| Entry |
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| Name |
(methyl)glyoxal oxidase;
glx1 (gene name);
glx2 (gene name)
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| Class |
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With oxygen as acceptor
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| Sysname |
(methyl)glyoxal:oxygen oxidoreductase
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| Reaction(IUBMB) |
(1) glyoxal + H2O + O2 = glyoxylate + H2O2 [RN: R11351];
(2) 2-oxopropanal + H2O + O2 = pyruvate + H2O2 [RN: R11352]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The enzyme, originally characterized from the white rot fungus Phanerochaete chrysosporium, utilizes a free radical-coupled copper complex for catalysis.
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| History |
EC 1.2.3.15 created 2016
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| Orthology |
| K20929 | glyoxal/methylglyoxal oxidase |
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| Reference |
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| Authors |
Kersten PJ, Kirk TK |
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| Title |
Involvement of a new enzyme, glyoxal oxidase, in extracellular H2O2 production by Phanerochaete chrysosporium. |
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| Journal |
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| Reference |
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| Authors |
Kersten PJ, Cullen D |
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| Title |
Cloning and characterization of cDNA encoding glyoxal oxidase, a H2O2-producing enzyme from the lignin-degrading basidiomycete Phanerochaete chrysosporium. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Kersten PJ, Witek C, vanden Wymelenberg A, Cullen D |
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| Title |
Phanerochaete chrysosporium glyoxal oxidase is encoded by two allelic variants: structure, genomic organization, and heterologous expression of glx1 and glx2. |
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| Journal |
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| Reference |
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| Authors |
Whittaker MM, Kersten PJ, Nakamura N, Sanders-Loehr J, Schweizer ES, Whittaker JW |
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| Title |
Glyoxal oxidase from Phanerochaete chrysosporium is a new radical-copper oxidase. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.2.3.15 |
| ExPASy - ENZYME nomenclature database: | 1.2.3.15 |
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