cannabidiolic acid synthase;
Catalysing the reaction X-H + Y-H = X-Y;
With oxygen as acceptor
cannabigerolate:oxygen oxidoreductase (cyclizing, cannabidiolate-forming)
cannabigerolate + O2 = cannabidiolate + H2O2 [RN:
Binds FAD covalently. Part of the cannabinoids biosynthetic pathway of the plant Cannabis sativa. The enzyme can also convert cannabinerolate to cannabidiolate with lower efficiency.
EC 220.127.116.11 created 2012
ec00999 Biosynthesis of various plant secondary metabolites
ec01110 Biosynthesis of secondary metabolites
K20502 cannabidiolic acid synthase
Taura F, Morimoto S, Shoyama Y
Purification and characterization of cannabidiolic-acid synthase from Cannabis sativa L.. Biochemical analysis of a novel enzyme that catalyzes the oxidocyclization of cannabigerolic acid to cannabidiolic acid.
Taura F, Sirikantaramas S, Shoyama Y, Yoshikai K, Shoyama Y, Morimoto S
Cannabidiolic-acid synthase, the chemotype-determining enzyme in the fiber-type Cannabis sativa.
ExplorEnz - The Enzyme Database: 18.104.22.168
ExPASy - ENZYME nomenclature database: 22.214.171.124