tetrahydrocannabinolic acid synthase;
Delta1-tetrahydrocannabinolic acid synthase
Catalysing the reaction X-H + Y-H = X-Y;
With oxygen as acceptor
cannabigerolate:oxygen oxidoreductase (cyclizing, Delta9-tetrahydrocannabinolate-forming)
cannabigerolate + O2 = Delta9-tetrahydrocannabinolate + H2O2 [RN:
A flavoprotein (FAD). The cofactor is covalently bound. Part of the cannabinoids biosynthetic pathway in the plant Cannabis sativa. The enzyme can also convert cannabinerolate (the (Z)-isomer of cannabigerolate) to Delta9-THCA with lower efficiency. Whereas the product was originally called Delta1-tetrahydrocannabinolate, the recommended name according to systematic peripheral numbering is Delta9-tetrahydrocannabinolate.
EC 126.96.36.199 created 2012
ec00999 Biosynthesis of various plant secondary metabolites
ec01110 Biosynthesis of secondary metabolites
K20501 tetrahydrocannabinolic acid synthase
CSAV: 115696884 115697880 Taxonomy
Taura, F., Morimoto, S. Shoyama, Y. and Mechoulam, R.
First direct evidence for the mechanism of Delta1-tetrahydrocannabinolic acid biosynthesis.
J Am Chem Soc 117:9766-9767 (1995)
Sirikantaramas S, Morimoto S, Shoyama Y, Ishikawa Y, Wada Y, Shoyama Y, Taura F
The gene controlling marijuana psychoactivity: molecular cloning and heterologous expression of Delta1-tetrahydrocannabinolic acid synthase from Cannabis sativa L.
Shoyama Y, Takeuchi A, Taura F, Tamada T, Adachi M, Kuroki R, Shoyama Y, Morimoto S
Crystallization of Delta1-tetrahydrocannabinolic acid (THCA) synthase from Cannabis sativa.
Shoyama Y, Tamada T, Kurihara K, Takeuchi A, Taura F, Arai S, Blaber M, Shoyama Y, Morimoto S, Kuroki R
Structure and function of 1-tetrahydrocannabinolic acid (THCA) synthase, the enzyme controlling the psychoactivity of Cannabis sativa.
ExplorEnz - The Enzyme Database: 188.8.131.52
ExPASy - ENZYME nomenclature database: 184.108.40.206