Entry
Name
PqqA peptide cyclase;
pqqE (gene name)
Class
Oxidoreductases;
Catalysing the reaction X-H + Y-H = X-Y;
With other, known, physiological acceptors
BRITE hierarchy
Sysname
PqqA peptide:S-adenosyl-L-methionine oxidoreductase (cyclizing)
Reaction(IUBMB)
a PqqA peptide + S-adenosyl-L-methionine = a PqqA peptide with linked Glu-Tyr residues + 5'-deoxyadenosine + L-methionine
Substrate
PqqA peptide;
S-adenosyl-L-methionine [CPD:
C00019 ]
Product
PqqA peptide with linked Glu-Tyr residues;
5'-deoxyadenosine [CPD:
C05198 ];
L-methionine [CPD:
C00073 ]
Comment
This bacterial enzyme, which is a member of the radical SAM protein family, catalyses the formation of a C-C bond between C-4 of glutamate and C-3 of tyrosine residues of the PqqA protein (which are separated by three amino acid residues). This is the first enzymic step in the biosynthesis of the bacterial enzyme cofactor pyrroloquinoline quinone (PQQ). The reaction is dependent on the presence of a reductant (flavodoxin) and the accessory protein PqqD.
History
EC 1.21.98.4 created 2018
Orthology
Genes
CLAP : NCTC11466_01757(moaA)
SMW : SMWW4_v1c09280(pqqE1) SMWW4_v1c24110(pqqE2)
SFJ : SAMEA4384070_2478(moaA_1)
SOF : NCTC11214_04411(moaA)
SNEM : NLX84_04535(pqqE) NLX84_12230(pqqE)
SSAR : SSARUM_002331(pqqE)
TPTY : NCTC11468_01821(moaA)
XFU : XFF4834R_chr15150(pqqE)
XPH : XppCFBP6546_03190(pqqE)
XHD : LMG31886_12310(pqqE)
PAEB : NCGM1900_4498(pqqE)
PCQ : PcP3B5_36390(moaA_3)
PPRC : PFLCHA0_c56280(pqqE2)
PZA : HU749_011875(pqqE) HU749_027350(pqqE)
PMUD : NCTC8068_04902(pqqE2)
PFW : PF1751_v1c50290(pqqE)
PBA : PSEBR_a2039 PSEBR_a5169
PPUU : PputUW4_02938(pqqE1) PputUW4_04969(pqqE2)
PFK : PFAS1_13845 PFAS1_27345
PSIL : PMA3_15635 PMA3_27715
PUM : HGP31_10670(pqqE) HGP31_20480(pqqE) HGP31_28635(pqqE)
PTRT : HU722_0027030(pqqE)
PAZE : KSS91_16390(pqqE) KSS91_26410(pqqE)
PTW : TUM18999_41790(pqqE)
PTAE : NCTC10697_00434(pqqE2)
PPHN : HU825_14935(pqqE) HU825_14975(pqqE)
PIZ : LAB08_R21590(pqqE) LAB08_R32420(pqqE) LAB08_R55640(pqqE)
PKM : PZ739_01940(pqqE) PZ739_11970(pqqE)
PNB : NK667_14190(pqqE) NK667_30285(pqqE)
PKJ : Q1W70_12680(pqqE) Q1W70_24555(pqqE)
PHOM : KJF94_12730(pqqE) KJF94_23995(pqqE)
PCUC : PSH97_12370(pqqE) PSH97_25580(pqqE)
PHF : NLY38_13830(pqqE) NLY38_14650(pqqE)
PSR : PSTAA_2101(pqqE-2) PSTAA_2108(pqqE)
PSC : A458_10365 A458_10410
PSJ : PSJM300_11100 PSJM300_11160
PSH : Psest_2270 Psest_2279
PSTU : UIB01_11565 UIB01_11600
PSED : DM292_08980(pqqE) DM292_09025
PCHL : LLJ08_10810(pqqE) LLJ08_10855(pqqE)
PBM : CL52_09085 CL52_09120
PKG : LW136_11695(pqqE) LW136_11740(pqqE)
SDEG : GOM96_01940(pqqE) GOM96_01980(pqqE)
PBAU : OS670_03750(pqqE) OS670_03820(pqqE)
MLQ : ASQ50_06675 ASQ50_07920
MARA : D0851_08185(pqqE) D0851_09770(pqqE)
MSHE : MAALD49_33520(pqqE)
MANP : EHN06_16380(pqqE) EHN06_17405(pqqE)
MMEE : NLK58_09000(pqqE) NLK58_10420(pqqE)
MISZ : MishRS11D_21300(pqqE)
GAI : IMCC3135_24225(mftC)
HSV : HNO53_16555(pqqE) HNO53_16620(pqqE) HNO53_19020(pqqE)
