KEGG   ENZYME: 1.21.3.1
Entry
EC 1.21.3.1                 Enzyme                                 
Name
isopenicillin-N synthase;
isopenicillin N synthetase
Class
Oxidoreductases;
Catalysing the reaction X-H + Y-H = X-Y;
With oxygen as acceptor
Sysname
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine:oxygen oxidoreductase (cyclizing)
Reaction(IUBMB)
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = isopenicillin N + 2 H2O
Reaction(KEGG)
(other) R04872
Substrate
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine;
O2 [CPD:C00007]
Product
isopenicillin N [CPD:C05557];
H2O [CPD:C00001]
Comment
Forms part of the penicillin biosynthesis pathway (for pathway, click here).
History
EC 1.21.3.1 created 2002
Pathway
ec00311  Penicillin and cephalosporin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K04126  isopenicillin-N synthase
Genes
BCOO119077147
FCD110843583
ANIAN2622.2
AORAO090038000544
AFVAFLA_009030
APUUAPUU_12363A
PCSPc21g21380(ips)
ABEARB_02225
TVETRV_00552
SCTSCAT_5683(pcbC)
SCYSCATT_56830
SCLFBB341_07795
STIRDDW44_23090
AABA4R43_03225
AMYYYIM_39180(cefE1)
PSUUPsuf_059690
 » show all
Reference
1  [PMID:1588566]
  Authors
Huffman GW, Gesellchen PD, Turner JR, Rothenberger RB, Osborne HE, Miller FD, Chapman JL, Queener SW.
  Title
Substrate specificity of isopenicillin N synthase.
  Journal
J Med Chem 35:1897-914 (1992)
DOI:10.1021/jm00088a028
Reference
2  [PMID:7791906]
  Authors
Roach PL, Clifton IJ, Fulop V, Harlos K, Barton GJ, Hajdu J, Andersson I, Schofield CJ, Baldwin JE
  Title
Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes.
  Journal
Nature 375:700-4 (1995)
DOI:10.1038/375700a0
  Sequence
[ani:AN2622.2]
Other DBs
ExplorEnz - The Enzyme Database: 1.21.3.1
IUBMB Enzyme Nomenclature: 1.21.3.1
ExPASy - ENZYME nomenclature database: 1.21.3.1
BRENDA, the Enzyme Database: 1.21.3.1
CAS: 78642-31-6

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