KEGG   ENZYME: 1.2.4.4Help
Entry
EC 1.2.4.4                  Enzyme                                 

Name
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring);
2-oxoisocaproate dehydrogenase;
2-oxoisovalerate (lipoate) dehydrogenase;
3-methyl-2-oxobutanoate dehydrogenase (lipoamide);
3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating);
alpha-keto-alpha-methylvalerate dehydrogenase;
alpha-ketoisocaproate dehydrogenase;
alpha-ketoisocaproic dehydrogenase;
alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase;
alpha-ketoisovalerate dehydrogenase;
alpha-oxoisocaproate dehydrogenase;
BCKDH;
BCOAD;
branched chain keto acid dehydrogenase;
branched-chain (-2-oxoacid) dehydrogenase (BCD);
branched-chain 2-keto acid dehydrogenase;
branched-chain 2-oxo acid dehydrogenase;
branched-chain alpha-keto acid dehydrogenase;
branched-chain alpha-oxo acid dehydrogenase;
branched-chain keto acid dehydrogenase;
branched-chain ketoacid dehydrogenase;
dehydrogenase, 2-oxoisovalerate (lipoate);
dehydrogenase, branched chain alpha-keto acid
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With a disulfide as acceptor
BRITE hierarchy
Sysname
3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)
Reaction(IUBMB)
3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine = [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2 [RN:R01701]
Reaction(KEGG)
Substrate
3-methyl-2-oxobutanoate [CPD:C00141];
[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine
Product
[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine [CPD:C15977];
CO2 [CPD:C00011]
Comment
Contains thiamine diphosphate. It acts not only on 3-methyl-2-oxobutanaoate, but also on 4-methyl-2-oxopentanoate and (S)-3-methyl-2-oxopentanoate, so that it acts on the 2-oxo acids that derive from the action of transaminases on valine, leucine and isoleucine. It is a component of the multienzyme 3-methyl-2-oxobutanoate dehydrogenase complex in which multiple copies of it are bound to a core of molecules of EC 2.3.1.168, dihydrolipoyllysine-residue (2-methylpropanoyl)transferase, which also binds multiple copies of EC 1.8.1.4, dihydrolipoyl dehydrogenase. It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.168.
History
EC 1.2.4.4 created 1972 (EC 1.2.4.3 created 1972, incorporated 1978), modified 2003
Pathway
ec00280  Valine, leucine and isoleucine degradation
ec00640  Propanoate metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K00166  2-oxoisovalerate dehydrogenase E1 component alpha subunit
K00167  2-oxoisovalerate dehydrogenase E1 component beta subunit
K11381  2-oxoisovalerate dehydrogenase E1 component
Genes
HSA: 593(BCKDHA) 594(BCKDHB)
PTR: 462845(BCKDHB) 468889(BCKDHA)
PPS: 100970081(BCKDHB) 100980379(BCKDHA)
GGO: 101128832(BCKDHA) 101132793(BCKDHB)
PON: 100173401(BCKDHB) 100462553(BCKDHA)
NLE: 100583180(BCKDHA) 100597493(BCKDHB)
MCC: 704978(BCKDHA) 718472(BCKDHB)
MCF: 102134149(BCKDHA) 102136327(BCKDHB)
CSAB: 103234732(BCKDHA) 103239988(BCKDHB)
RRO: 104676082(BCKDHA) 104682059(BCKDHB)
RBB: 108512608(BCKDHB) 108536156(BCKDHA)
CJC: 100402568(BCKDHB) 100407780(BCKDHA)
