KEGG   ENZYME: 1.2.99.8
Entry
EC 1.2.99.8                 Enzyme                                 
Name
glyceraldehyde dehydrogenase (FAD-containing);
glyceraldehyde oxidoreductase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With unknown physiological acceptors
Sysname
D-glyceraldehyde:acceptor oxidoreductase (FAD-containing)
Reaction(IUBMB)
D-glyceraldehyde + H2O + acceptor = D-glycerate + reduced acceptor [RN:R10324]
Reaction(KEGG)
R10324
Substrate
D-glyceraldehyde [CPD:C00577];
H2O [CPD:C00001];
acceptor [CPD:C00028]
Product
D-glycerate [CPD:C00258];
reduced acceptor [CPD:C00030]
Comment
The enzyme from the archaeon Sulfolobus acidocaldarius catalyses the oxidation of D-glyceraldehyde in the nonphosphorylative Entner-Doudoroff pathway. With 2,6-dichlorophenolindophenol as artificial electron acceptor, the enzyme shows a broad substrate range, but is most active with D-glyceraldehyde. It is not known which acceptor is utilized in vivo. The iron-sulfur protein contains FAD and molybdopterin guanine dinucleotide.
History
EC 1.2.99.8 created 2013
Pathway
ec00030  Pentose phosphate pathway
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K18020  glyceraldehyde dehydrogenase large subunit
K18021  glyceraldehyde dehydrogenase medium subunit
K18022  glyceraldehyde dehydrogenase small subunit
Genes
MOGMMB17_15015 MMB17_15020
ACUTMRB58_00990
BVJI5776_20625
KMEH0A61_00455(cutS_1)
RMARGBA65_20380
APEAPE_0708.1
STOSTK_17810 STK_17820 STK_17830
SOHD1869_10085 D1869_10090 D1869_10095
SSOSSO2636(cutB-2) SSO2637(cutC-2) SSO2639(cutA-4)
SOLSsol_0448 Ssol_0449 Ssol_0450
SSOASULA_0441 SULA_0442 SULA_0443
SSOLSULB_0443 SULB_0444 SULB_0445
SSOFSULC_0441 SULC_0442 SULC_0443
SSHIJ5U23_00855 J5U23_00856 J5U23_00857
SCASSACC_23020 SACC_23030 SACC_23040
SAISaci_2269(cutB) Saci_2270(cutC) Saci_2271(cutA)
SACNSacN8_11060 SacN8_11065 SacN8_11070
SACRSacRon12I_11305 SacRon12I_11310 SacRon12I_11315
SACSSUSAZ_10655 SUSAZ_10660 SUSAZ_10665
SISLS215_2835 LS215_2836 LS215_2837
SIAM1425_2673 M1425_2674 M1425_2675
SIMM1627_2727 M1627_2728 M1627_2729
SIDM164_2658 M164_2659 M164_2660
SIYYG5714_2849 YG5714_2850 YG5714_2851
SINYN1551_3036 YN1551_3037 YN1551_3038
SIILD85_2991 LD85_2992 LD85_2993
SIHSiH_2626 SiH_2627 SiH_2628
SIRSiRe_2566 SiRe_2567 SiRe_2568
SICSiL_2514 SiL_2515 SiL_2516
SULABFU36_09145 BFU36_09150 BFU36_09155
SULEGFS03_00865 GFS03_00870 GFS03_00875
SULOGFS33_06065 GFS33_06070 GFS33_06075
SULLEWF20_11525 EWF20_11530 EWF20_11535
MSEMsed_0297 Msed_0298 Msed_0299
MCNMcup_1768 Mcup_1769 Mcup_1770
MHKDFR87_05305 DFR87_05310 DFR87_05315
MPRUDFR88_05115 DFR88_05120 DFR88_05125
MTENGWK48_06640 GWK48_06645 GWK48_06650
MJNMjAS7_0922 MjAS7_0923 MjAS7_0924
AMANB6F84_13175 B6F84_13180 B6F84_13185
ABRIDFR85_13980 DFR85_13985 DFR85_13990
ASULDFR86_11150 DFR86_11155 DFR86_11160
ACIHHS5_05440 HS5_05450 HS5_05460
SAZOD1868_10800 D1868_10805 D1868_10810
CSTYKN1_14610 KN1_14620 KN1_14630 KN1_28990 KN1_29500
STEPIC006_0691 IC006_0692 IC006_0693
 » show all
Reference
1  [PMID:10095793]
  Authors
Kardinahl S, Schmidt CL, Hansen T, Anemuller S, Petersen A, Schafer G
  Title
The strict molybdate-dependence of glucose-degradation by the thermoacidophile Sulfolobus acidocaldarius reveals the first crenarchaeotic molybdenum containing enzyme--an aldehyde oxidoreductase.
  Journal
Eur J Biochem 260:540-8 (1999)
DOI:10.1046/j.1432-1327.1999.00201.x
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.2.99.8
IUBMB Enzyme Nomenclature: 1.2.99.8
ExPASy - ENZYME nomenclature database: 1.2.99.8
BRENDA, the Enzyme Database: 1.2.99.8

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