KEGG   ENZYME: 1.2.2.4Help
Entry
EC 1.2.2.4                  Enzyme                                 

Name
carbon-monoxide dehydrogenase (cytochrome b-561);
carbon monoxide oxidase;
carbon monoxide oxygenase (cytochrome b-561);
carbon monoxide:methylene blue oxidoreductase;
CO dehydrogenase;
carbon-monoxide dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With a cytochrome as acceptor
BRITE hierarchy
Sysname
carbon monoxide,water:cytochrome b-561 oxidoreductase
Reaction(IUBMB)
CO + H2O + 2 ferricytochrome b-561 = CO2 + 2 H+ + 2 ferrocytochrome b-561 [RN:R04698]
Reaction(KEGG)
R04698;
(other) R00276
Show
Substrate
CO [CPD:C00237];
H2O [CPD:C00001];
ferricytochrome b-561 [CPD:C05305]
Product
CO2 [CPD:C00011];
H+ [CPD:C00080];
ferrocytochrome b-561 [CPD:C05183]
Comment
Contains molybdopterin cytosine dinucleotide, FAD and [2Fe-2S]-clusters. Oxygen, methylene blue and iodonitrotetrazolium chloride can act as nonphysiological electron acceptors.
History
EC 1.2.2.4 created 1999 (EC 1.2.3.10 created 1990, incorporated 2003), modified 2003
Reference
1
  Authors
Meyer, O., Jacobitz, S. and Kruger, B.
  Title
Biochemistry and physiology of aerobic carbon monoxide-utilizing bacteria.
  Journal
FEMS Microbiol Rev 39:161-179 (1986)
Reference
2  [PMID:2808305]
  Authors
Jacobitz S, Meyer O.
  Title
Removal of CO dehydrogenase from Pseudomonas carboxydovorans cytoplasmic membranes, rebinding of CO dehydrogenase to depleted membranes, and restoration of respiratory activities.
  Journal
J Bacteriol 171:6294-9 (1989)
DOI:10.1128/JB.171.11.6294-6299.1989
Reference
3  [PMID:7354006]
  Authors
Meyer O, Schlegel HG.
  Title
Carbon monoxide:methylene blue oxidoreductase from Pseudomonas carboxydovorans.
  Journal
J Bacteriol 141:74-80 (1980)
Reference
4  [PMID:10430865]
  Authors
Dobbek H, Gremer L, Meyer O, Huber R.
  Title
Crystal structure and mechanism of CO dehydrogenase, a molybdo iron-sulfur flavoprotein containing S-selanylcysteine.
  Journal
Proc Natl Acad Sci U S A 96:8884-9 (1999)
DOI:10.1073/pnas.96.16.8884
Reference
5  [PMID:10966817]
  Authors
Hanzelmann P, Dobbek H, Gremer L, Huber R, Meyer O.
  Title
The effect of intracellular molybdenum in Hydrogenophaga pseudoflava on the crystallographic structure of the seleno-molybdo-iron-sulfur flavoenzyme carbon monoxide dehydrogenase.
  Journal
J Mol Biol 301:1221-35 (2000)
DOI:10.1006/jmbi.2000.4023
Other DBs
ExplorEnz - The Enzyme Database: 1.2.2.4
IUBMB Enzyme Nomenclature: 1.2.2.4
ExPASy - ENZYME nomenclature database: 1.2.2.4
UM-BBD (Biocatalysis/Biodegradation Database): 1.2.2.4
BRENDA, the Enzyme Database: 1.2.2.4
CAS: 395639-79-9

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