SBQ: 101033639(BCKDHB) 101049760(BCKDHA)
MMU: 12039(Bckdha) 12040(Bckdhb)
RNO: 25244(Bckdha) 29711(Bckdhb)
CGE: 100774234(Bckdha) 100774277(Bckdhb) 107978331
NGI: 103751518(Bckdha)
HGL: 101705928(Bckdha) 101725476(Bckdhb)
OCU: 100352048(BCKDHA) 100353682(BCKDHB)
TUP: 102478510(BCKDHB) 102488938(BCKDHA)
CFA: 474978(BCKDHB) 484488(BCKDHA)
AML: 100476045(BCKDHB) 100484116(BCKDHA)
UMR: 103657422(BCKDHB) 103677383(BCKDHA)
ORO: 101363773(BCKDHA) 105757080(BCKDHB)
FCA: 101080635(BCKDHB) 101087186(BCKDHA)
PTG: 102960450(BCKDHA) 102961522(BCKDHB)
AJU: 106976576(BCKDHB) 106987684(BCKDHA)
BTA: 282149(BCKDHA) 282150(BCKDHB)
BOM: 102284478(BCKDHA) 102284504 102284531(BCKDHB)
BIU: 109563728(BCKDHB) 109572632(BCKDHA)
PHD: 102318561(BCKDHA) 102338761(BCKDHB)
CHX: 102171071(BCKDHB) 102171539(BCKDHA)
OAS: 100145857(BCKDHA) 101113939(BCKDHB)
SSC: 100142666(BCKDHA) 100142669(BCKDHB)
CFR: 102504954(BCKDHA) 102512847(BCKDHB)
CDK: 105093370(BCKDHA) 105103856(BCKDHB)
BACU: 103004548(BCKDHA) 103010716(BCKDHB)
LVE: 103074708(BCKDHA) 103084139(BCKDHB)
OOR: 101282899(BCKDHB) 101285178(BCKDHA)
ECB: 100065300(BCKDHB) 100068678(BCKDHA)
EPZ: 103548489(BCKDHB) 103562535(BCKDHA)
EAI: 106842946(BCKDHB) 106843817(BCKDHA)
MYB: 102240537(BCKDHA) 102251028(BCKDHB)
MYD: 102772900(BCKDHB) 102774136(BCKDHA)
HAI: 109376595(BCKDHA) 109387808(BCKDHB)
RSS: 109442094 109446288(BCKDHB) 109458078(BCKDHA)
PALE: 102880923(BCKDHA) 102897408(BCKDHB)
LAV: 100654926(BCKDHA) 100658914(BCKDHB)
MDO: 100019333(BCKDHA) 100023799(BCKDHB)
SHR: 100929078(BCKDHB)
OAA: 100081828(BCKDHB) 100088094(BCKDHA)
GGA: 374210(BCKDHA) 395375(BCKDHB)
MGP: 100546491(BCKDHB)
CJO: 107307112(BCKDHA) 107312019(BCKDHB)
APLA: 101790102(BCKDHB)
ACYG: 106048592(BCKDHB)
TGU: 100229803(BCKDHB)
GFR: 102035852(BCKDHB)
FAB: 101817399(BCKDHB)
PMAJ: 107202246(BCKDHB)
CCAE: 111922254(BCKDHA) 111925781(BCKDHB)
CCW: 104692725(BCKDHB)
FPG: 101913651(BCKDHA) 101918832(BCKDHB)
FCH: 102056420(BCKDHA) 102056703(BCKDHB)
CLV: 102097651(BCKDHB)
EGZ: 104132743(BCKDHB)
AAM: 106489720(BCKDHB)
ASN: 102371000(BCKDHA) 102373010(BCKDHB)
AMJ: 102573276(BCKDHB) 102576924(BCKDHA)
PSS: 102445517(BCKDHB)
CMY: 102933976(BCKDHA) 102938690(BCKDHB)
CPIC: 101937607(BCKDHA) 101944574(BCKDHB)
ACS: 100554302(bckdha) 100558130(bckdhb)
PVT: 110080851(BCKDHB) 110088527(BCKDHA)
PBI: 103048497(BCKDHA) 103061299(BCKDHB)
GJA: 107109437(BCKDHB) 107119235(BCKDHA)
XLA: 100137712(bckdhb.S) 108698630(bckdha.L) 108700580(bckdha.S) 108704172(bckdhb.L)
XTR: 100036656(bckdha) 100496384(bckdhb)
NPR: 108783998(BCKDHB) 108786664(BCKDHA)
DRE: 554124(bckdha) 569980(bckdhb)
SRX: 107705067(bckdha) 107713906 107726253(bckdhb) 107758241
IPU: 108264709(bckdha) 108270547(bckdhb)
AMEX: 103035891(bckdhb) 103041479(bckdha)
TRU: 101068467(bckdhb) 101069065(bckdha)
LCO: 104925937 104929947(bckdhb) 109136714(bckdha)
NCC: 104941573(bckdha) 104964636
MZE: 101474711(bckdha) 101482476(bckdhb)
OLA: 101166649(bckdha) 101170333(bckdhb)
XMA: 102217625(bckdhb) 102219548(bckdha)
PRET: 103475058(bckdha) 103478247(bckdhb)
NFU: 107378906(bckdhb) 107380153(bckdha)
KMR: 108234210(bckdhb) 108248794(bckdha)
CSEM: 103377990(bckdha) 103388676(bckdhb)
