KEGG   ENZYME: 1.21.1.1
Entry
EC 1.21.1.1                 Enzyme                                 

Name
iodotyrosine deiodinase;
iodotyrosine dehalogenase 1;
DEHAL1
Class
Oxidoreductases;
Catalysing the reaction X-H + Y-H = X-Y
Sysname
L-tyrosine,iodide:NADP+ oxidoreductase (iodinating)
Reaction(IUBMB)
L-tyrosine + 2 NADP+ + 2 iodide = 3,5-diiodo-L-tyrosine + 2 NADPH + 2 H+ (overall reaction) [RN:R10059];
(1a) L-tyrosine + NADP+ + iodide = 3-iodo-L-tyrosine + NADPH + H+ [RN:R09521];
(1b) 3-iodo-L-tyrosine + NADP+ + iodide = 3,5-diiodo-L-tyrosine + NADPH + H+ [RN:R09522]
Reaction(KEGG)
Substrate
L-tyrosine [CPD:C00082];
NADP+ [CPD:C00006];
iodide [CPD:C00708];
3-iodo-L-tyrosine [CPD:C02515]
Product
3,5-diiodo-L-tyrosine [CPD:C01060];
NADPH [CPD:C00005];
H+ [CPD:C00080];
3-iodo-L-tyrosine [CPD:C02515]
Comment
The enzyme activity has only been demonstrated in the direction of 3-deiodination. Present in a transmembrane flavoprotein. Requires FMN.
History
EC 1.21.1.1 created 2010 as EC 1.22.1.1 transfered 2015 to EC 1.21.1.1
Orthology
K17231  iodotyrosine deiodinase
Genes
HSA: 389434(IYD)
PTR: 472159(IYD)
PPS: 100984862(IYD)
GGO: 101134826(IYD)
PON: 100127058(IYD)
NLE: 100604496(IYD)
MCC: 705471(IYD)
MCF: 102137987(IYD)
CSAB: 103240719(IYD)
RRO: 104678344(IYD)
RBB: 108539141(IYD)
CJC: 100414973(IYD)
SBQ: 101036070(IYD)
MMU: 70337(Iyd)
MCAL: 110303822(Iyd)
MPAH: 110338417(Iyd)
RNO: 308129(Iyd)
MUN: 110563030
CGE: 100766759(Iyd)
NGI: 103745746(Iyd)
HGL: 101721889(Iyd)
CCAN: 109694205(Iyd)
OCU: 100353029(IYD)
TUP: 102468639(IYD)
CFA: 476244(IYD)
VVP: 112919440(IYD)
AML: 100476845(IYD)
UMR: 103666913(IYD)
UAH: 113259558(IYD)
ORO: 101373266(IYD)
ELK: 111158731
FCA: 101100136(IYD)
PTG: 102961413(IYD)
PPAD: 109256433(IYD)
AJU: 106976275(IYD)
BTA: 534110(IYD)
BOM: 102270351(IYD)
BIU: 109564048(IYD)
BBUB: 102415802(IYD)
CHX: 102171610(IYD)
OAS: 101123564(IYD)
SSC: 403124(IYD)
CFR: 102518380(IYD)
CDK: 105100920(IYD)
BACU: 103018668(IYD)
LVE: 103070559(IYD)
OOR: 101281121(IYD)
DLE: 111169022(IYD)
PCAD: 102982392(IYD)
ECB: 100147582(IYD)
EPZ: 103548978(IYD)
EAI: 106837202(IYD)
MYB: 102251589(IYD)
MYD: 102768666(IYD)
MNA: 107535960(IYD)
HAI: 109380862(IYD)
DRO: 112297121(IYD)
PALE: 102879253(IYD)
RAY: 107513019(IYD)
MJV: 108405632(IYD)
LAV: 100655124(IYD)
TMU: 101346269
MDO: 100032091(IYD)
SHR: 100913424(IYD)
PCW: 110208654(IYD)
OAA: 100074313(IYD)
GGA: 421631(IYD)
MGP: 100542007(IYD)
CJO: 107311580(IYD)
NMEL: 110396831(IYD)
APLA: 101792350(IYD)
ACYG: 106034300(IYD)
TGU: 100219876(IYD)
