KEGG   ENZYME: 1.21.3.1
Entry
EC 1.21.3.1                 Enzyme                                 

Name
isopenicillin-N synthase;
isopenicillin N synthetase
Class
Oxidoreductases;
Catalysing the reaction X-H + Y-H = X-Y;
With oxygen as acceptor
Sysname
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine:oxygen oxidoreductase (cyclizing)
Reaction(IUBMB)
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = isopenicillin N + 2 H2O
Reaction(KEGG)
(other) R04872
Substrate
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine;
O2 [CPD:C00007]
Product
isopenicillin N [CPD:C05557];
H2O [CPD:C00001]
Comment
Forms part of the penicillin biosynthesis pathway (for pathway, click here).
History
EC 1.21.3.1 created 2002
Pathway
ec00311  Penicillin and cephalosporin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K04126  isopenicillin-N synthase
Genes
FCD: 110843583
ANI: AN2622.2
AOR: AO090038000544
AFV: AFLA_009030
PCS: Pc21g21380(ips)
ABE: ARB_02225
TVE: TRV_00552
SCT: SCAT_5683(pcbC)
SCY: SCATT_56830
SCLF: BB341_07795
AMYY: YIM_39180(cefE1)
 » show all
Reference
1  [PMID:1588566]
  Authors
Huffman GW, Gesellchen PD, Turner JR, Rothenberger RB, Osborne HE, Miller FD, Chapman JL, Queener SW.
  Title
Substrate specificity of isopenicillin N synthase.
  Journal
J Med Chem 35:1897-914 (1992)
DOI:10.1021/jm00088a028
Reference
2  [PMID:7791906]
  Authors
Roach PL, Clifton IJ, Fulop V, Harlos K, Barton GJ, Hajdu J, Andersson I, Schofield CJ, Baldwin JE
  Title
Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes.
  Journal
Nature 375:700-4 (1995)
DOI:10.1038/375700a0
  Sequence
[ani:AN2622.2]
Other DBs
ExplorEnz - The Enzyme Database: 1.21.3.1
IUBMB Enzyme Nomenclature: 1.21.3.1
ExPASy - ENZYME nomenclature database: 1.21.3.1
BRENDA, the Enzyme Database: 1.21.3.1
CAS: 78642-31-6

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