KEGG   ENZYME: 1.2.98.1
Entry
EC 1.2.98.1                 Enzyme                                 
Name
formaldehyde dismutase;
aldehyde dismutase;
cannizzanase;
nicotinoprotein aldehyde dismutase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With other, known, physiological acceptors
Sysname
formaldehyde:formaldehyde oxidoreductase
Reaction(IUBMB)
2 formaldehyde + H2O = formate + methanol [RN:R00614]
Reaction(KEGG)
R00614
Substrate
formaldehyde [CPD:C00067];
H2O [CPD:C00001]
Product
formate [CPD:C00058];
methanol [CPD:C00132]
Comment
The enzyme contains a tightly but noncovalently bound NADP(H) cofactor, as well as Zn2+ and Mg2+. Enzyme-bound NADPH formed by oxidation of formaldehyde to formate is oxidized back to NADP+ by reaction with a second formaldehyde, yielding methanol. The enzyme from the bacterium Mycobacterium sp. DSM 3803 also catalyses the reactions of EC 1.1.99.36, alcohol dehydrogenase (nicotinoprotein) and EC 1.1.99.37, methanol dehydrogenase (nicotinoprotein) [3]. Formaldehyde and acetaldehyde can act as donors; formaldehyde, acetaldehyde and propanal can act as acceptors [1,2].
History
EC 1.2.98.1 created 1986 as EC 1.2.99.4, modified 2012, transferred 2015 to EC 1.2.98.1
Pathway
ec00625  Chloroalkane and chloroalkene degradation
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K17067  formaldehyde dismutase / methanol dehydrogenase
K17068  formaldehyde dismutase
Genes
GPIGPICK_06680
GEBGM18_3226
GURGura_3568
DEXHWD60_01710(mdo)
DVNHQ394_08800(mdo)
DAEDtox_4270
MGOAFA91_03425
MDXBTO20_03135 BTO20_38200
MRFMJO55_25005(mdo)
MSMMSMEG_6242
MSGMSMEI_6081
MSBLJ00_30865
MSNLI99_30870
MSHLI98_30875
MVAMvan_5479
MCBMycch_5913
MNED174_25530
MYNMyAD_25070
MLLB1R94_22390
MRHMycrhN_3030
MAUUNCTC10437_05223(thcE)
MTYMTOK_19990
MPSCMPSYJ_14360
MANYMANY_50600
MPOFMPOR_01100
MMATMMAGJ_31270
ASDAS9A_4308
NFANFA_22240
NFRERS450000_01873(thcE)
RHARHA1_ro06057
RERRER_17770
REYO5Y_08520
REBXU06_08765
RQIC1M55_08995(mdo)
ROPROP_61160
ROAPd630_LPD02697
RPYY013_08845
RBYCEJ39_19735(mdo)
RHBNY08_1972
RAVAAT18_18670
RFAA3L23_00307
RHSA3Q41_03101
RRZCS378_08140(mdo)
RHUA3Q40_00401
RHQIM25_00685
RHODAOT96_19365
RRT4535765_03582(thcE)
RKOJWS14_33040(mdo)
RGOKYT97_09645(mdo)
ROZCBI38_20475
GBRGbro_1931
GPOGPOL_c18220 GPOL_c38190
GORKTR9_1872
GOQACH46_07270
GTABCM27_10050
GOCCXX93_15365(mdo)
GITC6V83_07720(mdo)
GRUGCWB2_09440(thcE)
GOMD7316_01326(mno) D7316_03687(thcE)
GAVC5O27_18320(mdo)
GODGKZ92_09040(mdo)
GAMGII34_08675(mdo)
GPDGII33_01450(mdo) GII33_08060(mdo)
GJIH1R19_09330(mdo)
GOILK459_01040(mdo) LK459_01660(mdo)
GHNMVF96_09455(mdo)
GAMIIHQ52_12330(mdo)
TSMASU32_17935
DTMBJL86_1140
DIZCT688_01100(mdo)
DPCA6048_01130
DKNNHB83_01010(mdo)
TOYFO059_05730(mdo)
SHYSHJG_2446
SHOSHJGH_2211
STUIGCM10017668_53940
ALXLVQ62_05600(mdo)
PHWG7075_01320(mdo)
NAROCFH99_06345(mdo)
NAQUENKNEFLB_00974(mno)
NROK8W59_04780(mdo)
NPCKUV85_09765(mdo)
NPSKRR39_16410(mdo)
NMLNamu_0777
SENSACE_2386
SACGFDZ84_34730(mdo)
AMQAMETH_5577(mdo)
PSEAWY02_13685
PSEEFRP1_00395 FRP1_00630
PSEHXF36_28100
PSEQAD006_08035 AD006_08270
PECQAD017_15870 AD017_16100
PHHAFB00_08750 AFB00_13725
PAUTPdca_61440 Pdca_62050
PBROHOP40_10780(mdo)
RRDRradSPS_2629
RUBGBA63_20895
RMARGBA65_20385(mdo)
 » show all
Reference
1
  Authors
Kato, N., Shirakawa, K., Kobayashi, H. and Sakazawa, C.
  Title
The dismutation of aldehydes by a bacterial enzyme.
  Journal
Agric Biol Chem 47:39-46 (1983)
Reference
2  [PMID:3514215]
  Authors
Kato N, Yamagami T, Shimao M, Sakazawa C
  Title
Formaldehyde dismutase, a novel NAD-binding oxidoreductase from Pseudomonas putida F61.
  Journal
Eur J Biochem 156:59-64 (1986)
DOI:10.1111/j.1432-1033.1986.tb09548.x
  Sequence
Reference
3  [PMID:19875438]
  Authors
Park H, Lee H, Ro YT, Kim YM
  Title
Identification and functional characterization of a gene for the methanol : N,N'-dimethyl-4-nitrosoaniline oxidoreductase from Mycobacterium sp. strain JC1 (DSM 3803).
  Journal
Microbiology 156:463-71 (2010)
DOI:10.1099/mic.0.034124-0
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.2.98.1
IUBMB Enzyme Nomenclature: 1.2.98.1
ExPASy - ENZYME nomenclature database: 1.2.98.1
BRENDA, the Enzyme Database: 1.2.98.1
CAS: 85204-94-0

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