LCF: 108876199(bckdha) 108887582(bckdhb)
SDU: 111216769(bckdha) 111227756(bckdhb)
HCQ: 109510859(bckdha) 109529677(bckdhb)
BPEC: 110163607(bckdha) 110171699(bckdhb)
MALB: 109963278(bckdha) 109972616(bckdhb)
ELS: 105029594(bckdha) 105030455(bckdhb)
SFM: 108924819(bckdha) 108937150(bckdhb)
LCM: 102353777(BCKDHB) 102362792 102364931(BCKDHA)
CMK: 103172759(bckdha) 103186186(bckdhb)
DME: Dmel_CG17691(CG17691) Dmel_CG8199(CG8199)
DSI: Dsimw501_GD17911(Dsim_GD17911) Dsimw501_GD18623(Dsim_GD18623) Dsimw501_GD28915(Dsim_GD28915)
CEL: CELE_F27D4.5(bckd-1B) CELE_Y39E4A.3(bckd-1A)
CBR: CBG00293 CBG00294(Cbr-tag-173) CBG15770 CBG15799
TSP: Tsp_11960
AQU: 100633338
LJA: Lj1g3v0912020.1(Lj1g3v0912020.1) Lj1g3v1340510.1(Lj1g3v1340510.1) Lj3g3v1591670.1(Lj3g3v1591670.1)
DOSA: Os07t0170100-01(Os07g0170100) Os12t0183100-01(Os12g0183100)
ATS: 109734458(LOC109734458) 109764102(LOC109764102)
ZMA: 100191513(pco079304) 100273293(pco118301)
SLB: AWJ20_2913(PDA1) AWJ20_885(PDB1)
NTE: NEUTE1DRAFT124643(NEUTE1DRAFT_124643) NEUTE1DRAFT88048(NEUTE1DRAFT_88048)
ANG: ANI_1_1232084(An09g02700) ANI_1_400114(An13g03150)
ABP: AGABI1DRAFT34834(AGABI1DRAFT_34834) AGABI1DRAFT40547(AGABI1DRAFT_40547)
ABV: AGABI2DRAFT206891(AGABI2DRAFT_206891) AGABI2DRAFT63983(AGABI2DRAFT_63983)
DDI: DDB_G0268020(bkdB) DDB_G0286335(bkdA)
DFA: DFA_02206(bkdB) DFA_07500(bkdA)
PYO: PY17X_1105300(PY03843) PY17X_1412900(PY05086)
PCB: PCHAS_110390(PC000864.02.0) PCHAS_141300(PC000407.01.0)
BBO: BBOV_III008200(17.m07717) BBOV_IV008190(23.m06335)
SMIN: v1.2.015623.t1(symbB.v1.2.015623.t1)
NGD: NGA_0175701(BKDA1) NGA_0175702(BKDA1)
PAY: PAU_02673
XNE: XNC1_1758
XNM: XNC2_1709
SML: Smlt3207
SMT: Smal_2640
SMZ: SMD_2785
PSUW: WQ53_14705
LEZ: GLE_3052(tkB)
LEM: LEN_1986
DKO: I596_3224
VNI: VIBNI_A0968(bkdA1) VIBNI_A0969(bkdA2)
PAE: PA2247(bkdA1) PA2248(bkdA2)
PAEV: N297_2320(bkdA1) N297_2321(bkdA2)
PAEI: N296_2320(bkdA1) N296_2321(bkdA2)
PAU: PA14_35520(bkdA2) PA14_35530(bkdA1)
PAP: PSPA7_2993(bkdA2) PSPA7_2994(bkdA1)
PAG: PLES_30561(bkdA2) PLES_30571(bkdA1)
PAF: PAM18_2792(bkdA2) PAM18_2793(bkdA1)
PNC: NCGM2_3256(bkdA1) NCGM2_3257(bkdA2)
PAEB: NCGM1900_4283(bkdA2) NCGM1900_4284(bkdA1)
PAEU: BN889_02451(bkdA1) BN889_02452(bkdA2)
PAEC: M802_2317(bkdA1) M802_2318(bkdA2)
PAEO: M801_2319(bkdA1) M801_2320(bkdA2)
PCQ: PcP3B5_35980(bkdA1) PcP3B5_35990(bkdA2)
PPU: PP_4401(bkdAA) PP_4402(bkdAB)
PPX: T1E_5099(bkdA1) T1E_5100(bkdA2)
PPUN: PP4_13590(bkdA2) PP4_13600(bkdA1)
PFL: PFL_2533(bkdA2) PFL_2534(bkdA1)
PPRC: PFLCHA0_c25960(bkdA1) PFLCHA0_c25970(bkdA2)
PPRO: PPC_2577(bkdA2) PPC_2578(bkdA1)
PFC: PflA506_3337(bkdA1) PflA506_3338(bkdA2)
PFW: PF1751_v1c34230(bkdA1) PF1751_v1c34240(bkdA2)
PEN: PSEEN3853(bkdA1) PSEEN3854(bkdA2)
PPUU: PputUW4_02962(bkdA1) PputUW4_02963(bkdA2)
PKC: PKB_2848(bkdA1) PKB_2849(bkdA2)
PSEC: CCOS191_1451(bkdA2) CCOS191_1452(bkdA1)
PSOS: POS17_2535(bkdA2) POS17_2536(bkdA1)
SON: SO_2339(bkdA1) SO_2340(bkdA2)
ILO: IL0177(acoA) IL1679 IL1680
PHA: PSHAa1631(bkdA2) PSHAa1632(BckdhA)
PSM: PSM_A1604(bkdA2) PSM_A1605(bckdhA)
PTN: PTRA_a2026(bkdA2) PTRA_a2027(bkdA1)
PEA: PESP_a2047(bkdA2) PESP_a2048(bkdA1)