HCAM : I4484_16065(pqqE) I4484_16125(pqqE) I4484_18745(pqqE)
HSX : HNO51_15990(pqqE) HNO51_16050(pqqE) HNO51_18700(pqqE)
HTX : EKK97_04775(pqqE) EKK97_18140(pqqE) EKK97_20955(pqqE)
PSE : NH8B_3462(pqqE) NH8B_4040(pqqE)
CNC : CNE_2c10110(pqqE) CNE_BB1p04390(pqqE)
CTI : RALTA_B0442(pqqE2) RALTA_B0668(pqqE1)
PSPW : BJG93_19555(pqqE) BJG93_33570(pqqE)
PDIO : PDMSB3_0595.1(pqqE)
PHUN : U0042_02475(pqqE) U0042_22610(pqqE)
PLG : NCTC10937_04973(moaA_2)
BUE : BRPE67_BCDS01120(pqqE)
TVL : FAZ95_12180(pqqE) FAZ95_34025(pqqE)
TCAR : U0034_08760(pqqE) U0034_17375(pqqE)
VAE : RZE79_09860(pqqE) RZE79_30630(pqqE)
DLS : P4826_09880(pqqE) P4826_10545(pqqE)
SMIO : CATMQ487_25520(pqqE)
AZA : AZKH_0824(pqqE) AZKH_1538(pqqE)
AZD : CDA09_04515 CDA09_08755
THAG : CKCBHOJB_02610(mftC_2) CKCBHOJB_03002(mftC_3)
AZQ : G3580_07735(pqqE) G3580_12720(pqqE)
SMEL : SM2011_b20208(pqqE)
SFH : SFHH103_05873(pqqE) SFHH103_06434(pqqE)
SFD : USDA257_c31250(pqqE)
SIX : BSY16_5730(pqqE) BSY16_6310(pqqE)
SAME : SAMCFNEI73_pC0402(pqqE)
RGA : RGR602_PC01538(pqqE)
NEN : NCHU2750_46890(pqqE)
BSEP : HAP48_0003620(pqqE)
BCAN : BcanWSM471_29725(pqqE)
VGO : GJW-30_1_00290(albA)
MAQU : Maq22A_c05275(pqqE)
MMES : MMSR116_16620(pqqE)
MTUN : MTUNDRAET4_0660(pqqE)
HDT : HYPDE_25328 HYPDE_28398 HYPDE_31223
FIL : BN1229_v1_0593(pqqE)
FIY : BN1229_v1_0595(pqqE)
RLI : RLO149_c036960(pqqE)
RMM : ROSMUCSMR3_01477(mftC)
AALU : ABWI00_03280 ABWI00_07880(pqqE) ABWI00_18870(pqqE)
SHO : SHJGH_0452 SHJGH_2194
SGS : AVL59_04180 AVL59_14250
SGM : GCM10017557_13140(pqqE)
SPUN : BFF78_08675 BFF78_37920 BFF78_41175
SCHA : CP983_07760(pqqE) CP983_17435(pqqE)
SGOB : test1122_26290(pqqE)
SMIB : SMIR_03230(pqqE) SMIR_05295
STRL : HEP84_40245 HEP84_41265(pqqE)
AGRA : AGRA3207_007108(pqqE)
SACG : FDZ84_00630(pqqE) FDZ84_32315(pqqE)
ARHD : VSH64_08510(pqqE) VSH64_15860(pqqE) VSH64_21105(pqqE)
AMYZ : HUW46_05812(mftC_2)
ACAB : QRX50_06445(pqqE) QRX50_28870(pqqE) QRX50_38170(pqqE)
AMYD : K1T34_19635(pqqE) K1T34_38390(pqqE) K1T34_39125(pqqE)
ABAR : AMYBAR_004750(pqqE) AMYBAR_005074(pqqE)
PSEE : FRP1_13220 FRP1_13965
PSEQ : AD006_20900 AD006_21630
PECQ : AD017_00480 AD017_01215
» show all
Taxonomy
Reference
Authors
Wecksler SR, Stoll S, Iavarone AT, Imsand EM, Tran H, Britt RD, Klinman JP
Title
Interaction of PqqE and PqqD in the pyrroloquinoline quinone (PQQ) biosynthetic pathway links PqqD to the radical SAM superfamily.
Journal
Reference
Authors
Latham JA, Iavarone AT, Barr I, Juthani PV, Klinman JP
Title
PqqD is a novel peptide chaperone that forms a ternary complex with the radical S-adenosylmethionine protein PqqE in the pyrroloquinoline quinone biosynthetic pathway.
Journal
Reference
Authors
Barr I, Latham JA, Iavarone AT, Chantarojsiri T, Hwang JD, Klinman JP
Title
Demonstration That the Radical S-Adenosylmethionine (SAM) Enzyme PqqE Catalyzes de Novo Carbon-Carbon Cross-linking within a Peptide Substrate PqqA in the Presence of the Peptide Chaperone PqqD.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 1.21.98.4