LSR: 110476008(IYD)
SCAN: 103820571(IYD)
GFR: 102034470(IYD)
FAB: 101817326(IYD)
PHI: 102107342(IYD)
PMAJ: 107202547(IYD)
CCAE: 111926697(IYD)
CCW: 104690271(IYD)
ETL: 114061120(IYD)
FPG: 101919057(IYD)
FCH: 102046732(IYD)
CLV: 102093624(IYD)
EGZ: 104133538(IYD)
NNI: 104013770(IYD)
ACUN: 113478457(IYD)
PADL: 103917035(IYD)
AAM: 106496910(IYD)
ASN: 102382246(IYD)
AMJ: 102570232(IYD)
PSS: 102454348(IYD)
CMY: 102935978(IYD)
CPIC: 101948894(IYD)
ACS: 100566819(iyd)
PVT: 110086269(IYD)
PBI: 103056683(IYD)
PMUR: 107287409(IYD)
TSR: 106551518(IYD)
PMUA: 114594248(IYD)
GJA: 107109504(IYD)
XLA: 447152(iyd.L)
XTR: 496718(iyd)
NPR: 108797441(IYD)
DRE: 100330940(si:ch211-286f9.2)
SANH: 107697889
SGH: 107558720 107590463(iyd)
CCAR: 109057743(iyd) 109060687
IPU: 108275850(iyd)
PHYP: 113530659(iyd)
AMEX: 103036643(iyd)
EEE: 113570295(iyd)
TRU: 101074588(iyd)
LCO: 104923576(iyd)
NCC: 104950033(iyd)
MZE: 101464367(iyd)
ONL: 100692784(iyd)
OLA: 111947100(iyd)
XMA: 102217045(iyd)
XCO: 114158612(iyd)
PRET: 103457674(iyd)
CVG: 107097376(iyd)
NFU: 107395153(iyd)
KMR: 108242444(iyd)
ALIM: 106520064(iyd)
AOCE: 111587259(iyd)
CSEM: 103381076(iyd)
POV: 109632477(iyd)
LCF: 108896829(iyd)
SDU: 111216311(iyd)
SLAL: 111651202(iyd)
HCQ: 109531800(iyd)
BPEC: 110156123(iyd)
MALB: 109973854(iyd)
SASA: 106608372(iyd)
SALP: 111959178(iyd)
ELS: 105017989(iyd)
SFM: 108920896(iyd)
PKI: 111841144(iyd)
LCM: 102346446(IYD)
CMK: 103179239(iyd)
RTP: 109920078(iyd)
SPU: 592720
APLC: 110984398
SKO: 100378150
DER: 6544037
DSI: Dsimw501_GD12829(Dsim_GD12829)
DSR: 110185196
DPE: 6596048
DMN: 108153127
DWI: 6646349
DAZ: 108612304
DNV: 108650180
DHE: 111604781
MDE: 101888214
LCQ: 111676833
AAG: 5572342
AALB: 109420216
AME: 413740
BIM: 100748968
BTER: 100647581
CCAL: 108632882
OBB: 114880209
SOC: 105195062
MPHA: 105832974
AEC: 105146911
ACEP: 105623675
PBAR: 105429559
VEM: 105567035
HST: 105189951
DQU: 106750633
CFO: 105256572
LHU: 105676104
PGC: 109857517
OBO: 105282046
PCF: 106789438
NVI: 100122307
CSOL: 105359306
MDL: 103576191
TCA: 654861
ATD: 109596450
NVL: 108559097
BMOR: 101741567
BMAN: 114246719
PMAC: 106711132
PRAP: 110992079
HAW: 110382329
TNL: 113493372
PXY: 105389069
BTAB: 109040035
CLEC: 106666802
ZNE: 110839726
FCD: 110843860
CEL: CELE_C02C2.5(sup-18)
CBR: CBG12270
BMY: Bm1_39515
OBI: 106878694
EPA: 110231843
AMIL: 114954678
SPIS: 111323578
DGT: 114524558
HMG: 100199794
AQU: 105316407
SDN: Sden_0863
SFR: Sfri_3203
SAZ: Sama_2969
SPL: Spea_0762
SHL: Shal_0814
SWD: Swoo_0947
SWP: swp_4286
SPSW: Sps_04908