PSPO: PSPO_a1577(bkdA1) PSPO_a1578(bkdA2)
PART: PARC_a1890(bkdA1) PARC_a1891(bkdA2)
PTU: PTUN_a2016(bkdA1) PTUN_a2017(bkdA2)
PNG: PNIG_a2138(bkdA2) PNIG_a2139(bkdA1)
PTD: PTET_a1855(bkdA2) PTET_a1856(bkdA1)
PSEN: PNC201_08390(bkdA1) PNC201_08395(bkdA2)
MHC: MARHY2009(bckdhA) MARHY2010(bkdA2)
MBS: MRBBS_2856(bkdA) MRBBS_2857(bkdB)
GNI: GNIT_1900(bkdA2) GNIT_1901(bkdA1)
PIN: Ping_2782
MICC: AUP74_00234(bfmBAB_1)
LPN: lpg2581
LPH: LPV_2911
LPO: LPO_2846
LPM: LP6_2613
LPF: lpl2503
LPP: lpp2633
LPC: LPC_0566
LPA: lpa_03775
LPE: lp12_2574
LLO: LLO_0636
LFA: LFA_2505
LHA: LHA_2872
LOK: Loa_00611
LCD: clem_02070(pdhB_1)
LLG: 44548918_02381(pdhB_2)
TMC: LMI_0355
HEL: HELO_2370(bkdA1) HELO_2371(bkdA2)
HCO: LOKO_01414(bfmBAA) LOKO_01415 LOKO_03072(pdhB)
KKO: Kkor_1768
KGE: TQ33_0687
BMAL: DM55_3786(bkdA1) DM55_3787(bkdA2)
BMAE: DM78_4392(bkdA2) DM78_4393(bkdA1)
BMAQ: DM76_4483(bkdA1) DM76_4484(bkdA2)
BMAF: DM51_3687(bkdA2) DM51_3688(bkdA1)
BMAZ: BM44_3745(bkdA1) BM44_3746(bkdA2)
BMAB: BM45_4521(bkdA1) BM45_4522(bkdA2)
BPS: BPSS2272(bkdA2) BPSS2273(bkdA1)
BPSE: BDL_5747(bkdA2) BDL_5748(bkdA1)
BPSM: BBQ_3831(bkdA1) BBQ_3832(bkdA2)
BPSU: BBN_5768(bkdA2) BBN_5769(bkdA1)
BPSD: BBX_4915(bkdA2) BBX_4916(bkdA1)
BPZ: BP1026B_II2447(bkdA2) BP1026B_II2449(bkdA1)
BPK: BBK_5052(bkdA2) BBK_5053(bkdA1)
BPSH: DR55_5457(bkdA1) DR55_5458(bkdA2)
BPSA: BBU_3716(bkdA1) BBU_3717(bkdA2)
BPSO: X996_5228(bkdA1) X996_5229(bkdA2)
BUT: X994_4776(bkdA1) X994_4777(bkdA2)
BTQ: BTQ_5590(bkdA2) BTQ_5591(bkdA1)
BTJ: BTJ_4245(bkdA2) BTJ_4246(bkdA1)
BTZ: BTL_5055(bkdA2) BTL_5056(bkdA1)
BTD: BTI_4842(bkdA1) BTI_4843(bkdA2)
BTV: BTHA_5166(bkdA1) BTHA_5167(bkdA2)
BTHE: BTN_4713(bkdA2) BTN_4714(bkdA1)
BTHM: BTRA_4979(bkdA2) BTRA_4980(bkdA1)
BTHL: BG87_5047(bkdA2) BG87_5048(bkdA1)
BOK: DM82_4058(bkdA1) DM82_4059(bkdA2)
BOC: BG90_3969(bkdA2) BG90_3970(bkdA1)
BCJ: BCAL1212(bkdA1) BCAL1213(bkdA2)
BCEN: DM39_6352(bkdA2) DM39_6353(bkdA1)
BCEW: DM40_1898(bkdA1) DM40_1899(bkdA2)
BCEO: I35_1123(bkdA1) I35_1124(bkdA2)
BCED: DM42_478(bkdA2) DM42_479(bkdA1)
BUB: BW23_5908(bkdA1) BW23_5909(bkdA2)
BGU: KS03_3386(bkdA2) KS03_3387(bkdA1)
BGO: BM43_7059(bkdA1) BM43_7060(bkdA2)
BUL: BW21_4368(bkdA1) BW21_4369(bkdA2)
BGP: BGL_2c02400(bkdA1) BGL_2c02410(bkdA2)
BPT: Bpet3510(bkdA2) Bpet3511(bkdA1)
VPD: VAPA_1c10760(bkdA1) VAPA_1c10770(bkdA2)
RTA: Rta_10480(bkdA1) Rta_10490(bkdA2)
TCL: Tchl_1479
GSU: GSU3019
CCX: COCOR_04759(bfmBAA) COCOR_04760(bkdA2)
SCL: sce1570(pdhB1) sce1571(pdhA) sce8001
CCRO: CMC5_066680 CMC5_066690(bkdA2)
BMX: BMS_1223 BMS_3178(pdhAB)
AMIH: CO731_01638(bkdA1) CO731_01639(bkdA2)
SME: SMc03201(bkdAa) SMc03202(bkdAb)
SMX: SM11_chr3104(bkdAa) SM11_chr3105(bkdAb) SM11_pD0027(pdh)
SMI: BN406_02789(bkdA1) BN406_02790(bkdA2) BN406_05113
SMEL: SM2011_b20020(pdh) SM2011_c03201(bkdAa) SM2011_c03202(bkdAb)
RHI: NGR_b11450 NGR_c29890(bkdA1) NGR_c29900(bkdA2)
EAD: OV14_0458(bkdA1) OV14_0459(bkdA2)
ATU: Atu3472(bkdA2) Atu3473(bkdA1)
ARA: Arad_3395(bkdA2)
ATF: Ach5_33310(bkdA2) Ach5_33320(bkdA1)
RET: RHE_PC00070(bkDa1) RHE_PC00071(bkDa2)
REL: REMIM1_PB00071(bkdA1) REMIM1_PB00072(bkdA2)
REP: IE4803_PD00070(bkdA1) IE4803_PD00071(bkdA2)
