Entry |
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Name |
(methyl)glyoxal oxidase;
glx1 (gene name);
glx2 (gene name)
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Class |
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With oxygen as acceptor
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Sysname |
(methyl)glyoxal:oxygen oxidoreductase
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Reaction(IUBMB) |
(1) glyoxal + H2O + O2 = glyoxylate + H2O2 [RN: R11351];
(2) 2-oxopropanal + H2O + O2 = pyruvate + H2O2 [RN: R11352]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
The enzyme, originally characterized from the white rot fungus Phanerochaete chrysosporium, utilizes a free radical-coupled copper complex for catalysis.
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History |
EC 1.2.3.15 created 2016
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Orthology |
K20929 | glyoxal/methylglyoxal oxidase |
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Reference |
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Authors |
Kersten PJ, Kirk TK |
Title |
Involvement of a new enzyme, glyoxal oxidase, in extracellular H2O2 production by Phanerochaete chrysosporium. |
Journal |
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Reference |
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Authors |
Kersten PJ, Cullen D |
Title |
Cloning and characterization of cDNA encoding glyoxal oxidase, a H2O2-producing enzyme from the lignin-degrading basidiomycete Phanerochaete chrysosporium. |
Journal |
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Sequence |
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Reference |
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Authors |
Kersten PJ, Witek C, vanden Wymelenberg A, Cullen D |
Title |
Phanerochaete chrysosporium glyoxal oxidase is encoded by two allelic variants: structure, genomic organization, and heterologous expression of glx1 and glx2. |
Journal |
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Reference |
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Authors |
Whittaker MM, Kersten PJ, Nakamura N, Sanders-Loehr J, Schweizer ES, Whittaker JW |
Title |
Glyoxal oxidase from Phanerochaete chrysosporium is a new radical-copper oxidase. |
Journal |
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Other DBs |
ExplorEnz - The Enzyme Database: | 1.2.3.15 |
ExPASy - ENZYME nomenclature database: | 1.2.3.15 |
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