CPS: CPS_3676
PSM: PSM_A2896
PSEO: OM33_03620
PSPO: PSPO_a0084
PART: PARC_a3728
PAGA: PAGA_a3651
AMAL: I607_13765
AMAE: I876_14150
AMAO: I634_13995
AMAD: I636_14135
AMAI: I635_14510
AMAG: I533_13755
AMAC: MASE_13720
AAUS: EP12_14500
ASP: AOR13_524
GNI: GNIT_3191
GPS: C427_0200
SAGA: M5M_17210
KGE: TQ33_1208
HOH: Hoch_2634
SIL: SPO1077
JAN: Jann_1728
PSF: PSE_4610
OTM: OSB_01100(nox)
RID: RIdsm_04696(nox_1)
MARU: FIU81_05845(fbiB)
ROT: FIV09_01195(nox)
MALU: KU6B_06870
SAL: Sala_2200
SPHI: TS85_14675
ELI: ELI_05535
ERF: FIU90_09530(yodC)
ANH: A6F65_01600(nox)
ADO: A6F68_02102(nfrA2)
TXI: TH3_16610
SFI: SFUL_5377
SALU: DC74_2304
SALL: SAZ_12880
STRE: GZL_06707
STRM: M444_24320
SRN: A4G23_00156(nox)
STRD: NI25_12565
SLAU: SLA_6171
SALJ: SMD11_5193
SLX: SLAV_12140(fbiB1)
SFK: KY5_5684c
NDK: I601_1221(nox)
SRO: Sros_1916
SEN: SACE_3932
AMD: AMED_4353
AMN: RAM_22170
AMM: AMES_4301
AMZ: B737_4301
AOI: AORI_3440
AMYY: YIM_37335(fbiB1)
SESP: BN6_24810
KAL: KALB_1623
ALO: CRK55490
SAQ: Sare_2247
CAI: Caci_2239
SNA: Snas_4783
MFF: MFFC18_12270(nox)
SGN: SGRA_2150
FLM: MY04_3755
GFO: GFO_0968
GFL: GRFL_2853
ZGA: ZOBELLIA_4305(iyd)
CTS: Ctha_1982
CPRV: CYPRO_1829
 » show all
Reference
1  [PMID:4394169]
  Authors
Rosenberg IN
  Title
Purification of iodotyrosine deiodinase from bovine thyroid.
  Journal
Metabolism 19:785-98 (1970)
DOI:10.1016/0026-0495(70)90076-4
Reference
2  [PMID:15289438]
  Authors
Gnidehou S, Caillou B, Talbot M, Ohayon R, Kaniewski J, Noel-Hudson MS, Morand S, Agnangji D, Sezan A, Courtin F, Virion A, Dupuy C
  Title
Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site.
  Journal
FASEB J 18:1574-6 (2004)
DOI:10.1096/fj.04-2023fje
  Sequence
[hsa:389434] [ssc:403124]
Reference
3  [PMID:16316988]
  Authors
Friedman JE, Watson JA Jr, Lam DW, Rokita SE
  Title
Iodotyrosine deiodinase is the first mammalian member of the NADH oxidase/flavin  reductase superfamily.
  Journal
J Biol Chem 281:2812-9 (2006)
DOI:10.1074/jbc.M510365200
Reference
4  [PMID:19436071]
  Authors
Thomas SR, McTamney PM, Adler JM, Laronde-Leblanc N, Rokita SE
  Title
Crystal structure of iodotyrosine deiodinase, a novel flavoprotein responsible for iodide salvage in thyroid glands.
  Journal
J Biol Chem 284:19659-67 (2009)
DOI:10.1074/jbc.M109.013458
  Sequence
[mmu:70337]
Other DBs
ExplorEnz - The Enzyme Database: 1.21.1.1
IUBMB Enzyme Nomenclature: 1.21.1.1
ExPASy - ENZYME nomenclature database: 1.21.1.1
BRENDA, the Enzyme Database: 1.21.1.1

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