REI: IE4771_PE00070(bkdA1) IE4771_PE00071(bkdA2)
RIR: BN877_II0488(bkdA2) BN877_II0489(bkdA1)
RGA: RGR602_PC01283(bkdA1) RGR602_PC01284(bkdA2)
RHN: AMJ98_PB00088(bkdA1) AMJ98_PB00089(bkdA2)
RPHA: AMC79_PA00095(bkdA1) AMC79_PA00096(bkdA2)
RHT: NT26_2593(bkdAb) NT26_2594(bkdAa)
RHX: AMK02_PB00087(bkdA1) AMK02_PB00088(bkdA2)
RHK: Kim5_PD00070(bkdA1) Kim5_PD00071(bkdA2)
REZ: AMJ99_PA00088(bkdA1) AMJ99_PA00089(bkdA2)
BMEL: DK63_2497(bkdA1) DK63_2498(bkdA2) DK63_3048 DK63_3185
BMEE: DK62_2215 DK62_2372 DK62_2907(bkdA2) DK62_2908(bkdA1)
BABO: DK55_2681(bkdA2) DK55_2682(bkdA1) DK55_2985 DK55_3141
BABR: DO74_2410 DO74_2567 DO74_3098(bkdA2) DO74_3099(bkdA1)
BABT: DK49_2144 DK49_2556(bkdA1) DK49_2557(bkdA2) DK49_3083
BABB: DK48_2656 DK48_2811 DK48_3115(bkdA1) DK48_3116(bkdA2)
BABU: DK53_2159 DK53_2684(bkdA2) DK53_2685(bkdA1) DK53_3098
BABS: DK51_2167(bkdA2) DK51_2168(bkdA1) DK51_2581 DK51_2721
BABC: DO78_2371(bkdA1) DO78_2372(bkdA2) DO78_2902 DO78_3059
BCAR: DK60_2238(bkdA1) DK60_2239(bkdA2) DK60_2766 DK60_2923
OAH: DR92_2935(bkdA2) DR92_2936(bkdA1)
BJA: blr6331(bkdA1) blr6332(bkdA2)
XAU: Xaut_1571
MAQU: Maq22A_c19015(acoA) Maq22A_c19020(acoB)
MMED: Mame_01542(pdhB)
BRN: D1F64_18965(pdhA)
SIL: SPO0585
RSP: RSP_1294
JAN: Jann_3081
RDE: RD1_2926(pdhB)
PAMN: pAMV3p0449(odbA) pAMV3p0450(odbB)
DSH: Dshi_2566
PGD: Gal_03423
RSU: NHU_04397
SPSE: SULPSESMR1_00014(bkdA1) SULPSESMR1_00015(bkdA2)
SPHK: SKP52_08350(bkdA1) SKP52_08355(bkdA2) SKP52_21445
SGI: SGRAN_0415(mfs) SGRAN_2143(bkdA1) SGRAN_2144(pdhB)
SPHU: SPPYR_0632(bkdA) SPPYR_0633(bkdA) SPPYR_1441(bkdA) SPPYR_1442(bkdA) SPPYR_2049(bkdA) SPPYR_2050(bkdA) SPPYR_3770
SJP: SJA_C1-12990(bkdA1) SJA_C1-13000(bkdA2)
SSY: SLG_09650(bkdA1) SLG_09660(bkdA2)
AAY: WYH_00347(bkdA1) WYH_00348(bkdA2)
ANH: A6F65_01538(bkdA1) A6F65_01539(bkdA2)
ADO: A6F68_02030(bkdA1) A6F68_02031(bkdA2)
MAG: amb0073
MAGX: XM1_2654
MAGN: WV31_20215
MAI: MICA_1997
MAN: A11S_1918
BSU: BSU24040(bkdAB) BSU24050(bkdAA)
BSH: BSU6051_24040(bkdAB) BSU6051_24050(bkdAA)
BSUT: BSUB_02578(bkdAB) BSUB_02579(bkdAA)
BSUL: BSUA_02578(bkdAB) BSUA_02579(bkdAA)
BSS: BSUW23_11885(bkdAB) BSUW23_11890(bkdAA)
BSO: BSNT_08836(bkdAB) BSNT_08837(bkdAA)
BSQ: B657_24040(bkdAB) B657_24050(bkdAA)
BSX: C663_2285(bkdAB) C663_2286(bkdAA)
BLI: BL01504(bkdAA) BL01505(bkdAB)
BLD: BLi02581(bkdAB) BLi02582(bkdAA)
BLH: BaLi_c26650(bkdAB) BaLi_c26660(bkdAA)
BAY: RBAM_022320(bkdAB) RBAM_022330(bkdAA)
BAQ: BACAU_2245(bkdAB) BACAU_2246(bkdAA)
BYA: BANAU_2384(bkdAB) BANAU_2385(bkdAA)
BAML: BAM5036_2155(bkdAB) BAM5036_2156(bkdAA)
BAMA: RBAU_2368(bkdAB) RBAU_2369(bkdAA)
BAMN: BASU_2157(bkdAB) BASU_2158(bkdAA)
BAMB: BAPNAU_1352(bkdAA) BAPNAU_1353(bkdAB)
BAMY: V529_25050(bkdAB) V529_25060(bkdAA)
BMP: NG74_02337(bfmBAB) NG74_02338(bfmBAA)
BAO: BAMF_2301(bkdAB) BAMF_2302(bkdAA)
BAZ: BAMTA208_12325(bkdAB) BAMTA208_12330(bkdAA)
BQL: LL3_02590(bkdA) LL3_02591(bkdA)
BXH: BAXH7_02513(bkdAB) BAXH7_02514(bkdAA)
BQY: MUS_2694(bkdAB) MUS_2695(bkdAA)
BHA: BH2762(bfmBAB) BH2763(bfmBAA)
BAN: BA_4383(bfmbAb) BA_4384(bfmbAa)
BAR: GBAA_4383(bfmbAb) GBAA_4384(bfmbAa)
BAH: BAMEG_4420(bfmbAb) BAMEG_4421(bfmbAa)
