KEGG   ENZYME: 1.2.7.6
Entry
EC 1.2.7.6                  Enzyme                                 
Name
glyceraldehyde-3-phosphate dehydrogenase (ferredoxin);
GAPOR;
glyceraldehyde-3-phosphate Fd oxidoreductase;
glyceraldehyde-3-phosphate ferredoxin reductase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With an iron-sulfur protein as acceptor
Sysname
D-glyceraldehyde-3-phosphate:ferredoxin oxidoreductase
Reaction(IUBMB)
D-glyceraldehyde-3-phosphate + H2O + 2 oxidized ferredoxin = 3-phospho-D-glycerate + 2 H+ + 2 reduced ferredoxin [RN:R07159]
Reaction(KEGG)
R07159
Substrate
D-glyceraldehyde-3-phosphate;
H2O [CPD:C00001];
oxidized ferredoxin [CPD:C00139]
Product
3-phospho-D-glycerate [CPD:C00197];
H+ [CPD:C00080];
reduced ferredoxin [CPD:C00138]
Comment
Contains tungsten-molybdopterin and iron-sulfur clusters. This enzyme is thought to function in place of glyceralde-3-phosphate dehydrogenase and possibly phosphoglycerate kinase in the novel Embden-Meyerhof-type glycolytic pathway found in Pyrococcus furiosus [1]. It is specific for glyceraldehyde-3-phosphate.
History
EC 1.2.7.6 created 2003
Pathway
ec00010  Glycolysis / Gluconeogenesis
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K11389  glyceraldehyde-3-phosphate dehydrogenase (ferredoxin)
Genes
GBZJZM60_01480
GURGura_2648
GSBGSUB_04300
DVEDESUT3_35540
DOLDole_2101
HTLHPTL_0438
ATMANT_14840
TTZFHG85_03385
TAMTheam_0376
TOPTOPB45_0887
TCMHL41_05125
THETF1847_01705
MJAMJ_1185
MFEMefer_0232
MVUMetvu_1517
MFSMFS40622_0815
MIFMetin_0063
MJHJH146_0660
MESGMLAUSG7_1051
MESAMLASG1_0727
MIGMetig_1727
MMPMMP0945
MMQMmarC5_0752
MMXMmarC6_1710
MMZMmarC7_0192
MMDGYY_05445
MMAKMMKA1_10440(gor)
MMAOMMOS7_10210(gor)
MMADMMJJ_00460
MAEMaeo_0444
MVNMevan_0244
MVOMvol_0992
MOKMetok_1283
METFCFE53_04735
PFUPF0464
PFIPFC_01435
PHOPH0457(PH0457)
PABPAB1315
PYNPNA2_1087
PYAPYCH_18690
PYSPy04_0640
PYCTQ32_02200
TKOTK2163
TONTON_1498
TGATGAM_0122(gor)
TSITSIB_1686
TBATERMP_01833
THEGQS_07935
THATAM4_1410
THMCL1_1206
TLTOCC_05826
THSTES1_1819
TNUBD01_1964
TEUTEU_01570
TGYX802_04465
THVADU37_CDS17140
TCHCHITON_1291
TPEPA0127_04735
TPIEA7C91_04780
TGGA3K92_09145
TCEA3L02_06445
TBSA3L01_08355
THHCDI07_07175
TSLA3L11_01785
TTDA3L14_10725
TPRFA3L09_00285
TRLA3L10_07815
TPAFA3L08_01460
THYA3L12_04140
TICFH039_11960
TCQTIRI35C_2006(gor)
THEMFPV09_09545
PPACPAP_09975
MEVMetev_1886
SMRSmar_1582
SHCShell_0821
IHOIgni_0296
IISEYM_02335
DKADKAM_0499
DFDDesfe_0557
DMUDesmu_0616
TAGTagg_0452
IAGIgag_1482
THGTCELL_0959
PFMPyrfu_0662
PDLPyrde_0538
PAIPAE1029
PISPisl_1226
PCLPcal_0664
PASPars_0189
PYRP186_2447
POGPogu_2290
TNETneu_0174
CMACmaq_0263
TTNTTX_2037(gor)
TUZTUZN_1446
VDIVdis_2526
VMOVMUT_0871
ASCASAC_0245
ACIASE86_02005
CLGCalag_1301
NAANps_00740
 » show all
Reference
1  [PMID:7721730]
  Authors
Mukund S, Adams MW
  Title
Glyceraldehyde-3-phosphate ferredoxin oxidoreductase, a novel tungsten-containing enzyme with a potential glycolytic role in the hyperthermophilic archaeon Pyrococcus furiosus.
  Journal
J Biol Chem 270:8389-92 (1995)
DOI:10.1074/jbc.270.15.8389
  Sequence
[pfu:PF0464]
Reference
2  [PMID:11265456]
  Authors
Roy R, Menon AL, Adams MW.
  Title
Aldehyde oxidoreductases from Pyrococcus furiosus.
  Journal
Methods Enzymol 331:132-44 (2001)
DOI:10.1016/S0076-6879(01)31052-2
  Sequence
[pfu:PF0464]
Other DBs
ExplorEnz - The Enzyme Database: 1.2.7.6
IUBMB Enzyme Nomenclature: 1.2.7.6
ExPASy - ENZYME nomenclature database: 1.2.7.6
BRENDA, the Enzyme Database: 1.2.7.6
CAS: 162995-20-2

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