tetrahydrocannabinolic acid synthase;
Delta1-tetrahydrocannabinolic acid synthase
Catalysing the reaction X-H + Y-H = X-Y;
With oxygen as acceptor
cannabigerolate:oxygen oxidoreductase (cyclizing, Delta9-tetrahydrocannabinolate-forming)
cannabigerolate + O2 = Delta9-tetrahydrocannabinolate + H2O2 [RN:
A flavoprotein (FAD). The cofactor is covalently bound. Part of the cannabinoids biosynthetic pathway in the plant Cannabis sativa. The enzyme can also convert cannabinerolate (the (Z)-isomer of cannabigerolate) to Delta9-THCA with lower efficiency. Whereas the product was originally called Delta1-tetrahydrocannabinolate, the recommended name according to systematic peripheral numbering is Delta9-tetrahydrocannabinolate.
EC 188.8.131.52 created 2012
ec00999 Biosynthesis of various plant secondary metabolites
ec01110 Biosynthesis of secondary metabolites
K20501 tetrahydrocannabinolic acid synthase
Taura, F., Morimoto, S. Shoyama, Y. and Mechoulam, R.
First direct evidence for the mechanism of Delta1-tetrahydrocannabinolic acid biosynthesis.
J Am Chem Soc 117:9766-9767 (1995)
Sirikantaramas S, Morimoto S, Shoyama Y, Ishikawa Y, Wada Y, Shoyama Y, Taura F
The gene controlling marijuana psychoactivity: molecular cloning and heterologous expression of Delta1-tetrahydrocannabinolic acid synthase from Cannabis sativa L.
Shoyama Y, Takeuchi A, Taura F, Tamada T, Adachi M, Kuroki R, Shoyama Y, Morimoto S
Crystallization of Delta1-tetrahydrocannabinolic acid (THCA) synthase from Cannabis sativa.
Shoyama Y, Tamada T, Kurihara K, Takeuchi A, Taura F, Arai S, Blaber M, Shoyama Y, Morimoto S, Kuroki R
Structure and function of 1-tetrahydrocannabinolic acid (THCA) synthase, the enzyme controlling the psychoactivity of Cannabis sativa.
ExplorEnz - The Enzyme Database: 184.108.40.206
ExPASy - ENZYME nomenclature database: 220.127.116.11