BAI: BAA_4402(bfmbAb) BAA_4403(bfmbAa)
BANV: DJ46_3069(bfmBAB) DJ46_3070(bfmBAA)
BCA: BCE_4233(bfmbAb) BCE_4234(bfmbAa)
BCZ: BCE33L3913(bfmbAb) BCE33L3914(bfmbAa)
BCR: BCAH187_A4291(bfmbAb) BCAH187_A4292(bfmbAa)
BCB: BCB4264_A4271(bfmbAb) BCB4264_A4272(bfmbAa)
BCU: BCAH820_4181(bfmbAb) BCAH820_4182(bfmbAa)
BCG: BCG9842_B0962(bfmbAa) BCG9842_B0963(bfmbAb)
BCQ: BCQ_3948(bfmbAb) BCQ_3949(bfmbAa)
BCX: BCA_4270(bfmbAb) BCA_4271(bfmbAa)
BAL: BACI_c41270(bfmbAb) BACI_c41280(bfmbAa)
BTK: BT9727_3904(bfmbAb) BT9727_3905(bfmbAa)
BTL: BALH_3771(bfmbAb) BALH_3772(bfmbAa)
BTB: BMB171_C3821(bfmbAb) BMB171_C3822(bfmbAa)
BTC: CT43_CH4174(bfmbAb) CT43_CH4175(bfmbAa)
BTM: MC28_3452(bfmBAB) MC28_3453(bfmBAA)
BTG: BTB_c43020(bfmBAB) BTB_c43030(bfmBAA)
BTW: BF38_5329(bfmBAB) BF38_5330(bfmBAA)
BWW: bwei_0784(bfmBAA) bwei_0785(bfmBAB)
BMYO: BG05_1859(bfmBAA) BG05_1860(bfmBAB)
BMYC: DJ92_1260(bfmBAB) DJ92_1261(bfmBAA)
BCL: ABC2450(bkdA2) ABC2451(bkdA1)
BPF: BpOF4_01415(bfmBAB) BpOF4_01420(bfmBAA)
BMQ: BMQ_4438(bkdAB) BMQ_4439(bkdAA)
BMD: BMD_4424(bkdAB) BMD_4425(bkdAA)
BMH: BMWSH_0796(bfmbAa) BMWSH_0797(bkdAB)
BMEG: BG04_1356(bfmBAB) BG04_1357(bfmBAA)
BCOA: BF29_692(bfmBAB) BF29_693(bfmBAA)
BJS: MY9_2423
BMET: BMMGA3_11320(bfmBAB) BMMGA3_11325(bfmBAA)
BACL: BS34A_26400(bkdAB) BS34A_26410(bkdAA)
BGY: BGLY_2859(bfmBAB) BGLY_2860(bfmBAA)
BKW: BkAM31D_16785(bfmBAB_2) BkAM31D_16790(bfmBAA)
BBEV: BBEV_1321(bfmBAA) BBEV_1322(bfmBAB)
GGH: GHH_c24500(bkdAB) GHH_c24510(bkdAA)
GEA: GARCT_02356(bfmBAB) GARCT_02357(bfmBAA)
AFL: Aflv_0962(bkdAA) Aflv_0963(bkdAB)
ANM: GFC28_3798 GFC28_3799(bfmBAB)
AAMY: GFC30_2566(bfmBAB) GFC30_2567
ANL: GFC29_1634(bfmBAB) GFC29_1635
AXL: AXY_11870(bkdA) AXY_11880(bkdB)
VPN: A21D_03291(bfmBAA) A21D_03292(bfmBAB)
SAU: SA1347(bfmBAB) SA1348(bfmBAA)
SAV: SAV1516(bfmBAB) SAV1517(bfmBAA)
SAW: SAHV_1504(bfmBAB) SAHV_1505(bfmBAA)
SAM: MW1469(bfmBAB) MW1470(bfmBAA)
SAR: SAR1594(bfmBAB) SAR1595(bfmBAA)
SUJ: SAA6159_01452(bfmBAB) SAA6159_01453(acoA)
SUK: SAA6008_01486(bfmBAB) SAA6008_01487(acoA)
SUZ: MS7_1534(bfmBAB) MS7_1535(bfmBAA)
SUX: SAEMRSA15_14370(bfmBAB) SAEMRSA15_14380(bfmBAA)
SUW: SATW20_15130(bfmBAB) SATW20_15140(bfmBAA)
SUF: SARLGA251_14230(bfmBAB) SARLGA251_14240(bfmBAA)
SAUS: SA40_1388(bfmBAB) SA40_1389(bfmBAA)
SAUU: SA957_1471(bfmBAB) SA957_1472(bfmBAA)
SAUG: SA268_1475(bfmBAB) SA268_1476(bfmBAA)
SAUZ: SAZ172_1531(bfmBAB) SAZ172_1532(bfmBAA)
SAUT: SAI1T1_2011020(bfmBAB) SAI1T1_2011030(bfmBAA)
SAUJ: SAI2T2_1011040(bfmBAB) SAI2T2_1011050(bfmBAA)
SAUK: SAI3T3_1011020(bfmBAB) SAI3T3_1011030(bfmBAA)
SAUQ: SAI4T8_1011030(bfmBAB) SAI4T8_1011040(bfmBAA)
SAUV: SAI7S6_1011040(bfmBAB) SAI7S6_1011050(bfmBAA)
SAUW: SAI5S5_1010990(bfmBAB) SAI5S5_1011000(bfmBAA)
SAUX: SAI6T6_1011000(bfmBAB) SAI6T6_1011010(bfmBAA)
SAUY: SAI8T7_1011030(bfmBAB) SAI8T7_1011040(bfmBAA)
SUY: SA2981_1475(bfmBAB) SA2981_1476(bfmBAA)
SAUB: C248_1559(bfmBAB) C248_1560(bfmBAA)
SAUC: CA347_1514(bfmBAB) CA347_1515
SHA: SH1398(bfmBAA) SH1399(bfmBAB)
SHH: ShL2_01282(acoA_2) ShL2_01283(bfmBAB_2)
SCA: SCA_1138(bfmBAB) SCA_1139(bfmBAA)
SLN: SLUG_13950(bfmBAA) SLUG_13960(bfmBAB)
