meyer O, Schlegel HG.

Title

Carbon monoxide:methylene blue oxidoreductase from Pseudomonas carboxydovorans.

Journal

J Bacteriol 141:74-80 (1980)

Reference

4 [PMID:10430865]

Authors

Dobbek H, Gremer L, Meyer O, Huber R.

Title

Crystal structure and mechanism of CO dehydrogenase, a molybdo iron-sulfur flavoprotein containing S-selanylcysteine.

Journal

Proc Natl Acad Sci U S A 96:8884-9 (1999)
DOI:10.1073/pnas.96.16.8884

Reference

5 [PMID:10966817]

Authors

Hanzelmann P, Dobbek H, Gremer L, Huber R, Meyer O.

Title

The effect of intracellular molybdenum in Hydrogenophaga pseudoflava on the crystallographic structure of the seleno-molybdo-iron-sulfur flavoenzyme carbon monoxide dehydrogenase.

Journal

J Mol Biol 301:1221-35 (2000)
DOI:10.1006/jmbi.2000.4023

Other DBs

ExplorEnz - The Enzyme Database:

1.2.2.4

IUBMB Enzyme Nomenclature:

1.2.2.4

ExPASy - ENZYME nomenclature database:

1.2.2.4

UM-BBD (Biocatalysis/Biodegradation Database):

1.2.2.4

BRENDA, the Enzyme Database:

1.2.2.4

CAS:	395639-79-9

All links

Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (2)   
   KEGG REACTION (2)   
Gene (1)   
   KEGG ORTHOLOGY (1)   
Protein sequence (33)   
   UniProt (31)   
   RefSeq(pep) (2)   
DNA sequence (238)   
   RefSeq(nuc) (2)   
   GenBank (117)   
   EMBL (119)   
Enzyme (1)   
   UMBBD-EC (1)   
All databases (283)   

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