KEGG   ENZYME: 1.20.9.1
Entry
EC 1.20.9.1                 Enzyme                                 

Name
arsenate reductase (azurin);
arsenite oxidase (ambiguous)
Class
Oxidoreductases;
Acting on phosphorus or arsenic in donors;
With a copper protein as acceptor
Sysname
arsenite:azurin oxidoreductase
Reaction(IUBMB)
arsenite + H2O + 2 oxidized azurin = arsenate + 2 reduced azurin + 2 H+ [RN:R05751]
Reaction(KEGG)
R05751;
(other) R09787
Substrate
arsenite [CPD:C06697];
H2O [CPD:C00001];
oxidized azurin [CPD:C05357]
Product
arsenate [CPD:C11215];
reduced azurin [CPD:C05358];
H+ [CPD:C00080]
Comment
Contains a molybdopterin centre comprising two molybdopterin guanosine dinucleotide cofactors bound to molybdenum, a [3Fe-4S] cluster and a Rieske-type [2Fe-2S] cluster. Isolated from beta-proteobacteria. Also uses a c-type cytochrome or O2 as acceptors.
History
EC 1.20.9.1 created 2001 as EC 1.20.98.1, transferred 2011 to EC 1.20.9.1
Orthology
K08355  arsenite oxidase small subunit
K08356  arsenite oxidase large subunit
Genes
VSP: VS_II0658 VS_II0659
VTA: A0943 A0944 B1225 B1226
MBS: MRBBS_1242(aoxB) MRBBS_1243(aoxA)
MPQ: ABA45_06345
MVS: MVIS_1833(aoxA)
MYA: MORIYA_1165 MORIYA_1166
AEH: Mlg_1558
GAI: IMCC3135_25220
HSI: BOX17_13460 BOX17_13465
RSL: RPSI07_mp0919(aoxA) RPSI07_mp0920(aoxB)
BMJ: BMULJ_05810(asoA) BMULJ_05811(asoB) BMULJ_05832(asoB) BMULJ_05833(asoA)
CABA: SBC2_73790(aioB) SBC2_73800(aioA)
HPSE: HPF_13640(aioB)
HAR: HEAR0478(aoxB) HEAR0479(aoxA)
THI: THI_3162(aoxB) THI_3163(aoxA)
SPLB: SFPGR_23330(soxF)
SULR: B649_04295
SMUL: SMUL_3119(aioB) SMUL_3120(aioA)
NIS: NIS_0033
AMIH: CO731_03145(aioB) CO731_03146(aioA)
RHT: NT26_p10029(aioB) NT26_p10030(aioA)
MSC: BN69_1400(aoxB) BN69_1401
RLI: RLO149_c022030(aoxA) RLO149_c022040(aoxB)
PMW: B2K_08810
TTR: Tter_2537
DGE: Dgeo_1251
DFC: DFI_03960
TRA: Trad_0410
TSC: TSC_c14680(aoxB) TSC_c14700(aoxA)
MRB: Mrub_2869
PND: Pla175_21920(aioB)
SUS: Acid_2926
ABAC: LuPra_00131(aioB)
NDE: NIDE3704(aoxA) NIDE3705(aoxB)
 » show all
Reference
1  [PMID:1331097]
  Authors
Anderson GL, Williams J, Hille R
  Title
The purification and characterization of arsenite oxidase from Alcaligenes faecalis, a molybdenum-containing hydroxylase.
  Journal
J Biol Chem 267:23674-82 (1992)
  Sequence
Reference
2  [PMID:11250197]
  Authors
Ellis PJ, Conrads T, Hille R, Kuhn P
  Title
Crystal structure of the 100 kDa arsenite oxidase from Alcaligenes faecalis in two crystal forms at 1.64 A and 2.03 A.
  Journal
Structure 9:125-32 (2001)
DOI:10.1016/S0969-2126(01)00566-4
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.20.9.1
IUBMB Enzyme Nomenclature: 1.20.9.1
ExPASy - ENZYME nomenclature database: 1.20.9.1
UM-BBD (Biocatalysis/Biodegradation Database): 1.20.9.1
BRENDA, the Enzyme Database: 1.20.9.1
CAS: 146907-46-2

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