SCAP: AYP1020_0815(bfmBAB) AYP1020_0816(bfmBAA)
LMOC: LMOSLCC5850_1431(bfmBAA) LMOSLCC5850_1432(bfmBAB)
LMOE: BN418_1615
LMOB: BN419_1610
LMOQ: LM6179_2115(bkdAA) LM6179_2116(bkdAB)
LMR: LMR479A_1459(bkdAA) LMR479A_1460(bkdAB)
LMOG: BN389_13960(bfmBAA) BN389_13970(bfmBAB)
LMOL: LMOL312_1368(bfmBAA) LMOL312_1369(bfmBAB)
LMQ: LMM7_1457(bkdA1) LMM7_1458(bkdA2)
LML: lmo4a_1429(bfmBAA) lmo4a_1430(bfmBAB)
LMW: LMOSLCC2755_1374(bfmBAA) LMOSLCC2755_1375(bfmBAB)
LMX: LMOSLCC2372_1433(bfmBAA) LMOSLCC2372_1434(bfmBAB)
LMZ: LMOSLCC2482_1424(bfmBAA) LMOSLCC2482_1425(bfmBAB)
LMON: LMOSLCC2376_1326(bfmBAA) LMOSLCC2376_1327(bfmBAB)
LMOS: LMOSLCC7179_1342(bfmBAA) LMOSLCC7179_1343(bfmBAB)
LMOO: LMOSLCC2378_1385(bfmBAA) LMOSLCC2378_1386(bfmBAB)
LMOY: LMOSLCC2479_1432(bfmBAA) LMOSLCC2479_1433(bfmBAB)
LMOT: LMOSLCC2540_1422(bfmBAA) LMOSLCC2540_1423(bfmBAB)
LMOA: LMOATCC19117_1379(bfmBAA) LMOATCC19117_1380(bfmBAB)
BBE: BBR47_23690(bkdA1)
PPM: PPSC2_14965(dxpS) PPSC2_14970(bckE1)
PPO: PPM_3008(dxpS) PPM_3009(bckE1)
PMS: KNP414_02694(bfmBAA) KNP414_02695(bfmBAB)
PLV: ERIC2_c12560(bfmBAA) ERIC2_c12570(bfmBAB)
PRI: PRIO_4646(bfmBAB) PRIO_4647(bfmBAA)
ASOC: CB4_03316(bfmBAB) CB4_03317(bfmBAA)
KUR: ASO14_1283 ASO14_1284(bfmBAB)
LCB: LCABL_16670(bkdB) LCABL_16680(bkdA)
LCW: BN194_16390(bfmBAB)
EFA: EF1659(bkdB) EF1660(bkdA)
EFL: EF62_2037(bkdB) EF62_2038(bkdA)
EFI: OG1RF_11371(bkdB) OG1RF_11372(bkdA)
EFS: EFS1_1415(bkdB) EFS1_1416(bkdA)
EFN: DENG_01831(bkdA2) DENG_01832(bkdA1)
EFQ: DR75_658(bfmBAB) DR75_659(bfmBAA)
ENE: ENT_10640
JDA: BW727_101907(bfmBAA) BW727_101908(bfmBAB)
CSS: Cst_c08650(acoB1)
CSD: Clst_0830(pdhE)
OVA: OBV_27000
SAY: TPY_3787(bkdA2) TPY_3788(bkdA1)
CSC: Csac_0874
ATE: Athe_0704
MMC: Mmcs_1976
MKM: Mkms_2022
MJL: Mjls_1956
MVQ: MYVA_2369
MTHN: 4412656_03742(acoB)
ASD: AS9A_2449
NFA: NFA_35780
NFR: ERS450000_00478(pdhB)
NSR: NS506_04175(bkdA)
RER: RER_04420(acoA_acoB)
ROP: ROP_28430
RHB: NY08_1992
RRT: 4535765_04190(pdhB)
MPH: MLP_13240
NCA: Noca_4454
KFL: Kfla_0894
PSIM: KR76_25410
SRO: Sros_6420
NML: Namu_2114
SEN: SACE_3884
AMD: AMED_7122(bkdA)
AMN: RAM_36570
AMM: AMES_7014(bkdA)
AMZ: B737_7014(bkdA)
AMQ: AMETH_1829(bkdA)
KAL: KALB_2837
ACTI: UA75_21855
ACAD: UA74_21380
AHG: AHOG_18860(pdhB)
SAQ: Sare_3610
MIL: ML5_3598
ASE: ACPL_1533
ACTN: L083_1776
AFS: AFR_08790
ACTS: ACWT_1412
TBI: Tbis_2156
AYM: YM304_17900(bkdA1) YM304_17910(bkdA2) YM304_38990
GVI: gll1094
ABAT: CFX1CAM_0234(bfmBAA) CFX1CAM_0235(bfmBAB)
CAP: CLDAP_19200(acoA_acoB) CLDAP_34870
TSC: TSC_c02390(acoB) TSC_c02400(acoA)
CTR: CT_340(pdhA_B)
CTD: CTDEC_0340(pdhA_B)
CTF: CTDLC_0340(pdhA_B)
CTA: CTA_0369(pdhA_2)
CTY: CTR_3381
CRA: CTO_0369
CTRQ: A363_00363
CTB: CTL0594
CTO: CTL2C_951
CTJ: JALI_3381
CTZ: CTB_3381
CSW: SW2_3451
CES: ESW3_3451
CTRB: BOUR_00360
CTEC: EC599_3501
CFS: FSW4_3451
CFW: FSW5_3451
CTFW: SWFP_3661
CTCH: O173_01855
CTRI: BN197_3431
CTRA: BN442_3431
CTCT: CTW3_01855
CMU: TC_0618
CMUR: Y015_03255
CMX: DNC_03135
CMZ: TAC_03255
CPN: CPn0033(pdhA_pdhB)
CPA: CP_0743
CPJ: pdhA_pdhB(pdhA_pdhB)
CPT: CpB0037
CPM: G5S_0669
CPEC: CPE3_0322
CPEO: CPE1_0322
CPER: CPE2_0322
CHB: G5O_0359
CHR: Cpsi_3261
CPSC: B711_0381
CPSN: B712_0357
CPSB: B595_0380
CPSG: B598_0360
CPSM: B602_0357
CPSI: B599_0356
CPSV: B600_0382
CPSW: B603_0363
CPST: B601_0358
CPSD: BN356_3251
CPSA: AO9_01720
CCA: CCA_00324(pdhA_pdhB)
CAB: CAB319
CABO: AB7_3581
CFE: CF0679(pdhAB)
PUV: PUV_02580(bkdB-B) PUV_02590(bkdA)
WCH: wcw_0464(pdhA1) wcw_0465(pdhB1)
SNG: SNE_A05470(bfmBAB)
OTE: Oter_4204
OBG: Verru16b_01586(bfmBAB)
CAA: Caka_2205
GES: VT84_03185(acoA_1) VT84_03815(bfmBAB) VT84_03820(bfmBAA)
KST: KSMBR1_3307(pdh)
PBAS: SMSP2_02972(acoA_2)
ACA: ACP_3156
ABAS: ACPOL_4126
ABAC: LuPra_05932(bfmBAB)
BTH: BT_0312
BTHO: Btheta7330_03065(bfmBAB)
BFR: BF1622
BXY: BXY_15220
BOA: Bovatus_00157(bfmBAB)
BCEL: BcellWH2_03587(bfmBAB)
PMUC: ING2E5A_1160(acoB1) ING2E5A_1267(acoB3)
PDI: BDI_0687
PSAC: PSM36_2182
BLQ: L21SP5_00503(bkdA2)
MBAS: ALGA_0753
SRM: SRM_00667(acoA_pdhA) SRM_02182(bkdA2)
PHE: Phep_3824
MUC: MuYL_0745
MGOT: MgSA37_00323(bfmBAB_1)
CHU: CHU_3183(dxs)
GFO: GFO_1616
GFL: GRFL_3286
FJO: Fjoh_2840
FJG: BB050_03756(bfmBAB)
FPS: FP1028(bfmBA)
FIN: KQS_06850(bfmBA)
ZPR: ZPR_2696
MARM: YQ22_18220
CBAL: M667_15670
CBAT: M666_15670
DDO: I597_1121(bfmBAB_2) I597_1939(bfmBAB_3)
ZGA: ZOBELLIA_4392(bkdA1)
MLT: VC82_2847
EAO: BD94_2725
ELB: VO54_03939(bfmBAB_2)
MPW: MPR_1189
CHZ: CHSO_1586(pdhA2)
CTAK: 4412677_00824(bfmBAB)
KOS: KORDIASMS9_01974(bfmBAB) KORDIASMS9_03561(bfmBAB)
MARF: CJ739_3508
FBA: FIC_01383
IAL: IALB_1650(bkdA)
MRO: MROS_2258
CABY: Cabys_3508
DTU: Dtur_0419
NDE: NIDE3114
NMV: NITMOv2_0059(bkdAB)
NJA: NSJP_0544(bfmBAB)
HTU: Htur_2793
 » show all
Taxonomy
Reference
1  [PMID:5656388]
  Authors
Bowden JA, Connelly JL.
  Title
Branched chain alpha-keto acid metabolism. II. Evidence for the common identity of alpha-ketoisocaproic acid and alpha-keto-beta-methyl-valeric acid dehydrogenases.
  Journal
J Biol Chem 243:3526-31 (1968)
Reference
2  [PMID:5689906]
  Authors
Connelly JL, Danner DJ, Bowden JA.
  Title
Branched chain alpha-keto acid metabolism. I. Isolation, purification, and partial characterization of bovine liver alpha-ketoisocaproic:alpha-keto-beta-methylvaleric acid dehydrogenase.
  Journal
J Biol Chem 243:1198-203 (1968)
Reference
3  [PMID:447664]
  Authors
Danner DJ, Lemmon SK, Besharse JC, Elsas LJ 2nd.
  Title
Purification and characterization of branched chain alpha-ketoacid dehydrogenase from bovine liver mitochondria.
  Journal
J Biol Chem 254:5522-6 (1979)
Reference
4  [PMID:283398]
  Authors
Pettit FH, Yeaman SJ, Reed LJ.
  Title
Purification and characterization of branched chain alpha-keto acid dehydrogenase complex of bovine kidney.
  Journal
Proc Natl Acad Sci U S A 75:4881-5 (1978)
DOI:10.1073/pnas.75.10.4881
  Sequence
[bta:282149]
Reference
5  [PMID:10966480]
  Authors
Perham RN.
  Title
Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions.
  Journal
Annu Rev Biochem 69:961-1004 (2000)
DOI:10.1146/annurev.biochem.69.1.961
Other DBs
ExplorEnz - The Enzyme Database: 1.2.4.4
IUBMB Enzyme Nomenclature: 1.2.4.4
ExPASy - ENZYME nomenclature database: 1.2.4.4
BRENDA, the Enzyme Database: 1.2.4.4
CAS: 9082-72-8

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